Abstract: In an internal combustion engine having at least one exhaust gas turbocharger and an engine crankcase with at least one ventilation unit, by means of which a mixture of gas and lubricant generated in the crankcase of the internal combustion engine can be removed from the engine crankcase, and which cooperates with at least one first separating unit, by means of which lubricant can be separated from the gas and lubricant mixture formed in the crankcase, at least one further separating unit is associated with the at least one exhaust gas turbocharger, by means of which lubricant of a mixture of the lubricant and gas formed in the exhaust gas turbocharger can be separated from the lubricant and gas mixture.