Patents by Inventor Kazuhiro Shima

Kazuhiro Shima has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Coated composition and its preparation process
    Patent number: 5290569
    Abstract: A process for preparing a coated composition comprising a pharmaceutically active substance stable to heat, which comprises centrifugally granualting a mixture comprising said active substance and a first thermomelting material as a binder under heating without using any solvent and coating the resultant granules with a second thermomelting material as a coating material under heating, the melting point of the second thermomelting material being lower than that of the first thermomelting material.
    Type: Grant
    Filed: June 8, 1992
    Date of Patent: March 1, 1994
    Assignee: Shionogi & Co., Ltd.
    Inventors: Noboru Nagafuzi, Takayuki Tsukada, Kazuhiro Shima, Yasushi Takagishi, Yusuke Suzuki, Yoshitaka Tomoda, Takashi Hayashi
  • Stable freeze-dried preparations of an anticancer platinum complex
    Patent number: 4767874
    Abstract: Stable freeze-dried preparations of an anticancer platinum complex, i.e. glycolato-cis-diammineplatinum (II), containing at least one member selected from the group consisting of glucan, water-soluble vinyl polymer, and polyethylene glycol as stabilizers, are very useful in the treatment of various cancers.
    Type: Grant
    Filed: September 10, 1986
    Date of Patent: August 30, 1988
    Assignee: Shionogi & Co., Ltd.
    Inventors: Kazuhiro Shima, Takayuki Tsukada, Hirotane Kagawa
  • Stable antibacterial lyophilizates
    Patent number: 4616083
    Abstract: A lyophilized preparation of 7.beta.-difluoromethylthioacetamido-7.alpha.-methoxy-3-[1-(2-hydroxyalkyl) -1H-tetrazol-5-yl]-thiomethyl-1-dethia-1-oxa-3-cephem-4-carboxylic acid alkali metal salt containing glucose, fructose, maltose, or an alkali metal salt of mineral acid or carboxylic acid as a stabilizer.
    Type: Grant
    Filed: August 17, 1984
    Date of Patent: October 7, 1986
    Assignee: Shionogi & Co., Ltd.
    Inventors: Kazuhiro Shima, Masayoshi Inoue, Takayuki Tsukada
  • Protection of lyophilized betalactams from color formation
    Patent number: 4418058
    Abstract: A stable preparation of a lyophilized .beta.-lactam antibacterial containing a 7.beta.-(.alpha.-carboxy-.alpha.-arylacetamido)-7.alpha.-methoxy-3-heteroc yclic thiomethyl-1-dethia-1-oxa-3-cephem-4-carboxylic acid (I) alkali metal salt as the antibacterial component and a sugar or sugar alcohol compound as the stabilizing agent.
    Type: Grant
    Filed: June 12, 1981
    Date of Patent: November 29, 1983
    Assignee: Shionogi & Co., Ltd.
    Inventors: Eizo Hirai, Kazuhiro Shima