Patents by Inventor Kazuhiro Aiba

Kazuhiro Aiba has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nerve cell device and method for evaluating neural activity
    Patent number: 11543404
    Abstract: The present invention provides a nerve cell device in which early observation of nerve activity (spikes, bursts, and the like) is made possible and the measured electric strength is increased by cultivating neurons upon a cell scaffold. By using this nerve cell device, imaging of intracellular signaling is also possible.
    Type: Grant
    Filed: November 15, 2018
    Date of Patent: January 3, 2023
    Assignee: STEM CELL & DEVICE LABORATORY, INC.
    Inventors: Kazuhiro Aiba, Norie Tooi, Kosuke Hori, Masaki Sudo
  • MEASUREMENT METHOD
    Publication number: 20210263015
    Abstract: The present invention provides a method for measuring the propagation of electric activity in neural network and/or axon by using a nerve cell device produced by seeding nerve cells on an oriented fiber sheet. According to the present invention, synapse function can be assessed by using propagation speed of neural network as an index.
    Type: Application
    Filed: July 11, 2019
    Publication date: August 26, 2021
    Inventors: Ikuro Suzuki, Aoi Odawara, Kazuhiro Aiba, Norie Tooi
  • DEVICE
    Publication number: 20210025870
    Abstract: The present invention provides a nerve cell device in which early observation of nerve activity (spikes, bursts, and the like) is made possible and the measured electric strength is increased by cultivating neurons upon a cell scaffold. By using this nerve cell device, imaging of intracellular signaling is also possible.
    Type: Application
    Filed: November 15, 2018
    Publication date: January 28, 2021
    Inventors: Kazuhiro Aiba, Norie Tooi, Kosuke Hori, Masaki Sudo
  • METHOD FOR SUBCULTURING PLURIPOTENT STEM CELLS
    Publication number: 20190078058
    Abstract: The present disclosure provides a method for subculturing pluripotent stem cells suitable for mass culture. The method for subculturing pluripotent stem cells includes: a culture step of culturing pluripotent stem cells to obtain a cell aggregation; and a dividing step of dividing the cell aggregation by passing the cell aggregation through a mesh-like film, which has a plurality of through-holes each having an opening dimension of 30 ?m to 80 ?m, at a speed of 15 cm/sec to 150 cm/sec.
    Type: Application
    Filed: November 5, 2018
    Publication date: March 14, 2019
    Inventors: Hideaki KAGAWA, Shun GOTO, Souichi KOHASHI, Norio NAKATSUJI, Kazuhiro AIBA
  • Pharmaceutical composition for prevention and treatment of amyotrophic lateral sclerosis
    Patent number: 9856210
    Abstract: The present invention provides a prophylactic or therapeutic agent for amyotrophic lateral sclerosis, containing a 1,3-diphenylurea derivative or multikinase inhibitor.
    Type: Grant
    Filed: September 2, 2011
    Date of Patent: January 2, 2018
    Assignee: Kyoto University
    Inventors: Haruhisa Inoue, Shiho Kitaoka, Kayoko Tsukita, Ryosuke Takahashi, Gaku Murakami, Norio Nakatsuji, Motonari Uesugi, Yasuyuki Asai, Ayako Asai, Yuji Amagai, Kazuhiro Aiba
  • QUALITY EVALUATION METHOD AND QUALITY EVALUATION DEVICE
    Publication number: 20170254741
    Abstract: A quality evaluation method includes an acquisition step of acquiring spectral data related to transmitted light or diffusely reflected light from a cell mass by irradiating the cell mass with measurement light including near-infrared light, and an evaluation step of evaluating quality of the cell mass, based on the spectral data of the cell mass acquired in the acquisition step.
    Type: Application
    Filed: May 19, 2017
    Publication date: September 7, 2017
    Inventors: Hiroshi Suganuma, Takuya Okuno, Asako Motomura, Shizuka Akieda, Manami Tsuji, Yuna Okina, Yoko Sugiyama, Kazuhiro Aiba, Li Liu
  • Method for inducing cardiac differentiation of pluripotent stem cell
    Patent number: 9587220
    Abstract: The present invention relates to a method for inducing cardiac differentiation of a pluripotent stem cell, which comprises the steps of (1) culturing a pluripotent stem cell in a medium containing one or more WNT signaling activators, and (2) culturing a cell produced in the step (1) in a medium containing one or more WNT signaling inhibitor.
    Type: Grant
    Filed: January 25, 2013
    Date of Patent: March 7, 2017
    Assignee: KYOTO UNIVERSITY
    Inventors: Norio Nakatsuji, Itsunari Minami, Motonari Uesugi, Kazuhiro Aiba
  • CELL EVALUATION METHOD
    Publication number: 20150219543
    Abstract: The present invention relates to a cell evaluation method comprising evaluating a cell differentiation degree based on a cell thickness.
    Type: Application
    Filed: February 4, 2015
    Publication date: August 6, 2015
    Inventors: Toyohiko YAMAUCHI, Tadashi FUKAMI, Norikazu SUGIYAMA, Hidenao IWAI, Yumi KAKUNO, Kentaro GOTO, Norio NAKATSUJI, Kazuhiro AIBA
  • METHOD FOR INDUCING CARDIAC DIFFERENTIATION OF PLURIPOTENT STEM CELL
    Publication number: 20150017718
    Abstract: The present invention relates to a method for inducing cardiac differentiation of a pluripotent stem cell, which comprises the steps of (1) culturing a pluripotent stem cell in a medium containing one or more WNT signaling activators, and (2) culturing a cell produced in the step (1) in a medium containing one or more WNT signaling inhibitor.
    Type: Application
    Filed: January 25, 2013
    Publication date: January 15, 2015
    Inventors: Norio Nakatsuji, Itsunari Minami, Motonari Uesugi, Kazuhiro Aiba
  • PHARMACEUTICAL COMPOSITION FOR PREVENTION AND TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS
    Publication number: 20130115622
    Abstract: Provided are a prophylactic and therapeutic agent for amyotrophic lateral sclerosis containing an HMG-CoA reductase inhibitor and a method of screening for a prophylactic and therapeutic drug for amyotrophic lateral sclerosis using an induced pluripotent stem cell derived from a patient with amyotrophic lateral sclerosis.
    Type: Application
    Filed: December 14, 2010
    Publication date: May 9, 2013
    Applicant: KYOTO UNIVERSITY
    Inventors: Haruhisa Inoue, Norio Nakatsuji, Shiho Kitaoka, Kayoko Tsukita, Ryosuke Takahashi, Gaku Murakami, Yuji Amagai, Kazuhiro Aiba