Patents by Inventor Kay Brune

Kay Brune has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combinations of flupirtine and sodium channel inhibiting substances for treating pains
    Patent number: 8557851
    Abstract: The invention relates to pharmaceutical combinations of potassium channel openers and sodium channel inhibitors, for treating pains which are accompanied by an increase in muscle tone.
    Type: Grant
    Filed: March 12, 2009
    Date of Patent: October 15, 2013
    Assignee: MEDA Pharma GmbH & Co. KG
    Inventors: Istvan Szelenyi, Kay Brune, Robert Hermann, Mathia Locher
  • COMBINATIONS OF RETIGABINE AND SODIUM CHANNEL INHIBITORS OR SODIUM CHANNEL-INFLUENCING ACTIVE COMPOUNDS FOR TREATING PAINS
    Publication number: 20100323987
    Abstract: The invention relates to pharmaceutical combinations of retigabine and sodium channel inhibitors for treating, pains which are accompanied by an increase in muscle tone.
    Type: Application
    Filed: August 30, 2010
    Publication date: December 23, 2010
    Applicant: Valeant Pharmaceuticals North America
    Inventors: Istvan SZELENYI, Kay BRUNE, Robert HERMANN, Mathias LOCHER
  • Combinations of retigabine and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains
    Patent number: 7799832
    Abstract: The invention relates to pharmaceutical combinations of retigabine and sodium channel inhibitors for treating pains which are accompanied by an increase in muscle tone.
    Type: Grant
    Filed: December 5, 2003
    Date of Patent: September 21, 2010
    Assignee: Valeant Pharmaceuticals North America
    Inventors: Istvan Szelenyi, Kay Brune, Robert Hermann, Mathias Locher
  • Indolyl-3-glyoxylic acid derivatives having antitumor action
    Patent number: 7579365
    Abstract: The invention relates to the use of N-substituted indole-3-glyoxylamides of the general formula I as antitumor agents and to a pharmaceutical composition having antitumor action, characterized in that it contains at least one of the compounds of the general formula 1, if appropriate also in the form of the physiologically tolerable acid addition salts or N-oxides. Furthermore, the invention also includes antitumor agents comprising as active compound one or more N-substituted indole-3-glyoxylamides according to the general formula 1 and, if appropriate, their physiologically tolerable acid addition salts and, if possible, N-oxides and a pharmaceutically utilizable carrier and/or diluent or auxiliary substance in the form of tablets, coated tablets, capsules, solutions for infusion or ampoules, suppositories, patches, powder preparations which can be employed by inhalation, suspensions, creams and ointments.
    Type: Grant
    Filed: December 4, 2002
    Date of Patent: August 25, 2009
    Assignee: ZIOPHRAM Oncology, Inc.
    Inventors: Bernd Nickel, Istvan Szelenyi, Jürgen Schmidt, Peter Emig, Dietmar Reichert, Eckhard Günther, Kay Brune, Guillaume Le Baut
  • COMBINATIONS OF POTASSIUM CHANNEL OPENERS AND SODIUM CHANNEL INHIBITORS OR SODIUM CHANNEL-INFLUENCING ACTIVE COMPOUNDS FOR TREATING PAINS
    Publication number: 20090176814
    Abstract: The invention relates to pharmaceutical combinations of potassium channel openers and sodium channel inhibitors. for treating pains which are accompanied by an increase in muscle tone.
    Type: Application
    Filed: March 12, 2009
    Publication date: July 9, 2009
    Applicant: Valeant Pharmaceuticals North America
    Inventors: Istvan SZELENYI, Kay BRUNE, Robert HERMANN, Mathias LOCHER
  • Indolyl-3-glyoxylic acid derivatives having antitumor action
    Publication number: 20080027110
    Abstract: The invention relates to the use of N-substituted indole-3-glyoxylamides of the general formula I as antitumor agents and to a pharmaceutical composition having antitumor action, characterized in that it contains at least one of the compounds of the general formula 1, if appropriate also in the form of the physiologically tolerable acid addition salts or N-oxides. Furthermore, the invention also includes antitumor agents comprising as active compound one or more N-substituted indole-3-glyoxylamides according to the general formula 1 and, if appropriate, their physiologically tolerable acid addition salts and, if possible, N-oxides and a pharmaceutically utilizable carrier and/or diluent or auxiliary substance in the form of tablets, coated tablets, capsules, solutions for infusion or ampoules, suppositories, patches, powder preparations which can be employed by inhalation, suspensions, creams and ointments.
    Type: Application
    Filed: August 20, 2007
    Publication date: January 31, 2008
    Inventors: Bernd Nickel, Istvan Szelenyi, Jurgen Schmidt, Peter Emig, Dietmar Reichert, Eckhard Gunther, Kay Brune, Guillaume Le Baut
  • N-substituted indole-3-glyoxylamides having anti-asthmatic, antiallergic and immunosuppressant/immuno-modulating action
    Patent number: 6919344
    Abstract: The invention relates to novel N-substituted indole-3-glyoxylamides, to processes for their preparation and to their pharmaceutical use. The compounds have antiasthmatic, antiallergic and immuno-suppressant/immunomodulating actions.
    Type: Grant
    Filed: April 1, 2003
    Date of Patent: July 19, 2005
    Assignee: ASTA MEDICA, Aktiengesellschaft
    Inventors: Guillaume Lebaut, Cécilia Menciu, Bernhard Kutscher, Peter Emig, Stefan Szelenyi, Kay Brune
  • Combinations of retigabine and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains
    Publication number: 20050090547
    Abstract: The invention relates to pharmaceutical combinations of retigabine and sodium channel inhibitors for treating pains which are accompanied by an increase in muscle tone.
    Type: Application
    Filed: December 5, 2003
    Publication date: April 28, 2005
    Inventors: Istvan Szelenyi, Kay Brune, Robert Hermann, Mathias Locher
  • Combinations of potassium channel openers and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains
    Publication number: 20050089559
    Abstract: The invention relates to pharmaceutical combinations of potassium channel openers and sodium channel inhibitors for treating pains which are accompanied by an increase in muscle tone.
    Type: Application
    Filed: December 5, 2003
    Publication date: April 28, 2005
    Inventors: Istvan Szelenyi, Kay Brune, Robert Hermann, Mathias Locher
  • N-substituted indole-3-glyoxylamides having anti-asthmatic, antiallergic and immunosuppressant/immuno-modulating action
    Publication number: 20030207892
    Abstract: The invention relates to novel N-substituted indole-3-glyoxylamides, to processes for their preparation and to their pharmaceutical use. The compounds have antiasthmatic, antiallergic and immuno-suppressant/immunomodulating actions.
    Type: Application
    Filed: April 1, 2003
    Publication date: November 6, 2003
    Inventors: Guillaume Lebaut, Cecilia Menciu, Bernhard Kutscher, Peter Emig, Stefan Szelenyi, Kay Brune
  • Indolyl-3-glyoxylic acid derivatives having antitumor action
    Publication number: 20030195360
    Abstract: The invention relates to the use of N-substituted indole-3-glyoxylamides of the general formula I as antitumor agents 1
    Type: Application
    Filed: December 4, 2002
    Publication date: October 16, 2003
    Applicant: ASTA Medica Aktiengesellschaft
    Inventors: Bernd Nickel, Istvan Szelenyi, Jurgen Schmidt, Peter Emig, Dietmar Reichert, Eckhard Gunther, Kay Brune, Guillaume Le Baut
  • United states patent office
    Publication number: 20030023093
    Abstract: The invention relates to the use of N-substituted indole-3-glyoxylamides of the general formula I as antitumor agents 1
    Type: Application
    Filed: March 19, 2001
    Publication date: January 30, 2003
    Applicant: ASTA Medica Aktiengesellschaft
    Inventors: Bernd Nickel, Istvan Szelenyi, Jurgen Schmidt, Peter Emig, Dietmar Reichert, Eckhard Gunther, Kay Brune, Guillaume Le Baut
  • N-substituted indole-3glyoxylamides having anti-asthmatic, antiallergic and immunosuppressant/immuno-modulating action
    Publication number: 20020161025
    Abstract: The invention relates to novel N-substituted indole-3-glyoxylamides, to processes for their preparation and to their pharmaceutical use. The compounds have antiasthmatic, antiallergic and immunosuppressant/immunomodulating actions.
    Type: Application
    Filed: January 30, 2002
    Publication date: October 31, 2002
    Inventors: Guillaume Lebaut, Cecilia Menciu, Bernhard Kutscher, Peter Emig, Stefan Szelenyi, Kay Brune
  • PROCESS FOR THE DIAGNOSTIC ASSESSMENT AND MONITORING, AS WELL AS MEDICAMENTS FOR THE THERAPY OF STATES OF SHOCK IN HUMANS
    Publication number: 20020039756
    Abstract: Patients suffering from shock illness exhibit increased levels of cyclophilins. Accordingly, methods for diagnosing, monitoring and treating shock patients are disclosed. Medicaments for therapeutically treating patients suffering from shock illness are also provided, for example, Cyclosporin A.
    Type: Application
    Filed: June 30, 1999
    Publication date: April 4, 2002
    Applicant: FOLEY AND LARDNER
    Inventors: HOLGER BANG, KAY BRUNE, ALBRECHT WENDEL, GESA TIEGS
  • N-substituted indole-3-glyoxylamides having anti-asthmatic, antiallergic and immunosuppressant/immuno-modulating action
    Patent number: 6344467
    Abstract: The invention relates to novel N-substituted indole-3-glyoxylamides, to processes for their preparation and to their pharmaceutical use. The compounds have antiasthmatic, antiallergic and immunosuppressant/immunomodulating actions.
    Type: Grant
    Filed: September 30, 1999
    Date of Patent: February 5, 2002
    Assignee: ASTA Medica AG
    Inventors: Guillaume Lebaut, Cécilia Menciu, Bernhard Kutscher, Peter Emig, Stefan Szelenyi, Kay Brune
  • Specific immunophilin ligands as antiasthmatics and immunosuppressants
    Patent number: 6258815
    Abstract: The novel specific immunophilin ligands of the general formula I have an antiasthmatic and immunosuppressive action and are suitable for the preparation of drugs.
    Type: Grant
    Filed: April 25, 1997
    Date of Patent: July 10, 2001
    Assignee: ASTA Medica Aktiengesellschaft
    Inventors: Dietmar Reichert, Bernhard Kutscher, Holger Bang, Kay Brune, Gerhard Quinkert, Hans-Günter Schaible
  • Immunophilin ligands
    Patent number: 6251932
    Abstract: The invention relates to an immunophilin ligand of Formula I and having antiasthmatic, antiallergic, antirheumatic, immunosuppressant, antipsoriatic and neuroprotectant properties,
    Type: Grant
    Filed: September 25, 1998
    Date of Patent: June 26, 2001
    Assignee: ASTA Medica AG
    Inventors: Dietmar Reichelt, Berhard Kutscher, István Szelényi, Hildegard Poppe, Gerhard Quinkert, Kay Brune, Holger Bang, Holger Deppe
  • Indolyl-3-glyoxylic acid derivatives having antitumor action
    Patent number: 6232327
    Abstract: The invention relates to the use of N-substituted indole-3-glyoxylamides of the general formula I as antitumor agents and to a pharmaceutical composition having antitumor action, characterized in that it contains at least one of the compounds of the general formula 1, if appropriate also in the form of the physiologically tolerable acid addition salts or N-oxides. Furthermore, the invention also includes antitumor agents comprising as active compound one or more N-substituted indole-3-glyoxylamides according to the general formula 1 and, if appropriate, their physiologically tolerable acid addition salts and, if possible, N-oxides and a pharmaceutically utilizable carrier and/or diluent or auxiliary substance in the form of tablets, coated tablets, capsules, solutions for infusion or ampoules, suppositories, patches, powder preparations which can be employed by inhalation, suspensions, creams and ointments.
    Type: Grant
    Filed: April 2, 1999
    Date of Patent: May 15, 2001
    Assignee: Asta Medica Aktiengesellschaft
    Inventors: Bernd Nickel, Istvan Szelenyi, Jürgen Schmidt, Peter Emig, Dietmar Reichert, Eckhard Günther, Kay Brune
  • 1,2,5-trisubstituted 1,2-dihydroindazol-3-ones having anti-asthmatic, anti-allergic, anti-inflammatory, immunomodulating and neuroprotective action, process for their preparation and their use as medicaments
    Patent number: 6180637
    Abstract: The invention relates to 1,2,5-trisubstituted 1,2-dihydroindazol-3-ones of formula (I) wherein X is —SO2—, —SO—, —(CH2)p—, —(CH2)p—O—, —(CH2)p—(C═O)—, —(CH2)p—(C═O)—NH—, —(CH2)p—CHOH—, —CHOH—(CH2)p—, —(CH2)p—CH═CH—, —CH═CH—(CH2)p—, Y is —(C═O)—, —(C═O)—NH—, —(C═O)—NH—(CH2)p—, —C═O)—(CH2)p—, —(CH2)p—, —(CH2)p—O—, —(CH2)p—(C═O)—, —(CH2)p—(C═O)—NH—, —(CH2)p—(C═O)—NH—(CH2)p—, —(CH2)p—CHOH—, —CHOH—(CH2)p—, —(CH2)p—CH═CH—, —CH═CH—(CH2)p—, Z is —O—, —O—(CH2)p—, —NH—, —NH—(
    Type: Grant
    Filed: May 5, 1999
    Date of Patent: January 30, 2001
    Assignee: Arzneimittelwerk Dresden GmbH
    Inventors: Rudolf Schindler, Norbert Höfgen, Hildegard Poppe, Kay Brune
  • 1,5- and 3-O-substituted 1H-indazoles having anti-asthmatic, anti-allergic, anti-inflammatory, immunomodulating and neuroprotective action, process for their preparation and their use as medicaments
    Patent number: 6166023
    Abstract: The invention relates to 1,5- and 3-O-substituted 1H-indazoles of formula (I) ##STR1##
    Type: Grant
    Filed: May 5, 1999
    Date of Patent: December 26, 2000
    Assignee: Arzneimittelwerk Dresden GmbH
    Inventors: Rudolf Schindler, Norbert Hofgen, Hildegard Poppe, Kay Brune