Patents by Inventor Kazuhisa Shimizu

Kazuhisa Shimizu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Block copolymer, micelle preparation, and anticancer agent containing the same as active ingredient
    Patent number: 9434822
    Abstract: A medicinal preparation is desired which has no harmful side effects such as hypersensitive reaction, heightens the water solubility of a sparingly water-soluble anticancer agent, maintains a high drug concentration in the blood, accumulates a drug in a tumor tissue at a high concentration, heightens the pharmacological effect of the sparingly water-soluble anticancer agent, and diminishes the side effects of the anticancer agent.
    Type: Grant
    Filed: August 20, 2013
    Date of Patent: September 6, 2016
    Assignee: Nippon Kayaku Kabushiki Kaisha
    Inventors: Kazuhisa Shimizu, Keizou Ishikawa, Takeshi Nakanishi
  • Novel Block Copolymer, Micelle Preparation, And Anticancer Agent Containing The Same As Active Ingredient
    Publication number: 20150259479
    Abstract: A medicinal preparation is desired which has no harmful side effects such as hypersensitive reaction, heightens the water solubility of a sparingly water-soluble anticancer agent, maintains a high drug concentration in the blood, accumulates a drug in a tumor tissue at a high concentration, heightens the pharmacological effect of the sparingly water-soluble anticancer agent, and diminishes the side effects of the anticancer agent.
    Type: Application
    Filed: June 2, 2015
    Publication date: September 17, 2015
    Inventors: Kazuhisa Shimizu, Keizou Ishikawa, Takeshi Nakanishi
  • Micellar Preparation Containing Sparingly Water-Soluble Anticancer Agent And Novel Block Copolymer
    Publication number: 20140142167
    Abstract: Micellar preparation in which the solubility of a sparingly water-soluble anticancer agent has been heightened and which after intravenous administration, enables a high blood concentration to be maintained. The preparation has high medicinal activity and/or reduced side effects, and is formed from a block copolymer represented by formula (1): [wherein R1 represents hydrogen or C1-5 alkyl; R2 represents C1-5 alkylene; R3 represents methylene or ethylene; R4 represents hydrogen or C1-4 acyl; R5 represents hydroxyl, optionally substituted aryl C2-8 alkoxyl, substituted C1-4 alkylamino, or amino having a residue of either an amino acid or a peptide derivative; n is an integer of 5 to 1,000; m is an integer of 2 to 300; and x is an integer of 1 to 300; provided that the proportion of hydroxy in the R5's is 0 to 99% and x is not larger than m] and a sparingly water-soluble anticancer agent.
    Type: Application
    Filed: December 17, 2013
    Publication date: May 22, 2014
    Applicants: Nanocarrier Kabushiki Kaisha, Nippon Kayaku Kabushiki Kaisha
    Inventors: Kazuhisa Shimizu, Toshitaka Murata, Katsuhiko Sagawa
  • Novel Block Copolymer, Micelle Preparation, And Anticancer Agent Containing The Same As Active Ingredient
    Publication number: 20140024703
    Abstract: A medicinal preparation is desired which has no harmful side effects such as hypersensitive reaction, heightens the water solubility of a sparingly water-soluble anticancer agent, maintains a high drug concentration in the blood, accumulates a drug in a tumor tissue at a high concentration, heightens the pharmacological effect of the sparingly water-soluble anticancer agent, and diminishes the side effects of the anticancer agent.
    Type: Application
    Filed: August 20, 2013
    Publication date: January 23, 2014
    Applicant: Nippon Kayaku Kabushiki Kaisha
    Inventors: Kazuhisa Shimizu, Keizou Ishikawa, Takeshi Nakanishi
  • Micellar preparation containing sparingly water-soluble anticancer agent and novel block copolymer
    Patent number: 7820759
    Abstract: A novel micellar preparation in which the solubility of a sparingly water-soluble anticancer agent has been heightened and which after intravenous administration, enables a high blood concentration to be maintained. The preparation has high medicinal activity and/or is reduced in side effects. The micellar preparation is formed from a block copolymer represented by the following general formula (1): [wherein R1 represents hydrogen or C1-5 alkyl; R2 represents C1-5 alkylene; R3 represents methylene or ethylene; R4 represents hydrogen or C1-4 acyl; R5 represents hydroxyl, optionally substituted aryl C2-8 alkoxyl, substituted C1-4 alkylamino, or amino having a residue of either an amino acid or a peptide derivative; n is an integer of 5 to 1,000; m is an integer of 2 to 300; and x is an integer of 1 to 300; provided that the proportion of hydroxy in the R5's is 0 to 99% and x is not larger than m] and a sparingly water-soluble anticancer agent.
    Type: Grant
    Filed: January 30, 2009
    Date of Patent: October 26, 2010
    Assignees: Nippon Kayaku Kabushiki Kaisha, Nanocarrier Kabushiki Kaisha
    Inventors: Kazuhisa Shimizu, Toshitaka Murata, Katsuhiko Sagawa
  • Micellar preparation containing sparingly water-soluble anticancer agent and novel block copolymer
    Publication number: 20090156742
    Abstract: A novel micellar preparation in which the solubility of a sparingly water-soluble anticancer agent has been heightened and which after intravenous administration, enables a high blood concentration to be maintained. The preparation has high medicinal activity and/or is reduced in side effects. The micellar preparation is formed from a block copolymer represented by the following general formula (1): [wherein R1 represents hydrogen or C1-5 alkyl; R2 represents C1-5 alkylene; R3 represents methylene or ethylene; R4 represents hydrogen or C1-4 acyl; R5 represents hydroxyl, optionally substituted aryl C2-8 alkoxyl, substituted C1-4 alkylamino, or amino having a residue of either an amino acid or a peptide derivative; n is an integer of 5 to 1,000; m is an integer of 2 to 300; and x is an integer of 1 to 300; provided that the proportion of hydroxy in the R5's is 0 to 99% and x is not larger than m] and a sparingly water-soluble anticancer agent.
    Type: Application
    Filed: January 30, 2009
    Publication date: June 18, 2009
    Inventors: Kazuhisa Shimizu, Toshitaka Murata, Katsuhiko Sagawa
  • Cap for writing instrument
    Patent number: D569437
    Type: Grant
    Filed: January 11, 2007
    Date of Patent: May 20, 2008
    Assignee: Pentel Kabushiki Kaisha
    Inventor: Kazuhisa Shimizu
  • Ballpoint pen
    Patent number: D575338
    Type: Grant
    Filed: October 17, 2006
    Date of Patent: August 19, 2008
    Assignee: Pentel Kabushiki Kaisha
    Inventor: Kazuhisa Shimizu
  • Ballpoint pen
    Patent number: D576676
    Type: Grant
    Filed: December 7, 2006
    Date of Patent: September 9, 2008
    Assignee: Pentel Kabushiki Kaisha
    Inventor: Kazuhisa Shimizu
  • Cap for a writing instrument
    Patent number: D580979
    Type: Grant
    Filed: June 21, 2007
    Date of Patent: November 18, 2008
    Assignee: Pentel Kabushiki Kaisha
    Inventor: Kazuhisa Shimizu
  • Cap for electronic pen
    Patent number: D584356
    Type: Grant
    Filed: March 8, 2007
    Date of Patent: January 6, 2009
    Assignee: Pentel Kabushiki Kaisha
    Inventor: Kazuhisa Shimizu
  • Ballpoint pen
    Patent number: D587752
    Type: Grant
    Filed: January 10, 2008
    Date of Patent: March 3, 2009
    Assignee: Pentel Kabushiki Kaisha
    Inventor: Kazuhisa Shimizu
  • Ballpoint pen
    Patent number: D597600
    Type: Grant
    Filed: January 10, 2008
    Date of Patent: August 4, 2009
    Assignee: Pentel Kabushiki Kaisha
    Inventor: Kazuhisa Shimizu
  • Mechanical pencil
    Patent number: D611535
    Type: Grant
    Filed: November 6, 2008
    Date of Patent: March 9, 2010
    Assignee: Pentel Kabushiki Kaisha
    Inventor: Kazuhisa Shimizu
  • Mechanical pencil
    Patent number: D630247
    Type: Grant
    Filed: February 16, 2010
    Date of Patent: January 4, 2011
    Assignee: Pentel Kabushiki Kaisha
    Inventor: Kazuhisa Shimizu
  • Correction pen
    Patent number: D648798
    Type: Grant
    Filed: January 4, 2011
    Date of Patent: November 15, 2011
    Assignee: Pentel Kabushiki Kaisha
    Inventor: Kazuhisa Shimizu
  • Correction tape transcriber
    Patent number: D648799
    Type: Grant
    Filed: November 24, 2009
    Date of Patent: November 15, 2011
    Assignee: Pentel Kabushiki Kaisha
    Inventor: Kazuhisa Shimizu
  • Mechanical pencil
    Patent number: D665024
    Type: Grant
    Filed: April 13, 2011
    Date of Patent: August 7, 2012
    Assignee: Pentel Kabushiki Kaisha
    Inventor: Kazuhisa Shimizu
  • Mechanical pencil
    Patent number: D698390
    Type: Grant
    Filed: October 17, 2012
    Date of Patent: January 28, 2014
    Assignee: Pentel Kabushiki Kaisha
    Inventor: Kazuhisa Shimizu
  • Mechanical pencil
    Patent number: D777256
    Type: Grant
    Filed: July 29, 2015
    Date of Patent: January 24, 2017
    Assignee: PENTEL KABUSHIKI KAISHA
    Inventor: Kazuhisa Shimizu