Abstract: Compounds or their pharmaceutically acceptable salts can inhibit the G12D mutant of Kirsten rat sarcoma (KRAS) protein and are expected to have utility as therapeutic agents, for example, for treating cancer. The disclosure also provides pharmaceutical compositions which comprise compounds disclosed herein or pharmaceutically acceptable salts thereof. The disclosure also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of cancer and for preparing pharmaceuticals for this purpose.

Abstract: Provided is a compound which is fluidized by light irradiation and is less colored. The compound is a compound represented by the following general formula (1), which is fluidized by light irradiation: R1—CH?N—R2??General Formula (1) wherein R1 is a substituted or unsubstituted cyclic hydrocarbon group or a substituted or unsubstituted heterocyclic group; and R2 is a substituted or unsubstituted heterocyclic group containing a nitrogen atom bonded to the nitrogen atom in the general formula (1).

Abstract: Provided is a compound that is fluidized by light irradiation and reversibly non-fluidized, is not significantly colored, and improves fixability and exhibits excellent image stability and color reproducibility when used for a toner. Provided is a compound represented by the following general formula (1), which is fluidized by light irradiation and reversibly non-fluidized: wherein Z1 and Z2 are CH or N, and Z1?Z2; R1 is an aromatic hydrocarbon group having a substituent Ra selected from the group consisting of an alkyl group, an alkoxy group and a halogen atom at each of two ortho positions with respect to Z1; and R2 is a substituted or unsubstituted aromatic heterocyclic group.

Abstract: A photoresponsive polymer includes a structural unit represented by the following general formula (1), the photoresponsive polymer being fluidized by light irradiation, and reversibly non-fluidized: [Chemical formula 1] R1—Z1?Z2—R2??General formula (1) in the formula, Z1 and Z2 each represent CH or N, and Z1?Z2, R1 represents an aromatic hydrocarbon group having a substituent Ra selected from the group consisting of an alkyl group, an alkoxy group, and a halogen atom at each of two ortho positions with respect to Z1, R2 represents an aromatic heterocyclic group with or without a substituent, and at least one of the R1 and the R2 is bonded to a group containing a structure derived from a polymerizable group.

Abstract: A centrifugal compressor includes: a housing including an intake flow path; a compressor impeller arranged in the intake flow path; an accommodation chamber formed upstream of the compressor impeller in a flow of intake air in the housing; a movable member arranged in the accommodation chamber; and an annular path formed in the housing, the annular path being connected to an outside of the housing, a heating medium supplied from the outside of the housing flowing through the annular path, at least a part of the annular path being located between the accommodation chamber and a leading edge of the compressor impeller.

Abstract: A centrifugal compressor includes: a housing including an intake flow path; a compressor impeller arranged in the intake flow path; an accommodation chamber formed upstream of the compressor impeller in a flow of intake air in the housing; a movable member arranged in the accommodation chamber; and an annular path formed in the housing, the annular path being connected to an outside of the housing, a heating medium supplied from the outside of the housing flowing through the annular path, at least a part of the annular path being located between the accommodation chamber and a leading edge of the compressor impeller.

Abstract: Provided is a compound that is fluidized by light irradiation and reversibly non-fluidized, and is not significantly colored. Provided is a photoresponsive compound represented by the following general formula (1), the photoresponsive compound being fluidized by light irradiation and reversibly non-fluidized: R1—Z1?Z2—R2??General formula (1) wherein Z1 and Z2 are N or CH, while Z1?Z2, R1 contains an aromatic hydrocarbon structure, R2 contains an aromatic heterocyclic structure, and a hydrogen atom is bonded to at least one carbon atom bonded adjacent to a carbon atom in the aromatic heterocyclic structure bonded to the Z2.

Abstract: Provided is a compound that is fluidized by light irradiation and reversibly non-fluidized, is not significantly colored, and improves fixability and exhibits excellent image stability and color reproducibility when used for a toner. Provided is a compound represented by the following general formula (1), which is fluidized by light irradiation and reversibly non-fluidized: wherein Z1 and Z2 are CH or N, and Z1?Z2; R1 is an aromatic hydrocarbon group having a substituent Ra selected from the group consisting of an alkyl group, an alkoxy group and a halogen atom at each of two ortho positions with respect to Z1; and R2 is a substituted or unsubstituted aromatic heterocyclic group.

Abstract: An information processing apparatus including circuitry. The circuitry receives a question from one of a user terminal apparatus and an administrator terminal apparatus. The circuitry performs determination as to whether the question is transmitted from the user terminal apparatus or transmitted from the administrator terminal apparatus. The circuitry searches for one or more answers including a word included in the question. The circuitry calculates a weighting of each of the one or more answers. When the determination result indicates that the question is transmitted from the user terminal apparatus, the circuitry transmits an answer having a weighting satisfying a predetermined threshold value of the weighting to the user terminal apparatus. When the determination result indicates the question is transmitted from the administrator terminal apparatus, the circuitry generates screen information of a screen for editing at least one of one or more answers.

Abstract: Provided is a compound which is fluidized by light irradiation and is less colored. The compound is a compound represented by the following general formula (1), which is fluidized by light irradiation: R1—CH?N—R2??General Formula (1) wherein R1 is a substituted or unsubstituted cyclic hydrocarbon group or a substituted or unsubstituted heterocyclic group; and R2 is a substituted or unsubstituted heterocyclic group containing a nitrogen atom bonded to the nitrogen atom in the general formula (1).

Abstract: A photoresponsive polymer includes a structural unit represented by the following general formula (1), the photoresponsive polymer being fluidized by light irradiation, and reversibly non-fluidized: [Chemical formula 1] R1—Z1?Z2—R2??General formula (1) in the formula, Z1 and Z2 each represent CH or N, and Z1?Z2, R1 represents an aromatic hydrocarbon group having a substituent Ra selected from the group consisting of an alkyl group, an alkoxy group, and a halogen atom at each of two ortho positions with respect to Z1, R2 represents an aromatic heterocyclic group with or without a substituent, and at least one of the R1 and the R2 is bonded to a group containing a structure derived from a polymerizable group.

Abstract: Provided is a resin composition used for forming a molded body by a hot melt extrusion method, wherein the resin composition contains a resin including a polymer body having a partial structure represented by the following Formula (1), —(X)n-J-A??Formua (1) in Formula (1), X represents —C(?O)—, —C(?O)NH—, —SiR1R2—, or —S—; R1 and R2 each represents a substituent; J represents a linking group; A represents a functional group; and n represents 1 or 0.

Abstract: A resin composition includes: a resin having a first group capable of forming at least two hydrogen bonds; and a photoisomerization compound having a second group capable of forming at least two hydrogen bonds complementarily with the first group and having a moiety that is reversibly isomerized by light.

Abstract: A compound that is fluidized by light irradiation and reversibly non-fluidized and is represented by the following general formula (1): In the general formula (1), Ar1 and Ar2 each independently represent an aromatic hydrocarbon group optionally having a substituent or an aromatic heterocyclic group optionally having a substituent, and Y, Z1, and Z2 each independently represent a hydrogen atom or a lower alkyl group.

Abstract: A photoresponsive polymer that is fluidized by light irradiation and reversibly non-fluidized and contains a structural unit represented by a general formula (1) shown below: wherein each substituent is defined as described in the specification.

Abstract: Provided is a compound that is fluidized by light irradiation and reversibly non-fluidized, and is not significantly colored. Provided is a photoresponsive compound represented by the following general formula (1), the photoresponsive compound being fluidized by light irradiation and reversibly non-fluidized: R1—Z1?Z2—R2??General formula (1) wherein Z1 and Z2 are N or CH, while Z1?Z2, R1 contains an aromatic hydrocarbon structure, R2 contains an aromatic heterocyclic structure, and a hydrogen atom is bonded to at least one carbon atom bonded adjacent to a carbon atom in the aromatic heterocyclic structure bonded to the Z2.

Abstract: An object of the present invention is to provide a photoresponsive polymer that sufficiently secures photoresponsiveness to be fluidized by light irradiation and reversibly non-fluidized, improves fixability, and further has good color reproducibility. Provided is a photoresponsive polymer containing a structural unit derived from a specific azomethine derivative, the photoresponsive polymer being fluidized by light irradiation and reversibly non-fluidized.

Abstract: An information processing apparatus communicable with a first terminal device is configured to transmit a message in response to receiving an inquiry. The information processing apparatus includes: reference information referenced when responding to the inquiry received from the first terminal device, which includes at least one set of a question item and a response corresponding to the question item; and history information including inquiries received from the first terminal device and messages that are transmitted or received with respect to the received inquiries.

Abstract: An information processing apparatus connectable with a user terminal via a network includes circuitry configured to acquire a question statement input to the user terminal by a user; search response information to be responded to the question statement; respond, to the user terminal, a response message based on the searched response information to the question statement; and control output of the response message to the question statement input to the user terminal such that a first response message responding to a first question input source used for inputting a first question statement, and a second response message responding to a second question input source used for inputting a second question statement are different even if the first question statement and the second question statement are similar or the same.

Abstract: A transparent electrode has excellent adhesion between a substrate and a conductive layer. A transparent electrode includes a substrate, an underlying layer, and a conductive layer sequentially stacked. The underlying layer contains at least one selected from a compound having a thiol group and a poly(meth)acrylate and a poly(meth)acrylamide each having an aminoethyl group.