Patents by Inventor Kaw-Yan Chua
Kaw-Yan Chua has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9447154Abstract: Isolated nucleic acids encoding an allergen of Dermatophagoides pteronyssinus, Der p III, are disclosed. A cDNA encoding a peptide having a Der p III activity and a predicted molecular weight of about 24,985 daltons is also described. The nucleic acids can be used as probes to detect the presence of Der p III nucleic acid in a sample or for the recombinant production of peptides having an activity of Der p III. Peptides having an activity of Der p III can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to house dust mites.Type: GrantFiled: January 23, 2009Date of Patent: September 20, 2016Assignee: MERCK PATENT GMBHInventors: Wayne R. Thomas, Kaw-Yan Chua, Bruce L. Rogers, Mei-chang Kuo
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Patent number: 8541000Abstract: The present invention relates to a new variant of the group 2 allergen from the house dust mite Dermatophagoides pteronyssinus, named Der p 2 variant, and uses thereof. The new variant exhibits cDNA and protein sequence diversity from other known Der p 2 variants.Type: GrantFiled: December 30, 2008Date of Patent: September 24, 2013Inventors: Kaw Yan Chua, Keh-Liang Lin, I-Chun Kuo, Chiung-Hui Huang
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Patent number: 8349334Abstract: We describe an Fve polypeptide being a fragment, homologue, variant or derivative of Fve protein, which comprises at least one biological activity of Fve protein. uses of such a polypeptide, etc, and nucleic acids encoding these, in the treatment and prevention of allergy and cancer are also disclosed.Type: GrantFiled: June 30, 2011Date of Patent: January 8, 2013Assignees: National University of Singapore, Agency for Science and ResearchInventors: Kaw Yan Chua, See Voon Seow, Prasanna Ratnakar Kolatkar
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Patent number: 8287875Abstract: Isolated nucleic acids encoding an allergen of Dermatophagoides pteronyssinus, Der p III, are disclosed. A cDNA encoding a peptide having a Der p III activity and a predicted molecular weight of about 24,985 daltons is also described. The nucleic acids can be used as probes to detect the presence of Der p III nucleic acid in a sample or for the recombinant production of peptides having an activity of Der p III. Peptides having an activity of Der p III can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to house dust mites.Type: GrantFiled: January 15, 2010Date of Patent: October 16, 2012Assignee: Merck Patent GmbHInventors: Wayne R. Thomas, Kaw-Yan Chua, Bruce L. Rogers, Mei-Chang Kuo
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Publication number: 20120003259Abstract: We describe an Fve polypeptide being a fragment, homologue, variant or derivative of Fve protein, which comprises at least one biological activity of Fve protein. uses of such a polypeptide, etc, and nucleic acids encoding these, in the treatment and prevention of allergy and cancer are also disclosed.Type: ApplicationFiled: June 30, 2011Publication date: January 5, 2012Applicants: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH, NATIONAL UNIVERSITY OF SINGAPOREInventors: Kaw Yan Chua, See Voon Seow, Prasanna Ratnakar Kolatkar
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Publication number: 20110318274Abstract: The present invention relates to a new variant of the group 2 allergen from the house dust mite Dermatophagoides pteronyssinus, named Der p 2 variant, and uses thereof. The new variant exhibits cDNA and protein sequence diversity from other known Der p 2 variants.Type: ApplicationFiled: December 30, 2008Publication date: December 29, 2011Inventors: Kaw Yan Chua, Keh-Liang Lin, I-Chun Kuo, Chiung-Hui Huang
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Nucleic acid molecules encoding a house dust mite allergen Der f VII, and antigenic peptides thereof
Patent number: 8003382Abstract: Isolated nucleic acids encoding allergens of the species Dermatophagoides pteronyssinus and Dermatophagoides farinae, Der p VII and Der f VII, respectively, are disclosed. A cDNA encoding a peptide having a Der p VII activity and a predicted molecular weight of about 22, 177 daltons is described. A cDNA encoding a peptide having Der f VII activity is also described. The nucleic acids of the invention can be used as probes to detect the presence of Der p VII or Der f VII nucleic acid in a sample or for the recombinant production of peptides having a Der p VII or Der f VII activity. Peptides having a Der p VII or Der f VII activity can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to house dust mite allergens.Type: GrantFiled: March 17, 2005Date of Patent: August 23, 2011Assignee: Merck Patent GmbHInventors: Wayne R. Thomas, Kaw-Yan Chua -
Patent number: 7998701Abstract: We describe an Fve polypeptide being a fragment, homologue, variant or derivative of Fve protein, which comprises at least one biological activity of Fve protein. Uses of such a polypeptide, etc, and nucleic acids encoding these, in the treatment and prevention of allergy and cancer are also disclosed.Type: GrantFiled: April 16, 2004Date of Patent: August 16, 2011Assignees: National University of Singapore, Agency for Science, Technology and Research (A*STAR)Inventors: Kaw Yan Chua, See Voon Seow, Prasanna Ratnakar Kolatkar
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Publication number: 20110117116Abstract: Isolated nucleic acids encoding an allergen of Dermatophagoides pteronyssinus, Der p III, are disclosed. A cDNA encoding a peptide having a Der p III activity and a predicted molecular weight of about 24,985 daltons is also described. The nucleic acids can be used as probes to detect the presence of Der p III nucleic acid in a sample or for the recombinant production of peptides having an activity of Der p III. Peptides having an activity of Der p III can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to house dust mites.Type: ApplicationFiled: January 15, 2010Publication date: May 19, 2011Applicant: MERCK PATENT GmbHInventors: Wayne R. THOMAS, Kaw-Yan Chua, Bruce L. Rogers, Mei-chang Kuo
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Publication number: 20110059522Abstract: Isolated nucleic acids encoding an allergen of Dermatophagoides pteronyssinus, Der p III, are disclosed. A cDNA encoding a peptide having a Der p III activity and a predicted molecular weight of about 24,985 daltons is also described. The nucleic acids can be used as probes to detect the presence of Der p III nucleic acid in a sample or for the recombinant production of peptides having an activity of Der p III. Peptides having an activity of Der p III can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to house dust mites.Type: ApplicationFiled: January 23, 2009Publication date: March 10, 2011Applicant: Merck Patent GmbHInventors: Wayne R. THOMAS, Kaw-Yan Chua, Bruce L. Rogers, Mei-chang Kuo
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Patent number: 7666429Abstract: Isolated nucleic acids encoding an allergen of Dermatophagoides pteronyssinus, Der p III, are disclosed. A cDNA encoding a peptide having a Der p III activity and a predicted molecular weight of about 24,985 daltons is also described. The nucleic acids can be used as probes to detect the presence of Der p III nucleic acid in a sample or for the recombinant production of peptides having an activity of Der p III. Peptides having an activity of Der p III can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to house dust mites.Type: GrantFiled: May 14, 2004Date of Patent: February 23, 2010Assignee: Merck Patent GmbHInventors: Wayne R. Thomas, Kaw-Yan Chua, Bruce L. Rogers, Mei-Chang Kuo
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Publication number: 20090169582Abstract: The invention relates to recombinant lactobacillus, use of the same and a pharmaceutical composition including the same. The recombinant lactobacillus includes a heterologous nucleic acid sequence. The heterologous nucleic acid sequence encodes at least an immunogenic fragment of the mite allergens Der p 1, Der p 2, or Blo t 5, or an immunogenic homolog thereof. A respective fragment of Der p 1 includes at least 8% of the amino acid sequence of the mite allergen. A method of modulating the immune response to an allergen in a mammal as well as a pharmaceutical composition and a kit are also disclosed.Type: ApplicationFiled: April 4, 2007Publication date: July 2, 2009Applicant: NATIONAL UNIVERSITY OF SINGAPOREInventors: Kaw Yan Chua, Lay Hong Renee Lim, Li Kiang Tan
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Publication number: 20090130130Abstract: There is provided an isolated polypeptide, derivative, isoform and/or fragment thereof, wherein the polypeptide is a mutant of a Group 5 allergen. There are also provided pharmaceutical compositions(s) and vaccine(s) for the treatment of subjects allergic to at least one Group 5 allergen.Type: ApplicationFiled: June 9, 2006Publication date: May 21, 2009Applicant: NATIONAL UNIVERSITY OF SINGAPOREInventors: Kaw Yan Chua, Fong Cheng Yi
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Publication number: 20060008873Abstract: Isolated DNA encoding allergens of Dermatophagoides (house dust mites) particularly of the species Dermatophagoides farinae and Dermatophagolides pteronyssinus, which are protein allergens or peptides which include at least one epitope of the protein allergen. In particular, DNA encoding two major D. farinae allergens, Der f I and Der f II and DNA encoding a D. pteronyssinus allergen, Der p I. In addition, the proteins or peptides encoded by the isolated DNA, their use as diagnostic and therapeutic reagents and methods of diagnosing and treating sensitivity to house dust mite allergens.Type: ApplicationFiled: December 23, 2003Publication date: January 12, 2006Inventors: Wayne Thomas, Kaw-Yan Chua
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Publication number: 20050260218Abstract: Isolated nucleic acids encoding allergens of the species Dermatophagoides pteronyssinus and Dermatophagoides farinae, Der p VII and Der f VII, respectively, are disclosed. A cDNA encoding a peptide having a Der p VII activity and a predicted molecular weight of about 22, 177 daltons is described. A cDNA encoding a peptide having Der f VII activity is also described. The nucleic acids of the invention can be used as probes to detect the presence of Der p VII or Der f VII nucleic acid in a sample or for the recombinant production of peptides having a Der p VII or Der f VII activity. Peptides having a Der p VII or Der f VII activity can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to house dust mite allergens.Type: ApplicationFiled: March 17, 2005Publication date: November 24, 2005Inventors: Wayne Thomas, Kaw-Yan Chua
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Patent number: 6905845Abstract: Isolated nucleic acids encoding allergens of the species Dermatophagoides pteronyssinus and Dermatophagoides farinae, Der p VII and Der f VII, respectively, are disclosed. A cDNA encoding a peptide having a Der p VII activity and a predicted molecular weight of about 22, 177 daltons is described. A cDNA encoding a peptide having Der f VII activity is also described. The nucleic acid of the invention can be used as probes to detect the presence of Der p VII or Der f VII nucleotide acid in a sample or for the recombinant production of peptides having a Der p VII or Der f VII activity. Peptides having a Der p VII or Der f VII activity can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to house dust mite allergens.Type: GrantFiled: December 19, 2001Date of Patent: June 14, 2005Assignee: Heska CorporationInventors: Wayne Robert Thomas, Kaw-Yan Chua
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Publication number: 20050123569Abstract: Isolated nucleic acids encoding an allergen of Dermatophagoides pteronyssinus, Der p III, are disclosed. A cDNA encoding a peptide having a Der p III activity and a predicted molecular weight of about 24,985 daltons is also described. The nucleic acids can be used as probes to detect the presence of Der p III nucleic acid in a sample or for the recombinant production of peptides having an activity of Der p III. Peptides having an activity of Der p III can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to house dust mites.Type: ApplicationFiled: May 14, 2004Publication date: June 9, 2005Inventors: Wayne Thomas, Kaw-Yan Chua, Bruce Rogers, Mei-chang Kuo
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Patent number: 6849427Abstract: A novel protein allergen Der p VII of Dermatophagoides pteronyssinus is described. A cDNA clone encoding Der p VII was isolated from a ?gt11 library of D. pteronyssinus cDNA. The nucleic acid sequence of Der p VII encodes a 198 residue mature processed protein having a predicted molecular weight of 22,177 daltons. Der p VII protein may be used as the active ingredient in therapeutic composition for the treatment of sensitivity to house dust mites. The protein may also be used in methods of diagnosing such sensitivity.Type: GrantFiled: June 22, 1993Date of Patent: February 1, 2005Assignee: ImmuLogic Pharmaceutical Corp.Inventors: Wayne Robert Thomas, Kaw-Yan Chua
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Patent number: 6752991Abstract: Isolated nucleic acids encoding an allergen of Dermatophagoides pteronyssinus, Der p III, are disclosed. A cDNA encoding a peptide having a Der p III activity and a predicted molecular weight of about 24,985 daltons is also described. The nucleic acids can be used as probes to detect the presence of Der p III nucleic acid in a sample or for the recombinant production of peptides having an activity of Der p III. Peptides having an activity of Der p III can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to house dust mites.Type: GrantFiled: June 5, 1995Date of Patent: June 22, 2004Assignee: Immulogic Pharmaceutical Co.Inventors: Wayne R. Thomas, Kaw-Yan Chua, Bruce L. Rogers, Mei-chang Kuo
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Patent number: 6689876Abstract: Isolated DNA encoding allergens of Dermatophagoides (house dust mites) particularly of the species Dermatophagoides farinae and Dermatophagoides pteronyssinus, which are protein allergens or peptides which include at least one epitope of the protein allergen. In particular, DNA encoding two major D. farinae allergens, Der f I and Der f II and DNA encoding a D. pteronyssinus allergen, Der p I. In addition, the proteins or peptides encoded by the isolated DNA, their use as diagnostic and therapeutic reagents and methods of diagnosing and treating sensitivity to house dust mite allergens.Type: GrantFiled: December 29, 1993Date of Patent: February 10, 2004Assignee: Immulogic Pharmaceutical CorporationInventors: Wayne Robert Thomas, Kaw-Yan Chua