Patents by Inventor Kazuhito Ohsawa

Kazuhito Ohsawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210401928
    Abstract: [Problem] The purpose of the present invention is to provide a novel technique associated with anti-obesity improvement. [Solution] The present invention relates to an anti-obesity agent comprising lactononadecapeptide (LNDP, Asn-Ile-Pro-Pro-Leu-Thr-Gln-Thr-Pro-Val-Val-Val-Pro-Pro-Phe-Leu-Gln-Pro-Glu) or a salt thereof. The present invention also relates to a pollakiuria improving agent and an autonomic nerve activity regulator each comprising LNDP.
    Type: Application
    Filed: October 17, 2019
    Publication date: December 30, 2021
    Applicant: ASAHI GROUP HOLDINGS, LTD.
    Inventors: Kohji OHKI, Koki SATO, Kazuhito OHSAWA
  • Patent number: 9523109
    Abstract: The invention provides a method for preparing a peptide for improving brain function, comprising hydrolyzing milk casein with an enzymatic catalyst comprising a protease to produce a hydrolysate comprising: (i) a peptide consisting of the amino acid sequence shown in SEQ ID NO: 1 or a variant thereof; (ii) a peptide consisting of the amino acid sequence shown in SEQ ID NO: 2 or a variant thereof; or (iii) a mixture of the peptides of (i) and (ii), wherein the production yield of each of the peptides is 2% or more, or the total production yield of the mixture is 10% or more. The invention also provides a food or drink or a pharmaceutical composition containing the hydrolysate.
    Type: Grant
    Filed: June 13, 2012
    Date of Patent: December 20, 2016
    Assignee: CALPIS CO., LTD.
    Inventors: Naoto Uchida, Hiroaki Goto, Kazuhito Ohsawa, Kohji Ohki
  • Patent number: 9067972
    Abstract: The present invention provides a peptide and a composition which are suitable for oral ingestion, and which have a skin aging-inhibiting activity, a collagen-production promoting activity, an epidermal turnover promoting activity, and a cutaneous cell-proliferating effect. The present invention also provides a medicament and a functional food which have a skin aging-inhibiting activity, a collagen-production promoting activity, and a cutaneous cell-proliferation promoting activity. The present invention provides a composition including at least one peptide of Asn-lle-Pro-Pro-Leu, lle-Pro-Pro-Leu, lle-Pro-Pro, Pro-Val-Val-Val-Pro-Pro, Val-Pro-Pro-Phe, Val-Pro-Pro, Phe-Pro-Pro-Gln, and Leu-Pro-Pro-Thr.
    Type: Grant
    Filed: September 2, 2010
    Date of Patent: June 30, 2015
    Assignee: CALPIS CO., LTD.
    Inventors: Kazuhito Ohsawa, Naoto Uchida, Hidehiko Baba, Michio Hatori, Kohji Ohki
  • Patent number: 8916524
    Abstract: The present invention provides a composition which may be ingested orally in a small dose for the purpose of improving brain function, and a method for improving brain function. The present invention is a composition for improving brain function, comprising, as an active ingredient, X-Pro-Pro-Y or a salt thereof, wherein X represent Val, Ile or Asn-Ile and Y represent Phe or Leu.
    Type: Grant
    Filed: September 15, 2011
    Date of Patent: December 23, 2014
    Assignee: Calpis Co., Ltd.
    Inventors: Kazuhito Ohsawa, Naoto Uchida, Kohji Ohki
  • Patent number: 8895512
    Abstract: The present invention provides a composition which may be ingested orally in a small dose for the purpose of improving brain function, and a method for improving brain function. The present invention is a composition for improving brain function, comprising, as an active ingredient, Phe-Pro.
    Type: Grant
    Filed: September 15, 2011
    Date of Patent: November 25, 2014
    Assignee: Calpis Co., Ltd.
    Inventors: Kazuhito Ohsawa, Naoto Uchida, Kohji Ohki
  • Publication number: 20140342991
    Abstract: The present invention provides a composition which may be ingested orally in a small dose for the purpose of improving brain function, and a method for improving brain function. The present invention is a composition for improving brain function, comprising, as an active ingredient, X-Pro-Pro-Y or a salt thereof, wherein X represent Val, Ile or Asn-Ile and Y represent Phe or Leu.
    Type: Application
    Filed: July 31, 2014
    Publication date: November 20, 2014
    Inventors: Kazuhito OHSAWA, Naoto UCHIDA, Kohji OHKI
  • Patent number: 8569241
    Abstract: Provided are a composition for improving the brain function, which can be orally taken at a low dose, and a method therefor. The composition for improving the brain function contains, as the active ingredient, X-Pro-Pro-Leu-Thr-Gln-Thr-Pro-Val-Val-Val-Pro-Pro-Phe-Leu-Gln-Pro-Glu-Y (wherein X is nil or represents Ile or Asn-Ile; and Y is nil or represents Val-Met), X-Val-Val-Val-Pro-Pro-Phe-Leu-Gln-Pro-Glu-Y (wherein X is abscent or represents Thr-Gln-Thr-Pro, Pro-Leu-Thr-Gln-Thr-Pro, Leu-Thr-Gln-Thr-Pro or Pro; and Y is abscent or represents Val-Met), or a salt of the same. The method for improving the brain function comprises administering said peptide or a salt of the same.
    Type: Grant
    Filed: June 25, 2012
    Date of Patent: October 29, 2013
    Assignee: Calpis Co., Ltd.
    Inventors: Kazuhito Ohsawa, Naoto Uchida, Kohji Ohki, Hiroaki Goto
  • Patent number: 8367614
    Abstract: There is provided a rheumatoid arthritis inhibitor for oral intake that has an inhibitory effect on rheumatoid arthritis and is excellent in safety. The rheumatoid arthritis inhibitor for oral intake of the present invention contains, as an active component, a casein hydrolysate containing free amino acids and peptides obtained by hydrolyzing animal milk casein to have an average chain length of not longer than 2.1 in terms of the number of amino acid residues, or a mixture of free amino acids and peptides contained in the hydrolysate.
    Type: Grant
    Filed: June 15, 2011
    Date of Patent: February 5, 2013
    Assignee: Calpis Co., Ltd
    Inventors: Michio Hatori, Kohji Ohki, Naomi Hashimura, Tatsuhiko Hirota, Kazuhito Ohsawa
  • Patent number: 8344101
    Abstract: The present invention provides a composition which may be ingested orally in a small dose for the purpose of improving brain function, and a method for improving brain function. The present invention is a composition for improving brain function, the composition comprising, as an active ingredient, X-Met-His-Gln-Pro-His-Gln-Pro-Leu-Pro-Pro-Thr-Val-Met-Phe-Pro-Pro-Gln-Ser-Val-Leu (SEQ ID NO: 6) or a salt thereof, wherein X is absent or represents Ser-Trp or Leu-Gln-Ser-Trp (SEQ ID NO: 7).
    Type: Grant
    Filed: September 24, 2010
    Date of Patent: January 1, 2013
    Assignee: Calpis Co., Ltd.
    Inventors: Kazuhito Ohsawa, Naoto Uchida, Kohji Ohki
  • Patent number: 8343925
    Abstract: The present invention provides a composition which may be ingested orally in a small dose for the purpose of improving brain function, and a method for improving brain function. The present invention is a composition for improving brain function, the composition comprising, as an active ingredient, Xaa-Pro-Pro (wherein Xaa represents Ile, Leu or Ser).
    Type: Grant
    Filed: September 24, 2010
    Date of Patent: January 1, 2013
    Assignee: Calpis Co., Ltd.
    Inventors: Kazuhito Ohsawa, Naoto Uchida, Kohji Ohki
  • Patent number: 8343924
    Abstract: The present invention provides a composition which may be ingested orally in a small dose for the purpose of improving brain function, and a method for improving brain function. The present invention is a composition for improving brain function, comprising, as an active ingredient, X-Val-Arg-Gly-Pro-Phe-Pro-Ile-Ile-Val (SEQ ID NO: 5), wherein X is absent or represents Pro.
    Type: Grant
    Filed: September 24, 2010
    Date of Patent: January 1, 2013
    Assignee: Calpis Co., Ltd.
    Inventors: Kazuhito Ohsawa, Naoto Uchida, Kohji Ohki
  • Publication number: 20120328735
    Abstract: The present invention relates to a method for preparing a casein-derived peptide by fermentation of a lactic acid bacterium. The present invention also relates to a composition containing the peptide, and a method for preparing a functional food.
    Type: Application
    Filed: June 13, 2012
    Publication date: December 27, 2012
    Inventors: Naoto Uchida, Hiroaki Goto, Kazuhito Ohsawa, Kohji Ohki
  • Publication number: 20120329722
    Abstract: The invention provides a method for preparing a peptide for improving brain function, comprising hydrolyzing milk casein with an enzymatic catalyst comprising a protease to produce a hydrolysate comprising: (i) a peptide consisting of the amino acid sequence shown in SEQ ID NO: 1 or a variant thereof; (ii) a peptide consisting of the amino acid sequence shown in SEQ ID NO: 2 or a variant thereof; or (iii) a mixture of the peptides of (i) and (ii), wherein the production yield of each of the peptides is 2% or more, or the total production yield of the mixture is 10% or more. The invention also provides a food or drink or a pharmaceutical composition containing the hydrolysate.
    Type: Application
    Filed: June 13, 2012
    Publication date: December 27, 2012
    Inventors: Naoto Uchida, Hiroaki Goto, Kazuhito Ohsawa, Kohji Ohki
  • Publication number: 20120277160
    Abstract: Provided are a composition for improving the brain function, which can be orally taken at a low dose, and a method therefor. The composition for improving the brain function contains, as the active ingredient, X-Pro-Pro-Leu-Thr-Gln-Thr-Pro-Val-Val-Val-Pro-Pro-Phe-Leu-Gln-Pro-Glu-Y (wherein X is nil or represents Ile or Asn-Ile; and Y is nil or represents Val-Met), X-Val-Val-Val-Pro-Pro-Phe-Leu-Gln-Pro-Glu-Y (wherein X is abscent or represents Thr-Gln-Thr-Pro, Pro-Leu-Thr-Gln-Thr-Pro, Leu-Thr-Gln-Thr-Pro or Pro; and Y is abscent or represents Val-Met), or a salt of the same. The method for improving the brain function comprises administering said peptide or a salt of the same.
    Type: Application
    Filed: June 25, 2012
    Publication date: November 1, 2012
    Inventors: Kazuhito OHSAWA, Naoto UCHIDA, Kohji OHKI, Hiroaki GOTO
  • Publication number: 20120083451
    Abstract: The present invention provides a composition which may be ingested orally in a small dose for the purpose of improving brain function, and a method for improving brain function. The present invention is a composition for improving brain function, comprising, as an active ingredient, X-Pro-Pro-Y or a salt thereof, wherein X represent Val, Ile or Asn-Ile and Y represent Phe or Leu.
    Type: Application
    Filed: September 15, 2011
    Publication date: April 5, 2012
    Inventors: Kazuhito OHSAWA, Naoto Uchida, Kohji Ohki
  • Publication number: 20120077752
    Abstract: The present invention provides a composition which may be ingested orally in a small dose for the purpose of improving brain function, and a method for improving brain function. The present invention is a composition for improving brain function, comprising, as an active ingredient, Phe-Pro.
    Type: Application
    Filed: September 15, 2011
    Publication date: March 29, 2012
    Inventors: Kazuhito OHSAWA, Naoto Uchida, Kohji Ohki
  • Publication number: 20120015882
    Abstract: The present invention provides an orally ingestible composition and a method for regulating an autonomic nervous activity. In particular, the present invention provides an orally ingestible composition capable of suppressing an increase in a sympathetic nervous activity, and an orally ingestible composition capable of promoting a parasympathetic nervous activity. The present invention is a composition for regulating an autonomic nervous activity, comprising, as an active ingredient, Tyr-Pro or a salt thereof.
    Type: Application
    Filed: September 26, 2011
    Publication date: January 19, 2012
    Inventors: Naoto Uchida, Kazuhito Ohsawa, Kohji Ohki, Yasunori Nakamura, Hidehiko Baba
  • Publication number: 20110251129
    Abstract: There is provided a rheumatoid arthritis inhibitor for oral intake that has an inhibitory effect on rheumatoid arthritis and is excellent in safety. The rheumatoid arthritis inhibitor for oral intake of the present invention contains, as an active component, a casein hydrolysate containing free amino acids and peptides obtained by hydrolyzing animal milk casein to have an average chain length of not longer than 2.1 in terms of the number of amino acid residues, or a mixture of free amino acids and peptides contained in the hydrolysate.
    Type: Application
    Filed: June 15, 2011
    Publication date: October 13, 2011
    Applicant: CALPIS CO., LTD.
    Inventors: Michio HATORI, Kohji OHKI, Naomi HASHIMURA, Tatsuhiko HIROTA, Kazuhito OHSAWA
  • Publication number: 20110160139
    Abstract: The present invention provides a composition which may be ingested orally in a small dose for the purpose of improving brain function, and a method for improving brain function. The present invention is a composition for improving brain function, comprising, as an active ingredient, X-Val-Arg-Gly-Pro-Phe-Pro-Ile-Ile-Val (SEQ ID NO: 5), wherein X is absent or represents Pro.
    Type: Application
    Filed: September 24, 2010
    Publication date: June 30, 2011
    Inventors: Kazuhito OHSAWA, Naoto UCHIDA, Kohji OHKI
  • Publication number: 20110160138
    Abstract: The present invention provides a composition which may be ingested orally in a small dose for the purpose of improving brain function, and a method for improving brain function. The present invention is a composition for improving brain function, the composition comprising, as an active ingredient, X-Met-His-Gln-Pro-His-Gln-Pro-Leu-Pro-Pro-Thr-Val-Met-Phe-Pro-Pro-Gln-Ser-Val-Leu (SEQ ID NO: 6) or a salt thereof, wherein X is absent or represents Ser-Trp or Leu-Gln-Ser-Trp (SEQ ID NO: 7).
    Type: Application
    Filed: September 24, 2010
    Publication date: June 30, 2011
    Inventors: Kazuhito OHSAWA, Naoto Uchida, Kohji Ohki