Abstract: A multi-cylinder internal combustion engine, such as for a vehicle, having some of the cylinders connected to a first exhaust manifold and the remaining cylinders connected to a second exhaust manifold. The exhaust gases in the first exhaust manifold are used for driving the turbine section of a first turbocharger, the compressor section of which forces the air or air-fuel mixture into the intake manifold for distribution to the cylinders. The exhaust gases discharged from the first turbocharger are then supplied through an intermediate conduit to the compressor section of a second turbocharger, the turbine section of which is driven by the exhaust gases from the second exhaust manifold. The compressor section of the second turbocharger communicates with the intake manifold so that the fraction of the exhaust gases which are pressurized by the second turbocharger are mixed with the air or air-fuel mixture therein.