Abstract: An objective of the present invention is to provide target tissue-specific antigen-binding molecules, antigen-binding molecules whose antigen-binding activity varies depending on the concentration of an unnatural compound, libraries comprising a plurality of the antigen-binding molecules which are different from one another, pharmaceutical compositions comprising the antigen-binding molecules, methods of screening for the antigen-binding molecules, and methods for producing the antigen-binding molecules. The present inventors created antigen-binding domains whose antigen-binding activity varies depending on the concentration of a small molecule compound or antigen-binding molecules containing an antigen-binding domain, and libraries comprising a plurality of the antigen-binding domains which are different from one another or antigen-binding domains, and demonstrated that the above-noted objective could be achieved by using the libraries.

Abstract: An objective of the present invention is to provide antigen-binding molecules whose antigen-binding activity changes depending on the concentration of a small molecule compound specific to a target tissue, polynucleotides encoding the antigen-binding molecules, vectors containing the polynucleotides, cells carrying the vectors, libraries containing a plurality of the antigen-binding molecules that are different from one another, pharmaceutical compositions containing the antigen-binding molecules, methods of screening for the antigen-binding molecules, methods of producing the same, and the like.

Abstract: An objective of the present invention is to provide target tissue-specific antigen-binding molecules, antigen-binding molecules whose antigen-binding activity varies depending on the concentration of an unnatural compound, libraries comprising a plurality of the antigen-binding molecules which are different from one another, pharmaceutical compositions comprising the antigen-binding molecules, methods of screening for the antigen-binding molecules, and methods for producing the antigen-binding molecules. The present inventors created antigen-binding domains whose antigen-binding activity varies depending on the concentration of a small molecule compound or antigen-binding molecules containing an antigen-binding domain, and libraries comprising a plurality of the antigen-binding domains which are different from one another or antigen-binding domains, and demonstrated that the above-noted objective could be achieved by using the libraries.

Abstract: A manufacturing equipment diagnosis support system includes: a data collector which collects and records respective data in plural apparatuses to be monitored provided in manufacturing equipment; a data analysis device; and a display. The data analysis device includes: a data analysis range setting unit which sets an analysis range of data, by an item of data and time period; a data grouping unit which classifies the data into a category based on specification and use condition of the apparatus to be monitored, and a category based on a physical quantity which the data shows, to group the data; a feature extracting unit which extracts a feature in each of the data items; an unusual phenomenon specifying unit which specifies an unusual phenomenon candidate item; and a testing unit which tests whether there is a significant difference or not between the unusual phenomenon candidate item and an other data item.

Abstract: An objective of the present invention is to provide target tissue-specific antigen-binding molecules, antigen-binding molecules whose antigen-binding activity varies depending on the concentration of an unnatural compound, libraries comprising a plurality of the antigen-binding molecules which are different from one another, pharmaceutical compositions comprising the antigen-binding molecules, methods of screening for the antigen-binding molecules, and methods for producing the antigen-binding molecules. The present inventors created antigen-binding domains whose antigen-binding activity varies depending on the concentration of a small molecule compound or antigen-binding molecules containing an antigen-binding domain, and libraries comprising a plurality of the antigen-binding domains which are different from one another or antigen-binding domains, and demonstrated that the above-noted objective could be achieved by using the libraries.

Abstract: In an energy-saving-operation recommending system, a total energy consumption of plural facilities during passage of one material to be rolled through a rolling line is calculated, and the total energy consumption is divided by a width and a length of the material to be rolled before rolling to calculate an energy consumption reference value that defines energy consumption per unit width and unit length of the material to be rolled. The energy consumption reference value is stored in association with a steel grade and a target post-rolling plate thickness of the material to be rolled. An energy consumption reference value corresponding to a steel grade and a target post-rolling plate thickness of a material to be next rolled on the rolling line is obtained. The energy consumption reference value is multiplied by a width and a length of the material to be next rolled to calculate predicted energy consumption.

Abstract: The material structure prediction apparatus includes a temperature calculator calculating temperatures at calculation points, based on a temperature condition, a nucleation count calculator calculating a nucleation count in the calculation target region, a precipitated phase generation point determining module determining, from the calculation points, a precipitated phase generation point, a grain growth calculator calculating a grain growth of the precipitated phase at the precipitated phase generation point, and a material structure prediction module predicting the structure of the material, based on the grain growth of the precipitated phase.

Abstract: A manufacturing equipment diagnosis support system includes: a data collector which collects and records respective data in plural apparatuses to be monitored provided in manufacturing equipment; a data analysis device; and a display. The data analysis device includes: a data analysis range setting unit which sets an analysis range of data, by an item of data and time period; a data grouping unit which classifies the data into a category based on specification and use condition of the apparatus to be monitored, and a category based on a physical quantity which the data shows, to group the data; a feature extracting unit which extracts a feature in each of the data items; an unusual phenomenon specifying unit which specifies an unusual phenomenon candidate item; and a testing unit which tests whether there is a significant difference or not between the unusual phenomenon candidate item and an other data item.

Abstract: An objective of the present invention is to provide target tissue-specific antigen-binding molecules, antigen-binding molecules whose antigen-binding activity varies depending on the concentration of an unnatural compound, libraries comprising a plurality of the antigen-binding molecules which are different from one another, pharmaceutical compositions comprising the antigen-binding molecules, methods of screening for the antigen-binding molecules, and methods for producing the antigen-binding molecules. The present inventors created antigen-binding domains whose antigen-binding activity varies depending on the concentration of a small molecule compound or antigen-binding molecules containing an antigen-binding domain, and libraries comprising a plurality of the antigen-binding domains which are different from one another or antigen-binding domains, and demonstrated that the above-noted objective could be achieved by using the libraries.

Abstract: In an energy-saving-operation recommending system, a total energy consumption of plural facilities during passage of one material to be rolled through a rolling line is calculated, and the total energy consumption is divided by a width and a length of the material to be rolled before rolling to calculate an energy consumption reference value that defines energy consumption per unit width and unit length of the material to be rolled. The energy consumption reference value is stored in association with a steel grade and a target post-rolling plate thickness of the material to be rolled. An energy consumption reference value corresponding to a steel grade and a target post-rolling plate thickness of a material to be next rolled on the rolling line is obtained. The energy consumption reference value is multiplied by a width and a length of the material to be next rolled to calculate predicted energy consumption.

Abstract: The material structure prediction apparatus includes a temperature calculator calculating temperatures at calculation points, based on a temperature condition, a nucleation count calculator calculating a nucleation count in the calculation target region, a precipitated phase generation point determining module determining, from the calculation points, a precipitated phase generation point, a grain growth calculator calculating a grain growth of the precipitated phase at the precipitated phase generation point, and a material structure prediction module predicting the structure of the material, based on the grain growth of the precipitated phase.

Abstract: According to a certain embodiment, a control setup deice (200) includes an execution parameter information storage area (206d) for storing execution parameter information, an SGF table storage area (206b) for storing SGF tables, a finish spray code table storage area (206c) for storing finish spray code tables, a composition data storage area (206e) for storing composition data tables representing composition data of steel type families, and a control setup determiner (201b) operable when a detemination of a set of control set-points in steel type families is requested, to determine a set of control set-points based on a composition data table, a composition data and a combination of a target plate thickness and a target plate width contained in a setup request signal, first control information, and execution parameter information, and when a determination of a set of control set-points in steel types is requested, to determine a set of control set-points based on second control information, a steel type and

Abstract: A microstructural feature and material property monitoring device for a metallic material that can easily adjust relative position between an irradiation position of laser beams applied to the metallic material to propagate pulsed ultrasonic waves in the metallic material and detection position of a laser interferometer, and therefore can accurately monitor the microstructural feature and material property of the metallic material. The device relatively moves the irradiation position of the laser beams generated by a laser oscillator and the detection position of the laser interferometer. The irradiation position of the laser beams generated from a laser oscillator and the detection position of the laser interferometer are controlled to be aligned with a relative position according to the microstructural feature and material property of the metallic material based on the time from the transmission of the pulsed ultrasonic waves to the detection by the laser interferometer.

Abstract: A process line control apparatus which controls a process line including an annealing furnace (3) including a heating process apparatus executing a heating process and a cooling process apparatus executing a cooling process, the heating and cooling processes being continuously executed on a steel material, the apparatus having feed forward control means (112, 113) for measuring quality of the steel material by a material quality measuring apparatus (6) installed in an inlet stage (1) preceding the heating process in the annealing furnace (3), and on the basis of measurement results, determining modifications for respective temperature set values set by temperature setting means (111) for the heating and cooling apparatuses in the annealing furnace (3), and feedback control means (114, 115) for measuring the quality of the steel material by a material quality measuring apparatus (7) installed in an outlet stage (5) succeeding the cooling process in the annealing furnace (3), and on the basis of measurement res

Abstract: A microstructural feature and material property monitoring device for a metallic material that can easily adjust relative position between an irradiation position of laser beams applied to the metallic material to propagate pulsed ultrasonic waves in the metallic material and detection position of a laser interferometer, and therefore can accurately monitor the microstructural feature and material property of the metallic material. The device relatively moves the irradiation position of the laser beams generated by a laser oscillator and the detection position of the laser interferometer. The irradiation position of the laser beams generated from a laser oscillator and the detection position of the laser interferometer are controlled to be aligned with a relative position according to the microstructural feature and material property of the metallic material based on the time from the transmission of the pulsed ultrasonic waves to the detection by the laser interferometer.

Abstract: An imaging system 10 includes an image source providing an image having a resolution of X by Y pixels. The system also includes a digital mirror device 16 that includes an array of mirror elements. Each mirror element includes an edge that is not parallel to an edge of a neighboring mirror element. The array 16 includes fewer than X*Y mirror elements.

Abstract: This invention matches the material quality of a product to target data, even when a materials quality model is insufficient in prediction accuracy. Heating a metallic material, rolling, forging, or leveling the metallic material, and cooling the metallic material are each conducted at least once. Prior to manufacture of a metallic product of a desired size and shape, qualitative data of the metallic material are measured at a position by a materials quality sensor in a manufacturing line, and modifications based on measured data are made to heating, processing, or cooling conditions in at least one of the steps, upstream of the materials measured data sensor so that the quality of the metallic material at the measuring position agrees with target data.

Abstract: The invention matches the material quality of a product to target data, even when a materials quality model is insufficient in prediction accuracy. Heating a metallic material, rolling, forging, or leveling the metallic material, and cooling the metallic material are each conducted at least once. Prior to manufacture of a metallic product of a desired size and shape, qualitative data of the metallic material are measured at a position by materials, quality sensor in a manufacturing line, and modifications based on measured data are made to heating, processing, or cooling conditions in at least one of the steps, upstream of the materials measured data sensor so that the quality of the metallic material at the measuring position agrees with target data.

Abstract: An imaging system 10 includes an image source providing an image having a resolution of X by Y pixels. The system also includes a digital mirror device 16 that includes an array of mirror elements. Each mirror element includes an edge that is not parallel to an edge of a neighboring mirror element. The array 16 includes fewer than X*Y mirror elements.

Abstract: An imaging system 10 includes an image source providing an image having a resolution of X by Y pixels. The system also includes a digital mirror device 16 that includes an array of mirror elements. Each mirror element includes an edge that is not parallel to an edge of a neighboring mirror element. The array 16 includes fewer than X*Y mirror elements.