Patents by Inventor Kayvan R. KESHARI

Kayvan R. KESHARI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hyperpolarized and deuterium exchanged hyperpolarizedC and N-labeled xanthine, arginine, glutamine, and urea probes
    Patent number: 11330999
    Abstract: The present technology provides 13C- and 15N-labeled probes for imaging one or more mammalian cells using magnetic resonance. Thus, 13C- and 15N-labeled arginine (compound of formula I), xanthine (compounds of formula II and formula III), urea (compounds of formula IV), and glutamine (compounds of formula V), stereoisomers, tautomers, and pharmaceutically acceptable salts thereof are provided. Further methods of making the labelled probes and methods of using the probes to detect arginase, xanthine oxidase, and glutaminase metabolites and activity are provided.
    Type: Grant
    Filed: September 10, 2018
    Date of Patent: May 17, 2022
    Assignee: MEMORIAL SLOAN KETTERING CANCER CENTER
    Inventors: Andrew Cho, Roozbeh Eskandari, Valentina Di Gialleonardo, Kayvan R. Keshari
  • HYPERPOLARIZED AND DEUTERIUM EXCHANGED HYPERPOLARIZED13C AND 15N-LABELED XANTHINE, ARGININE, GLUTAMINE, AND UREA PROBES
    Publication number: 20200260983
    Abstract: The present technology provides 13C- and 15N-labeled probes for imaging one or more mammalian cells using magnetic resonance. Thus, 13C- and 15N-labeled arginine (compound of formula I), xanthine (compounds of formula II and formula III), urea (compounds of formula IV), and glutamine (compounds of formula V), stereoisomers, tautomers, and pharmaceutically acceptable salts thereof are provided. Further methods of making the labelled probes and methods of using the probes to detect arginase, xanthine oxidase, and glutaminase metabolites and activity are provided.
    Type: Application
    Filed: September 10, 2018
    Publication date: August 20, 2020
    Applicant: MEMORIAL SLOAN KETTERING CANCER CENTER
    Inventors: Andrew CHO, Roozbeh ESKANDARI, Valentina D. GIALLEONARDO, Kayvan R. KESHARI