Patents by Inventor Kazuhiro Aoyagi
Kazuhiro Aoyagi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10828265Abstract: Melts or ionic liquids containing amorphous propranolol, topical formulations and patches for transdermal drug delivery, and methods of making and using thereof are described herein. The melts or ionic liquids may be in a topical drug delivery formulation or patch to be applied to the skin. The drug delivery formulation or patch contains a sufficient amount of the amorphous propranolol to deliver a therapeutically effective amount of the amorphous propranolol to the patient in need of treatment, such as for the treatment or amelioration of infantile hemangioma. The formulations have a low viscosity and reduced skin irritation compared to the crystalline propranolol free base (PFB). The melts or ionic liquids can be formed by a salt metathesis reaction.Type: GrantFiled: December 11, 2017Date of Patent: November 10, 2020Assignee: The Regents of the University of CaliforniaInventors: Kazuhiro Aoyagi, Michael Zakrewsky, Samir Mitragotri
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Patent number: 10717904Abstract: An adhesive preparation containing bisoprolol includes a backing and a pressure-sensitive adhesive layer formed on one side of the backing. The pressure-sensitive adhesive layer contains a polymer prepared through copolymerization of monomer components including a hydroxyl group-containing monomer and an alkyl (meth)acrylate monomer (component (A)), a polymer prepared through copolymerization of monomer components including a methyl methacrylate monomer and a butyl methacrylate monomer (component (B)), and bisoprolol (component (C)).Type: GrantFiled: June 17, 2016Date of Patent: July 21, 2020Assignee: TOA EIYO LTD.Inventors: Eriko Abe, Yu Tachikawa, Satoshi Ameyama, Naoko Urushihara, Jun Ishikura, Tetsuya Nakamura, Akira Yokouchi, Yoshitaka Inoue, Kazuhiro Aoyagi, Tomoya Tanaka, Naohiro Nishida, Kunihiro Minami
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Publication number: 20180194977Abstract: An adhesive preparation containing bisoprolol includes a backing and a pressure-sensitive adhesive layer formed on one side of the backing. The pressure-sensitive adhesive layer contains a polymer prepared through copolymerization of monomer components including a hydroxyl group-containing monomer and an alkyl (meth)acrylate monomer (component (A)), a polymer prepared through copolymerization of monomer components including a methyl methacrylate monomer and a butyl methacrylate monomer (component (B)), and bisoprolol (component (C)).Type: ApplicationFiled: June 17, 2016Publication date: July 12, 2018Applicant: TOA EIYO LTD.Inventors: Eriko ABE, Yu TACHIKAWA, Satoshi AMEYAMA, Naoko URUSHIHARA, Jun ISHIKURA, Tetsuya NAKAMURA, Akira YOKOUCHI, Yoshitaka INOUE, Kazuhiro AOYAGI, Tomoya TANAKA, Naohiro NISHIDA, Kunihiro MINAMI
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Publication number: 20180169033Abstract: Melts or ionic liquids containing amorphous propranolol, topical formulations and patches for transdermal drug delivery, and methods of making and using thereof are described herein. The melts or ionic liquids may be in a topical drug delivery formulation or patch to be applied to the skin. The drug delivery formulation or patch contains a sufficient amount of the amorphous propranolol to deliver a therapeutically effective amount of the amorphous propranolol to the patient in need of treatment, such as for the treatment or amelioration of infantile hemangioma. The formulations have a low viscosity and reduced skin irritation compared to the crystalline propranolol free base (PFB). The melts or ionic liquids can be formed by a salt metathesis reaction.Type: ApplicationFiled: December 11, 2017Publication date: June 21, 2018Inventors: Kazuhiro Aoyagi, Michael Zakrewsky, Samir Mitragotri
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Publication number: 20160367494Abstract: A patch preparation includes a support and a pressure-sensitive adhesive layer formed on one surface of the support. The pressure-sensitive adhesive layer includes: (A) a polymer prepared by copolymerizing monomer components including a hydroxyl group-containing monomer and an alkyl (meth)acrylate monomer; (B) a polymer prepared by copolymerizing monomer components including a methyl methacrylate monomer and a butyl methacrylate monomer; and (C) a basic drug, provided that bisoprolol and a salt thereof are excluded.Type: ApplicationFiled: June 17, 2016Publication date: December 22, 2016Applicant: NITTO DENKO CORPORATIONInventors: Yu TACHIKAWA, Satoshi AMEYAMA, Eriko ABE, Tetsuya NAKAMURA, Naoko URUSHIHARA, Jun ISHIKURA, Kazuhiro AOYAGI, Yoshitaka INOUE, Akira YOKOUCHI, Tomoya TANAKA
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Patent number: 9326952Abstract: The invention is intended to provide an adhesive patch which contains a drug except bisoprolol and which effectively inhibits the occurrence of oozing out or sticking out of the adhesive layer components from the exposed area of the adhesive layer of the adhesive patch during storage as well as the occurrence of oozing out of the drug from the adhesive layer thereby preventing the reduction in drug content. The support, the release liner and the adhesive layer constituting the adhesive patch each are formed to have a rectangular planar shape and the entire adhesive patch are formed to have a rectangular planar shape, and a protrudent part is formed on the support-side surface of the adhesive patch at a corner thereof. In addition, the adhesive patch may be formed to have a middle part and a peripheral part, and the protrudent part may be formed at a corner of the rectangular middle part.Type: GrantFiled: February 23, 2011Date of Patent: May 3, 2016Assignee: NITTO DENKO CORPORATIONInventors: Yoshihiro Iwao, Kensuke Matsuoka, Kazuhiro Aoyagi
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Patent number: 9005174Abstract: The invention is intended to provide an adhesive patch which contains a drug except bisoprolol and which effectively inhibits the occurrence of oozing out or sticking out of the adhesive layer components from the exposed area of the adhesive layer of the adhesive patch during storage as well as the occurrence of oozing out of the drug from the adhesive layer thereby preventing the reduction in drug content. The support, the release liner and the adhesive layer constituting the adhesive patch each are formed to have a rectangular planar shape and the entire adhesive patch are formed to have a rectangular planar shape, and a protrudent part is formed on the support-side surface of the adhesive patch at a corner thereof. In addition, the adhesive patch may be formed to have a middle part and a peripheral part, and the protrudent part may be formed at a corner of the rectangular middle part.Type: GrantFiled: February 23, 2011Date of Patent: April 14, 2015Assignee: Nitto Denko CorporationInventors: Yoshihiro Iwao, Kensuke Matsuoka, Kazuhiro Aoyagi
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Patent number: 8974816Abstract: The present invention provides a water resistant patch preparation having a central part and a peripheral part, which preparation is comprised of a support and an adhesive layer comprising a drug, which is formed on one surface of the support, wherein at least a part of a lateral end of the adhesive layer in the peripheral part is located inside a lateral end of the support, and the adhesive layer in the peripheral part has a thickness smaller than that of the adhesive layer in the central part.Type: GrantFiled: August 31, 2010Date of Patent: March 10, 2015Assignee: Nitto Denko CorporationInventors: Kazuhiro Aoyagi, Yoshihiro Iwao, Kensuke Matsuoka
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Publication number: 20140158571Abstract: A packaging structure (100) for a patch includes a first and second base materials (120, 130) which have a peripheral edge part laminated with each other, and the patch is included therein. The first and second base materials (120, 130) have a first to forth sides (121 to 124, 131-134). At least one of the first and second base materials (120, 130) has a first to third opening parts (125 to 127, 135 to 137). The first to third opening parts (125 to 127, 135 to 137) guides so as to open toward the inner peripheral edge (120c1, 120c2, 120c4, 130c1, 130c2, 130c4) of the sealing part (120c, 130c).Type: ApplicationFiled: July 13, 2012Publication date: June 12, 2014Applicants: TOA EIYO LTD., NITTO DENKO CORPORATIONInventors: Kensuke Matsuoka, Yoshihiro Iwao, Jun Harima, Masakatsu Konno, Kazuhiro Aoyagi, Tomoya Tanaka, Mikio Toyota, Yasuhiko Akita, Tadashi Matsui
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Publication number: 20130006203Abstract: The invention is intended to provide an adhesive patch which effectively inhibits the occurrence of oozing out or sticking out of the adhesive layer components from the exposed area of the adhesive layer of the adhesive patch during storage as well as the occurrence of oozing of bisoprolol or a salt thereof from the adhesive layer thereby preventing the reduction in drug content. The support, the release liner and the adhesive layer constituting the adhesive patch each are formed to have a rectangular planar shape and the entire adhesive patch are formed to have a rectangular planar shape, and a protrudent part is formed on the support-side surface of the adhesive patch at a corner thereof. In addition, the adhesive patch may be formed to have a middle part and a peripheral part, and the protrudent part may be formed at a corner of the rectangular middle part.Type: ApplicationFiled: February 23, 2011Publication date: January 3, 2013Applicants: TOA EIYO LTD., NITTO DENKO CORPORATIONInventors: Yoshihiro Iwao, Kensuke Matsuoka, Kazuhiro Aoyagi, Jun Harima, Masakatsu Konno
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Publication number: 20120323191Abstract: The invention is intended to provide an adhesive patch which contains a drug except bisoprolol and which effectively inhibits the occurrence of oozing out or sticking out of the adhesive layer components from the exposed area of the adhesive layer of the adhesive patch during storage as well as the occurrence of oozing out of the drug from the adhesive layer thereby preventing the reduction in drug content. The support, the release liner and the adhesive layer constituting the adhesive patch each are formed to have a rectangular planar shape and the entire adhesive patch are formed to have a rectangular planar shape, and a protrudent part is formed on the support-side surface of the adhesive patch at a corner thereof. In addition, the adhesive patch may be formed to have a middle part and a peripheral part, and the protrudent part may be formed at a corner of the rectangular middle part.Type: ApplicationFiled: February 23, 2011Publication date: December 20, 2012Applicant: NITTO DENKO CORPORATIONInventors: Yoshihiro Iwao, Kensuke Matsuoka, Kazuhiro Aoyagi
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Publication number: 20120189796Abstract: The present invention relates to a sheet-shaped patch including a pressure-sensitive adhesive layer on one surface of a backing to provide a pressure-sensitive adhesive surface showing adhesiveness at ordinary temperature and further including a release liner covering the pressure-sensitive adhesive surface. More specifically, the present invention relates to a sheet-shaped patch where the release liner is formed in a state of being splittable by a parting line. The patch ensures that the pressure-sensitive adhesive surface can be kept from being largely exposed due to slight stress before use and at the same time, the release liner can be easily split when using the patch.Type: ApplicationFiled: January 25, 2012Publication date: July 26, 2012Applicant: NITTO DENKO CORPORATIONInventors: Kazuhiro AOYAGI, Yoshihiro IWAO, Kensuke MATSUOKA, Tomoya TANAKA
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Publication number: 20110059155Abstract: The present invention provides a water resistant patch preparation having a central part and a peripheral part, which preparation is comprised of a support and an adhesive layer comprising a drug, which is formed on one surface of the support, wherein at least a part of a lateral end of the adhesive layer in the peripheral part is located inside a lateral end of the support, and the adhesive layer in the peripheral part has a thickness smaller than that of the adhesive layer in the central part.Type: ApplicationFiled: August 31, 2010Publication date: March 10, 2011Applicant: NITTO DENKO CORPORATIONInventors: Kazuhiro AOYAGI, Yoshihiro IWAO, Kensuke MATSUOKA
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Publication number: 20100080989Abstract: The present invention provides a pressure-sensitive adhesive sheet for laser processing, which includes a base and a pressure-sensitive adhesive layer provided on one surface of the base, the pressure-sensitive adhesive layer having an absorption coefficient at a wavelength of 355 nm of from 50 cm?1 to 900 cm?1, the pressure-sensitive adhesive layer containing a light-absorbing agent in which an absorbance of the light-absorbing agent in a 0.01% by weight acetonitrile solution at a wavelength of 355 nm is from 0.01 to 1.20, and in which the pressure-sensitive adhesive sheet is to be used at the time when a workpiece is laser-processed by a laser light having a wavelength of an ultraviolet region or a laser light enabling light absorption via multiphoton absorption process.Type: ApplicationFiled: October 1, 2009Publication date: April 1, 2010Applicant: NITTO DENKO CORPORATIONInventors: Fumiteru ASAI, Tomokazu TAKAHASHI, Keiko MAEKAWA, Kazuhiro AOYAGI
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Patent number: 5903369Abstract: An optical wireless communication method and apparatus that uses Manchester code via a connector connected with a personal computer. The Manchester data from the computer are converted to NRZ transmission data to be temporarily stored and read out. A frame of the read out data is appended with a head leader identifying a sender and end data at the head and end of the frame to be converted to the DMI transmission optical data. The optical data inserted between the head leader and END data are receivable being distinguished from the optical signal of the sender and optical noises. The DMI entitative data removed from the head leader and end data are converted to data of the Manchester code in the reverse course to the sender to be delivered as the Manchester data via a connector. As the optical data with the head leader and end data are distinguishable from the optical signal of the sender and optical noises, high sensitive optical receivers are available.Type: GrantFiled: January 2, 1997Date of Patent: May 11, 1999Assignees: LTEL Corporation, ITT Canon Co., Ltd., Showa Electric Wire & Cable Co., Ltd.Inventors: Masahiro Hirayama, Eiichi Nakata, Kazuhiro Aoyagi
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Patent number: 5706115Abstract: An optical wireless communication method and apparatus configured to distinguish optical LAN data from optical noise is disclosed. The apparatus communicates using Manchester coded data via a connector connected to a personal computer. The Manchester coded data from the computer are converted to NRZ transmission data to be temporarily stored and read out. A frame of the read out data is appended with a head leader, and end data, at the head and end of the frame respectively to be convened to the DMI transmission optical data. The optical data inserted between the head leader and END data are receivable and can be distinguished from optical noise. The DMI received data removed from the head leader and end data are convened to data of the Manchester code in contrast with the transmission side to be delivered as the Manchester data via the connector. As the optical data with the head leader and end data are distinguishable from optical noise, high sensitive optical receivers are available.Type: GrantFiled: February 23, 1996Date of Patent: January 6, 1998Assignees: LTEL Corporation, ITT Canon Co., Ltd., Showa Electric Wire & Cable Co., Ltd.Inventors: Masahiro Hirayama, Eiichi Nakata, Kazuhiro Aoyagi