Patents by Inventor Kazuhiko Morino

Kazuhiko Morino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of constructing recombinant proteoliposome for diagnostic use
    Patent number: 8563291
    Abstract: [PROBLEMS] To provide a method for preparation of recombinant proteoliposomes suitable for diagnostic applications, a detection plate coated with the recombinant proteoliposomes, a detection kit and so on. [PROBLEM-SOLVING MEANS] Recombinant proteoliposomes are prepared by fusion of budded virus particles of a recombinant baculovirus, expressing a target membrane receptor (such as human thyroid-stimulating hormone receptor, acetylcholine receptor, insulin receptor, ?1 adrenergic receptor, asialoglycoprotein receptor, etc., each participating in an autoantibody-related disease), with liposomes. Compared with the recombinant baculoviruses, these proteoliposomes have an improved ability to bind to an autoantibody and makes it possible to produce easily a kit for its detection.
    Type: Grant
    Filed: February 15, 2007
    Date of Patent: October 22, 2013
    Assignee: Mie University
    Inventors: Tetsuro Yoshimura, Kanta Tsumoto, Kouji Imamura, Kazuhiko Morino, Jun Kobayashi
  • Antibody library
    Patent number: 8101553
    Abstract: An antibody library is prepared by selecting a light chain variable region capable of binding to the variable region of heavy chain to reproduce an active conformation and using the same. Because of being capable of maintaining the diversity of the heavy chain variable region at a high ratio in vitro, the antibody library of the present invention is expected as enabling the acquisition of antibodies with various binding activities.
    Type: Grant
    Filed: February 22, 2001
    Date of Patent: January 24, 2012
    Assignee: Medical & Biological Laboratories Co., Ltd.
    Inventors: Yoshikazu Kurosawa, Yasushi Akahori, Yoshitaka Iba, Kazuhiko Morino, Midori Shinohara, Motohide Takahashi, Yoshinobu Okuno, Kimiyasu Shiraki
  • Method of Constructing Recombinant Proteoliposome for Diagnostic Use
    Publication number: 20090186364
    Abstract: [PROBLEMS] To provide a method for preparation of recombinant proteoliposomes suitable for diagnostic applications, a detection plate coated with the recombinant proteoliposomes, a detection kit and so on. [PROBLEM-SOLVING MEANS] Recombinant proteoliposomes are prepared by fusion of budded virus particles of a recombinant baculovirus, expressing a target membrane receptor (such as human thyroid-stimulating hormone receptor, acetylcholine receptor, insulin receptor, ?1 adrenergic receptor, asialoglycoprotein receptor, etc., each participating in an autoantibody-related disease), with liposomes. Compared with the recombinant baculoviruses, these proteoliposomes have an improved ability to bind to an autoantibody and makes it possible to produce easily a kit for its detection.
    Type: Application
    Filed: February 15, 2007
    Publication date: July 23, 2009
    Applicant: MIE UNIVERSITY
    Inventors: Tetsuro Yoshimura, Kanta Tsumoto, Kouji Imamura, Kazuhiko Morino, Jun Kobayashi