Abstract: Provided is a substance capable of effectively suppressing cancer metastasis or a pharmaceutical composition that effectively acts on an inflammatory disease. The pharmaceutical composition is a pharmaceutical composition containing, as an active ingredient, an antibody or an antibody fragment thereof having antigen-binding activity for an S100A8/A9 heterodimer, and blocks interaction between S100A8/A9 and a group of receptors therefor, to thereby strongly suppress cancer metastasis both in vitro and in vivo, or alleviate inflammation. That is, the anti-S100A8/A9 antibody or the antibody fragment thereof can strongly suppress cancer metastasis or alleviate inflammation, by virtue of its blocking action on the interaction between S100A8/A9 and the group of receptors therefor.

Abstract: A program stored in a non-transitory medium and being executable by a computer of an information processing apparatus causes the computer to: execute a reading process for reading a plurality of pieces of text data arranged in one column or in one row; and be ready to accept a first operation by a user. In a case of accepting the first operation, the program causes the computer to execute: an obtaining process for obtaining a number of pieces of text objects to be included in specific label data; a generating process for extracting text data by the number of pieces obtained in the obtaining process, and for generating specific records each consisting of the number of pieces of text data; and an auto associating process for associating each text data included in each of the records with one of the text objects included in the specific label data.

Abstract: A non-transitory medium storing a program executable by a computer of an information processing apparatus, the program, when executed by the computer, causing the computer to execute: a designating process for designating a database file including a plurality of text data; an associating process for associating the database file designated in the designating process with a text object; and a specific printing process for generating label data, for each of the text data included in the database file, with each of the text data written in the text object, and for causing a label printer to execute printing based on the label data generated.

Abstract: An audio signal processing circuit is provided which comprises an ADC which samples an audio signal at a predetermined sampling frequency, a high-band compensation processor which compensates a signal sampled by the ADC to a frequency band which is higher than a signal band sampled by the sampling frequency, and an encoding unit which encodes a signal processed by the high-band compensation processor.

Abstract: A synchronous pattern detection section checks coincidence between a predetermined reference synchronous pattern and a bit pattern included in a data stream. Each time a bit pattern which coincides with the reference synchronous pattern is detected, the synchronous pattern detection section extracts a frame length of a data frame corresponding to the bit pattern which is detected, and stores the extracted frame length in a storage section. Each time a bit pattern which coincides with the reference synchronous pattern is detected in the synchronous pattern detection section, a synchronization determination section determines whether or not the bit pattern detected by the synchronous pattern detection section is a correct synchronous pattern, based on a plurality of frame lengths stored in the storage section and a bit length of a data stream which is obtained after detection of the bit pattern. With this structure, a synchronous pattern included in the data stream can be detected with higher precision.

Abstract: A music replay circuit is provided which includes a header analyzing unit which analyzes a header included in each of a plurality of frames in a data stream which are compressed music data and extracts bitrate information included in the header, a decoder which decodes the data stream analyzed by the header analyzing unit, a high-frequency correction unit which generates data in which high-frequency music data is interpolated, for music data decoded by the decoder, and a process setting unit which controls the process applied by the high-frequency correction unit based on the bitrate information extracted by the header analyzing unit, wherein the process setting unit control the process by the high-frequency correction unit according to the bitrate information extracted for each frame.

Abstract: An audio signal processing circuit is provided which comprises an ADC which samples an audio signal at a predetermined sampling frequency, a high-band compensation processor which compensates a signal sampled by the ADC to a frequency band which is higher than a signal band sampled by the sampling frequency, and an encoding unit which encodes a signal processed by the high-band compensation processor.

Abstract: The audio reproduction system amplifies and reproduces both a digital audio signal and an analog audio signal. After delta sigma modulation by a ?? modulator, the digital audio signal is pulse width modulated by a first PWM converter and supplied to a selector. The analog audio signal is compared with a PWM carrier signal by a second PWM converter, converted to a PWM signal, and supplied to the selector. A signal selected by the selector is then amplified by a class D amplifier.

Abstract: A music replay circuit is provided which comprises a header analyzing unit which analyzes a header included in each of a plurality of frames in a data stream which are compressed music data and extracts bitrate information included in the header, a decoder which decodes the data stream analyzed by the header analyzing unit, a high-frequency correction unit which generates data in which high-frequency music data is interpolated, for music data decoded by the decoder, and a process setting unit which controls the process applied by the high-frequency correction unit based on the bitrate information extracted by the header analyzing unit, wherein the process setting unit control the process by the high-frequency correction unit according to the bitrate information extracted for each frame,

Abstract: The present invention provides a process of preparing a compound of the formula [I]: wherein X is a group of the formula: —N? or —CH?; R1 is a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a cyano group or an amino group optionally substituted by a lower alkyl group; Ring A is a nitrogen-containing heterocyclic group; Ring B is an optionally substituted benzene ring or an optionally substituted pyridine ring; and R3 is a hydrogen atom or a lower alkyl group, or a pharmaceutically acceptable salt thereof, which is useful as an inhibitor of activated blood coagulation factor X.

Abstract: The present invention provides a process of preparing a compound of the formula [I]: wherein X is a group of the formula: —N? or —CH?; R1 is a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a cyano group or an amino group optionally substituted by a lower alkyl group; Ring A is a nitrogen-containing heterocyclic group; Ring B is an optionally substituted benzene ring or an optionally substituted pyridine ring; and R3 is a hydrogen atom or a lower alkyl group, or a pharmaceutically acceptable salt thereof, which is useful as an inhibitor of activated blood coagulation factor X.

Abstract: A synchronous pattern detection section checks coincidence between a predetermined reference synchronous pattern and a bit pattern included in a data stream. Each time a bit pattern which coincides with the reference synchronous pattern is detected, the synchronous pattern detection section extracts a frame length of a data frame corresponding to the bit pattern which is detected, and stores the extracted frame length in a storage section. Each time a bit pattern which coincides with the reference synchronous pattern is detected in the synchronous pattern detection section, a synchronization determination section determines whether or not the bit pattern detected by the synchronous pattern detection section is a correct synchronous pattern, based on a plurality of frame lengths stored in the storage section and a bit length of a data stream which is obtained after detection of the bit pattern. With this structure, a synchronous pattern included in the data stream can be detected with higher precision.

Abstract: There is disclosed an azetidinone compound of the formula [I]: ##STR1## wherein Ring B is a benzene ring which may have substituent(s), R.sup.1 is a hydroxy-substituted lower alkyl group which may have substituent(s), X is oxygen atom and the like, Y is oxygen atom and the like, and Z is a methylene group which may have substituent(s), which is useful as a synthetic intermediate of the 1.beta.-methylcarbapenem-type antibacterial agent.

Abstract: An image data encoding apparatus encodes image data at a high speed while minimizing the deterioration of the image quality on a reproduced screen. The apparatus includes an encoding circuit, a code quantity counter and a control circuit. The control circuit compares a total code quantity with a reference code quantity. When the total code quantity exceeds the reference code quantity, the control circuit further compares an excessive quantity with a brought forward code quantity. The control circuit instructs an interruption of generation of the code image data by the encoding circuit when the excessive quantity is larger than the brought forward code quantity.

Abstract: There is disclosed an azetidinone compound of the formula ?I!: ##STR1## wherein Ring B is a benzene ring which may have substituent(s), R.sup.1 is a hydroxy-substituted lower alkyl group which may have substituent(s), X is oxygen atom and the like, Y is oxygen atom and the like, and Z is a methylene group which may have substituent(s), which is useful as a synthetic intermediate of the 1 .beta.-methylcarbapenem-type antibacterial agent.

Abstract: An image processing apparatus for storing image data into or from a frame memory is disclosed. The image data includes plural pieces of element data arranged in a matrix form of first predetermined numbers of rows and columns. The image processing apparatus includes a memory controller for controlling access to the frame memory for writing or reading the image data in or from the frame memory. The memory controller is configured to access the frame memory in either a raster unit consisting of one line of plural pieces of element data in the first predetermined numbers of rows and columns or a block unit consisting of plural pieces of element data arranged in a matrix of second predetermined numbers of rows and columns. The second predetermined number is smaller than the first predetermined number. A raster access address generator is connected to the memory controller and generates a raster access address for accessing the frame memory to write or read the image data in the raster unit.

Abstract: Novel process for preparing azetidinone compound of the formula ?III!: ##STR1## wherein R.sup.1 is H or lower alkyl, R.sup.2 and R.sup.3 combine together with the adjacent nitrogen to form heterocyclic group, and R.sup.4 is protected or unprotected hydroxy-substituted lower alkyl, which comprises reacting an alkanamide compound of the formula ?I!: ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 are the same as defined above, with a compound of the formula ?II!: ##STR3## wherein L.sup.1 is a leaving group and R.sup.4 is the same as defined above, in the presence of a base, said compound ?Ill! being useful as synthetic intermediate for 1-methylcarbapenem derivative having excellent antibacterial activity.

Abstract: There is disclosed an azetidinone compound of the formula [I]: ##STR1## wherein Ring B is a benzene ring which may have substituent(s), R.sup.1 is a hydroxy-substituted lower alkyl group which may have substituent(s), X is oxygen atom and the like, Y is oxygen atom and the like, and Z is a methylene group which may have substituent(s), which is useful as a synthetic intermediate of the 1.beta.-methylcarbapenem-type antibacterial agent.

Abstract: Disclosed is a process for preparing a .beta.-lactam compound represented by the formula: ##STR1## wherein R.sup.1 represents a hydroxy-substituted lower alkyl group or an amino group each of which may be protected; R.sup.2 represents hydrogen atom or an ester residue; X represents a methylene group which may be substituted by a lower alkyl group, sulfur atom or a group represented by the formula: --A--CH.sub.2 -- where A represents sulfur atom, oxygen atom or methylene group; and W represents an active ester residue of hydroxyl group,or a salt thereof, which comprises the steps of treating a 1-aza-3-thia-bicycloalkane compound represented by the formula: ##STR2## wherein R.sup.1, R.sup.2 and X have the same meanings as defined above, or a salt thereof with a base in the presence of a desulfurizing agent and then reacting the resulting compound with an active esterifying agent of hydroxyl group.

Abstract: A method for removing substituted or unsubstituted allyl group from .beta.-lactam compound having substituted or unsubstituted allyl group-protecting carboxyl group, which comprises treating said .beta.-lactam compound with palladium catalyst in the presence of allyl-scavenger in aqueous organic solvent, by which the substituted or unsubstituted group can be easily and effectively removed under moderate conditions so that the desired compound can be obtained in high yield at low cost.