Patents by Inventor Kazuhiko Nakagawa

Kazuhiko Nakagawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210003579
    Abstract: Disclosed is a method for assisting a determination of an efficacy of an immune checkpoint inhibitor, the method comprising: measuring a free protein marker in a liquid sample collected from a subject; and determining the efficacy of the immune checkpoint inhibitor in the subject based on a result of the measurement, wherein the free protein marker is at least one selected from free Cytotoxic T lymphocyte antigen-4 (CTLA-4), free Programmed cell death-1 (PD-1) and free Programmed cell death-ligand 1 (PD-L1).
    Type: Application
    Filed: September 23, 2020
    Publication date: January 7, 2021
    Applicants: KYOTO UNIVERSITY, Kinki University, ONO PHARMACEUTICAL CO., LTD., SYSMEX CORPORATION
    Inventors: Tasuku HONJO, Kenji CHAMOTO, Hidetoshi HAYASHI, Kazuhiko NAKAGAWA, Megumi GOTO, Hitoshi UGA
  • Publication number: 20200173999
    Abstract: A method for selecting an individual to be a candidate for administration of an immune checkpoint inhibitor in treatment of a tumor, comprising: (1) a step of collecting a tumor tissue from the individual, (2) a step of determining the extent of B7-H3 expression in the tumor tissue collected in step (1), and (3) a step of selecting the individual as an individual to be a candidate for administration of the immune checkpoint inhibitor if the B7-H3 expression level is considered to be negative, is provided.
    Type: Application
    Filed: December 25, 2017
    Publication date: June 4, 2020
    Applicants: KINKI UNIVERSITY, DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Kimio Yonesaka, Kazuhiko Nakagawa, Kenji Hirotani
  • Publication number: 20200115467
    Abstract: The present invention is directed to methods of identifying and treating a human subject harboring a tumor or other disease comprising assessing HRG gene expression at a protein level in the human subject and administering a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at a protein level is assessed as high. The present invention is also directed to methods of identifying a human subject harboring a tumor or other disease comprising assessing HRG gene expression at a protein level in the human subject and withholding a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at a protein level is assessed as low.
    Type: Application
    Filed: August 21, 2019
    Publication date: April 16, 2020
    Applicants: Daiichi Sankyo Co., Ltd., U3 Pharma GmbH, Kinki University, Amgen, Inc.
    Inventors: Matthias SCHNEIDER, Sabine BLUM, Renee Jeanne MENDELL-HARARY, Daniel J. FREEMAN, Robert Allen BECKMAN, Xiaoping JIN, Kimio YONESAKA, Kazuhiko NAKAGAWA
  • Publication number: 20200061031
    Abstract: [Problem] To provide a therapeutic agent and a therapeutic method for EGFR-TKI-resistant non-small cell lung cancer. [Solution] Provided are: a therapeutic agent that contains an anti-HER3 antibody-drug conjugate as an active ingredient, or a therapeutic method characterized by administering an anti-HER3 antibody-drug conjugate.
    Type: Application
    Filed: February 27, 2018
    Publication date: February 27, 2020
    Applicants: KINKI UNIVERSITY, DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Kimio YONESAKA, Kazuhiko NAKAGAWA, Kenji HIROTANI
  • Publication number: 20190002988
    Abstract: The present invention relates to a RET fusion gene such as a CCDC6-RET fusion gene as a biomarker to monitor the activity of the compound 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone or a pharmaceutically acceptable salt thereof, and especially its monoethanesulphonate salt form, when used alone or optionally in combination with further pharmaceutically active ingredients and/or further treatments. The present invention also relates to specific uses of said specific compound in the treatment of cancers.
    Type: Application
    Filed: December 5, 2016
    Publication date: January 3, 2019
    Inventors: Hidetoshi HAYASHI, Kazuhiko NAKAGAWA, Kazuto NISHIO, Kunio OKAMOTO, Kazuko SAKAI, Toshio SHIMIZU, Masayuki TAKEDA, Kaoru TANAKA
  • Publication number: 20170166654
    Abstract: The present invention is directed to methods of identifying and treating a human subject harboring a tumor or other disease comprising assessing HRG gene expression at a protein level in the human subject and administering a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at a protein level is assessed as high. The present invention is also directed to methods of identifying a human subject harboring a tumor or other disease comprising assessing HRG gene expression at a protein level in the human subject and withholding a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at a protein level is assessed as low.
    Type: Application
    Filed: October 19, 2016
    Publication date: June 15, 2017
    Applicants: Daiichi Sankyo Co. Ltd., U3 Pharma GmbH, Kinki University, Amgen, Inc.
    Inventors: Matthias SCHNEIDER, Sabine BLUM, Renee Jeanne MENDELL-HARARY, Daniel J. FREEMAN, Robert Allen BECKMAN, Xiaoping JIN, Kimio YONESAKA, Kazuhiko NAKAGAWA
  • Patent number: 9680081
    Abstract: Problem There is proposed an innovative cross-sectional structure, with an idea contrary to the conventional one, utilizing the non-reactivity between Cu and Ta (or between Ag and Nb, Ta) in a high-temperature short-time heat treatment, thus achieving (1) the suppression of the low magnetic-field instability, (2) excellent wire drawability of a precursor wire, and (3) the reduction of the cost required for the incorporation of a stabilizer. Means for Resolution There is proposed a structure having an assembly of a plurality of single wires, wherein the assembly is covered with an outer cover (skin) formed from Nb or Ta, wherein each of the single wires has an Nb/Al composite filament region which is formed from a composite of Nb and Al mixed in an Nb:Al molar ratio of 3:1, and which is covered with a partition formed from Nb or Ta, and further covered with an interfilamentary barrier formed from Cu or Ag disposed around the partition.
    Type: Grant
    Filed: November 15, 2012
    Date of Patent: June 13, 2017
    Assignees: NATIONAL INSTITUTE FOR MATERIAL SCIENCE, INTER-UNIVERSITY RESEARCH INSTITUTE CORPORATION HIGH ENERGY ACCELERATOR RESEARCH ORGANIZATION
    Inventors: Takao Takeuchi, Kiyosumi Tsuchiya, Kazuhiko Nakagawa
  • Patent number: 9518762
    Abstract: A hot water supply system includes a plurality of water heaters, one of which is designated as a master, and the rest(s) of which is/are designated as (a) slave(s). A control unit that is provided for each of the water heaters operates a water heater, for which the control unit is provided, as the master or the slave, the master controls the slave(s), and the master and the slave(s) control hot water supply.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: December 13, 2016
    Assignee: PURPOSE CO., LTD.
    Inventors: Yasutaka Hatada, Kazuhiko Nakagawa, Katumi Naitoh
  • Patent number: 9182159
    Abstract: A water heater includes one or a plurality of heat pumps that heat tap water or return water from a hot water supply part, a circulation line that supplies hot water heated in the heat pumps to the hot water supply part, and introduces the return water from the hot water supply part to the heat pumps, an incoming water pipe that joins to between the hot water supply part in the circulation line and the heat pumps and supplies the tap water, a circulation pump that returns the return water to the heat pumps and circulates the return water through the circulation line, and a control unit that controls operation or stop of the circulation pump according to driving operation time or elapsed stop time by linking a combustion process of the heat pumps.
    Type: Grant
    Filed: October 14, 2010
    Date of Patent: November 10, 2015
    Assignee: PURPOSE COMPANY LIMITED
    Inventors: Yasutaka Hatada, Kazuhiko Nakagawa, Katumi Naitoh
  • Patent number: 9177700
    Abstract: A precursor for a Nb3Sn superconductor wire to be manufactured by the internal diffusion method, includes a plurality of Nb-based single core wires, each of which includes a Nb-based core coated with a Cu-based coating including a Cu-based matrix, a plurality of Sn-based single core wires, each of which includes a Sn-based core coated with a Cu-based coating including a Cu-based matrix; and a cylindrical diffusion barrier including Ta or Nb, in which the plurality of Nb-based single core wires and the plurality of Sn-based single core wires are regularly disposed, wherein the plurality of Nb-based single core wires include Nb-based single core wires having a Cu/Nb ratio of 0.4 or more, wherein the Cu/Nb ratio is a cross sectional area ratio of the Cu-based coating to the Nb-based core.
    Type: Grant
    Filed: September 9, 2013
    Date of Patent: November 3, 2015
    Assignee: SH COPPER PRODUCTS CO., LTD.
    Inventors: Yoshihide Wadayama, Katsumi Ohata, Kazuhiko Nakagawa, Morio Kimura
  • Publication number: 20150147326
    Abstract: The present invention is directed to methods of identifying and treating a human subject harboring a tumor or other disease comprising assessing HRG gene expression at a protein level in the human subject and administering a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at a protein level is assessed as high. The present invention is also directed to methods of identifying a human subject harboring a tumor or other disease comprising assessing HRG gene expression at a protein level in the human subject and withholding a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at a protein level is assessed as low.
    Type: Application
    Filed: September 30, 2014
    Publication date: May 28, 2015
    Applicants: Daiichi Sankyo Company, Limited, U3 Pharma GmbH, Kinki University
    Inventors: Matthias SCHNEIDER, Sabine BLUM, Renee Jeanne MENDELL-HARARY, Daniel J. FREEMAN, Robert Allen BECKMAN, Xiaoping JIN, Kimio YONESAKA, Kazuhiko NAKAGAWA
  • Publication number: 20140379147
    Abstract: A hot water supply system includes a plurality of water heaters, one of which is designated as a master, and the rest(s) of which is/are designated as (a) slave(s). A control unit that is provided for each of the water heaters operates a water heater, for which the control unit is provided, as the master or the slave, the master controls the slave(s), and the master and the slave(s) control hot water supply.
    Type: Application
    Filed: September 5, 2014
    Publication date: December 25, 2014
    Applicant: PURPOSE CO., LTD.
    Inventors: Yasutaka Hatada, Kazuhiko Nakagawa, Katumi Naitoh
  • Patent number: 8868251
    Abstract: A hot water supply system including a water heater that includes a storage unit storing at least device information of another water heater, and performs hot water supply control by which the water heater cooperates with the other water heater, these water heaters being able to supply hot water according to a hot water supply request; one or a plurality of the other water heater that is connected to the water heater in parallel, and supplies hot water according to the hot water supply control by the water heater; communication connection means that communicably connects the water heater and the other water heater; water supply means that supplies water to the water heater and the other water heater; and hot water supply means that supplies hot water heated by the water heater and the other water heater to a hot water supply destination.
    Type: Grant
    Filed: February 28, 2011
    Date of Patent: October 21, 2014
    Assignee: Purpose Company Limited
    Inventors: Yasutaka Hatada, Kazuhiko Nakagawa, Katumi Naitoh
  • Patent number: 8802384
    Abstract: The present invention relates to biomarkers to monitor the activity of the compound 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone or a pharmaceutically acceptable salt thereof, and especially its monoethanesulphonate salt form, when used alone or optionally in combination with further pharmaceutically active ingredients and/or further treatments, such as for example radiotherapy.
    Type: Grant
    Filed: March 9, 2010
    Date of Patent: August 12, 2014
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Tokuzo Arao, Kanae Kudo, Kazuhiko Nakagawa, Kazuto Nishio
  • Publication number: 20140221215
    Abstract: A precursor for a Nb3Sn superconductor wire to be manufactured by the internal diffusion method, includes a plurality of Nb-based single core wires, each of which includes a Nb-based core coated with a Cu-based coating including a Cu-based matrix, a plurality of Sn-based single core wires, each of which includes a Sn-based core coated with a Cu-based coating including a Cu-based matrix; and a cylindrical diffusion barrier including Ta or Nb, in which the plurality of Nb-based single core wires and the plurality of Sn-based single core wires are regularly disposed, wherein the plurality of Nb-based single core wires include Nb-based single core wires having a Cu/Nb ratio of 0.4 or more, wherein the Cu/Nb ratio is a cross sectional area ratio of the Cu-based coating to the Nb-based core.
    Type: Application
    Filed: September 9, 2013
    Publication date: August 7, 2014
    Applicant: SH Copper Products Co., Ltd.
    Inventors: Yoshihide Wadayama, Katsumi Ohata, Kazuhiko Nakagawa, Morio Kimura
  • Patent number: 8778841
    Abstract: A precursor for a Nb3Sn superconductor wire to be manufactured by the internal diffusion method. The precursor includes Nb-based single core wires, Sn-based single core wires, and a cylindrical diffusion barrier made of Ta or Nb. Each Nb-based single core wire includes a Nb-based core coated with a Cu-based coating made of a Cu-based matrix. Each Sn-based single core wire includes a Sn-based core coated with a Cu-based coating made of a Cu-based matrix. The Nb-based single core wires and the Sn-based single core wires are regularly disposed in the diffusion barrier. The Nb-based single core wires includes at least two kinds of Nb-based single core wires having different Cu/Nb ratios and the Cu/Nb ratio is a cross sectional area ratio of the Cu-based coating to the Nb-based core.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: July 15, 2014
    Assignee: SH Copper Products Co., Ltd.
    Inventors: Yoshihide Wadayama, Katsumi Ohata, Kazuhiko Nakagawa, Morio Kimura
  • Patent number: 8598188
    Abstract: This invention relates to an antitumor agent comprising carboplatin and a combination drug of tegafur/gimeracil/oteracil potassium to be administered to a cancer patient selected according to an expression level of thymidylate synthase gene.
    Type: Grant
    Filed: March 8, 2010
    Date of Patent: December 3, 2013
    Assignees: Kinki University, Taiho Pharmaceutical Co., Ltd.
    Inventors: Kazuhiko Nakagawa, Isamu Okamoto
  • Publication number: 20130053250
    Abstract: An Nb3Sn superconductor wire is manufactured by heating a precursor for an Nb3Sn superconductor wire. The precursor includes a Cu tube made of Cu or Cu-alloy, assemblies, each of which includes Nb filaments disposed in the Cu tube, and each of the Nb filaments includes an Nb core made of Nb or Nb-alloy. Each of the assemblies also includes Sn filaments disposed in the Cu tube, and each of the Sn filaments includes a Sn core made of Sn or Sn-alloy. The precursor also includes reinforcing filaments disposed in the Cu tube for dividing the assemblies such that the assemblies are not adjacent to each other. By heating the precursor, Sn in the Sn core is diffused into the Nb core to produce Nb3Sn.
    Type: Application
    Filed: August 23, 2012
    Publication date: February 28, 2013
    Applicant: HITACHI CABLE, LTD.
    Inventors: Katsumi OHATA, Yoshihide WADAYAMA, Kazuhiko NAKAGAWA, Morio KIMURA
  • Publication number: 20120149579
    Abstract: A precursor for a Nb3Sn superconductor wire to be manufactured by the internal diffusion method. The precursor includes Nb-based single core wires, Sn-based single core wires, and a cylindrical diffusion barrier made of Ta or Nb. Each Nb-based single core wire includes a Nb-based core coated with a Cu-based coating made of a Cu-based matrix. Each Sn-based single core wire includes a Sn-based core coated with a Cu-based coating made of a Cu-based matrix. The Nb-based single core wires and the Sn-based single core wires are regularly disposed in the diffusion barrier. The Nb-based single core wires includes at least two kinds of Nb-based single core wires having different Cu/Nb ratios and the Cu/Nb ratio is a cross sectional area ratio of the Cu-based coating to the Nb-based core.
    Type: Application
    Filed: September 23, 2011
    Publication date: June 14, 2012
    Applicant: HITACHI CABLE, LTD.
    Inventors: Yoshihide Wadayama, Katsumi Ohata, Kazuhiko Nakagawa, Morio Kimura
  • Publication number: 20120138149
    Abstract: A hot water supply system including a water heater that includes a storage unit storing at least device information of another water heater, and performs hot water supply control by which the water heater cooperates with the other water heater, these water heaters being able to supply hot water according to a hot water supply request; one or a plurality of the other water heater that is connected to the water heater in parallel, and supplies hot water according to the hot water supply control by the water heater; communication connection means that communicably connects the water heater and the other water heater; water supply means that supplies water to the water heater and the other water heater; and hot water supply means that supplies hot water heated by the water heater and the other water heater to a hot water supply destination.
    Type: Application
    Filed: February 28, 2011
    Publication date: June 7, 2012
    Applicant: TAKAGI INDUSTRIAL CO., LTD.
    Inventors: Yasutaka Hatada, Kazuhiko Nakagawa, Katumi Naitoh