Patents by Inventor Kazuhiko Fujiwara
Kazuhiko Fujiwara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240303239Abstract: The scanning range of an inner table can be limited in the join processing irrespective of the existence of search conditions or a partition key, and the performance of the join processing can be improved. There is a column range index representing a range of values stored in a table. When a join result of a current stage is an outer table related to a join of a next stage in a join of each stage of the join processing, a database management apparatus identifies whether there is a possibility that an inner table related to a join of a next stage includes a hit record in an inner table related to a join of a current stage based on a column range index corresponding to a join column of a current stage and a column range index corresponding to a join column of a next stage.Type: ApplicationFiled: September 19, 2023Publication date: September 12, 2024Inventors: Norifumi NISHIKAWA, Shinji FUJIWARA, Mayuko OZAWA, Kazuhiko MOGI, Kazuo GODA, Yuto HAYAMIZU
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Patent number: 12086411Abstract: A database is stored in a plurality of pages that are a plurality of logical storage areas constituting a logical storage space. Data writing to a database in the logical storage space is performed in a page unit. A storage control apparatus coupled to an external storage and including a cache device writes data to the cache device in a page unit. The storage control apparatus determines whether an execution condition on external writing that is writing to the external storage is satisfied. When a result of the determination is true, the storage control apparatus writes data stored in the cache device to the external storage in a bulk unit that is larger than a page unit and is a writing unit in which consistency is maintained.Type: GrantFiled: August 24, 2022Date of Patent: September 10, 2024Assignee: HITACHI, LTD.Inventors: Kazuhiko Mogi, Shinji Fujiwara
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Patent number: 11609181Abstract: A spectrum analysis apparatus is an apparatus for analyzing an analysis object on the basis of a spectrum of light generated in the analysis object containing any one or two or more of a plurality of reference objects, and includes an array conversion unit, a processing unit, a learning unit, and an analysis unit. The array conversion unit generates two-dimensional array data on the basis of a spectrum of light generated in the reference object or the analysis object. The processing unit includes a deep neural network. The analysis unit causes the array conversion unit to generate the two-dimensional array data on the basis of the spectrum of light generated in the analysis object, inputs the two-dimensional array data to the deep neural network, and analyzes the analysis object on the basis of data output from the deep neural network.Type: GrantFiled: September 26, 2018Date of Patent: March 21, 2023Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Masashi Fukuhara, Kazuhiko Fujiwara, Yoshihiro Maruyama
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Publication number: 20230034756Abstract: A cell analysis method includes a mixing step of mixing a cell as an analyte, a metal ion solution, and a reducing agent to prepare a mixture solution, a metal microstructure generation step of reducing metal ions in the mixture solution by reducing action of the reducing agent to generate a metal microstructure on a support, and attaching the cell or a cell-derived substance to the metal microstructure, a drying step of, after the metal microstructure generation step, drying the support, a measurement step of, after the drying step, irradiating the metal microstructure on the support with excitation light, and measuring a spectrum of Raman scattered light generated by the excitation light irradiation, and an analysis step of analyzing the cell based on the spectrum of the Raman scattered light.Type: ApplicationFiled: January 14, 2021Publication date: February 2, 2023Applicant: HAMAMATSU PHOTONICS K.K.Inventors: Kazuhiko FUJIWARA, Sayaka KAZAMI, Yoshihiro MARUYAMA
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Publication number: 20220172045Abstract: A convolutional neural network decision basis extraction apparatus includes a contribution rate calculation unit and a basis extraction unit. The contribution rate calculation unit obtains a contribution rate of a weight of a fully connected layer to an output label of an output layer. The basis extraction unit extracts a decision basis of a CNN based on a feature map input to the fully connected layer, the weight of the fully connected layer, and the above contribution rate.Type: ApplicationFiled: February 25, 2020Publication date: June 2, 2022Applicant: HAMAMATSU PHOTONICS K.K.Inventors: Masashi FUKUHARA, Kazuhiko FUJIWARA, Yoshihiro MARUYAMA
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Publication number: 20210190679Abstract: A spectrum analysis apparatus is an apparatus for analyzing an analysis object on the basis of a spectrum of light generated in the analysis object containing any one or two or more of a plurality of reference objects, and includes an array conversion unit, a processing unit, a learning unit, and an analysis unit. The array conversion unit generates two-dimensional array data on the basis of a spectrum of light generated in the reference object or the analysis object. The processing unit includes a deep neural network. The analysis unit causes the array conversion unit to generate the two-dimensional array data on the basis of the spectrum of light generated in the analysis object, inputs the two-dimensional array data to the deep neural network, and analyzes the analysis object on the basis of data output from the deep neural network.Type: ApplicationFiled: September 26, 2018Publication date: June 24, 2021Applicant: HAMAMATSU PHOTONICS K.K.Inventors: Masashi FUKUHARA, Kazuhiko FUJIWARA, Yoshihiro MARUYAMA
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Publication number: 20210181116Abstract: An analyte analysis method includes, in one example, a mixing step of mixing an analyte, a metal ion solution, and a reducing agent to prepare a mixture solution, a metal microstructure generation step of reducing metal ions in the mixture solution by reducing action of the reducing agent in the mixture solution to generate a metal microstructure on a support, and attaching the analyte or a substance derived from the analyte to the metal microstructure, a measurement step of irradiating the metal microstructure on the support with excitation light, and measuring a spectrum of Raman scattered light generated by the excitation light irradiation, and an analysis step of analyzing the analyte based on the spectrum of the Raman scattered light.Type: ApplicationFiled: July 16, 2019Publication date: June 17, 2021Applicant: HAMAMATSU PHOTONICS K.K.Inventors: Kazuhiko FUJIWARA, Yoshihiro MARUYAMA
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Patent number: 10948419Abstract: A concentration measurement method is a method for measuring a concentration of an analyte in a measurement solution containing the analyte having reducing action, and includes a mixing step of preparing a mixture solution by mixing a metal ion solution, a complexing agent, and a pH adjusting agent to prepare an intermediate mixture solution, and mixing the intermediate mixture solution and the measurement solution, a metal microstructure generation step of generating a metal microstructure on a support by reducing metal ions in the mixture solution by the reducing action of the analyte in the mixture solution, a measurement step of measuring an optical response of the metal microstructure on the support, and an analysis step of determining a concentration of the analyte in the measurement solution on the basis of a measurement result of the optical response.Type: GrantFiled: November 15, 2016Date of Patent: March 16, 2021Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Kazuhiko Fujiwara, Yoshihiro Maruyama
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Publication number: 20180328852Abstract: A concentration measurement method is a method for measuring a concentration of an analyte in a measurement solution containing the analyte having reducing action, and includes a mixing step of preparing a mixture solution by mixing a metal ion solution, a complexing agent, and a pH adjusting agent to prepare an intermediate mixture solution, and mixing the intermediate mixture solution and the measurement solution, a metal microstructure generation step of generating a metal microstructure on a support by reducing metal ions in the mixture solution by the reducing action of the analyte in the mixture solution, a measurement step of measuring an optical response of the metal microstructure on the support, and an analysis step of determining a concentration of the analyte in the measurement solution on the basis of a measurement result of the optical response.Type: ApplicationFiled: November 15, 2016Publication date: November 15, 2018Applicant: HAMAMATSU PHOTONICS K.K.Inventors: Kazuhiko FUJIWARA, Yoshihiro MARUYAMA
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Patent number: 8822670Abstract: A method of synthesizing a cDNA chain using an insoluble carrier having on the surface thereof a polymer substance containing a first unit having a group derived from a phosphoric ester composing the hydrophilic portion of phospholipid, and a second unit having a group derived from carboxylic acid having an electron-attractive substituent bound to a carbonyl group, which includes immobilizing a polynucleotide for DNA elongation; bringing a solution containing an RNA fragment, nucleotide monomers, and a reverse transcriptase or an enzyme having polymerase activity into contact with the surface of the insoluble carrier; and allowing the polynucleotide for DNA elongation immobilized on the surface of the carrier to elongate using the RNA fragment contained in the solution as a template, to thereby form a single-strand cDNA.Type: GrantFiled: August 9, 2006Date of Patent: September 2, 2014Assignees: Sumitomo Bakelite Company, Ltd., Kenji KinoshitaInventors: Kenji Kinoshita, Toru Yakabe, Kentaro Fujimoto, Kanehisa Yokoyama, Kazuhiko Fujiwara
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Patent number: 8778363Abstract: To provide an oil-in-water emulsion skin care cosmetic composition which, without the addition of a pharmaceutical agent and a film-forming agent or the like thereto, effects an excellent elastic or resilient feeling to skin and is excellent in non-stickiness and stability. An oil-in-water emulsion skin care cosmetic composition, comprising (a) a paraffin wax and/or a polyethylene wax, (b) a microcrystalline wax, and (c) an animal/plant-derived wax which contains, as the main ingredient thereof, an ester of a higher fatty acid having from 20 to 32 carbon atoms and an alcohol having from 28 to 34 carbon atoms, and has a melting point of from 75 to 100° C., in which the ratio of component (a) to component (b) is from 70/30 to 95/5 (by mass).Type: GrantFiled: December 16, 2009Date of Patent: July 15, 2014Assignee: Shiseido Company, Ltd.Inventors: Rie Yamamoto, Kazuhiko Fujiwara, Ayumi Asai, Tomomi Furukawara
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Publication number: 20130280310Abstract: A sheet-like cosmetic is formed by impregnating a laminated sheet having two or more non-woven fabric layer composed of ultra-fine fibers with a cosmetic containing 1 wt % or more of a specific liquid oil component. An average diameter is specified, and select portions are impregnated with a cosmetic containing 1-30 wt % of one, two or more liquid oil components selected from hydrocarbon oils, higher alcohols, higher fatty acids, ester oils, liquid fats/oils, and silicone oils.Type: ApplicationFiled: April 23, 2012Publication date: October 24, 2013Inventors: Kazunobu SUZUKI, Satoko KISHIMOTO, Kazuhiko FUJIWARA, Taira OMORI, Masanobu TAKEDA
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Patent number: 8524263Abstract: The present invention is a sheet-like cosmetic produced by impregnating a non-woven fabric with a cosmetic comprising (A) 4-methoxysalicylic acid or a salt thereof and (B) a water soluble polysaccharide. It also provides a sheet-like cosmetic that additionally comprises (C) an oil component, (D) an alkyl-modified carboxyvinyl polymer, (E) a water soluble polymer other than said (B) and (D), and (F) hydroxylamine or a derivative thereof. The object of the present invention is to improve the texture upon use, such as the stickiness and the friction, of a sheet-like cosmetic produced by impregnating a non-woven fabric with a cosmetic comprising 4-methoxysalicylic acid or a salt thereof.Type: GrantFiled: August 18, 2010Date of Patent: September 3, 2013Assignee: Shiseido Company, Ltd.Inventors: Kazunobu Suzuki, Rie Yamamoto, Kenji Ito, II, Kazuhiko Fujiwara
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Patent number: 8486997Abstract: An external preparation for skin containing an alkylresorcinol and being excellent in temperature stability (especially high-temperature stability) and photostability. More particularly an external preparation for skin comprising (a) from 0.01 to 5% by mass of 4-isobutyl resorcinol or a salt thereof, and (b) from 0.01 to 5% by mass of one or more selected from L-ascorbic acid or a salt thereof and a 3-O-alkyl-L-ascorbic acid or a salt thereof. If desired, (c) one or more compounds selected from (c-1) a sterol skeleton-having compound (e.g., POE phytosterols, POE cholestanols), (c-2) a vitamin E derivative, (c-3) a compound such as polyglycerin fatty acid esters, polyoxybutene-polyglycerin alkyl ethers, sucrose fatty acid esters, and (c-4) a sorbitan skeleton-having compound may be incorporated in the preparation.Type: GrantFiled: May 29, 2009Date of Patent: July 16, 2013Assignee: Shiseido CompanyInventors: Keisuke Shinto, Takayuki Sakiguchi, Kazuhiko Fujiwara
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Patent number: 8435742Abstract: [Object] It is to provide a method and a kit capable of detecting or quantifying a target RNA simply and rapidly from trace amounts of RNA in a sample, in a case such as when one or more kinds of pathogenic microorganisms are to be detected or quantified. [Solving Means] The method comprises the steps of 1) synthesizing cDNA from a sample containing the target RNA using a liquid-phase primer having a promoter sequence and a reverse transcriptase to obtain a cDNA-RNA complex, 2) degrading the RNA of the complex, 3) synthesizing a double-stranded DNA via the cDNA obtained in the step 2) and the solid-phase primer, 4) synthesizing RNA from the double-stranded DNA, 5) synthesizing cDNA via the RNA obtained in the step 4) and the solid-phase primer to obtain a cDNA-RNA complex, 6) degrading the RNA of the complex obtained in step 5), 7) synthesizing a double-stranded DNA via the cDNA obtained in the step 6) and the liquid-phase primer, and 8) quantifying the double-stranded DNAs obtained in the steps 3) and 7).Type: GrantFiled: November 4, 2008Date of Patent: May 7, 2013Assignee: Yamaguchi UniversityInventors: Mutsunori Shirai, Hajime Fukunaga, Kazuhiko Fujiwara, Kanehisa Yokoyama, Kentaro Fujimoto
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Publication number: 20120172433Abstract: To provide an oil-in-water emulsion skin care cosmetic composition which, without the addition of a pharmaceutical agent and a film-forming agent or the like thereto, effects an excellent elastic or resilient feeling to skin and is excellent in non-stickiness and stability. An oil-in-water emulsion skin care cosmetic composition, comprising (a) a paraffin wax and/or a polyethylene wax, (b) a microcrystalline wax, and (c) an animal/plant-derived wax which contains, as the main ingredient thereof, an ester of a higher fatty acid having from 20 to 32 carbon atoms and an alcohol having from 28 to 34 carbon atoms, and has a melting point of from 75 to 100° C., in which the ratio of component (a) to component (b) is from 70/30 to 95/5 (by mass).Type: ApplicationFiled: December 16, 2009Publication date: July 5, 2012Applicant: SHISEIDO COMPANY, LTD.Inventors: Rie Yamamoto, Kazuhiko Fujiwara, Ayumi Asai, Tomomi Furukawara
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Publication number: 20120076844Abstract: The present invention is a sheet-like cosmetic produced by impregnating a non-woven fabric with a cosmetic comprising (A) 4-methoxysalicylic acid or a salt thereof and (B) a water soluble polysaccharide. It also provides a sheet-like cosmetic that additionally comprises (C) an oil component, (D) an alkyl-modified carboxyvinyl polymer, (E) a water soluble polymer other than said (B) and (D), and (F) hydroxylamine or a derivative thereof. The object of the present invention is to improve the texture upon use, such as the stickiness and the friction, of a sheet-like cosmetic produced by impregnating a non-woven fabric with a cosmetic comprising 4-methoxysalicylic acid or a salt thereof.Type: ApplicationFiled: August 18, 2010Publication date: March 29, 2012Applicant: SHISEIDO COMPANY, LTD.Inventors: Kazunobu Suzuki, Rie Yamamoto, Kenji Ito, II, Kazuhiko Fujiwara
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Patent number: 8088580Abstract: The present invention provides an RNA detection method detecting, from a reaction system containing a target sample, a target RNA chain originated from the target sample, using a surface having on the surface thereof a polymer substance which contains a first unit having a group derived from a phosphate ester composing the hydrophilic portion of a phospholipid and a second unit having a carboxylic acid derivative group composed of an electron-attractive substitutional group bound to a carbonyl group, while being provided with at least one reaction space, the reaction space having an immobilized nucleic acid primer immobilized therein.Type: GrantFiled: June 1, 2007Date of Patent: January 3, 2012Assignee: Sumitomo Bakelite Company, Ltd.Inventors: Kenji Kinoshita, Kanehisa Yokoyama, Kentaro Fujimoto, Toru Yakabe, Shin Saito, Kazuhiko Fujiwara
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Publication number: 20110213030Abstract: An external preparation for skin containing an alkylresorcinol and being excellent in temperature stability (especially high-temperature stability) and photostability. More particularly an external preparation for skin comprising (a) from 0.01 to 5% by mass of 4-isobutyl resorcinol or a salt thereof, and (b) from 0.01 to 5% by mass of one or more selected from L-ascorbic acid or a salt thereof and a 3-O-alkyl-L-ascorbic acid or a salt thereof. If desired, (c) one or more compounds selected from (c-1) a sterol skeleton-having compound (e.g., POE phytosterols, POE cholestanols), (c-2) a vitamin E derivative, (c-3) a compound such as polyglycerin fatty acid esters, polyoxybutene-polyglycerin alkyl ethers, sucrose fatty acid esters, and (c-4) a sorbitan skeleton-having compound may be incorporated in the preparation.Type: ApplicationFiled: May 29, 2009Publication date: September 1, 2011Applicant: SHISEIDO COMPANY, LTD.Inventors: Keisuke Shinto, Takayuki Sakiguchi, Kazuhiko Fujiwara
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Patent number: 7968290Abstract: A method of detecting a gene including immobilizing a primer for DNA elongation onto an insoluble carrier having on the surface thereof a polymer substance containing a first unit having a phosphorylcholine group and a second unit having a carboxylic acid-derived group having an electron-attractive substituent bound to a carbonyl group; annealing the template DNA fragments or RNA fragments with the primer for DNA elongation, so as to elongate the DNA primer while incorporating therein an enzyme, thereby allowing coloration of a chromogenic reagent by its enzymatic action; and judging whether the DNA fragments or RNA fragments of the gene presents or not, based on the degree of coloration.Type: GrantFiled: May 16, 2006Date of Patent: June 28, 2011Assignee: Sumitomo Bakelite Co., Ltd.Inventors: Kenji Kinoshita, Kazuhiko Fujiwara, Kanehisa Yokoyama, Kentaro Fujimoto, Toru Yakabe