Patents by Inventor Kayoko Okamoto

Kayoko Okamoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of producing sustained-release preparation
    Patent number: 6267981
    Abstract: This invention provides a sustained-release preparation comprising a biodegradable polymer metal salt and broactive polypeptide, with enhanced entrapment of the bioactive polypeptides, a suppression of initial burst, and a constant long-term release of the bioactive polypeptides.
    Type: Grant
    Filed: May 15, 2000
    Date of Patent: July 31, 2001
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Kayoko Okamoto, Yutaka Yamagata, Yasutaka Igari, Masafumi Misaki
  • Matrix for sustained-release preparation
    Patent number: 5665394
    Abstract: The present invention relates to a matrix for sustained-release preparation comprising an ester formed at a terminal carboxyl group of a straight-chain polyester which essentially consists of an .alpha.-hydroxymonocarboxylic acid. The matrix is stable to light, heat, moisture, coloring etc., and is of low toxicity. The sustained-release preparation produced by using the ester of the present invention offers stable drug release over an extended period of time, ensuring sustained stable effect. Furthermore, the sustained-release preparation does not show excess drug release just after administration.
    Type: Grant
    Filed: September 30, 1996
    Date of Patent: September 9, 1997
    Assignees: Takeda Chemical Industries, Ltd., Wako Purechemical Industries, Ltd.
    Inventors: Yasutaka Igari, Akira Saikawa, Kayoko Okamoto, Shigeru Kamei, Masahisa Oka, Atsunori Sano
  • Matrix for sustained-release preparation
    Patent number: 5594091
    Abstract: The present invention relates to a matrix for sustained-release preparation comprising an ester formed at a terminal carboxyl group of a straight-chain polyester which essentially consists of an .alpha.-hydroxymonocarboxylic acid. The matrix is stable to light, heat, moisture, coloring etc., and is of low toxicity. The sustained-release preparation produced by using the ester of the present invention offers stable drug release over an extended period of time, ensuring sustained stable effect. Furthermore, the sustained-release preparation does not show excess drug release just after administration.
    Type: Grant
    Filed: February 21, 1995
    Date of Patent: January 14, 1997
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Yasutaka Igari, Akira Saikawa, Kayoko Okamoto, Shigeru Kamei, Masahisa Oka, Atsunori Sano
  • Method of producing sustained-release preparation
    Patent number: 5534269
    Abstract: A method of producing a sustained-release preparation which includes permitting a water-soluble polypeptide to permeate into a biodegradable matrix in the aqueous solution. The production method of the present invention makes possible the permeation of a water-soluble polypeptide into a biodegradable matrix without bringing the water-soluble polypeptide into contact with an organic solvent. Hence the water-soluble polypeptide is prepared without affecting the water-soluble polypeptide bioactivity and is thus effective for use as a pharmaceutical.
    Type: Grant
    Filed: July 5, 1994
    Date of Patent: July 9, 1996
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Yasutaka Igari, Kazumichi Yamamoto, Kayoko Okamoto, Yutaka Yamagata