Abstract: Compositions for reducing alcohol consumption and/or treating alcohol hangover contain a first active agent containing at least one cannabinoid compound, a second active agent effective in reducing one or more symptoms of alcohol hangover, and a carrier. In some forms, the carrier is an anhydrous liposphere concentrate (ALC) containing a lipid system including lipid, optionally a water miscible solvent, and one or more surfactants and/or one or more phospholipids. In a preferred embodiment, the carrier spontaneously forms a nanodispersion of nanolipids or lipospheres, upon addition to an aqueous medium, which contain the cannabinoid compound and other compounds from the active agents. The compositions can be used to form oral dosage formulations for delivery of the cannabinoid compound.