Patents by Inventor Kazuhisa NAOI

Kazuhisa NAOI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250076283
    Abstract: The present invention provides a method for measuring in vitro pharmacokinetics of a molecule, the method including steps of: (a) contacting a molecule with a cell expressing FcRn in an aqueous medium to allow the cell to take up the molecule to be an uptake amount higher than 0.068 pmol/2×105 cells, in which step (a) has at least one feature selected from the following (i) to (iii): (i) a period of the contact of the molecule with the cell is 5 hours or more; (ii) the cell after the contact with the molecule is not washed under acidic conditions; and (iii) the cell expresses a target of the molecule on a surface of the cell; and (b) measuring in vitro pharmacokinetics of the molecule, in which the molecule contains an FcRn-binding domain, and the like.
    Type: Application
    Filed: May 19, 2022
    Publication date: March 6, 2025
    Inventors: Yuki NOGUCHI, Kazuhisa OZEKI, Kazuki SATO, Sotaro NAOI, Haruka TSUTSUI, Noriaki OHMINATO
  • Patent number: 12235261
    Abstract: The present invention provides a method for measuring a cellular uptake amount of a molecule, comprising (i) adding the molecule to an organ-derived cell population to perform incubation, (ii) sorting the organ-derived cell population based on the expression levels of CD31 and CD45, and (iii) after steps (i) and (ii), measuring the amount of the molecule incorporated into the cell population sorted in the step (ii), wherein the molecule is incorporated into cells via a cell surface receptor.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: February 25, 2025
    Assignee: CHUGAI SEIYAKU KABUSHIKI KAISHA
    Inventors: Yuki Noguchi, Takeru Nambu, Kazuhisa Ozeki, Noriaki Ohminato, Toshito Nakagawa, Sotaro Naoi
  • Patent number: 11831416
    Abstract: A sending device divides a message that is to be sent to a receiving device into a plurality of partial messages each having a length equal to or less than a predetermined length. The sending device puts the plurality of partial messages in a queue. The sending device takes one partial message out of the queue among the plurality of partial messages and sends the one partial message to the receiving device. The sending device receives notification information indicating that the sent partial message has been displayed in a display area. The sending device takes a next partial message out of the queue among the plurality of partial messages and sends the next partial message to the receiving device after the notification information is received.
    Type: Grant
    Filed: September 11, 2018
    Date of Patent: November 28, 2023
    Assignee: Rakuten Group, Inc.
    Inventor: Kazuhisa Naoi
  • Publication number: 20210336911
    Abstract: A sending device divides a message that is to be sent to a receiving device into a plurality of partial messages each having a length equal to or less than a predetermined length. The sending device puts the plurality of partial messages in a queue. The sending device takes one partial message out of the queue among the plurality of partial messages and sends the one partial message to the receiving device. The sending device receives notification information indicating that the sent partial message has been displayed in a display area. The sending device takes a next partial message out of the queue among the plurality of partial messages and sends the next partial message to the receiving device after the notification information is received.
    Type: Application
    Filed: September 11, 2018
    Publication date: October 28, 2021
    Applicant: Rakuten, Inc.
    Inventor: Kazuhisa NAOI