Patents by Inventor Kazuki Nakabayashi
Kazuki Nakabayashi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210325408Abstract: Disclosed is a method for assisting prediction of exacerbation of respiratory infection, comprising measuring a biomarker in a specimen collected from a subject suffering from a respiratory infection or a subject suspected of having a respiratory infection, wherein the biomarker is at least one selected from the group consisting of IFN?3, CCL17, CXCL11, IP-10, IL-6 and CXCL9, and a measured value of the biomarker is used as an index to predict exacerbation of the respiratory infection.Type: ApplicationFiled: April 15, 2021Publication date: October 21, 2021Applicants: NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE, SYSMEX CORPORATIONInventors: Masashi MIZOKAMI, Masaya SUGIYAMA, Norio OHMAGARI, Noriko KINOSHITA, Youichi TAKAHAMA, Kazuki NAKABAYASHI
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Patent number: 8945841Abstract: Methods of judging the lymph node metastasis of stomach cancer, apparatuses for judging the lymph node metastasis of stomach cancer and kits used therefor are disclosed.Type: GrantFiled: January 7, 2008Date of Patent: February 3, 2015Assignee: Sysmex CorporationInventors: Hideki Takata, Kayo Shoji, Kazuki Nakabayashi, Yasuhiro Otomo
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Publication number: 20140162895Abstract: The invention provides a system adapted to a method for determining behavior of thyroid tumor. The system comprises a processor, and a memory, under control of said processor, including software instructions adapted to enable the system to perform operations.Type: ApplicationFiled: November 27, 2013Publication date: June 12, 2014Applicant: SYSMEX CORPORATIONInventors: Hiroyuki SHIMIZU, Kazuki NAKABAYASHI, Motonari DAITO
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Patent number: 8465924Abstract: A treatment solution for preparing a sample solution for nucleic acid amplification reaction is described. The treatment solution comprises dimethyl sulfoxide and aqueous solvent. The sample solution prepared by treating a biological sample with the treatment solution is used in the amplification reaction of a nucleic acid, whereby the nucleic acid can be efficiently recovered from a biological sample, and the influence of an inhibitor during nucleic acid amplification can be effectively reduced.Type: GrantFiled: December 6, 2005Date of Patent: June 18, 2013Assignee: Sysmex CorporationInventors: Yasuhiro Otomo, Kazuhiko Takeda, Shigeki Abe, Kazuki Nakabayashi
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Patent number: 8187809Abstract: The present invention provides a novel marker capable of accurately diagnosing the lymph node metastasis of stomach cancer. An mRNA, or a fragment thereof, coding for at least one protein selected from TFF1, AGR2, PRSS8, MUC1, MUC4 and MUC17 can be useful as a lymph node metastasis marker.Type: GrantFiled: January 11, 2008Date of Patent: May 29, 2012Assignee: Sysmex CorporationInventors: Hideki Takata, Takayuki Takahata, Kazuki Nakabayashi, Kayo Shoji, Yasuhiro Otomo
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Publication number: 20120095301Abstract: In order to provide a method of testing lymph node metastasis in cervical cancer which can determine the presence of lymph node metastasis in cervical cancer with higher accuracy, the method includes acquiring information about mRNA expression level of at least one gene selected from the group consisting of SERPINB5, CK15, CK4, PI3, and ANXA8 contained in a measurement sample prepared from a lymph node tissue from a cervical cancer patient which may have cervical cancer metastasis; and determining whether cervical cancer has spread to the lymph node tissue based on the information about mRNA expression level acquired.Type: ApplicationFiled: October 13, 2011Publication date: April 19, 2012Applicant: SYSMEX CORPORATIONInventors: Kazuki NAKABAYASHI, Kayo HIYAMA
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Publication number: 20110311981Abstract: A method of determining a lymph node metastasis in a lung cancer, comprising: acquiring mRNA expression level of stratifin contained in a measurement sample prepared by using a lymph node tissue of a lung cancer patient who may have a lymph node metastasis; and determining that the lymph node tissue is a lymph node metastasis of the lung cancer when the acquired mRNA expression level of stratifin is overexpressed. An apparatus and a computer program product are also disclosed.Type: ApplicationFiled: June 15, 2011Publication date: December 22, 2011Applicant: SYSMEX CORPORATIONInventors: Kayo Hiyama, Yuichiro Yoshida, Masaki Kobayashi, Kazuki Nakabayashi
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Patent number: 8053193Abstract: The invention provides a method for judging whether cancer cells are present or not in a sample, comprising a obtaining step of obtaining values related to an expression level of a caner marker gene and a housekeeping gene; a first comparing step of comparing the value related to the expression level of the cancer marker gene with a first threshold value; a normalizing step of normalizing the value related to the expression level of the cancer marker gene based on the value related to the expression level of the housekeeping gene; a second comparing step of comparing the normalized value with a second threshold value; and a judging step of judging whether cancer cells are present or not in the sample based on comparison results obtained in the first and second comparing steps, as well as an apparatus for judging whether cancer cells are present or not.Type: GrantFiled: July 18, 2008Date of Patent: November 8, 2011Assignee: Sysmex CorporationInventors: Yasuhiro Otomo, Kazuki Nakabayashi, Kayo Shoji, Hideki Takata
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Publication number: 20110076689Abstract: The present invention provides a means and method for detecting TYR mRNA. As a primer for detecting TYP mRNA, a primer comprising a first sequence at the 5? end side and a second sequence at the 3? end side, wherein the first sequence has 10 to 30 nucleotides in length, and the first sequence is a sequence of a polynucleotide capable of hybridizing with a strand complementary to a first region which is a partial region of SEQ ID NO: 1; and wherein the second sequence has 10 to 30 nucleotides in length, and the second sequence is a sequence of a polynucleotide capable of hybridizing with a second region located in the 3? end side from the first region in SEQ ID NO: 1 is used.Type: ApplicationFiled: May 29, 2009Publication date: March 31, 2011Applicant: SYSMEX CORPORATIONInventors: Kayo Hiyama, Kazuki Nakabayashi, Yasuhiro Otomo
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Publication number: 20110053168Abstract: Disclosed is a primer for detecting mRNA for CK7. The primer comprises a first sequence on its 5?-terminal side and a second sequence on its 3?-terminal side. The first sequence has a length of 10 to 30 nucleotides, and can hybridize with a strand complementary to a first region which is a region contained in the sequence depicted in SEQ ID NO:1. The second sequence has a length of 10 to 30 nucleotides, and can hybridize with a second region which is located on the 3?-terminal side from the first region in the sequence depicted in SEQ ID NO:1.Type: ApplicationFiled: March 12, 2009Publication date: March 3, 2011Applicant: SYSMEX CORPORATIONInventors: Kayo Hiyama, Kazuki Nakabayashi, Yasuhiro Otomo, Hideki Takata
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Publication number: 20090081671Abstract: The invention provides a method for judging whether cancer cells are present or not in a sample, comprising a obtaining step of obtaining values related to an expression level of a caner marker gene and a housekeeping gene; a first comparing step of comparing the value related to the expression level of the cancer marker gene with a first threshold value; a normalizing step of normalizing the value related to the expression level of the cancer marker gene based on the value related to the expression level of the housekeeping gene; a second comparing step of comparing the normalized value with a second threshold value; and a judging step of judging whether cancer cells are present or not in the sample based on comparison results obtained in the first and second comparing steps, as well as an apparatus for judging whether cancer cells are present or not.Type: ApplicationFiled: July 18, 2008Publication date: March 26, 2009Applicant: SYSMEX CORPORATIONInventors: Yasuhiro Otomo, Kazuki Nakabayashi, Kayo Shoji, Hideki Takata
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Publication number: 20080227094Abstract: Methods of judging the lymph node metastasis of stomach cancer, apparatuses for judging the lymph node metastasis of stomach cancer and kits used therefor are disclosed.Type: ApplicationFiled: January 7, 2008Publication date: September 18, 2008Applicant: SYSMEX CORPORATIONInventors: Hideki Takata, Kayo Shoji, Kazuki Nakabayashi, Yasuhiro Otomo
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Publication number: 20080182259Abstract: The present invention provides a novel marker capable of accurately diagnosing the lymph node metastasis of stomach cancer. An mRNA, or a fragment thereof, coding for at least one protein selected from TFF1, AGR2, PRSS8, MUC1, MUC4 and MUC17 can be useful as a lymph node metastasis marker.Type: ApplicationFiled: January 11, 2008Publication date: July 31, 2008Applicant: SYSMEX CORPORATIONInventors: Hideki Takata, Takayuki Takahata, Kazuki Nakabayashi, Kayo Shoji, Yasuhiro Otomo
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Publication number: 20080166771Abstract: In detecting a nucleic acid by using the nucleic acid amplification method, it is intended to shorten the time required for the measurement so as to systematically and efficiently examine a gene, etc. To achieve this object, use is made of a method of directly amplifying a nucleic acid by treating a collected biological sample wherein a means of inhibiting the degradation activity of the nucleic acid is introduced during or after the step of homogenizing the biological sample and thus the nucleic acid is directly amplified without isolating/purifying the nucleic acid component from the biological sample. In this method, the means of inhibiting the degradation activity of the nucleic acid is introduced at an acidic pH value (more specifically, from pH 2.5 to pH 5) with the use of a salt interacting with a substance inhibiting the nucleic acid amplification reaction and/or the nucleic acid component so as to directly amplify the nucleic acid without isolating/purifying the nucleic acid component.Type: ApplicationFiled: July 12, 2007Publication date: July 10, 2008Inventors: Sachiyo Tada, Tomokazu Yoshida, Keiichiro Shohmi, Masahiro Nishida, Kazuki Nakabayashi, Koichi Yamagata
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Patent number: 7312053Abstract: In detecting a nucleic acid by using the nucleic acid amplification method, it is intended to shorten the time required for the measurement so as to systematically and efficiently examine a gene, etc. To achieve this object, use is made of a method of directly amplifying a nucleic acid by treating a collected biological sample wherein a means of inhibiting the degradation activity of the nucleic acid is introduced during or after the step of homogenizing the biological sample and thus the nucleic acid is directly amplified without isolating/purifying the nucleic acid component from the biological sample. In this method, the means of inhibiting the degradation activity of the nucleic acid is introduced at an acidic pH value (more specifically, from pH 2.5 to pH 5) with the use of a salt interacting with a substance inhibiting the nucleic acid amplification reaction and/or the nucleic acid component so as to directly amplify the nucleic acid without isolating/purifying the nucleic acid component.Type: GrantFiled: January 8, 2003Date of Patent: December 25, 2007Assignee: Sysmex CorporationInventors: Sachiyo Tada, Tomokazu Yoshida, Keiichiro Shohmi, Masahiro Nishida, Kazuki Nakabayashi, Koichi Yamagata
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Publication number: 20070287157Abstract: A method and apparatus for judging the presence or absence of metastasis of malignant tumor is herein described. The method comprising: measuring an absolute amount of a tumor marker; and judging the presence or absence of metastasis of malignant tumor by comparing the absolute amount with a predetermined threshold value. The apparatus comprising: a measuring assembly for obtaining information related to an absolute amount of a tumor marker; and a computer for obtaining absolute amount of the tumor marker based on the information related to the absolute amount of the tumor marker, and judging the presence or absence of metastasis by comparing the absolute amount of the tumor marker with a predetermined threshold value.Type: ApplicationFiled: June 8, 2007Publication date: December 13, 2007Applicant: SYSMEX CORPORATIONInventors: Kazuki Nakabayashi, Yasuhiro Otomo, Motonari Daito, Hideki Takata, Kayo Hiyama
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Publication number: 20070172857Abstract: The present invention relates to a primer and method for detecting lymph node metastasis of a cancer cell derived from a colon cancer by detecting a marker in a sample prepared from a lymph node obtained from a living body, wherein the marker is a mRNA or a fragment of the mRNA, the mRNA being transcribed from a gene coding a specific protein.Type: ApplicationFiled: December 22, 2006Publication date: July 26, 2007Applicant: SYSMEX CORPORATIONInventors: Motonari Daito, Takayuki Takahata, Riko Sonoda, Yasuhiro Otomo, Kazuki Nakabayashi
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Publication number: 20060188911Abstract: A genetic testing method for specifically amplifying a DNA complementary to a target nucleic acid existing in a biologic sample, measuring the amplified DNA, and generating diagnosis support information on the basis of a measurement result is described that includes steps of: (a) specifically amplifying a DNA complementary to an internal standard nucleic acid by using a known amount of the internal standard nucleic acid in the absence of the biologic sample component, and obtaining a first measurement result on the basis of the amplification, wherein the DNA has a property to be specifically amplified in the presence of the biologic sample component; (b) specifically amplifying the DNA complementary to the target nucleic acid in the presence of the biologic sample component, and obtaining a second measurement result on the basis of the amplification; and (c) comparing the first and second measurement results to obtain diagnosis support information.Type: ApplicationFiled: February 16, 2006Publication date: August 24, 2006Inventors: Yasuhiro Otomo, Kazuki Nakabayashi, Motonari Daito
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Publication number: 20060121515Abstract: A treatment solution for preparing a sample solution for nucleic acid amplification reaction is described. The treatment solution comprises dimethyl sulfoxide and aqueous solvent. The sample solution prepared by treating a biological sample with the treatment solution is used in the amplification reaction of a nucleic acid, whereby the nucleic acid can be efficiently recovered from a biological sample, and the influence of an inhibitor during nucleic acid amplification can be effectively reduced.Type: ApplicationFiled: December 6, 2005Publication date: June 8, 2006Inventors: Yasuhiro Otomo, Kazuhiko Takeda, Shigeki Abe, Kazuki Nakabayashi
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Publication number: 20050089857Abstract: In detecting a nucleic acid by using the nucleic acid amplification method, it is intended to shorten the time required for the measurement so as to systematically and efficiently examine a gene, etc. To achieve this object, use is made of a method of directly amplifying a nucleic acid by treating a collected biological sample wherein a means of inhibiting the degradation activity of the nucleic acid is introduced during or after the step of homogenizing the biological sample and thus the nucleic acid is directly amplified without isolating/purifying the nucleic acid component from the biological sample. In this method, the means of inhibiting the degradation activity of the nucleic acid is introduced at an acidic pH value (more specifically, from pH 2.5 to pH 5) with the use of a salt interacting with a substance inhibiting the nucleic acid amplification reaction and/or the nucleic acid component so as to directly amplify the nucleic acid without isolating/purifying the nucleic acid component.Type: ApplicationFiled: January 8, 2003Publication date: April 28, 2005Applicant: SYSMEX CORPORATIONInventors: Sachiyo Tada, Tomokazu Yoshida, Keiichiro Shohmi, Masahiro Nishida, Kazuki Nakabayashi, Koichi Yamagata