Patents by Inventor Kazumi Ogata
Kazumi Ogata has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8048911Abstract: A melanin eliminator preparation comprising a metal chelate compound represented by the following formula (I), wherein M denotes a metal, and R denotes hydroxyl, O-lower alkyl, an amine bonded at N, an amino acid bonded at N, or a peptide bonded at N, or a pharmacologically acceptable salt thereof.Type: GrantFiled: December 3, 2008Date of Patent: November 1, 2011Assignee: OGA Research, Inc.Inventor: Kazumi Ogata
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Publication number: 20100152288Abstract: Provided are novel ?-lipoic acid derivatives represented by the following formula (I), which have a tyrosinase inhibiting activity, a melanin production suppressing activity and an elastase inhibiting activity. (In the formula, M denotes a metal, and A denotes an amino acid which is bound via N.Type: ApplicationFiled: March 1, 2010Publication date: June 17, 2010Applicant: Senju Pharmaceutical Co. Ltd.Inventors: Kazumi OGATA, Takahiro Sakaue, Kazuhiko Ito
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Patent number: 7700080Abstract: A novel ?-lipoic acid derivative represented by the following formula (I). It has a tyrosinase inhibiting activity, melanin production inhibitory activity, and elastase inhibiting activity. (I) (In the formula, M represents a metal and A denotes an amino acid residue bonded through the nitrogen atom.).Type: GrantFiled: March 18, 2002Date of Patent: April 20, 2010Assignee: Senju Pharmaceutical Co., Ltd.Inventors: Kazumi Ogata, Takahiro Sakaue, Kazuhiko Ito
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Publication number: 20090093541Abstract: A melanin eliminator preparation comprising a metal chelate compound represented by the following formula (I), wherein M denotes a metal, and R denotes hydroxyl, O-lower alkyl, an amine bonded at N, an amino acid bonded at N, or a peptide bonded at N, or a pharmacologically acceptable salt thereof.Type: ApplicationFiled: December 3, 2008Publication date: April 9, 2009Applicant: OGA RESEARCH, INCInventor: Kazumi OGATA
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Publication number: 20060122100Abstract: A melanin eliminator preparation comprising a metal chelate compound represented by the following formula (I), wherein M denotes a metal, and R denotes hydroxyl, O-lower alkyl, an amine bonded at N, an amino acid bonded at N, or a peptide bonded at N, or a pharmacologically acceptable salt thereof.Type: ApplicationFiled: September 11, 2003Publication date: June 8, 2006Applicant: OGA Research, IncorporatedInventor: Kazumi Ogata
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Patent number: 6828348Abstract: L-Ascorbic acid-2-O-maleic acid-&agr;-tocopherol diester.1-propanol adduct or its pharmacologically acceptable salt; cosmetic components, antioxidants, radical scavengers, anti-inflammatory agents and elastase inhibitors containing the same as the active ingredient; and a process for producing the above-described adduct characterized by comprising extracting a solution containing L-ascorbic acid-2-O-maleic acid-&agr;-tocopherol diester with a solvent, distilling off the solvent, and adding to the residue 1-propanol mixed with an organic solvent followed by crystallization.Type: GrantFiled: November 25, 2003Date of Patent: December 7, 2004Assignee: Senju Pharmaceutical Co., Ltd.Inventors: Kazumi Ogata, Noriko Saito, Kazuhiko Yamada, Genta Maruyama
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Publication number: 20040171676Abstract: L-Ascorbic acid-2-O-maleic acid-&agr;-tocopherol diester.1-propanol adduct or its pharmacologically acceptable salt; cosmetic components, antioxidants, radical scavengers, anti-inflammatory agents and elastase inhibitors containing the same as the active ingredient; and a process for producing the above-described adduct characterized by comprising extracting a solution containing L-ascorbic acid-2-O-maleic acid-&agr;-tocopherol diester with a solvent, distilling off the solvent, and adding to the residue 1-propanol mixed with an organic solvent followed by crystallization.Type: ApplicationFiled: November 25, 2003Publication date: September 2, 2004Inventors: Kazumi Ogata, Noriko Saito, Kazuhiko Yamada, Genta Maruyama
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Publication number: 20040092586Abstract: A novel a-lipoic acid derivative represented by the following formula (I). It has tyrosinase inhibitory activity, melanin production inhibitory activity, and elastase inhibitory activity. (I) (In the formula, M represents a metal and A represents an amino acid residue bonded through the nitrogen atom.).Type: ApplicationFiled: September 17, 2003Publication date: May 13, 2004Inventors: Kazumi Ogata, Takahiro Sakaue, Kazuhiko Ito
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Publication number: 20030125572Abstract: According to the present invention, there are provided diester compounds of maleic acid (or fumaric acid) or their pharmacologically acceptable salts represented by the formula: 1Type: ApplicationFiled: November 21, 2002Publication date: July 3, 2003Applicant: SENJU PHARMACEUTICAL CO., LTD.Inventors: Kazumi Ogata, Noriko Saito, Shinya Ogino
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Patent number: 6387882Abstract: The present invention provides novel vitamin E derivatives represented by the following formula (I) wherein: R1 and R2 are the same or different and each denotes hydrogen or methyl, R3 denotes an S-linked SH compound (glutathione, &ggr;-glutamylcysteine, cysteine, penicillamine, an ester thereof or cysteamine), and R4 denotes hydroxyl, a N-substituted amino acid (glycine, &bgr;-alanine, &ggr;-aminobutyric acid, 5-aminovaleric acid, &egr;-aminocaproic acid, anthranilic acid, tranexamic acid, proline, an ester thereof, aminoethylsulfonic acid , aminoethylsulfinic acid) or serotonin, or a pharmacologically acceptable salt thereof, which are useful as hepatopathy suppressing agents, anticataract agents, cerebral metabolism improving agents, antioxidants and cosmetic components.Type: GrantFiled: June 15, 2000Date of Patent: May 14, 2002Assignee: Senju Pharmaceutical Co., Ltd.Inventors: Kazumi Ogata, Hidetoshi Nakao, Kazuhiko Ito, Takahiro Sakaue, Masahito Iemura, Yutaka Inoue
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Patent number: 6358515Abstract: A hydroquinone compound is represented by the following formula or a pharmacologically acceptable salt thereof with W, R, R1-4, and B1-2 defined herein.Type: GrantFiled: July 30, 1999Date of Patent: March 19, 2002Assignee: Senju Pharmaceutical Co., Ltd.Inventors: Kazumi Ogata, Hidetoshi Nakao, Kazuhiko Ito, Takahiro Sakaue, Sachiko Inoue, Masahito Iemura
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Patent number: 6310067Abstract: Urocanic acid derivatives useful as antiallergic agents represented by the following formula (I) or a pharmacologically acceptable salt thereof: wherein R2 denotes hydrogen or lower alkyl, R3 denotes nitro, amino, cyano or COOR2, wherein R2 in said COOR2 is as defined above, and Q denotes carbon or nitrogen.Type: GrantFiled: August 3, 2000Date of Patent: October 30, 2001Assignee: Senju Pharmaceutical Co., Ltd.Inventors: Kazumi Ogata, Kazuhiko Ito, Takahiro Sakaue, Sachiko Inoue, Shinya Ogino
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Patent number: 6277834Abstract: A medicament for reducing side effects of adrenocortical hormones comprising a phosphodiester compound of the following formula or a pharmacologically acceptable salt thereof wherein R1 and R2 are the same or different and each denotes hydrogen or methyl.Type: GrantFiled: December 11, 2000Date of Patent: August 21, 2001Assignee: Senju Pharmaceutical Co. Ltd.Inventors: Kazumi Ogata, Takahiro Sakaue, Masahito Iemura
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Publication number: 20010008893Abstract: A hydroquinone derivative useful as an intraocular pressure lowering, anti-hypertensive and radical scavenging agent represented by the following formula 1Type: ApplicationFiled: July 30, 1999Publication date: July 19, 2001Inventors: KAZUMI OGATA, HIDETOSHI NAKAO, KAZUHIKO ITO, TAKAHIRO SAKAUE, SACHIKO INOUE, MASAHITO IEMURA
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Patent number: 5981530Abstract: The present invention provides a piperazine derivative of the following formula or a pharmacologically acceptable salt thereof ##STR1## wherein R.sub.1 represents a benzene ring, naphthalene ring, quinoline ring, indole ring or chroman ring that may be substituted by lower alkyl, lower alkoxy and/or hydroxy; R.sub.2 and R.sub.3 independently represent hydrogen or lower alkyl.The compound of the present invention has potent antiallergic activity and can therefore be used with advantage in the treatment of various allergic diseases.Type: GrantFiled: March 26, 1996Date of Patent: November 9, 1999Assignee: Senju Pharmaceutical Co., Ltd.Inventors: Kazumi Ogata, Takahiro Sakaue, Kazuhiko Ito, Hidetoshi Nakao
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Patent number: 5807845Abstract: The present invention provides a pharmaceutical composition for the therapy of acne vulgaris which comprises a phosphoric diester compound of the following formula or a pharmacologically acceptable salt thereof ##STR1## wherein R.sub.1 and R.sub.2 may be the same or different and each represents hydrogen or methyl.Type: GrantFiled: July 29, 1997Date of Patent: September 15, 1998Assignee: Senju Pharmaceutical Co., Ltd.Inventors: Kazumi Ogata, Takahiro Sakaue, Sachiko Matsuura, Masahito Iemura
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Patent number: 5789409Abstract: This invention provides a benzylpiperazine derivative of formula (I) and a pharmacologically acceptable salt thereof ##STR1## wherein R.sub.1 represents a pyridine ring or a group of either formula (IV) or formula (V); R.sub.2 represents hydrogen or lower alkyl ##STR2## wherein R.sub.3 represents hydrogen, lower alkyl, a pyridine ring or a benzene ring which may be substituted by halogen; X represents halogen ##STR3## wherein R.sub.4 and R.sub.5 may be the same or different and each represents hydrogen, lower alkyl, lower alkoxy, halogen or carboxy.Type: GrantFiled: July 9, 1996Date of Patent: August 4, 1998Assignee: Senju Pharmaceutical Co., Ltd.Inventors: Kazumi Ogata, Kazuhiko Ito, Takahiro Sakaue, Shinya Ogino
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Patent number: 5776922Abstract: 1. A corticoid derivative of the general formula ##STR1## wherein R represents hydrogen, hydroxy, methyl or methylene; inclusive of the acylation product thereof where the 17-position of the steroid skeleton is hydroxy and the ketone form thereof where R is hydroxy, or a physiologically acceptable salt thereof.Since the corticosteroid derivative of this invention is readily soluble in water and has antiallergic, antiinflammatory and antioxidant activities, it can be used with advantage in the prevention and therapy of various allergic diseases, inflammatory diseases, cataract and various ischemic organ diseases.Type: GrantFiled: July 29, 1996Date of Patent: July 7, 1998Assignee: Senju Pharmaceutical Co., Ltd.Inventors: Kazumi Ogata, Hideki Tsuruoka, Takahiro Sakaue, Hidetoshi Nakao
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Patent number: 5773652Abstract: An improved method for isolating and purifying a glutathione derivative is disclosed. More particularly, the invention provides a method for isolating and purifying S-(1, 2-dicarboxyethyl)glutathione or its pharmacologically acceptable salt from a reaction mixture available upon reacting glutathione or its salt with either fumaric acid or its salt or maleic acid or its salt, which comprises a first step of converting the S-(1, 2-dicarboxyethyl)glutathione or salt thereof in the reaction mixture to the corresponding copper salt, dissolving the copper salt in an aqueous solution of acetic acid, formic acid or propionic acid, and removing the contaminant glutathione, oxidized glutathione and fumaric acid copper salts with the aid of activated carbon and a second step of dissolving or suspending the isolated S-(1,2-dicarboxyethyl)glutathione copper salt in water and blowing hydrogen sulfide gas through the resulting aqueous solution or suspension to remove copper.Type: GrantFiled: September 3, 1997Date of Patent: June 30, 1998Assignee: Senju Pharmaceutical Co., Ltd.Inventors: Kazumi Ogata, Hideki Tsuruoka
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Patent number: 5753658Abstract: Presented is a novel quinolonecarboxylic acid derivative of the formula I and its pharmaceutically acceptable salt: ##STR1## wherein R.sub.1 is hydrogen, halogen or lower alkoxy, R.sub.2 is hydrogen, lower alkyl, lower alkoxy, --NH.sub.2, --NHCOCH.sub.3 or halogen,R.sub.3 is lower alkyl, and z is a group represented by the formula II or III: ##STR2## wherein R.sub.4 and R.sub.5 are identical or different and are hydrogen or lower alkyl. A method of preparation of these compound and a method of treatment of diseases caused by bacterial infection are also presented.Type: GrantFiled: February 8, 1994Date of Patent: May 19, 1998Assignee: Senju Pharmaceutical Co., Ltd.Inventors: Kazumi Ogata, Yuuichi Isowaki, Hidetoshi Nakao, Shuuichi Nishihata