Patents by Inventor Kazumasa Yokoyama

Kazumasa Yokoyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4252827
    Abstract: 50-95 Parts by weight of a perfluorocarbon compound such as perfluorodecalin, perfluoromethyldecalin, perfluoro alkylcyclohexanes having 3 to 5 carbon atoms in the alkyl, perfluoro alkyltetrahydrofurans having 5 to 7 carbon atoms in the alkyl, perfluoro alkyltetrahydropyrans having 4 to 6 carbon atoms in the alkyl, perfluoroalkanes having 9 to 11 carbon atoms, and 50-5 parts by weight of a perfluoro tert.-amine such as perfluoro tert.-alkylamines having 9-11 carbon atoms, perfluoro N-alkylpiperidines having 4 to 6 carbon atoms in the alkyl, and perfluoro N-alkylmorpholines having 5 to 7 carbon atoms in the alkyl are emulsified in an aqueous medium by the aid of a high-molecular-weight nonionic surfactant have a molecular weight of about 2,000 to 20,000, and phospholipids as emulsifying agent, and fatty acids having 8 to 22 carbon atoms or salts or monoglycerides thereof as emulsifying adjuvant.The resulting oxygen-transferable emulsion having a particle size of 0.05 to 0.25.mu.
    Type: Grant
    Filed: May 23, 1979
    Date of Patent: February 24, 1981
    Assignee: The Green Cross Corporation
    Inventors: Kazumasa Yokoyama, Kouichi Yamanouchi, Ryoichiro Murashima, Yoshio Tsuda
  • Patent number: 4186253
    Abstract: An organ to be transplanted, such as kidney, can effectively be preserved by perfusion for a considerably long time by the use of a perfusate which is made by mixing a Ringer's solution modified by increasing potassium ion to 8-20 meq/l, a stable perfluorocarbon compound emulsion and albumin, so that the concentration of the perfluorocarbon compound is 7.5 to 12.5% (W/V) and that of albumin is 1-8% (W/V) based on the perfusate.
    Type: Grant
    Filed: October 10, 1978
    Date of Patent: January 29, 1980
    Assignee: The Green Cross Corporation
    Inventors: Kazumasa Yokoyama, Masakazu Iwai, Hiroyuki Okamoto, Noboru Yamada
  • Patent number: 4049683
    Abstract: A method for preparing a vegetable oil labelled with .sup.14 C or .sup.3 H, characterized by transesterifying a vegetable oil with at least one of the chemically same fatty acids labelled with .sup.14 C or .sup.3 H as those constituting said vegetable oil. The resulting labelled vegetable oil can be used in measuring biological metabolic activity of man or an animal or as a biological tracer reagent.
    Type: Grant
    Filed: June 3, 1975
    Date of Patent: September 20, 1977
    Assignee: The Green Cross Corporation
    Inventors: Hiroyuki Okamoto, Yoshio Tsuda, Kazumasa Yokoyama
  • Patent number: 3993581
    Abstract: Oxygen-transferable perfluorocarbon compounds having 9 to 11 carbon atoms such as perfluorodecalin, perfluoro(C.sub.3.sub.-5 -alkylcyclohexanes), perfluoro(C.sub.4.sub.-6 -alkyl tetrahydropyrans), perfluoro(C.sub.5.sub.-7 -alkyltetrahydrofurans), perfluoro(C.sub.5.sub.-7 -alkylmorpholins) and perfluoro(C.sub.9.sub.-11 -trialkylamines) are emulsified in a physiologically acceptable aqueous solution such as Ringer's solution by the aid of a phospholipid as emulsifier and a fatty acid of 8 to 22 carbon atoms, alkali metal salt or monoglyceride thereof as emulsifying adjuvant. The emulsion is stable for a considerable period of time and contains particles having a particle size ranging from 0.05 to 0.3 .mu.. It is usable as a blood substitute or a perfurate for preservation of the internal organs.
    Type: Grant
    Filed: July 2, 1974
    Date of Patent: November 23, 1976
    Assignee: The Green Cross Corporation
    Inventors: Kazumasa Yokoyama, Koichi Yamanouchi, Ryoichiro Murashima, Ryozo Watanabe
  • Patent number: 3962439
    Abstract: Oxygen-transferable perfluorocarbon compounds having 9 to 11 carbon atoms such as perfluorodecalin, perfluoro(C.sub.3-5 -alkylcyclohexanes), perfluoro(C.sub.4-6 -alkyl tetrahydropyrans), perfluoro(C.sub.5-7 -alkyltetrahydrofurans), perfluoro(C.sub.5-7 -alkylmorpholins) and perfluoro(C.sub.9-11 -trialkylamines) are emulsified in a physiologically acceptable aqueons solution such as Ringer's solution by the aid of a phospholipid as emulsifier and a fatty acid of 8 to 22 carbon atoms, alkali metal salt or monoglyceride thereof as emulsifying adjuvant. The emulsion is stable for a considerable period of time and contains particles having a particle size ranging from 0.05 to 0.3 .mu.. It is usable as a blood substitute or a perfusate for preservation of the internal organs.
    Type: Grant
    Filed: February 4, 1974
    Date of Patent: June 8, 1976
    Assignee: The Green Cross Corporation
    Inventors: Kazumasa Yokoyama, Koichi Yamanouchi, Ryoichiro Murashima, Ryozo Watanabe
  • Patent number: 3958014
    Abstract: An injectable fluorocarbon emulsion capable of carrying oxygen, which can be used as artificial blood and organ perfusate, is prepared by emulsifying a fluorocarbon, having an ability to dissolve at least 30 V/V % of oxygen under a 100% oxygen atmosphere at an atmospheric pressure, in an aqueous salt solution with a surfactant, centrifuging the resulting aqueous emulsion thereby to reduce the fluorocarbon particles in the emulsion in size to particle sizes of the order of about 0.05 to 0.25 .mu., and then sterilizing the thus obtained emulsion under rotation. The resulting fluorocarbon emulsion can be used as an emergency blood substitute for transfusion.
    Type: Grant
    Filed: March 20, 1973
    Date of Patent: May 18, 1976
    Assignees: The Green Cross Corporation, Tanabe Seiyaku Co., Ltd.
    Inventors: Ryozo Watanabe, Tadakazu Suyama, Kazumasa Yokoyama, Yohei Odaka