Patents by Inventor Kazuhiro Kuboe
Kazuhiro Kuboe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250197565Abstract: Activated polyethylene glycol with high purity can be obtained by a method including: a step (a) of reacting polyethylene glycol having a hydroxyl group with one or more active carbonic acid reagents selected from the group consisting of disuccinimidyl carbonate and p-nitrophenylchloroformate in presence of a base in an aprotic solvent which is immiscible with water, to obtain a composition containing an active carbonic acid ester of polyethylene glycol and the active carbonic acid reagent being unreacted, a step (b) of partially removing the active carbonic acid reagent by filtering the composition obtained in the step (a), and then obtaining a composition by adding an alcohol containing an acidic functional group to react with the unreacted active carbonic acid reagent, and a step (c) of removing a reaction product of the alcohol containing an acidic functional group and the active carbonic acid reagent, the alcohol containing an acidic functional group, and a decomposition product of the active carbonicType: ApplicationFiled: March 6, 2023Publication date: June 19, 2025Applicant: NOF CORPORATIONInventors: Takaaki HAYASHI, Shuhei KINOSHITA, Kazuhiro KUBO
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Patent number: 10092655Abstract: The invention provides a cationic lipid capable of achieving higher intracellular delivery efficiency than conventional cationic lipids, when used as a lipid membrane structure which is a carrier for delivering functional nucleic acid. The cationic lipid is represented by the formula (1): wherein each symbol is as defined herein.Type: GrantFiled: August 7, 2015Date of Patent: October 9, 2018Assignees: NOF CORPORATION, NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITYInventors: Shota Sasaki, Masaki Ota, Kazuhiro Kubo, Hideyoshi Harashima, Hidetaka Akita, Hiroto Hatakeyama, Yuki Noguchi, Kota Tange, Yuta Nakai, Nayuta Shimizu
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Publication number: 20170274086Abstract: The invention provides a cationic lipid capable of achieving higher intracellular delivery efficiency than conventional cationic lipids, when used as a lipid membrane structure which is a carrier for delivering functional nucleic acid. The cationic lipid is represented by the formula (1): wherein each symbol is as defined herein.Type: ApplicationFiled: August 7, 2015Publication date: September 28, 2017Applicants: NOF CORPORATION, NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITYInventors: Shota SASAKI, Masaki OTA, Kazuhiro KUBO, Hideyoshi HARASHIMA, Hidetaka AKITA, Hiroto HATAKEYAMA, Yuki NOGUCHI, Kota TANGE, Yuta NAKAI, Nayuta SHIMIZU
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Patent number: 9708628Abstract: The present invention relates to a compound represented by the formula (1) wherein Xa and Xb are each independently X1 or X2; s is 1 or 2, R4 is an alkyl group having 1-6 carbon atoms, na and nb are each independently 0 or 1, R1a and R1b are each independently an alkylene group having 1-6 carbon atoms, R2a and R2b are each independently an alkylene group having 1-6 carbon atoms, Ya and Yb are each independently an ester bond, an amide bond, a carbamate bond, an ether bond or a urea bond, and R3a and R3b are each independently a sterol residue, a liposoluble vitamin residue or an aliphatic hydrocarbon group having 12-22 carbon atoms, and use thereof.Type: GrantFiled: May 16, 2014Date of Patent: July 18, 2017Assignees: NOF Corporation, National University Corporation Hokkaido UniversityInventors: Kota Tange, Masaya Arai, Kazuhiro Kubo, Hidetaka Akita, Hideyoshi Harashima, Hiroto Hatakeyama, Ryohei Ishiba, Masami Ukawa, Hiroki Tanaka
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Patent number: 9373815Abstract: Provided is an organic EL device which can prevent invasion of moisture to an organic EL element. The organic EL device has an organic EL element in which a first electrode layer, a functional layer, and a second electrode layer are stacked in sequence on a transparent substrate having a planar expanse, and an inorganic sealing layer for sealing at least an emission area of the organic EL element. A soft adhesion layer is stacked directly onto the inorganic sealing layer with a planar expanse, and the soft adhesion layer is made of a resin, and has flexibility.Type: GrantFiled: September 5, 2013Date of Patent: June 21, 2016Assignee: KANEKA CORPORATIONInventors: Takahiro Washio, Kazuhiro Kubo, Motoi Sasaki, Hideo Yamagishi, Akira Nishikawa, Katsuhiko Hayashi
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Patent number: 9371271Abstract: In production of a cationic lipid having at least one methylene group sandwiched between adjacent two cis form double bonds in the molecule, isomerization from a cis form to a trans form is suppressed. A compound represented by the following formula (I): R1—X??(I) (in Formula, R1 represents a hydrocarbon group having at least one methylene group sandwiched between adjacent two cis form double bonds in the molecule and having the carbon number of 8 to 24 and X represents a releasing group) is reacted with (B) a compound having at least one of each of tertiary amino group and hydroxyl group in the molecule in a saturated hydrocarbon solvent having the carbon number of 5 to 10 in the presence of an alkali catalyst.Type: GrantFiled: June 21, 2013Date of Patent: June 21, 2016Assignee: NOF CORPORATIONInventors: Kazuhiro Kubo, Kota Tange, Masaki Ohta
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Publication number: 20150228926Abstract: Provided is an organic EL device which can prevent invasion of moisture to an organic EL element. The organic EL device has an organic EL element in which a first electrode layer, a functional layer, and a second electrode layer are stacked in sequence on a transparent substrate having a planar expanse, and an inorganic sealing layer for sealing at least an emission area of the organic EL element. A soft adhesion layer is stacked directly onto the inorganic sealing layer with a planar expanse, and the soft adhesion layer is made of a resin, and has flexibility.Type: ApplicationFiled: September 5, 2013Publication date: August 13, 2015Inventors: Takahiro Washio, Kazuhiro Kubo, Motoi Sasaki, Hideo Yamagishi, Akira Nishikawa, Katsuhiko Hayashi
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Publication number: 20150191416Abstract: In production of a cationic lipid having at least one methylene group sandwiched between adjacent two cis form double bonds in the molecule, isomerization from a cis form to a trans form is suppressed. A compound represented by the following formula (I): R1—X??(I) (in Formula, R1 represents a hydrocarbon group having at least one methylene group sandwiched between adjacent two cis form double bonds in the molecule and having the carbon number of 8 to 24 and X represents a releasing group) is reacted with (B) a compound having at least one of each of tertiary amino group and hydroxyl group in the molecule in a saturated hydrocarbon solvent having the carbon number of 5 to 10 in the presence of an alkali catalyst.Type: ApplicationFiled: June 21, 2013Publication date: July 9, 2015Applicant: NOF CORPORATIONInventors: Kazuhiro Kubo, Kota Tange, Masaki Ohta
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Patent number: 8896260Abstract: A power supply unit for a press machine having a converter (converter circuit) connected to a commercial AC power supply, and an inverter (inverter circuit) connected to a press motor, includes an electrical energy bank, an inrush prevention circuit, an inrush prevention instruction signal generation section, and a contactor switch section, wherein contactors of the inrush prevention circuit are switched from on ON state to an OFF state and inrush prevention resistors of the inrush prevention circuit are connected to AC phase current paths on condition that the inrush prevention instruction signal generation section has generated and output an inrush prevention instruction signal (Sres) during press operation.Type: GrantFiled: December 4, 2012Date of Patent: November 25, 2014Assignee: Aida Engineering, Ltd.Inventor: Kazuhiro Kuboe
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Publication number: 20140335157Abstract: The present invention relates to a compound represented by the formula (1) wherein Xa and Xb are each independently X1 or X2; s is 1 or 2, R4 is an alkyl group having 1-6 carbon atoms, na and nb are each independently 0 or 1, R1a and R1b are each independently an alkylene group having 1-6 carbon atoms, R2a and R2b are each independently an alkylene group having 1-6 carbon atoms, Ya and Yb are each independently an ester bond, an amide bond, a carbamate bond, an ether bond or a urea bond, and R3a and R3b are each independently a sterol residue, a liposoluble vitamin residue or an aliphatic hydrocarbon group having 12-22 carbon atoms, and use thereof.Type: ApplicationFiled: May 16, 2014Publication date: November 13, 2014Inventors: Kota TANGE, Masaya ARAI, Kazuhiro KUBO, Hidetaka AKITA, Hideyoshi HARASHIMA, Hiroto HATAKEYAMA, Ryohei ISHIBA, Masami UKAWA, Hiroki TANAKA
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Patent number: 8720328Abstract: A control system of a servo press and a control method are provided for preventing an overload on a pressure capability of a press and a torque capability of a drive system. A control device of a servo press for pressing by transferring a drive force of a servomotor to a slide via a drive mechanism includes: a motion calculation unit for calculating slide target position data; a torque calculation unit for calculating process torque for pressing and control torque for speed change of the servo motor on the basis of slide target position data; a process system limit unit for limiting the calculated process torque to predetermined process limitation torque; and a drive system limit unit for limiting combined torque of the limited process torque and the control torque to predetermined drive limitation torque. The servo motor is driven on the basis of a command of drive limitation torque.Type: GrantFiled: November 4, 2011Date of Patent: May 13, 2014Assignee: AIDA Engineering, Ltd.Inventor: Kazuhiro Kuboe
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Patent number: 8557929Abstract: A method for producing a biodegradable polyoxyalkylene derivative, includes: reacting a biodegradable polyoxyalkylene compound represented by the formula (1) as defined herein with a compound represented by one of the formulae (I) to (IV) as defined herein in a presence of an alkaline solid salt, the biodegradable polyoxyalkylene derivative being represented by the formula (2) as defined herein.Type: GrantFiled: September 28, 2007Date of Patent: October 15, 2013Assignee: NOF CorporationInventors: Kazuhiro Kubo, Shigeru Kitano, Chika Ito
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Patent number: 8445712Abstract: A phospholipid derivative represented by the following formula (1) wherein each symbol is as described in the specification; a liposome containing the phospholipid derivative, and the like.Type: GrantFiled: November 12, 2010Date of Patent: May 21, 2013Assignees: NOF Corporation, Osaka Prefecture University Public CorporationInventors: Masaya Arai, Kazuhiro Kubo, Shoichi Yokoyama, Kenji Kono
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Publication number: 20130074710Abstract: Provided is a low-cost servo press promoting energy saving by driving a press machine by a driving system suited for the magnitude of a load on a worked object. It includes a first motor coupled to a slide drive shaft to ascend/descend a slide, a second servo motor driving a flywheel, a clutch coupling/decoupling the second servo motor to/from the slide drive shaft, and a press controller controlling rotation of the first and second servo motors and coupling/decoupling of the clutch. The press controller controls to decouple the clutch when the press is small-loaded, thereby ascending/descending the slider by driving the first servo motor, and to couple the clutch when the press is large-loaded, thereby ascending/descending the slider by driving the first and second servo motors.Type: ApplicationFiled: September 10, 2012Publication date: March 28, 2013Applicant: AIDA Engineering, Ltd.Inventors: Kazuhiro Kuboe, Akira Yamanouchi
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Patent number: 8342000Abstract: A servo-press machine determining whether or not a drive power supply voltage between a positive power supply path and a negative power supply path that connect a power supply device and a motor rotation control section is lower than an induced voltage of a servomotor, and correcting speed-related data based on slide motion information when the servo-press machine has determined that the drive power supply voltage is lower than the induced voltage.Type: GrantFiled: January 22, 2009Date of Patent: January 1, 2013Assignee: Aida Engineering, Ltd.Inventor: Kazuhiro Kuboe
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Publication number: 20120258165Abstract: A phospholipid derivative represented by the following formula (1) wherein each symbol is as described in the specification; a liposome containing the phospholipid derivative, and the like.Type: ApplicationFiled: November 12, 2010Publication date: October 11, 2012Applicants: OSAKA PREFECTURE UNIVERSITY PUBLIC CORPORATION, NOF CORPORATIONInventors: Masaya Arai, Kazuhiro Kubo, Shoichi Yokoyama, Kenji Kono
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Publication number: 20120111207Abstract: A control system of a servo press and a control method are provided for preventing an overload on a pressure capability of a press and a torque capability of a drive system. A control device of a servo press for pressing by transferring a drive force of a servomotor to a slide via a drive mechanism includes: a motion calculation unit for calculating slide target position data; a torque calculation unit for calculating process torque for pressing and control torque for speed change of the servo motor on the basis of slide target position data; a process system limit unit for limiting the calculated process torque to predetermined process limitation torque; and a drive system limit unit for limiting combined torque of the limited process torque and the control torque to predetermined drive limitation torque. The servo motor is driven on the basis of a command of drive limitation torque.Type: ApplicationFiled: November 4, 2011Publication date: May 10, 2012Applicant: AIDA ENGINEERING, LTD.Inventor: Kazuhiro Kuboe
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Publication number: 20110193224Abstract: In a semiconductor device, a pad electrode is disposed on a surface of a semiconductor substrate, and a surface-protective film is disposed on the surface of the semiconductor substrate and the pad electrode. The surface-protective film has an opening to expose a part of the pad electrode. A bump electrode is disposed on the part of the pad electrode exposed from the opening, and a bump is disposed on the bump electrode. The surface-protective film further has a slit at a location above the pad electrode. The slit has a frame shape surrounding a periphery of the bump electrode. The slit extends from a surface of the surface-protective film, which is opposite to the semiconductor substrate, and reaches the pad electrode.Type: ApplicationFiled: February 3, 2011Publication date: August 11, 2011Applicants: DENSO CORPORATION, MITSUMI ELECTRIC CO., LTD.Inventors: Hiroyasu Ito, Kazuhiro Kubo
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Patent number: 7891223Abstract: A transfer press machine which can accurately and promptly check interference and can be easily handled is provided.Type: GrantFiled: October 28, 2005Date of Patent: February 22, 2011Assignee: Aida Engineering, Ltd.Inventors: Sotoyuki Kaneko, Hiroshi Hosoya, Kazuhiro Kuboe
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Publication number: 20090202619Abstract: A polyoxyalkylene chain-containing lipid derivative, which is represented by the following formula (1): wherein L, Y, W, X1, X2, X3, OA, Z, m1, m2, m3, n1, n2 and n3 are as defined in the specification.Type: ApplicationFiled: February 17, 2006Publication date: August 13, 2009Applicants: THE UNIVERSITY OF TOKUSHIMA, NOF CORPORATIONInventors: Hiroshi Kiwada, Tatsuhiro Ishida, Chika Ito, Kazuhiro Kubo, Kenji Sakanoue, Hiroshi Kikuchi