Patents by Inventor Kazuhiko Michishita

Kazuhiko Michishita has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel hydrocortisone derivative
    Patent number: 4290962
    Abstract: 17.alpha.-butyryloxy-11.beta.-hydroxy-21-propionyloxy-4-pregnen-3,20-dione, i.e., hydrocortisone 17-butyrate 21-propionate of the present invention is prepared by acylating hydrocortisone 17-butyrate with propionic acid anhydride or halide. The compound of the present invention has excellent anti-inflammatory effect, percutaneous absorption and less side effect.
    Type: Grant
    Filed: March 26, 1979
    Date of Patent: September 22, 1981
    Assignee: Taisho Pharmaceutical Co., Ltd.
    Inventors: Yasuhide Tachi, Kazuhiko Michishita, Jozi Nakagami, Jiro Sawada, Mitsunori Washitake, Yoshiaki Kamano
  • Method for preparing 17 .alpha.-ester-21-halo pregnanes
    Patent number: 4113680
    Abstract: One-step method for preparing 17 .alpha.-ester-21-halo pregnanes by reacting 17 .alpha., 21-cyclic orthoesters of 17 .alpha., 21-dihydroxy pregnanes with a halo compound in the presence of an organic polar solvent, simultaneously resulting in halogenation at 21-position and esterification at 17 .alpha.-position of said 17 .alpha., 21-cyclic orthoesters, the reaction proceeding in a short period of time without, or substantially without, any unfavorable side-reactions.
    Type: Grant
    Filed: March 29, 1976
    Date of Patent: September 12, 1978
    Assignee: Taisho Pharmaceutical Co., Ltd.
    Inventors: Yoshiaki Kamano, Kazuhiko Michishita, Teruya Seki, Ichiro Tanaka