Patents by Inventor Kazuhito Harada

Kazuhito Harada has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TETRAHYDROBENZOFURODIAZEPINONE COMPOUND AND PHARMACEUTICAL USE THEREOF
    Publication number: 20240116943
    Abstract: The present invention provides a compound having a Pim-1 inhibitory activity. The present invention provides a compound of Formula [I] or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the same, and a pharmaceutical use thereof, and the like. wherein each symbol is as defined in the description.
    Type: Application
    Filed: March 21, 2023
    Publication date: April 11, 2024
    Inventors: Masafumi Inoue, Yosuke Ogoshi, Takayuki Furukawa, Takuya Machida, Ikuo Mitani, Kazuhito Harada, Yuichi Nakagawa, Nobutaka Yamaoka
  • Tetrahydrobenzofurodiazepinone compound and pharmaceutical use thereof
    Patent number: 11643417
    Abstract: The present invention provides a compound having a Pim-1 inhibitory activity. The present invention provides a compound of Formula [I] or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the same, and a pharmaceutical use thereof, and the like. wherein each symbol is as defined in the description.
    Type: Grant
    Filed: October 4, 2021
    Date of Patent: May 9, 2023
    Assignee: Japan Tobacco Inc.
    Inventors: Masafumi Inoue, Yosuke Ogoshi, Takayuki Furukawa, Takuya Machida, Ikuo Mitani, Kazuhito Harada, Yuichi Nakagawa, Nobutaka Yamaoka
  • TETRAHYDROBENZOFURODIAZEPINONE COMPOUND AND PHARMACEUTICAL USE THEREOF
    Publication number: 20220162220
    Abstract: The present invention provides a compound having a Pim-1 inhibitory activity. The present invention provides a compound of Formula [I] or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the same, and a pharmaceutical use thereof, and the like. wherein each symbol is as defined in the description.
    Type: Application
    Filed: October 4, 2021
    Publication date: May 26, 2022
    Applicant: Japan Tobacco Inc.
    Inventors: Masafumi Inoue, Yosuke Ogoshi, Takayuki Furukawa, Takuya Machida, Ikuo Mitani, Kazuhito Harada, Yuichi Nakagawa, Nobutaka YAMAOKA
  • Triazole compounds and uses related thereto
    Patent number: 8153631
    Abstract: The present invention provides a triazole compound of the following formula: a prodrug thereof or a pharmaceutically acceptable salt thereof. The above-mentioned triazole compound has superior HSD1 inhibitory activity, and is useful as an HSD1 inhibitor, a therapeutic drug of diabetes or a therapeutic drug of obesity or a therapeutic drug of metabolic syndrome.
    Type: Grant
    Filed: November 19, 2009
    Date of Patent: April 10, 2012
    Assignee: Amgen Inc.
    Inventors: Jay P. Powers, Mario G. Cardozo, Hiroyuki Goto, Kazuhito Harada, Katsuaki Imamura, Makoto Kakutani, Isamu Matsuda, Yasuhiro Ohe, Shinji Yata
  • HETEROCYCLIC COMPOUNDS
    Publication number: 20110245223
    Abstract: The present invention provides a compound represented by the following formula [1?] or a salt thereof: wherein ring A, R2, R3, R4 and X are as defined in the description, and an agent for the treatment or prophylaxis of a pathology involving glucocorticoid, or a 11?HSD1 inhibitor, containing the compound or a salt thereof.
    Type: Application
    Filed: December 1, 2010
    Publication date: October 6, 2011
    Applicant: Japan Tobacco Inc.
    Inventors: Hiroshi Yamamoto, Yasuhiro Ohe, Hiroyuki Goto, Kazuhito Harada, Shinji Yata, Takashi Ito, Jun Nishiu, Makoto Kakutani, Shunsuke Fujii, Kota Asahina
  • Triazole compounds and uses related thereto
    Patent number: 7683059
    Abstract: The present invention provides a triazole compound of the following formula: a prodrug thereof or a pharmaceutically acceptable salt thereof. The above-mentioned triazole compound is useful as a therapeutic drug for the treatment of diabetes, obesity or metabolic syndrome.
    Type: Grant
    Filed: September 5, 2006
    Date of Patent: March 23, 2010
    Assignee: Amgen Inc.
    Inventors: Mario G. Cardozo, Jay P. Powers, Hiroyuki Goto, Kazuhito Harada, Katsuaki Imamura, Makoto Kakutani, Isamu Matsuda, Yasuhiro Ohe, Shinji Yata
  • TRIAZOLE COMPOUNDS AND USES RELATED THERETO
    Publication number: 20100062972
    Abstract: The present invention provides a triazole compound of the following formula: a prodrug thereof or a pharmaceutically acceptable salt thereof. The above-mentioned triazole compound has superior HSD1 inhibitory activity, and is useful as an HSD1 inhibitor, a therapeutic drug of diabetes or a therapeutic drug of obesity or a therapeutic drug of metabolic syndrome.
    Type: Application
    Filed: November 19, 2009
    Publication date: March 11, 2010
    Inventors: JAY P. POWERS, Mario G. CARDOZO, Hiroyuki GOTO, Kazuhito HARADA, Katsuaki IMAMURA, Makoto KAKUTANI, Isamu MATSUDA, Yasuhiro OHE, Shinji YATA
  • METHOD FOR PRODUCING PYRROLIDINE COMPOUND
    Publication number: 20100010219
    Abstract: Provided is a method capable of efficiently producing a compound having a superior HSD1 inhibitory action and a compound useful as a synthetic intermediate therefor, with superior achievability of asymmetric synthesis (i.e., superior selectivity), superior yield, superior safety and superior industrial workability at a low cost. A method of producing a compound represented by the following formula [8]: or a salt thereof, or a solvate thereof, from a compound represented by the following formula [2]: or a reactive derivative thereof, or a salt thereof, or a solvate thereof.
    Type: Application
    Filed: June 5, 2009
    Publication date: January 14, 2010
    Applicant: JAPAN TOBACCO INC.
    Inventors: Kazuhito Harada, Takashi Ito
  • Triazole Compounds and Uses Related Thereto
    Publication number: 20080249084
    Abstract: The present invention provides a triazole compound of the following formula: a prodrug thereof or a pharmaceutically acceptable salt thereof. The above-mentioned triazole compound is useful as a therapeutic drug for the treatment of diabetes, obesity or metabolic syndrome.
    Type: Application
    Filed: October 27, 2004
    Publication date: October 9, 2008
    Inventors: Jay P. Powers, Mario G. Cardozo, Hiroyuki Goto, Kazuhito Harada, Katsuaki Imamura, Makoto Kakutani, Isamu Matsuda, Yasuhiro Ohe, Shinji Yata
  • Heterocyclic compounds
    Publication number: 20070072908
    Abstract: The present invention provides a compound represented by the following formula [1?] or a salt thereof: wherein ring A, R2, R3, R4 and X are as defined in the description, and an agent for the treatment or prophylaxis of a pathology involving glucocorticoid, or a 11?HSD1 inhibitor, containing the compound or a salt thereof.
    Type: Application
    Filed: June 8, 2006
    Publication date: March 29, 2007
    Applicant: JAPAN TOBACCO INC.
    Inventors: Hiroshi Yamamoto, Yasuhiro Ohe, Hiroyuki Goto, Kazuhito Harada, Shinji Yata, Takashi Ito, Jun Nishiu, Makoto Kakutani, Shunsuke Fujii, Kota Asahina