Patents by Inventor Kazuki Okai

Kazuki Okai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Salt of (2S, 3S)-3-[[(1S)-1-isobutoxymethyl-3-methylbutyl]carbamoyl]oxirane-2-carboxylic acid
    Patent number: 8163942
    Abstract: The invention relates to purification of (2S,3S)-3-[[(1S)-1-isobutoxymethyl-3-methylbutyl]carbamoyl]oxirane-2-carboxylic acid [hereinafter, referred to as the carboxylic acid] using the salt of the carboxylic acid with an organic amine selected from the group consisting of piperazine, adamantane amines and others. The invention also relates to providing crystalline sodium salt of the carboxylic acid. The sodium salt is usable as a material for preparing medicaments and improved in storage stability, and has the following characteristics: DSC: exothermic peak observed at a temperature in the range of 170 to 175° C. with weight decrease; and characteristic absorption bands of infrared absorption spectrum (KBr tablet): 3255, 2950, 2860, 1670, 1630, 1550, 1460, 1435, 1395, 1365, 1310, 1260, 1110, 890 cm?1.
    Type: Grant
    Filed: September 13, 2010
    Date of Patent: April 24, 2012
    Assignee: Velcura Therapeutics, Inc.
    Inventors: Atsushi Tendo, Toshihiro Takahashi, Tomio Yamakawa, Kazuki Okai, Susumu Nihashi
  • SALT OF (2S, 3S) -3- [ [ (1S) -1- ISOBUTOXYMETHYL-3-METHYLBUTYL] CARBAMYL] OXIRANE-2-CARBOXYLIC ACID
    Publication number: 20110003993
    Abstract: The invention relates to purification of (2S,3S)-3-[[(1S)-1-isobutoxymethyl-3-methylbutyl]carbamoyl]oxirane-2-carboxylic acid [hereinafter, referred to as the carboxylic acid] using the salt of the carboxylic acid with an organic amine selected from the group consisting of piperazine, adamantane amines and others. The invention also relates to providing crystalline sodium salt of the carboxylic acid. The sodium salt is usable as a material for preparing medicaments and improved in storage stability, and has the following characteristics: DSC: exothermic peak observed at a temperature in the range of 170 to 175° C. with weight decrease; and characteristic absorption bands of infrared absorption spectrum (KBr tablet): 3255, 2950, 2860, 1670, 1630, 1550, 1460, 1435, 1395, 1365, 1310, 1260, 1110, 890 cm×1.
    Type: Application
    Filed: September 13, 2010
    Publication date: January 6, 2011
    Applicant: NIPPON CHEMIPHAR CO., LTD.
    Inventors: Atsushi TENDO, Toshihiro TAKAHASHI, Tomio YAMAKAWA, Kazuki OKAI, Susumu NIHASHI
  • Salt of (2S, 3S)-3-[[(1S)-1-isobutoxymethyl-3-methylbutyl] carbamoyl] oxirane-2-carboxylic acid
    Patent number: 7795458
    Abstract: The invention relates to purification of (2S,3S)-3-[[(1S)-1-isobutoxymethyl-3-methylbutyl]carbamoyl]oxirane-2-carboxylic acid [hereinafter, referred to as the carboxylic acid] using the salt of the carboxylic acid with an organic amine selected from the group consisting of piperazine, adamantane amines and others. The invention also relates to providing crystalline sodium salt of the carboxylic acid. The sodium salt is usable as a material for preparing medicaments and improved in storage stability, and has the following characteristics: DSC: exothermic peak observed at a temperature in the range of 170 to 175° C. with weight decrease; and characteristic absorption bands of infrared absorption spectrum (KBr tablet) 3255, 2950, 2860, 1670, 1630, 1550, 1460, 1435, 1395, 1365, 1310, 1260, 1110, 890 cm?1.
    Type: Grant
    Filed: August 21, 2009
    Date of Patent: September 14, 2010
    Assignee: Nippon Chemiphar Co., Ltd
    Inventors: Atsushi Tendo, Toshihiro Takahashi, Tomio Yamakawa, Kazuki Okai, Susumu Nihashi
  • SALT OF (2S, 3S)-3-[[ (1S)-1-ISOBUTOXYMETHYL-3-METHYLBUTYL] CARBAMOYL] OXIRANE-2-CARBOXYLIC ACID
    Publication number: 20090312563
    Abstract: The invention relates to purification of (2S,3S)-3-[[(1S)-1-isobutoxymethyl-3-methylbutyl]carbamoyl]oxirane-2-carboxylic acid [hereinafter, referred to as the carboxylic acid] using the salt of the carboxylic acid with an organic amine selected from the group consisting of piperazine, adamantane amines and others. The invention also relates to providing crystalline sodium salt of the carboxylic acid. The sodium salt is usable as a material for preparing medicaments and improved in storage stability, and has the following characteristics: DSC: exothermic peak observed at a temperature in the range of 170 to 175° C. with weight decrease; and characteristic absorption bands of infrared absorption spectrum (KBr tablet) 3255, 2950, 2860, 1670, 1630, 1550, 1460, 1435, 1395, 1365, 1310, 1260, 1110, 890 cm?1.
    Type: Application
    Filed: August 21, 2009
    Publication date: December 17, 2009
    Applicant: NIPPON CHEMIPHAR CO., LTD.
    Inventors: Atsushi TENDO, Toshihiro TAKAHASHI, Tomio YAMAKAWA, Kazuki OKAI, Susumu NIHASHI
  • Salt of (2S, 3S) -3- [[(1S) -1- isobutoxymethyl-3-methylbutyl] carbamoly] oxirane-2-carboxylic acid
    Patent number: 7585988
    Abstract: The invention relates to purification of (2S,3S)-3-[[(1S)-1-isobutoxymethyl-3-methylbutyl]carbamoyl]oxirane-2-carboxylic acid [hereinafter, referred to as the carboxylic acid] using the salt of the carboxylic acid with an organic amine selected from the group consisting of piperazine, adamantane amines and others. The invention also relates to providing crystalline sodium salt of the carboxylic acid. The sodium salt is usable as a material for preparing medicaments and improved in storage stability, and has the following characteristics: DSC: exothermic peak observed at a temperature in the range of 170 to 175° C. with weight decrease; and characteristic absorption bands of infrared absorption spectrum (KBr tablet): 3255, 2950, 2860, 1670, 1630, 1550, 1460, 1435, 1395, 1365, 1310, 1260, 1110, 890 cm?1.
    Type: Grant
    Filed: April 22, 2004
    Date of Patent: September 8, 2009
    Assignee: Nippon Chemiphar Co., Ltd.
    Inventors: Atsushi Tendo, Toshihiro Takahashi, Tomio Yamakawa, Kazuki Okai, Susumu Nihashi
  • Salt of (2s, 3s) -3- [ [ (is) -1- isobutoxymethyl-3-methylbutyl] carbamoly] oxirane-2-carboxylic acid
    Publication number: 20060252826
    Abstract: The invention relates to purification of (2S,3S)-3-[[(1S)-1-isobutoxymethyl-3-methylbutyl]carbamoyl]oxirane-2-carboxylic acid [hereinafter, referred to as the carboxylic acid] using the salt of the carboxylic acid with an organic amine selected from the group consisting of piperazine, adamantane amines and others. The invention also relates to providing crystalline sodium salt of the carboxylic acid. The sodium salt is usable as a material for preparing medicaments and improved in storage stability, and has the following characteristics: DSC: exothermic peak observed at a temperature in the range of 170 to 175° C. with weight decrease; and characteristic absorption bands of infrared absorption spectrum (KBr tablet): 3255, 2950, 2860, 1670, 1630, 1550, 1460, 1435, 1395, 1365, 1310, 1260, 1110, 890 cm?1.
    Type: Application
    Filed: April 22, 2004
    Publication date: November 9, 2006
    Applicant: NIPPON CHEMIPHAR CO., LTD.
    Inventors: Atsushi Tendo, Toshihiro Takahashi, Tomio Yamakawa, Kazuki Okai, Susumu Nihashi
  • N-Acrylcarnosine aluminum salts
    Patent number: 4339379
    Abstract: An N-acylcarnosine aluminum salt of the formula, ##STR1## wherein R represents a lower alkyl group having 1 to 6 carbon atoms is effective for use as an anti-ulcer agent.
    Type: Grant
    Filed: October 7, 1980
    Date of Patent: July 13, 1982
    Assignee: Nippon Chemiphar Co., Ltd.
    Inventors: Mitsuo Masaki, Toru Yamanaka, Mitsuko Yoshioka, Kazuki Okai