Patents by Inventor Kazuhiko Takeuchi

Kazuhiko Takeuchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9867919
    Abstract: A production method for a medical instrument includes a plurality of integrated hollow fiber membrane producing a base material forming a cylindrically-shaped body. Each of the hollow fiber membranes sequentially passes through a first point, a second point, a third point, a fourth point, and a fifth point that are set on a core member. In an outward path heading toward the third point from the second point, the hollow fiber membrane reaches the third point from the second point at the shortest distance while being wound in the circumferential direction of the core member. Moreover, in a homeward path heading toward the fifth point from the fourth point, the hollow fiber membrane reaches the fifth point from the fourth point at the shortest distance while being wound in the circumferential direction of the core member in the same direction as in the case of the outward path.
    Type: Grant
    Filed: September 24, 2014
    Date of Patent: January 16, 2018
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Kazuhiko Takeuchi, Eisuke Sasaki
  • Patent number: 9867920
    Abstract: An Oxygenator as a medical instrument includes at least one first hollow fiber membrane layer comprised of a plurality of integrated first hollow fiber membranes, and forms a shape of a cylindrical body as a whole, and at least one second hollow fiber membrane layer disposed at the outer circumferential side of the first hollow fiber membrane layer in a state of being concentric with the first hollow fiber membrane layer, has a plurality of integrated second hollow fiber membranes, and forms a shape of a cylindrical body as a whole. Moreover, each of the first hollow fiber membranes is wound around a central axis, and each of the second hollow fiber membranes is wound around a central axis. The number of times the second hollow fiber membranes are wound is smaller than the number of times the first hollow fiber membranes are wound.
    Type: Grant
    Filed: September 24, 2014
    Date of Patent: January 16, 2018
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Kazuhiko Takeuchi, Eisuke Sasaki
  • Patent number: 9839736
    Abstract: A production method for a medical instrument includes a plurality of integrated hollow fiber membrane producing a base material forming a cylindrically-shaped body. Each of the hollow fiber membranes sequentially passes through a first point, a second point, a third point, a fourth point, and a fifth point that are set on a core member. In an outward path heading toward the third point from the second point, the hollow fiber membrane reaches the third point from the second point at the shortest distance while being wound in the circumferential direction of the core member. Moreover, in a homeward path heading toward the fifth point from the fourth point, the hollow fiber membrane reaches the fifth point from the fourth point at the shortest distance while being wound in the circumferential direction of the core member in the same direction as in the case of the outward path.
    Type: Grant
    Filed: September 24, 2014
    Date of Patent: December 12, 2017
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Kazuhiko Takeuchi, Eisuke Sasaki
  • Patent number: 9283311
    Abstract: An oxygenator includes: a housing; a hollow fiber membrane bundle stored in the housing and having multiple integrated hollow fiber membranes with a gas exchange function; a gas inlet portion and a gas outlet portion provided on the upstream and downstream of gas passages in lumens of the hollow fiber membranes, respectively; a blood inlet portion and a blood outlet portion provided on the upstream and downstream of blood passages outside the hollow fiber membranes, respectively; a first filter member provided on the hollow fiber membrane bundle in contact with a blood outlet portion side surface so as to cover substantially the entire surface and has a function to catch bubbles in blood; and a second filter member that is separated from the first filter member, positioned between the first filter member and the blood outlet portion, and has a function to catch bubbles in blood.
    Type: Grant
    Filed: September 30, 2013
    Date of Patent: March 15, 2016
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventor: Kazuhiko Takeuchi
  • Patent number: 9199023
    Abstract: An oxygenator includes a housing; a hollow fiber membrane layer that is stored in the housing and has multiple integrated hollow fiber membranes with a gas exchange function; a gas inlet portion and a gas outlet portion that are provided on the upstream and downstream of gas passages in lumens of the hollow fiber membranes, respectively; and a blood inlet portion and a blood outlet portion that are provided on the upstream and downstream of blood passages outsides of the hollow fiber membranes, respectively. The hollow fiber membranes in the hollow fiber membrane layer are fixed relative to each other at one end portion and the other end portion thereof. Conditions 30??60 and OD?4.5×? are met where ? [?m] is an average separation distance between the adjacent hollow fiber membranes at a fixed portion of the hollow fiber membrane layer and OD [?m] is the outer diameter of the hollow fiber membrane.
    Type: Grant
    Filed: September 30, 2013
    Date of Patent: December 1, 2015
    Inventor: Kazuhiko Takeuchi
  • Publication number: 20150010434
    Abstract: An Oxygenator as a medical instrument includes at least one first hollow fiber membrane layer comprised of a plurality of integrated first hollow fiber membranes, and forms a shape of a cylindrical body as a whole, and at least one second hollow fiber membrane layer disposed at the outer circumferential side of the first hollow fiber membrane layer in a state of being concentric with the first hollow fiber membrane layer, has a plurality of integrated second hollow fiber membranes, and forms a shape of a cylindrical body as a whole. Moreover, each of the first hollow fiber membranes is wound around a central axis, and each of the second hollow fiber membranes is wound around a central axis. The number of times the second hollow fiber membranes are wound is smaller than the number of times the first hollow fiber membranes are wound.
    Type: Application
    Filed: September 24, 2014
    Publication date: January 8, 2015
    Applicant: Terumo Kabushiki Kaisha
    Inventors: Kazuhiko Takeuchi, Eisuke Sasaki
  • Publication number: 20150010433
    Abstract: A production method for a medical instrument includes a plurality of integrated hollow fiber membrane producing a base material forming a cylindrically-shaped body. Each of the hollow fiber membranes sequentially passes through a first point, a second point, a third point, a fourth point, and a fifth point that are set on a core member. In an outward path heading toward the third point from the second point, the hollow fiber membrane reaches the third point from the second point at the shortest distance while being wound in the circumferential direction of the core member. Moreover, in a homeward path heading toward the fifth point from the fourth point, the hollow fiber membrane reaches the fifth point from the fourth point at the shortest distance while being wound in the circumferential direction of the core member in the same direction as in the case of the outward path.
    Type: Application
    Filed: September 24, 2014
    Publication date: January 8, 2015
    Applicant: Terumo Kabushiki Kaisha
    Inventors: Kazuhiko TAKEUCHI, Eisuke Sasaki
  • Publication number: 20140030146
    Abstract: An oxygenator includes a housing; a hollow fiber membrane layer that is stored in the housing and has multiple integrated hollow fiber membranes with a gas exchange function; a gas inlet portion and a gas outlet portion that are provided on the upstream and downstream of gas passages in lumens of the hollow fiber membranes, respectively; and a blood inlet portion and a blood outlet portion that are provided on the upstream and downstream of blood passages outsides of the hollow fiber membranes, respectively. The hollow fiber membranes in the hollow fiber membrane layer are fixed relative to each other at one end portion and the other end portion thereof. Conditions 30??60 and OD?4.5×? are met where ? [?m] is an average separation distance between the adjacent hollow fiber membranes at a fixed portion of the hollow fiber membrane layer and OD [?m] is the outer diameter of the hollow fiber membrane.
    Type: Application
    Filed: September 30, 2013
    Publication date: January 30, 2014
    Applicant: TERUMO KABUSHIKI KAISHA
    Inventor: Kazuhiko TAKEUCHI
  • Publication number: 20140030149
    Abstract: An oxygenator includes: a housing; a hollow fiber membrane bundle stored in the housing and having multiple integrated hollow fiber membranes with a gas exchange function; a gas inlet portion and a gas outlet portion provided on the upstream and downstream of gas passages in lumens of the hollow fiber membranes, respectively; a blood inlet portion and a blood outlet portion provided on the upstream and downstream of blood passages outside the hollow fiber membranes, respectively; a first filter member provided on the hollow fiber membrane bundle in contact with a blood outlet portion side surface so as to cover substantially the entire surface and has a function to catch bubbles in blood; and a second filter member that is separated from the first filter member, positioned between the first filter member and the blood outlet portion, and has a function to catch bubbles in blood.
    Type: Application
    Filed: September 30, 2013
    Publication date: January 30, 2014
    Applicant: TERUMO KABUSHIKI KAISHA
    Inventor: Kazuhiko TAKEUCHI
  • Patent number: 8242186
    Abstract: In a method for producing a lactic acid oligomer by subjecting an aqueous lactic acid solution to a polycondensation reaction under microwave irradiation, the polycondensation reaction is carried out under reduced pressure in the absence of a polymerization catalyst and an organic solvent. An initial polycondensation reaction is carried out under normal pressure, and thereafter, a reaction is carried out under reduced pressure. The pressure is reduced stepwise to give a final pressure of 2000 Pa or less. A lactic acid oligomer which has a high purity and is safe from hygiene point of view can be obtained at a low cost in a short time.
    Type: Grant
    Filed: December 19, 2007
    Date of Patent: August 14, 2012
    Assignee: National Institute of Advanced Industrial Science and Technology
    Inventors: Ritsuko Nagahata, Masako Momotake, Kazuhiko Takeuchi, Takashi Nakamura
  • Patent number: 7959596
    Abstract: An extracorporeal circuit, which makes it possible to efficiently collect priming solution by displacing the priming solution with blood after the priming solution is fed to the extracorporeal circuit to prime the extracorporeal circuit, includes a circuit body including first and second tubes, a feed bag that feeds the priming solution, a blood reservoir in which a liquid is temporarily stored, a third tube that branches out from the middle of the first tube, and a collection bag which communicates with the third tube and into which the priming solution is collected through the third tube. After the priming solution is fed from the feed bag to prime at least a housing, when the priming solution in the housing is displaced by blood, the priming solution in the housing is transferred and collected in the collection bag due to a height difference between the liquid level and the collection bag.
    Type: Grant
    Filed: April 17, 2008
    Date of Patent: June 14, 2011
    Assignee: Terumo Kabushiki Kaisha
    Inventors: Mitsuaki Ogihara, Kazuhiko Takeuchi
  • Patent number: 7947007
    Abstract: A bubble trap for removing bubbles from blood flowing through an extracorporeal circuit includes device body possessing blood inlet and outlet ports, and a negative-pressure chamber at the upper part of the device body that is adapted to be connected to a gas evacuator at a gas outlet port so that a negative-pressure state can be kept therein. Two communication passages provide communication between the gas outlet port and the device body. On the first communication passage, a liquid-repellant or water-repellent filter is provided in a manner crossing the passage. On the second communication passage, a valve member is arranged. Within the device body, a buoyant float is provided. A mechanism is provided to remove bubbles from the blood by the cooperation of the float and the valve member.
    Type: Grant
    Filed: April 9, 2007
    Date of Patent: May 24, 2011
    Assignee: Terumo Kabushiki Kaisha
    Inventors: Hidetaka Nakayama, Mitsuaki Ogihara, Kazuhiko Takeuchi
  • Patent number: 7922683
    Abstract: An extracorporeal circulator comprising a line for extracting blood from a patient, a pump for supplying blood, an artificial lung section performing gas exchange on blood, a line for supplying blood passed through the artificial lung section to the patient, a unit for removing bubbles mixed into the blood, a controller for controlling the flow rate of blood being supplied such that bubbles are not fed to the patient, and a line for detouring blood delivered from the blood pump to return it to the blood pump.
    Type: Grant
    Filed: July 21, 2005
    Date of Patent: April 12, 2011
    Assignee: Terumo Kabushiki Kaisha
    Inventors: Mitsuaki Ogihara, Hidetaka Nakayama, Kazuhiko Takeuchi, Yuki Ishikura, Akiyasu Ito
  • Publication number: 20100125110
    Abstract: In a method for producing a lactic acid oligomer by subjecting an aqueous lactic acid solution to a polycondensation reaction under microwave irradiation, the polycondensation reaction is carried out under reduced pressure in the absence of a polymerization catalyst and an organic solvent. An initial polycondensation reaction is carried out under normal pressure, and thereafter, a reaction is carried out under reduced pressure. The pressure is reduced stepwise to give a final pressure of 2000 Pa or less. A lactic acid oligomer which has a high purity and is safe from hygiene point of view can be obtained at a low cost in a short time.
    Type: Application
    Filed: December 19, 2007
    Publication date: May 20, 2010
    Inventors: Ritsuko Nagahata, Masako Momotake, Kazuhiko Takeuchi, Takashi Nakamura
  • Publication number: 20100004479
    Abstract: A process for producing a carbonic ester, characterized in that an aromatic monohydroxy compound or an aliphatic monohydroxy compound is subjected to oxidative carbonylation with carbon monoxide and oxygen in the presence of a palladium catalyst using a compound having a carbonate bond as a reaction solvent. A process for producing a polycarbonate, characterized in that an aromatic dihydroxy compound or an aliphatic dihydroxy compound is subjected to oxidative carbonylation with carbon monoxide and oxygen in the presence of a palladium catalyst using a compound having a carbonate bond as a reaction solvent is also described. The carbonic ester can be produced with a higher yield and at a higher reaction rate and, also, a polycarbonate having a higher molecular weight as compared with the conventional method can be produced with a higher yield and at a higher reaction rate.
    Type: Application
    Filed: July 30, 2009
    Publication date: January 7, 2010
    Applicants: NATIONAL INSTIT. OF ADVANCE INDUST SCIENCE AND TECH, Idemitsu Kosan Co., Ltd.
    Inventors: Masaya Okamoto, Ju-ichi Sugiyama, Kazuhiko Takeuchi, Mitsuru Ueda
  • Publication number: 20090175762
    Abstract: An oxygenator unit includes a venous reservoir, a centrifugal pump, an oxygenator, a connection part for connecting the reservoir and the pump, a connection part for connecting the pump and the oxygenator, and a unit frame. The unit frame includes a reservoir receiving part, a pump receiving part provided at the position under a blood outlet of the venous reservoir disposed at the reservoir receiving part, and an oxygenator receiving part provided at the position in the vicinity of the blood outlet of the centrifugal pump disposed on the pump receiving part. The reservoir is disposed at the reservoir receiving part, the pump is disposed at the pump receiving part; and the oxygenator is disposed at the oxygenator receiving part, and they are held by the unit frame, resulting in a unit.
    Type: Application
    Filed: January 6, 2009
    Publication date: July 9, 2009
    Applicant: Terumo Kabushiki Kaisha
    Inventors: Mitsuaki Ogihara, Norikazu Ishida, Kazuhiko Takeuchi
  • Publication number: 20080262405
    Abstract: An extracorporeal circuit, which makes it possible to efficiently collect priming solution by displacing the priming solution with blood after the priming solution is fed to the extracorporeal circuit to prime the extracorporeal circuit, includes a circuit body including first and second tubes, a feed bag that feeds the priming solution, a blood reservoir in which a liquid is temporarily stored, a third tube that branches out from the middle of the first tube, and a collection bag which communicates with the third tube and into which the priming solution is collected through the third tube. After the priming solution is fed from the feed bag to prime at least a housing, when the priming solution in the housing is displaced by blood, the priming solution in the housing is transferred and collected in the collection bag due to a height difference between the liquid level and the collection bag.
    Type: Application
    Filed: April 17, 2008
    Publication date: October 23, 2008
    Applicant: TERUMO KABUSHIKI KAISHA
    Inventors: Mitsuaki Ogihara, Kazuhiko Takeuchi
  • Publication number: 20080221498
    Abstract: An extracorporeal circulator comprising a line for extracting blood from a patient, a pump for supplying blood, an artificial lung section performing gas exchange on blood, a line for supplying blood passed through the artificial lung section to the patient, a unit for removing bubbles mixed into the blood, a controller for controlling the flow rate of blood being supplied such that bubbles are not fed to the patient, and a line for detouring blood delivered from the blood pump to return it to the blood pump.
    Type: Application
    Filed: July 21, 2005
    Publication date: September 11, 2008
    Applicant: TERUMO KABUSHIKI KAISHA
    Inventors: Mitsuaki Ogihara, Hidetaka Nakayama, Kazuhiko Takeuchi, Yuki Ishikura, Akiyasu Ito
  • Publication number: 20070239097
    Abstract: A bubble trap for removing bubbles from blood flowing through an extracorporeal circuit includes device body possessing blood inlet and outlet ports, and a negative-pressure chamber at the upper part of the device body that is adapted to be connected to a gas evacuator at a gas outlet port so that a negative-pressure state can be kept therein. Two communication passages provide communication between the gas outlet port and the device body. On the first communication passage, a liquid-repellant or water-repellent filter is provided in a manner crossing the passage. On the second communication passage, a valve member is arranged. Within the device body, a buoyant float is provided. A mechanism is provided to remove bubbles from the blood by the cooperation of the float and the valve member.
    Type: Application
    Filed: April 9, 2007
    Publication date: October 11, 2007
    Applicant: Terumo Kabushiki Kaisha
    Inventors: Hidetaka Nakayama, Mitsuaki Ogihara, Kazuhiko Takeuchi
  • Publication number: 20050234259
    Abstract: A process for producing a carbonic ester, characterized in that an aromatic monohydroxy compound or an aliphatic monohydroxy compound is subjected to oxidative carbonylation with carbon monoxide and oxygen in the presence of a palladium catalyst using a compound having a carbonate bond as a reaction solvent. A process for producing a polycarbonate, characterized in that an aromatic dihydroxy compound or an aliphatic dihydroxy compound is subjected to oxidative carbonylation with carbon monoxide and oxygen in the presence of a palladium catalyst using a compound having a carbonate bond as a reaction solvent is also described. The carbonic ester can be produced with a higher yield and at a higher reaction rate and, also, a polycarbonate having a higher molecular weight as compared with the conventional method can be produced with a higher yield and at a higher reaction rate.
    Type: Application
    Filed: March 27, 2003
    Publication date: October 20, 2005
    Applicants: NATIONAL INSTIT OF ADVANCE INDUST SCIENCE AND TECH, Idemitsu Kosan Co., Ltd
    Inventors: Masaya Okamoto, Jun-ichi Sugiyama, Kazuhiko Takeuchi, Mitsuru Ueda