Abstract: Provided is a substance capable of effectively suppressing cancer metastasis or a pharmaceutical composition that effectively acts on an inflammatory disease. The pharmaceutical composition is a pharmaceutical composition containing, as an active ingredient, an antibody or an antibody fragment thereof having antigen-binding activity for an S100A8/A9 heterodimer, and blocks interaction between S100A8/A9 and a group of receptors therefor, to thereby strongly suppress cancer metastasis both in vitro and in vivo, or alleviate inflammation. That is, the anti-S100A8/A9 antibody or the antibody fragment thereof can strongly suppress cancer metastasis or alleviate inflammation, by virtue of its blocking action on the interaction between S100A8/A9 and the group of receptors therefor.

Abstract: The present invention can provide novel compounds useful as orally administrable growth hormone releaser, more specifically a benzimidazolidinone derivative of formula (1) or a pharmaceutically acceptable salt thereof: (1) wherein R1 is optionally substituted alkyl or the like; R2, R3 and R4 are each hydrogen, optionally substituted alkyl, or the like; R5 is optionally substituted aryl; q is 0 or 1; and W1 is a group represented by formula (2): (2) n is 1, 2 or 3; m is 0, 1, 2 or 3; R6 and R7 are each hydrogen, optionally substituted alkyl, or the like; and R8 and R9 are each hydrogen, optionally substituted alkyl, or the like.

Abstract: The present invention can provide novel compounds useful as orally administrable growth hormone releaser, more specifically a benzimidazolidinone derivative of formula (1) or a pharmaceutically acceptable salt thereof:

Abstract: There is disclosed a cold storage which improves a door insulating performance, and which is preferable particularly for low-temperature insulation of chemicals, and the like. A low-temperature insulating showcase is formed by openably closing a storage chamber opening constituted in an insulation box by a door, the door is constituted of a transparent panel and a see-through composite layer glass, and a panel is detachably attached to the storage chamber side of the composite layer glass.

Abstract: An oxindole of Formula 1 or a prodrug thereof, or a pharmaceutically acceptable salt thereof is useful for growth hormone releaser: wherein R1, R2, R3 and R4 are independently hydrogen, optionally substituted alkyl etc; R5 is optionally substituted aryl or optionally substituted heteroaryl; Z is —O— or —NH—; one of W1 and W2 is hydrogen, alkyl or —Y—CON(R10)R11; the other of W1 and W2 is n is 1, 2 or 3; m is 0, 1, 2 or 3; Y is single bond or C1-C3 alkylene; R6 and R7 are independently hydrogen, optionally substituted alkyl etc; R8 and R9 are independently hydrogen, optionally substituted alkyl etc; R10 and R11 are independently hydrogen, alkyl etc.