Abstract: Provided is a blood diagnosis method and a dialysis machine, using a diagnostic marker which is versatile and which can contribute to the improvements in dialysis treatment and the evaluation of clinical effects, the method including a step for collecting a blood sample from a dialysis patient before and after dialysis; and a step for making a diagnosis regarding the collected blood sample based on a biomarker, wherein the biomarker is identified in advance based on the correlation between the urea clear space (CS) or the cellular membrane clearance (Kc) and profiles of mRNA or proteins.

Abstract: The present invention provides a biochip cartridge wherein an elastic body is used for a substrate member in order to stabilize the feeding of blood or solution and whereby it is possible to avoid the risk of accidental contact of the operator with solutions due to mishandling. The biochip cartridge comprises a tabular substrate member formed using an elastic material and a flexible cover airtightly attached to the surface of the substrate member, wherein at least an area for storing biopolymers, an area for detecting desired biopolymers from the biopolymers that have been preprocessed, and a flow path for connecting the areas is formed on the substrate member, so that biopolymers can be successively moved from the biopolymer storage area to the biopolymer detection area through the flow path.

Abstract: Provided is a blood diagnosis method of providing a diagnostic marker which is general and which contributes to dialysis treatment and evaluation of clinical effects. The method includes a step of collecting blood samples from a dialysis patient before and/or after dialysis and a step of performing a gene diagnosis based on mRNA markers on the collected blood samples. The mRNA markers are previously identified on the basis of correlations between clinical data and mRNA profiles.

Abstract: The present invention relates to a method of extracting nucleic acid or protein, in which multi-layer dendrimers are formed on the surface of fine particles, amino radicals for capturing nucleic acid or protein are formed on the surface of these dendrimers, and nucleic acid or protein is extracted using these amino radicals. The present invention can greatly and easily increase the recovery ratio of nucleic acid or protein.

Abstract: Provided is a blood diagnosis method of providing a diagnostic marker which is general and which contributes to dialysis treatment and evaluation of clinical effects. The method includes a step of collecting blood samples from a dialysis patient before and/or after dialysis and a step of performing a gene diagnosis based on mRNA markers on the collected blood samples. The mRNA markers are previously identified on the basis of correlations between clinical data and mRNA profiles.

Abstract: The present invention provides a dendrimer-based biochip, wherein a flow channel through which a solution containing biopolymer molecules is flowed is formed in the substrate of the biochip, a plurality of dendrimer molecules one end of each of which is bound to the walls of the flow channel are formed thereon, and probe biopolymer or antibody molecules are bound to the tips of the dendrimer molecules so that, if the probe biopolymer molecules are bound, then target biopolymer molecules can be captured by means of a complementary combination and, if the antibody molecules are bound, then protein can be extracted by means of antigen-antibody reaction, whereby biopolymers can be retrieved in a highly efficient manner.

Abstract: The present invention separates and purifies a negatively charged target biopolymer from among biological samples without involving fluid movements. In other words, a first solution containing said biological samples and a second solution for preserving a separated and purified biopolymer are partitioned by a gel, thereby allowing said target biopolymer to move from within said first solution through said gel into said second solution using electrophoresis or a combination of electrophoresis and magnetophoresis so that said target biopolymer is separated and purified.

Abstract: The present invention provides a dendrimer-based biochip, wherein a flow channel through which a solution containing biopolymer molecules is flowed is formed in the substrate of the biochip, a plurality of dendrimer molecules one end of each of which is bound to the walls of the flow channel are formed thereon, and probe biopolymer or antibody molecules are bound to the tips of the dendrimer molecules so that, if the probe biopolymer molecules are bound, then target biopolymer molecules can be captured by means of a complementary combination and, if the antibody molecules are bound, then protein can be extracted by means of antigen-antibody reaction, whereby biopolymers can be retrieved in a highly efficient manner.

Abstract: The present invention relates to a method of extracting nucleic acid or protein, in which multi-layer dendorimers are formed on the surface of fine particles, amino radicals for capturing nucleic acid or protein are formed on the surface of these dendorimers, and nucleic acid or protein is extracted using these amino radicals. The present invention can greatly and easily increase the recovery ratio of nucleic acid or protein.

Abstract: The present invention relates to biopolymer detection methods based on antigen-antibody interactions, wherein the methods show improved S/N ratios, improved detection sensitivities, and reduced detection times. The present invention also relates to application of these methods to biochips. The invention further relates to antibody fixation methods wherein antibody molecules are immobilized to amide group-containing gels, or amide group-containing gels on insoluble substances. Using such gels prevents the nonspecific adsorption of antibody-binding molecules. By embedding these antibody-binding molecules in such gels, their antibody-binding activity is prevented from deteriorating.

Abstract: The present invention provides a dendrimer-based biochip, wherein a flow channel through which a solution containing biopolymer molecules is flowed is formed in the substrate of the biochip, a plurality of dendrimer molecules one end of each of which is bound to the walls of the flow channel are formed thereon, and probe biopolymer or antibody molecules are bound to the tips of the dendrimer molecules so that, if the probe biopolymer molecules are bound, then target biopolymer molecules can be captured by means of a complementary combination and, if the antibody molecules are bound, then protein can be extracted by means of antigen-antibody reaction, whereby biopolymers can be retrieved in a highly efficient manner.

Abstract: The present invention allows the injection of liquid absorbent into a waste liquid tank, which is provided in a sealed diagnostic cartridge, and the absorption and gelation of hazardous substances such as waste liquid containing disease-causing bacteria and the like or endocrine-disrupting chemicals in said diagnostic cartridge by means of said liquid absorbent in said waste liquid tank, thereby facilitating the prevention of said hazardous substances in said waste liquid tank from being dispersed externally.

Abstract: The present invention separates and purifies a negatively charged target biopolymer from among biological samples without involving fluid movements. In other words, a first solution containing said biological samples and a second solution for preserving a separated and purified biopolymer are partitioned by a gel, thereby allowing said target biopolymer to move from within said first solution through said gel into said second solution using electrophoresis or a combination of electrophoresis and magnetophoresis so that said target biopolymer is separated and purified.

Abstract: The present invention provides a biochip cartridge wherein an elastic body is used for a substrate member in order to stabilize the feeding of blood or solution and whereby it is possible to avoid the risk of accidental contact of the operator with solutions due to mishandling.

Abstract: The present invention relates to biopolymer detection utilizing antigen-antibody reaction, intended to improve the S/N ratio, to increase the detection sensitivity, and to shorten the detection time.

Abstract: According to the present invention, biopolymers are fixed to a substrate by attaching probe DNA to magnetic beads and fixing the above magnetic beads to the substrate by attracting them using a magnetic attraction.

Abstract: The present invention realizes a system which enables to smoothly and efficiently study and search for disease condition, disease names, treatment methods, medication methods and other information and to smoothly and efficiently follow the procedure of paying expenses necessary for the above process. It also provides a medical data processing system in which data analysis units for medical use are connected to a communications network, wherein a database is installed as a portal site which will be accessed by the data analysis units. The present invention comprises a content server having databases for storing disease condition, disease names, treatment methods, medication methods, and other information, an analysis server for correlating the comparison result with an individual patient as a diagnostic analysis and outputting personal information, and a billing/inventory control server for outputting fee information appropriate for the comparison result included in the personal information.

Abstract: The present invention relates to a genetic diagnosis/analysis apparatus using detection chips for detecting gene expression, gene representation, or the SNPs of genes, from samples of blood, bodily fluids, or affected parts collected from patients, and comprises gene detection means for preprocessing samples and detecting gene expression, gene representation, or the SNPs of genes and an analyzer for analyzing the results of detection by the gene detection means by referring to diagnostic protocols and for obtaining information about the disease in question and other related information.