Patents by Inventor Kazuhiro Sugihara

Kazuhiro Sugihara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11357819
    Abstract: The present invention is a cytocidal agent including a peptide consisting of an amino acid sequence represented by SEQ ID NO: 1 and a site selectively binding to a target molecule, in which the peptide consisting of an amino acid sequence represented by SEQ ID NO: 1 is a peptide exclusively consisting of L-amino acids, a peptide in which, in amino acid sequences represented by SEQ ID NO: 1, the first to the 14th amino acids are D-amino acids, and the 15th to 19th amino acids are L-amino acids, a peptide in which, in amino acid sequences represented by SEQ ID NO: 1, the first to 14th amino acids are L-amino acids, and the 15th to the 19th amino acids are D-amino acids, or a peptide exclusively consisting of D-amino acids.
    Type: Grant
    Filed: August 23, 2018
    Date of Patent: June 14, 2022
    Assignee: FUJITA ACADEMY
    Inventors: Kazuhiro Sugihara, Naohiro Kanayama, Yuichiro Onodera, Toshiaki Shibata, Michiko Fukuda, Motohiro Nonaka
  • Patent number: 11191804
    Abstract: An object of the present invention is to provide a peptide drug that is able to selectively induce apoptosis in target cells. The present invention is a cytocidal agent containing a fusion peptide of an endosome escape peptide and an apoptosis-inducing peptide, which consists of an amino acid sequence represented by SEQ ID NO: 1, and the said cytocidal agent as a therapeutic agent for a disease caused by abnormal proliferation of cells.
    Type: Grant
    Filed: December 28, 2018
    Date of Patent: December 7, 2021
    Assignee: FUJITA ACADEMY
    Inventors: Kazuhiro Sugihara, Naohiro Kanayama, Toshiaki Shibata, Yuichiro Onodera
  • Publication number: 20210260202
    Abstract: Compositions and methods related to annexin 1-binding compounds. Also compositions comprising a moiety and a peptide comprising an amino acid sequence that can bind to a carbohydrate receptor on a cell. Isolated nucleic acids comprising a nucleic acid sequence encoding a peptide comprising an amino acid sequence that can bind to a carbohydrate receptor on a cell. Methods comprising administering to a subject a composition comprising a moiety and a peptide comprising an amino acid sequence that can bind to a carbohydrate receptor on a cell. Methods of targeting a tumor cell in a subject comprising administering to the subject a peptide comprising an amino acid sequence that can bind to a carbohydrate receptor on a cell. Methods of targeting a tumor cell in a subject comprising administering to the subject a composition comprising a moiety and a peptide comprising an amino acid sequence that can bind to a carbohydrate receptor on a cell.
    Type: Application
    Filed: April 26, 2021
    Publication date: August 26, 2021
    Inventors: Michiko Fukuda, Kazuhiro Sugihara, Naohira Kanayama
  • Publication number: 20200330549
    Abstract: An object of the present invention is to provide a peptide drug that is able to selectively induce apoptosis in target cells. The present invention is a cytocidal agent containing a fusion peptide of an endosome escape peptide and an apoptosis-inducing peptide, which consists of an amino acid sequence represented by SEQ ID NO: 1, and the said cytocidal agent as a therapeutic agent for a disease caused by abnormal proliferation of cells.
    Type: Application
    Filed: December 28, 2018
    Publication date: October 22, 2020
    Inventors: Kazuhiro SUGIHARA, Naohiro KANAYAMA, Toshiaki SHIBATA, Yuichiro ONODERA
  • Publication number: 20200289608
    Abstract: The present invention is a cytocidal agent including a peptide consisting of an amino acid sequence represented by SEQ ID NO: 1 and a site selectively binding to a target molecule, in which the peptide consisting of an amino acid sequence represented by SEQ ID NO: 1 is a peptide exclusively consisting of L-amino acids, a peptide in which, in amino acid sequences represented by SEQ ID NO: 1, the first to the 14 amino acids are D-amino acids, and the 15th to 19th amino acids are L-amino acids, a peptide in which, in amino acid sequences represented by SEQ ID NO: 1, the first to 14th amino acids are L-amino acids, and the 15th to the 1.9th amino acids are D-amino acids, or a peptide exclusively consisting of D-amino acids.
    Type: Application
    Filed: August 23, 2018
    Publication date: September 17, 2020
    Inventors: Kazuhiro SUGIHARA, Naohiro KANAYAMA, Yuichiro ONODERA, Toshiaki SHIBATA, Michiko FUKUDA, Motohiro NONAKA
  • Patent number: 9943333
    Abstract: The present invention relates to an agent for activating mammalian sperm and a method for activating sperm by use of the activating agent. More specifically, the present invention relates to a sperm activating agent containing endo-?-galactosidase and/or FGF, which accelerate motility of mammalian sperm, for use in in-vitro fertilization and artificial insemination by husband and a sperm activating method by adding endo-?-galactosidase and/or FGF.
    Type: Grant
    Filed: September 19, 2013
    Date of Patent: April 17, 2018
    Assignees: NATIONAL UNIVERSITY CORPORATION, HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Kazuhiro Sugihara, Michiko Fukuda
  • Publication number: 20170326245
    Abstract: Compositions and methods related to annexin 1-binding compounds. Also compositions comprising a moiety and a peptide comprising an amino acid sequence that can bind to a carbohydrate receptor on a cell. Isolated nucleic acids comprising a nucleic acid sequence encoding a peptide comprising an amino acid sequence that can bind to a carbohydrate receptor on a cell. Methods comprising administering to a subject a composition comprising a moiety and a peptide comprising an amino acid sequence that can bind to a carbohydrate receptor on a cell. Methods of targeting a tumor cell in a subject comprising administering to the subject a peptide comprising an amino acid sequence that can bind to a carbohydrate receptor on a cell. Methods of targeting a tumor cell in a subject comprising administering to the subject a composition comprising a moiety and a peptide comprising an amino acid sequence that can bind to a carbohydrate receptor on a cell.
    Type: Application
    Filed: April 4, 2017
    Publication date: November 16, 2017
    Inventors: Michiko Fukuda, Kazuhiro Sugihara, Naohira Kanayama
  • Patent number: 9783576
    Abstract: Disclosed are compositions and methods for selectively targeting an endometriosis cell. Also disclosed are compositions and methods for treating endometriosis.
    Type: Grant
    Filed: June 11, 2014
    Date of Patent: October 10, 2017
    Assignee: Sanford-Burnham Medical Research Institute
    Inventors: Michiko Fukuda, Kazuhiro Sugihara
  • Patent number: 9610359
    Abstract: Disclosed are conjugates comprising the annexin 1-binding peptide IFLLWQR covalently linked to a therapeutic or detectable agent. Also disclosed are compositions comprising a moiety and a peptide comprising an amino acid sequence that can bind to a carbohydrate receptor on a cell. Also disclosed are isolated nucleic acids comprising a nucleic acid sequence encoding a peptide comprising an amino acid sequence that can bind to a carbohydrate receptor on a cell. Also disclosed are methods comprising administering to a subject a composition comprising a moiety and a peptide comprising an amino acid sequence that can bind to a carbohydrate receptor on a cell. Also disclosed are methods of targeting a tumor cell in a subject comprising administering to the subject a peptide comprising an amino acid sequence that can bind to a carbohydrate receptor on a cell.
    Type: Grant
    Filed: December 23, 2010
    Date of Patent: April 4, 2017
    Assignees: Burnham Institute for Medical Research, Hamamatsu University School of Medicine
    Inventors: Michiko Fukuda, Kazuhiro Sugihara, Naohira Kanayama
  • Publication number: 20160145308
    Abstract: Disclosed are compositions and methods for selectively targeting an endometriosis cell. Also disclosed are compositions and methods for treating endometriosis.
    Type: Application
    Filed: June 11, 2014
    Publication date: May 26, 2016
    Inventors: Michiko FUKUDA, Kazuhiro SUGIHARA
  • Publication number: 20150245852
    Abstract: The present invention relates to an agent for activating mammalian sperm and a method for activating sperm by use of the activating agent. More specifically, the present invention relates to a sperm activating agent containing endo-?-galactosidase and/or FGF, which accelerate motility of mammalian sperm, for use in in-vitro fertilization and artificial insemination by husband and a sperm activating method by adding endo-?-galactosidase and/or FGF.
    Type: Application
    Filed: September 19, 2013
    Publication date: September 3, 2015
    Applicant: National University Corporation Hamamatsu University School of Medicine
    Inventors: Kazuhiro Sugihara, Michiko Fukuda
  • Publication number: 20120251453
    Abstract: Disclosed are conjugates comprising the annexin 1-binding peptide IFLLWQR covalently linked to a therapeutic or detectable agent. Also disclosed are compositions comprising a moiety and a peptide comprising an amino acid sequence that can bind to a carbohydrate receptor on a cell. Also disclosed are isolated nucleic acids comprising a nucleic acid sequence encoding a peptide comprising an amino acid sequence that can bind to a carbohydrate receptor on a cell. Also disclosed are methods comprising administering to a subject a composition comprising a moiety and a peptide comprising an amino acid sequence that can bind to a carbohydrate receptor on a cell. Also disclosed are methods of targeting a tumor cell in a subject comprising administering to the subject a peptide comprising an amino acid sequence that can bind to a carbohydrate receptor on a cell.
    Type: Application
    Filed: December 23, 2010
    Publication date: October 4, 2012
    Inventors: Michiko Fukuda, Kazuhiro Sugihara, Naohira Kanayama
  • Patent number: 4960633
    Abstract: A microwave absorptive composite suitable for use in ships, aircrafts and the like comprises an outermost layer of a thermosetting resin-impregnated, fibrous sheet; an intermediate layer of a normally liquid, carbonblack-containing silicone rubber sheet; and an innermost layer of a reinforced thermosetting resin sheet, the three layers being integrally laminated in that order. The silicone rubber is curable at room temperature or with heat.
    Type: Grant
    Filed: April 20, 1987
    Date of Patent: October 2, 1990
    Assignee: The Yokohama Rubber Co., Ltd.
    Inventors: Misao Hiza, Hajime Yamazaki, Kazuhiro Sugihara, Tetsu So
  • Patent number: 4923736
    Abstract: A multi-layered microwave absorber suitable for use in ships, aircrafts and the like comprises a plurality of layers differing in impedance which are bonded together into an integral sheet structure by a silicone-type adhesive compound applied to a coat thickness of less than 0.1 mm. The absorber is capable of wave absorption over a wide band, free from deformation or distortion, and highly heat-resistant and weather-proof. A method of manufacturing the multi-layered microwave absorber is also disclosed.
    Type: Grant
    Filed: April 20, 1987
    Date of Patent: May 8, 1990
    Assignee: The Yokohama Rubber Co., Ltd.
    Inventors: Misao Hiza, Hajime Yamazaki, Kazuhiro Sugihara, Tetsu So