Abstract: Disclosed are methods of RNA-triggered protein cleavage by the CRISPR Cas7-11-Csx29 complex. A guide RNA specifically hybridizes to a RNA target, and Csx29 cleaves Csx30 when Cas7-11:Csx29 complex binds to the target RNA.

Abstract: In an object detection device for detecting an object, a single sensor unit includes a light emitting unit and a light receiving unit. The light receiving unit includes a two-dimensional array of light receiving elements and outputs a light reception signal in response to a light reception state of a set of the light receiving elements for each pixel. The sensor unit is configured to, based on the light reception signals, acquire first information indicating reception intensity of the reflected light at each pixel, second information indicating reception intensity of background light that is light other than the reflected light, at each pixel, and third information indicating a distance to the object at each pixel as a pixel value of the pixel. A detection unit is configured to use all of the first to third information included in the pixel values of the respective pixels to detect the object.

Abstract: A manufacturing method of a multilayer ceramic electronic device includes: forming each of stack units by forming each of internal electrode patterns on each of dielectric green sheets, the each of internal electrode patterns including Ni, Sn and Au; forming a multilayer structure by stacking the each of stack units; and firing the multilayer structure, whereby each internal electrode layer is formed from the each of internal electrode patterns and each dielectric layer is formed from the each of the dielectric green sheets wherein, in the each internal electrode layer, an Au concentration near each interface between the each internal electrode layer and the each dielectric layer is larger than an Au concentration in each center portion in a thickness direction.

Abstract: An object recognition device of the present disclosure divides a reflection intensity image and a background light image acquired from a light sensor into the same number of subregions. The object recognition device calculates a feature amount for partial image data of each of the subregions of the reflection intensity image and partial image data of each of the subregions of the background light image that have been divided. The object recognition device compares the feature amounts calculated for the partial image data of the reflection intensity image and the partial image data of the background light image in the same one of the subregions and selects the feature amount with which an object is more easily recognized as the selected partial image data. The object recognition device recognizes the object based on overall image data configured by the selected partial image data pieces that have been selected.

Abstract: A ranging controller controls a ranging device to measure a distance to a reflection point by detecting a reflection light reflected from the reflection point to which a scan light is emitted. The ranging device is adapted to a movable object. The ranging controller includes a processor that: determines whether an execution condition for executing a calibration of the ranging device is satisfied; controls the ranging device to execute a calibration mode in a case where the processor determines that the execution condition is satisfied; and executes the calibration based on a ranging result of the ranging device in the calibration mode.

Abstract: This disclosure provides systems, methods, and compositions for RNA-guided RNA-targeting CRISPR effectors for the treatment of diseases, and for use as diagnostics. In addition, nucleotide deaminase functionalized CRISPR systems for RNA editing RNA knockdown, viral resistance, splicing modulation, RNA tracking, translation modulation, and epi-transcriptomic modifications are disclosed.

Abstract: A composite polymer electrolyte membrane comprising a nanofiber sheet having a basis weight of 1.5 g/m2 or more and 4.0 g/m2 or less, and a proton-conducting polymer, the electrolyte membrane having a sheet shape in which the proton-conducting polymer and the nanofiber sheet are combined, and having an average coefficient of linear expansion of 300 ppm/K or less from 20° C. to 120° C. in an in-plane direction of the sheet shape.

Abstract: A hydrogel 1 having a laminate structure of layer A 10 and layer B 20, wherein layer A 10 contains a monomer-derived component, water, a humectant, a water-insoluble polymer having tackiness and an amphiphilic polymer, the water-insoluble polymer is contained in a proportion of 3 to 20 wt % based on a total amount of layer A, and the amphiphilic polymer is a polyvinyl alcohol having a saponification degree of 50 to 75% and is contained in a proportion of 0.05 to 5 wt % based on the total amount of layer A; layer B 20 contains a monomer-derived component, water and a humectant and is substantially free of a water-insoluble polymer having tackiness and a polyvinyl alcohol; and an amount of the water based on a total amount of layer B is the amount of water based on the total amount of layer A±10 wt %.

Abstract: The present invention is intended to provide a gel sheet having a formulation providing an adhesive force on the skin side suitable for the skin (i.e., a gel having a low adhesive force and being able to withstand a tip pressure of a terminal and the like), and concurrently having a sufficient adhesive force against an electrode element on the side opposite to the skin side. The present invention is a gel sheet having a laminated structure of a layer A and a layer B, characterized in that the storage elastic modulus of the layer A at 23° C. and 10 Hz is 12,000 to 40,000 Pa, and the storage elastic modulus of the layer B at 23° C. and 10 Hz is 2,000 to 10,000 Pa.

Abstract: A hydrogel comprising a polymer matrix formed from a copolymer of an acrylic monomer and a crosslinkable monomer, a water-soluble polymer, water, and a polyhydric alcohol, the hydrogel having a tensile strength of 0.5 N/20 mm to 3.0 N/20 mm.

Abstract: An object recognition device of the present disclosure divides a reflection intensity image and a background light image acquired from a light sensor into the same number of subregions. The object recognition device calculates a feature amount for partial image data of each of the subregions of the reflection intensity image and partial image data of each of the subregions of the background light image that have been divided. The object recognition device compares the feature amounts calculated for the partial image data of the reflection intensity image and the partial image data of the background light image in the same one of the subregions and selects the feature amount with which an object is more easily recognized as the selected partial image data. The object recognition device recognizes the object based on overall image data configured by the selected partial image data pieces that have been selected.

Abstract: A route retrieval apparatus includes a route retrieval unit configured to perform route retrieval from a departure place to a destination, the route retrieval retrieving a route using one or two or more pieces of moving means among a plurality of pieces of moving means including sharing type moving means in which a vehicle with a relatively small riding capacity is used by unspecified people, and perform the route retrieval from the departure place to the destination, the route retrieval retrieving a route including usage of the sharing type moving means, such that the usage of the sharing type moving means is restricted to at least one of usage from the departure place or a periphery of the departure place and usage for reaching the destination or a periphery of the destination.

Abstract: A power supply system includes a high voltage battery, a first DCDC converter connected to the high voltage battery, a low voltage lead battery configured to be charged from the high voltage battery via the first DCDC converter, a low voltage lithium battery connected to a low voltage power supply circuit, the low voltage lead battery, and a load, a second DCDC converter connected to the low voltage power supply circuit and disposed between the low voltage lead battery and the low voltage lithium battery, a bypass circuit connected to the low voltage power supply circuit to bypass the second DCDC converter, and a control device configured to watch the low voltage lithium battery and control on/off of a switch unit provided in the bypass circuit.

Abstract: Processing circuitry of an in-vehicle cooling system regulates the flow rate of the coolant passing through a radiator, thereby regulating the coolant temperature to a target coolant temperature. The processing circuitry sets the target coolant temperature to a specified standard target coolant temperature when the engine is not operating in a specified temperature increase permitting range, and sets the target coolant temperature to a high target coolant temperature, which is higher than the standard target coolant temperature, when the engine is operating in the temperature increase permitting range. The processing circuitry changes the target coolant temperature in the temperature increase permitting range to a temperature lower than the high target coolant temperature and higher than or equal to the standard target coolant temperature, when the hydraulic oil temperature is higher than or equal to a specified temperature increase suppressing temperature.

Abstract: The present invention provides light chain amino acid substitutions that improve the FVIII cofactor function-substituting activity of ACE910 (Emicizumab), novel light chains showing FVIII cofactor function-substituting activity, and heavy chain amino acid substitutions that improve the FVIII cofactor function-substituting activity of novel light chain-containing bispecific antibodies.

Abstract: In an object detection device for detecting an object, a single sensor unit includes a light emitting unit and a light receiving unit. The light receiving unit includes a two-dimensional array of light receiving elements and outputs a light reception signal in response to a light reception state of a set of the light receiving elements for each pixel. The sensor unit is configured to, based on the light reception signals, acquire first information indicating reception intensity of the reflected light at each pixel, second information indicating reception intensity of background light that is light other than the reflected light, at each pixel, and third information indicating a distance to the object at each pixel as a pixel value of the pixel. A detection unit is configured to use all of the first to third information included in the pixel values of the respective pixels to detect the object.

Abstract: In a ranging device for measuring a distance to an object, a distance image acquisition unit is configured to, using light reception signal, acquire a distance image that indicates, at each pixel, a distance to the object within a region illuminated with illumination light. A background light image acquisition unit is configured to, using the light reception signals, acquire a background light image that indicates an intensity of background light received at each pixel. An information acquirer is configured to acquire intensity-related information related to the intensity of the background light. A resolution controller is configured to control a resolution of the distance image and a resolution of the background light image by setting a size of pixel regions independently for each of the distance image and the background light image according to the intensity of the background light indicated by the intensity-related information.

Abstract: An object of the present invention is to provide a gel sheet comprising an intermediate base, having no variation in adhesiveness. A gel sheet 1 comprising a gel material 10 and an intermediate base 20 embedded in the gel material 10, wherein when T represents the thickness of the gel sheet 1, and S represents the amplitude of the intermediate base 20, a relation represented by the following expression (1) is satisfied: S/T?0.

Abstract: Providing a rotary packaging machine which can improve production efficiency and mass productivity, which can be rendered smaller-sized with the result of reduction in a footprint and which can cause various devices and apparatuses arranged at each packaging station to function in a stable manner. The rotary packaging machine P in accordance with the invention has four grip pairs intermittently moved to each packaging station simultaneously, and all the grip pairs include grips configured to be located on a circumference L of an imaginary circle that is concentric with a disk-shaped rotating body.

Abstract: The invention relates to cytosol penetrating antigen binding molecules containing cell surface antigen binding domains, cytosolic antigen binding domains and cytosol penetrating domains; pharmaceutical compositions comprising said antigen binding molecules; methods of delivering said antigen binding molecules specifically into cytosols of target cells; methods of depleting, suppressing or activating cytosolic antigens specifically in target cells by using said antigen binding molecules; and pharmaceutical compositions for preventing or treating diseases in patients comprising said antigen binding molecules. The invention also relates to cytosol penetrating antigen binding molecules containing cytosol penetrating domains and Fc regions, wherein the Fc regions comprising one or more amino acid modifications that enhance multimerization of said cytosol penetrating antigen binding molecules.