Abstract: Provided are methods for treating various spondyloarthritic and psoriatic conditions, including types of axial spondyloarthritis (axSpA), psoriatic arthritis (PsA), and psoriasis (PsO), with the JAK1 inhibitor, upadacitinib free base or pharmaceutically acceptable salt thereof. In various aspects, provided are methods for treating active non-radiographic axSpA (nr-axSpA), methods for treating active ankylosing spondylitis (AS), methods for treating active psoriatic arthritis (PsA), and methods for treating active psoriasis (PsO).

Abstract: The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-?]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthrritis), kits, methods of synthesis, and products-by -process.

Abstract: The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-?]pyrrolo[2.3-]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis), kits, methods of synthesis, and products-by-process.

Abstract: The present disclosure relates to pharmaceutical compositions of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and corresponding methods of treating psoriatic arthritis.

Abstract: Provided are methods for treating various spondyloarthritic and psoriatic conditions, including types of axial spondyloarthritis (axSpA), psoriatic arthritis (PsA), and psoriasis (PsO), with the JAK1 inhibitor, upadacitinib free base or pharmaceutically acceptable salt thereof. In various aspects, provided are methods for treating active non-radiographic axSpA (nr-axSpA), methods for treating active ankylosing spondylitis (AS), methods for treating active psoriatic arthritis (PsA), and methods for treating active psoriasis (PsO).

Abstract: A diaper system is provided for adapting an adjustable diaper to accommodate different individuals and their growth. The adjustable diaper may include an insertion assembly and a cover assembly. The cover assembly has an interior surface and an exterior surface on opposing sides of its wing shape, forming an anterior wing end and a posterior wing end interconnected by a crotch portion. Along and inward from each wing end of each surface the cover assembly may provide a plurality of waist fasteners of adjustably securing the adjustable diaper about the ever-growing waist of a wearer. The exterior surface between the anterior and the posterior wing ends provides a plurality of fasteners for adapting the height and width of the adjustable diaper. The insertion assembly may be removably secured within pockets formed on both ends of the interior surface of the cover assembly for easy replacement.

Abstract: Methods, systems, and products for abstracting business logic into centralized database controls are disclosed herein. In one general embodiment, a method, executed by a computer system, includes identifying data use code in business logic: analyzing the data use code to determine a general data model: and implementing the general data model in the centralized database controls. The general data model is an abstraction embodying the functionality inherent in the data use code. In specific embodiments, identifying data use code in the business logic may be carried out by identifying the data use code in at least one subcomponent of the business logic, such as a user interface code component, a database coding, a table, or a file. The computer system may remove the data use code from the business logic or designate the data use code for removal.

Abstract: Methods, systems, and products for abstracting business logic into centralized database controls are disclosed herein. In one general embodiment, a method, executed by a computer system, includes identifying data use code in business logic: analyzing the data use code to determine a general data model: and implementing the general data model in the centralized database controls. The general data model is an abstraction embodying the functionality inherent in the data use code. In specific embodiments, identifying data use code in the business logic may be carried out by identifying the data use code in at least one subcomponent of the business logic, such as a user interface code component, a database coding, a table, or a file. The computer system may remove the data use code from the business logic or designate the data use code for removal.

Abstract: A system, method, and computer program product for benchmarking a stream processing system are disclosed. The method comprises generating a plurality of correlated test streams. A semantically related data set is embedded within each of the test streams in the plurality of correlated test streams. The plurality of correlated test streams is provided to at least one stream processing system. A summary is generated for each of the semantically related embedded data sets. A common identifier, which is transparent to the system being tested, is embedded within each stream in the plurality of correlated test streams. The common identifier is extracted from the output data set generated by the stream processing system. At least one of the stored copies of the summaries and the common identifier are compared to an output data set including a set of zero or more correlation results generated by the stream processing system.

Abstract: An automatic planning system is provided for stream processing workflow composition. End users provide requests to the automatic planning system. The requests are goal-based problems to be solved by the automatic planning system, which then generates plan graphs to form stream processing applications. A scheduler deploys and schedules the stream processing applications for execution within an operating environment. The operating environment then returns the results to the end users.

Abstract: A system and method for workload generation include a processor for identifying a workload model by determining each of a hierarchy for workload generation, time scales for workload generation, and states and transitions at each of the time scales, and defining a parameter by determining each of fields for user specific attributes, application specific attributes, network specific attributes, content specific attributes, and a probability distribution function for each of the attributes; a user level template unit corresponding to a relatively slow time scale in signal communication with the processor; an application level template corresponding to a relatively faster time scale in signal communication with the processor; a stream level template corresponding to a relatively fastest time scale in signal communication with the processor; and a communications adapter in signal communication with the processor for defining a workload generating unit responsive to the template units.

Abstract: An exemplary method is provided for managing and mitigating security risks through planning. A first security-related information of a requested product is received. A second security-related information of resources that are available for producing the requested product is received. A multi-stage process with security risks managed by the first security-related information and the second security-related information is performed to produce the requested product.

Abstract: A system and method for optimizing a storage system to support full utilization of storage space are provided. With the system and method, data objects/containers of data objects are assigned retention values when they are created. These retention values may be dynamically modified based on a modification function associated with the data objects/containers. When storage space needs to be freed for the storage of new data objects/containers, the retention values of existing data objects/containers provide a prioritization as to which data objects/containers should be deleted from the storage system and the order by which these data objects/containers are to be deleted to make available storage space for the new data objects/containers. The identification of the data objects/containers that are to be deleted may be based on a dynamically modified delete threshold, a sorted list of retention values, or the like.

Abstract: A system and method for optimizing a storage system to support short data object lifetimes and highly utilized storage space are provided. With the system and method, data objects are clustered based on when they are anticipated to be deleted. When an application stores data, the application provides an indicator of the expected lifetime of the data, which may be a retention value, a relative priority of the data object, or the like. Data objects having similar expected lifetimes are clustered together in common data structures so that clusters of objects may be deleted efficiently in a single operation. Expected lifetimes may be changed by applications automatically. The system automatically determines how to handle these changes in expected lifetime using one or more of copying the data object, reclassifying the container in which the data object is held, and ignoring the change in expected lifetime for a time to investigate further changes in expected lifetime of other data objects.

Abstract: The invention is a process to recover a high pressure hydrogen rich gas stream from synthesis gas. The synthesis gas is separated into a hydrogen-enriched permeate and a hydrogen-depleted non-permeate by use of a membrane. The permeate experiences a substantial pressure drop of between about 500 psi (23.9 KPa) to 700 psi (33.5 kPa) as it passes through the membrane. The pressure of the non-permeate gas is unchanged by the membrane. The non-permeate gas pressure is reduced to between about 200 and about 500 psi for use in a combustion turbine. The hydrogen-rich permeate is compressed to between about 800 and 3000 psi (143.6 kPa) for use in subsequent operations, i.e., for use in hydrotreating of crude oil. The non-permeate gas is expanded in a manner to provide energy which is used to compress the permeate gas.

Abstract: During the hydrotreating process, hydrogen sulfide and short chain hydrocarbons such as methane, ethane, propane, butane and pentane are formed. The separation of gas from hydrotreated liquid hydrocarbons is achieved using a stripper and a flash drum. High pressure steam or nitrogen is contacted with the hydrotreated liquid hydrocarbon material. This high pressure steam strips the volatiles, i.e., hydrogen, the volatile hydrocarbons, hydrogen sulfide, and the like, from the oil. The gaseous stream is then separated and cooled to remove condensables, including primarily water, short chain hydrocarbons, and hydrogen sulfide in the water. The condensables are advantageously sent to the gasifier, where the hydrocarbons are gasified, the water moderates the gasifier temperature and increases the yield of hydrogen, and where hydrogen sulfide is routed with the produced synthesis gas to the acid gas removal process.

Abstract: The invention is a process to recover a high pressure hydrogen-rich gas stream from a purge gas stream taken from a hydrotreater. This purge gas stream is admixed with synthesis gas that was the original source of the hydrogen to form a gaseous mixture. This mixed gas comprising purge gas and synthesis gas is advantageously treated to remove acid gases and possibly other impurities. The mixed gas is then treated to extract a hydrogen-rich gas and a hydrogen-depleted gas using, for example, a membrane. At least a portion of the hydrogen-rich gas is then heated and compressed as necessary and is recycled to the hydrotreater.

Abstract: The invention provides an improved ammonium synthesis process. A synthesis gas is separated with a membrane into a hydrogen-rich gas and a hydrogen-depleted gas. The hydrogen rich gas is shifted with steam to convert carbon monoxide to carbon dioxide and hydrogen. Carbon dioxide is removed from the shifted gas, and remaining carbon oxides are methanized. This gas is admixed with nitrogen and with recycled ammonia synthesis feedstock gas. This ammonia synthesis feedstock gas is then cycled in an ammonia synthesis reactor. A purge gas stream is withdrawn from the ammonia synthesis feedstock gas and is admixed with the hydrogen-depleted gas. The hydrogen-depleted gas and the purge gas are combusted, usually in a combustion turbine, to generate heat or power. Lower purity hydrogen can therefore be used in the synthesis of the ammonia.

Abstract: The invention is a process of removing solids, particularly catalyst fines, from an asphaltene-containing hydrocarbon liquid. The process comprises contacting an asphaltene-containing hydrocarbon liquid with a solvent to create a mixture. The solvent is typically an alkane such as, propane to pentanes. Then, solids are removed from the mixture by any known process. Finally, additional solvent may be added, and the mixture heated until asphaltenes precipitate into a separate phase. The asphaltenes are removed from the mixture. The mixture is then further heated to recover the solvent from the deasphalted hydrocarbon liquid. The asphaltenes are advantageously gasified.

Abstract: A scrubbing tower and high pressure settler assembly, and the process for using same to remove particulates from a hot partial oxidation gas stream is disclosed. The scrubbing tower and high pressure settler assembly has a dip tube, a bottom portion, a top portion, and a high pressure settler. The dip tube transports partial oxidation gas from an injection point on the exterior of the scrubbing tower into a volume of water contained in the bottom portion of the scrubbing tower. A blowdown port capable of removing particulate matter is connected to the bottom portion of the assembly. A series of trays is provided in the top portion of the scrubbing tower. The top portion of the scrubbing tower also has inlet ports for receiving water and an outlet port for releasing the scrubbed partial oxidation gas. The use of the high pressure settler facilitates higher particulate settling rates as well as higher scrubbing efficiencies.