Abstract: The present invention provides a drug for at least one of prevention and treatment of cardiac failure capable of suppressing cardiac depression and the onset of cardiac failure in ventricular remodeling, and a method for screening the drug. The drug for at least one of prevention and treatment of cardiac failure of the present invention contains a compound that inhibits a functional expression of ASK1 protein in a cardiomyocyte as an active ingredient, and a method for screening a drug for at least one of prevention and treatment of cardiac failure of the present invention includes selecting a medicinal component for at least one of prevention and treatment of cardiac failure from a drug candidate compound by using inhibition of a functional expression of ASK1 protein as an indication. As shown in FIG.

Abstract: High chromium steel, for use at high temperature, of a mixed structure containing ferrite and 0.02-0.09% C, less than 1.0% Si, 0.1-2.0% Mn, 7.0-13.0% chromium, 1.2-3.0% Mo, and the rest being iron and the usual impurities, or further adding aluminum in an amount less than 0.1% to said composition, or further adding 0.001-0.1% boron and less than 0.1% Ti necessary to cause the boron to act effectively, said steel being heated at temperatures lower than about 1050.degree. C. to prevent the oxidation of the steel.