Patents by Inventor Kazumi Nishijima

Kazumi Nishijima has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyridocarbazole derivatives having cgmp-pde inhibitory activity
    Patent number: 6197768
    Abstract: The invention relates to novel pyridocarbazole derivatives having highly selective action in inhibiting cyclic GMP-phosphodiesterase (hereinafter abbreviated as cGMP-PDE), processes for producing such derivatives, agents containing at least one of such derivatives as an active ingredient for preventing and/or treating pulmonary hypertension, ischemic heart diseases or diseases against which the cGMP-PDE inhibitory action is effective, and intermediates useful for the production of pyridocarbazole derivatives.
    Type: Grant
    Filed: September 10, 1999
    Date of Patent: March 6, 2001
    Assignee: Mochida Pharmaceutical Co., Ltd.
    Inventors: Masayuki Ohashi, Toshiyuki Shudo, Kazumi Nishijima, Tatsuto Notsu, Akira Kikuchi, Kazutoshi Yanagibashi, Hidemitsu Nishida
  • Pyridocarbazole derivatives having cGMP-PDE inhibitory activity
    Patent number: 6018046
    Abstract: The invention relates to novel pyridocarbazole derivatives having highly selective action in inhibiting cyclic GMP-phosphodiesterase (hereinafter abbreviated as cGMP-PDE), processes for producing such derivatives, agents containing at least one of such derivatives as an active ingredient for preventing and/or treating pulmonary hypertension, ischemic heart diseases or diseases against which the cGMP-PDE inhibitory action is effective, and intermediates useful for the production of pyridocarbazole derivatives.
    Type: Grant
    Filed: January 29, 1998
    Date of Patent: January 25, 2000
    Assignee: Mochida Pharmaceutical Co., Ltd.
    Inventors: Masayuki Ohashi, Toshiyuki Shudo, Kazumi Nishijima, Tatsuto Notso, Akira Kikuchi, Kazutoshi Yanagibashi, Hidemitsu Nishida
  • 4,5-dihydro-6H-imidazo[4,5,1-ij]quinolin-6-one-6-oxime-O-sulfonic acid derivatives useful for treating hypertension or edema
    Patent number: 5151431
    Abstract: The present invention relates to novel 4,5-dihydro-6H-imidazo[4,5,1-ij]quinolin-6-one-6-oxime-O-sulfonic acid compounds, processes for producing said compounds, intermediate compounds, i.e. novel 4,5-dihydro-6H-imidazo[4,5,1-ij]quinolin-6-one compounds and 4,5-dihydro-6H-imidazo[4,5,1-ij]quinolin-6-one-6-oxime compounds in the synthesis of said compounds, processes for producing said intermediate compounds, and pharmaceutical or veterinary compositions containing said compounds.The present invention is based on the selection of the substituents of 4,5-dihydro-6H-imidazo[4,5,1-ij]-quinolin-6-one-6-oxime-O-sulfonic acid compounds at 2-position, namely 2-(2-penten-3-yl)-, 2-cyclohexyl-, 2-naphthyl-, 2-thienyl-, etc.The compounds of the present invention containing these substituents have potent hypotensive, anti-oedematous and diuretic effects as well as an activity of removing ascites. The compounds of the present invention are extremely useful for treatment of diseases and disorders mentioned above.
    Type: Grant
    Filed: June 20, 1990
    Date of Patent: September 29, 1992
    Assignees: Mochida Pharmaceutical Co., Ltd., Hodogaya Chemical Co., Ltd.
    Inventors: Hitoshi Inaba, Kazumi Nishijima, Kazuo Kato, Ichiro Yamamoto, Ei Mochida, Kikuo Ohtomo