Abstract: A pressure reducing valve includes a body, an annular valve seat, a valve element, and a pressing mechanism configured to press the valve element. The pressing mechanism includes a plug provided downstream of the valve seat and having a plug hole, and a pin including a sliding portion and an upstream end, the sliding portion having a shaft shape and being inserted in the plug hole such that a gap is provided between the sliding portion and an inner peripheral surface of the plug hole, and the upstream end being provided upstream of the sliding portion so as to contact the valve element. A fitting length of the sliding portion with respect to the plug hole and the gap between the sliding portion and the plug hole satisfy 0.0005 L<C<0.00908 L, where L indicates the fitting length, and C indicates the gap.

Abstract: A pressure reducing valve includes a body, an annular valve seat, a valve element, and a pressing mechanism configured to press the valve element. The pressing mechanism includes a plug provided downstream of the valve seat and having a plug hole, and a pin including a sliding portion and an upstream end, the sliding portion having a shaft shape and being inserted in the plug hole such that a gap is provided between the sliding portion and an inner peripheral surface of the plug hole, and the upstream end being provided upstream of the sliding portion so as to contact the valve element. A fitting length of the sliding portion with respect to the plug hole and the gap between the sliding portion and the plug hole satisfy 0.0005 L<C<0.00908 L, where L indicates the fitting length, and C indicates the gap.

Abstract: A valve main unit, in which a high pressure valve is to be provided, includes a channel for hydrogen gas. An internal surface of the channel is constituted by an oxidation layer formed by performing anodizing on an aluminum-based alloy. The oxidation layer of the channel is formed by performing the anodizing under a condition in which the oxidation layer with a thickness of 8 ?m or less is formed at an external surface of the valve main unit, the external surface having an opening communicating with the channel.

Abstract: A valve device includes: a poppet that is formed in a hollow shaft shape except for a leading end, has a tapered closure part at the leading end and a side hole passing through a wall of the hollow shaft-shaped part, and rotates around a shaft center thereof during opening and closing actions; and a valve seat having a sloped seat surface with which the closure part of the poppet comes into contact when closing the valve device. The closure part of the poppet or the seat surface of the valve seat, whichever has a higher hardness, has a cut mark of the opposite direction from a direction of rotation of the poppet around the shaft center that occurs during the valve closing action.

Abstract: A hard magnetic material formed of material powders made of a R—Fe—N compound containing a light rare earth element as R, or material powders made of a Fe—N compound is used as material powders. There is formed a compact in which a density of the hard magnetic material powders differs between an outer face side portion and an inside portion of the compact such that a rate of progress of powder bonding due to microwave heating is higher in the inside portion of the compact than in the outer face side portion of the compact when an outer face of the compact is irradiated with microwaves. Then, the outer face of the compact is irradiated with the microwaves to cause the microwave heating, thereby bonding the hard magnetic material powders by oxide films which are formed on the hard magnetic material powders.

Abstract: A valve device includes: a poppet that is formed in a hollow shaft shape except for a leading end, has a tapered closure part at the leading end and a side hole passing through a wall of the hollow shaft-shaped part, and rotates around a shaft center thereof during opening and closing actions; and a valve seat having a sloped seat surface with which the closure part of the poppet comes into contact when closing the valve device. The closure part of the poppet or the seat surface of the valve seat, whichever has a higher hardness, has a cut mark of the opposite direction from a direction of rotation of the poppet around the shaft center that occurs during the valve closing action.

Abstract: An electricity storage member in an electricity storage device is manufactured by a step of folding a positive electrode material foil and folding a negative electrode material foil, a step of arranging the positive and negative electrode material foils with a separator foil interposed therebetween, and a step of positioning the positive and negative electrode material foils by relatively moving the positive and negative electrode material foils toward each other so as to insert one end of a second material foil among the positive and negative electrode material foils into a bottom of a valley of the first material foil, and restraining the one end of the second material foil with the bottom of the valley of the first material foil.

Abstract: A valve main unit, in which a high pressure valve is to be provided, includes a channel for hydrogen gas. An internal surface of the channel is constituted by an oxidation layer formed by performing anodizing on an aluminum-based alloy. The oxidation layer of the channel is formed by performing the anodizing under a condition in which the oxidation layer with a thickness of 8 ?m or less is formed at an external surface of the valve main unit, the external surface having an opening communicating with the channel.

Abstract: The present invention provides a novel compound having an excellent antitumor effect. The compound of the present invention is represented by the following general formula (1) wherein R1 and R2 are aryl or the like; A is lower alkylene; Ring X is optionally substituted arylene; E is bond or lower alkenylene; Ring Y is optionally substituted heterocycloalkylene containing one or more nitrogen atoms, one of which is attached to the adjacent carbonyl group; G is —NH-G2-, —N(lower alkyl)-G2-, —NH—CH2-G2-, —N(lower alkyl)-CH2-G2- or —CH2-G2-, [wherein G2 binds to R2, G2-R2 is bond-R2, phenylene-G3-R2, phenylene-G4-O—R2, phenylene-G5-NH—R2, phenylene-G6-N(lower alkyl)-R2 or quinolinediyl-O—R2, the phenylene of said phenylene-containing groups being optionally substituted with one or more substituents; G3-R2 is —O-lower alkylene-R2 or the like; G4-O— is lower alkylene-O— or the like; G5 is lower alkylene; G6 is lower alkylene].

Abstract: The present invention provides a STAT3/5 activation inhibitor containing an aromatic compound represented by the general formula or a salt thereof as an active ingredient: Wherein X1 represents a nitrogen atom or a group —CH?, R1 represents a group —Z—R6, in which Z represents a group —CO—, a group —CH(OH)— or the like, R6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group —O—, a group —CO—, a group —CH(OH)— or a lower alkylene group, and A represents a group

Abstract: The present invention provides a novel compound having an excellent antitumor effect. The compound of the present invention is represented by the following general formula (1) wherein R1 and R2 are aryl or the like; A is lower alkylene; Ring X is optionally substituted arylene; E is bond or lower alkenylene; Ring Y is optionally substituted heterocycloalkylene containing one or more nitrogen atoms, one of which is attached to the adjacent carbonyl group; G is —NH-G2-, —N(lower alkyl)-G2-, —NH—CH2-G2-, —N(lower alkyl)-CH2-G2- or —CH2-G2-, [wherein G2 binds to R2, G2-R2 is bond-R2, phenylene-G3-R2, phenylene-G4-O—R2, phenylene-G5-NH—R2, phenylene-G6-N(lower alkyl)-R2 or quinolinediyl-O—R2, the phenylene of said phenylene-containing groups being optionally substituted with one or more substituents; G3-R2 is —O-lower alkylene-R2 or the like; G4-O— is lower alkylene-O— or the like; G5 is lower alkylene; G6 is lower alkylene].

Abstract: The compound of the present invention is represented by the following general formula (1): [wherein X1 represents a nitrogen atom or a group —CH?; R1 represents a group —Z—R6, wherein Z represents a group —CO—, a group —CH(OH)—, or the like, and R6 represents a 5- to 15-membered monocyclic, dicyclic, or tricyclic, saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms, or sulfur atoms; R2 represents a hydrogen atom, a halogen atom or a lower alkylene group; Y represents a group —O—, a group —CO—, a group —CH(OH)—, a lower alkylene group, or the like; and A represents a group or the like, wherein R3 represents a hydrogen atom, a lower alkoxy group, or the like, p represents 1 or 2, and R4 represents an imidazolyl lower alkyl group or the like.

Abstract: An object of the present invention is to provide a STAT3/5 activation inhibitor. The present invention provides a STAT3/5 activation inhibitor containing an aromatic compound represented by the general formula or a salt thereof as an active ingredient: wherein X1 represents a nitrogen atom or a group —CH?, R1 represents a group —Z—R6, in which Z represents a group —CO—, a group —CH(OH)— or the like, R6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group —O—, a group —CO—, a group —CH(OH)— or a lower alkylene group, and A represents a group wherein R3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R4 represents an imidazolyl lower alkyl group or the like.

Abstract: The present invention provides a novel compound, which has an excellent effect of suppressing the generation of collagen and less side effects, with being excellent in terms of safety. The compound of the present invention is represented by the following general formula (1): [wherein X1 represents a nitrogen atom or a group —CH?; R1 represents a group —Z—R6, wherein Z represents a group —CO—, a group —CH(OH)—, or the like, and R6 represents a 5- to 15-membered monocyclic, dicyclic, or tricyclic, saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms, or sulfur atoms; R2 represents a hydrogen atom, a halogen atom or a lower alkylene group; Y represents a group —O—, a group —CO—, a group —CH(OH)—, a lower alkylene group, or the like; and A represents a group or the like, wherein R3 represents a hydrogen atom, a lower alkoxy group, or the like, p represents 1 or 2, and R4 represents an imidazolyl lower alkyl group or the like.

Abstract: An object of the present invention is to provide a STAT3/5 activation inhibitor. The present invention provides a STAT3/5 activation inhibitor containing an aromatic compound represented by the general formula or a salt thereof as an active ingredient: wherein X1 represents a nitrogen atom or a group —CH?, R1 represents a group —Z—R6, in which Z represents a group —CO—, a group —CH(OH)— or the like, R6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group —O—, a group —CO—, a group —CH(OH)— or a lower alkylene group, and A represents a group wherein R3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R4 represents an imidazolyl lower alkyl group or the like.

Abstract: A machine tool includes a wheel rotation spindle supported rotatably for holding a tool for processing a work by rotation; a tool changing unit for exchanging a tool provided at a predetermined position for the tool held on the side of the wheel rotation spindle; a rotation balance adjustment device for adjusting the balance due to the rotation of the wheel rotation spindle; a tool information memory section for storing the tool information including the balance data of the tool held on the side of the wheel rotation spindle; and a control section for actuating the rotation balance adjustment device on the basis of the tool information of the tool held on the wheel rotation spindle stored in the tool information memory section thereby to implement the control of the rotation balance adjustment.

Abstract: The present invention provides a novel compound, which has an excellent effect of suppressing the generation of collagen and less side effects, with being excellent in terms of safety. The compound of the present invention is represented by the following general formula (1): [wherein X1 represents a nitrogen atom or a group —CH?; R1 represents a group -Z-R6, wherein Z represents a group —CO—, a group —CH(OH)—, or the like, and R6 represents a 5- to 15-membered monocyclic, dicyclic, or tricyclic, saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms, or sulfur atoms; R2 represents a hydrogen atom, a halogen atom or a lower alkylene group; Y represents a group —O—, a group —CO—, a group —CH(OH)—, a lower alkylene group, or the like; and A represents a group or the like, wherein R3 represents a hydrogen atom, a lower alkoxy group, or the like, p represents 1 or 2, and R4 represents an imidazolyl lower alkyl group or the like.

Abstract: A grinding machine rotatably carrying a finish grinding wheel and a super-finish grinding wheel respectively on first and second wheel heads practices a method of grinding workpiece surfaces to super-finish surfaces with micro oil pockets. A surface of a workpiece rotatably carried on the machine is first ground with the finish grinding wheel to a predetermined diameter under the control of a sizing device. The workpiece surface is then ground with the super-finish grinding wheel to a target diameter under the control of a sizing device. The super-finish grinding is performed to the extent that peaks of a section curve representing the roughness of the workpiece surface attained by the finish grinding are removed but bottoms of the surface curve are left to a depth when the target diameter is reached, so that the bottoms so left of the roughness constitute the micro oil pockets.

Abstract: A CAD/CAM device for an electric discharge machine comprises a check unit (32) for checking whether or not a level (HC) of a clamp is lower than a safe level (HLS) of the machining solution surface before conducting actual machining. The machining tank (7) can be automatically driven so that machining solution surface level HL is set at safe level (HLS). Therefore, before the process of actual machining, it is possible to check whether or not the clamp device (5) is soaked in the machining solution (8) when machining is actually conducted.

Abstract: A CAD/CAM device for an electric discharge machine comprises a check means (32) for checking whether or not a level (HC) of a clamp is lower than a safe level (HLS) Of the machining solution surface when the safe level (HLS) Of the surface of the machining solution, which is obtained when a predetermined safe distance is added to an upper level of the workpiece (W) on the basis of drawing data (19) of the workpiece, is found and when the safe level (HLS) of the surface of the machining solution is compared with a level (HC) of a clamp which is found when a length of the electrode (E) is added to a level of a machining finishing position of the workpiece with respect to the predetermined reference position on the basis of drawing data (18) of the electrode before conducting actual machining. The machining tank (7) can be automatically driven so that machining solution surface level HL is set at safe level (HLS) while safe level (HLS) necessary for actual machining is being recognized.