Abstract: The invention enables more efficient CTL induction by applying a transdermal preparation containing a WT1 protein-derived cancer antigen peptide and an ether-type additive, which is liquid at 20° C., to a WT1 protein-derived cancer antigen peptide. The ether-type additive is represented by the formula (1): R1—O—R2 (1), wherein R1 is a hydrocarbon group having 8-24 carbon atoms, and R2 is a group represented by the formula (2): or a group represented by the formula (3): —(CH2CH2O)mH (3), wherein m is an integer of 1-18.

Abstract: A gear shift control system controls an actuator so that a pushing force will be a constant gearing-phase pushing force, during a gearing phase. The gear shift control system performs control on the basis of the number of rotation of the engine in the gearing phase, which is measured at the start of the gearing phase, so that the constant gearing-phase pushing force will increase as a number of rotation of the engine in the gearing phase increases. Thus, the hitting sound due to collision between the sleeve and the shift gear in shifting gears is reduced.

Abstract: A shifting operation detecting apparatus includes a gearbox and a shift change apparatus. The shift change apparatus includes a shifting operation unit, a shifting operation receiving section, a swing lever and a connecting member. A shift operation detector is disposed between the swing lever in an outer shaft section of the shifting operation receiving section and a gearbox case to directly detect a pivoted state of the shifting operation receiving section, and the connecting member is connected to the swing lever from the gearbox case side.

Abstract: A gear shift control system controls an actuator so that a pushing force will be a constant gearing-phase pushing force, during a gearing phase. The gear shift control system performs control on the basis of the number of rotation of the engine in the gearing phase, which is measured at the start of the gearing phase, so that the constant gearing-phase pushing force will increase as a number of rotation of the engine in the gearing phase increases. Thus, the hitting sound due to collision between the sleeve and the shift gear in shifting gears is reduced.

Abstract: A shifting operation detecting apparatus includes a gearbox and a shift change apparatus. The shift change apparatus includes a shifting operation unit, a shifting operation receiving section, a swing lever and a connecting member. A shift operation detector is disposed between the swing lever in an outer shaft section of the shifting operation receiving section and a gearbox case to directly detect a pivoted state of the shifting operation receiving section, and the connecting member is connected to the swing lever from the gearbox case side.

Abstract: The invention enables more efficient CTL induction by applying a transdermal preparation containing a WT1 protein-derived cancer antigen peptide and an ether-type additive, which is liquid at 20° C., to a WT1 protein-derived cancer antigen peptide. The ether-type additive is represented by the formula (1): R1—O—R2 (1), wherein R1 is a hydrocarbon group having 8-24 carbon atoms, and R2 is a group represented by the formula (2): or a group represented by the formula (3): —(CH2CH2O)mH (3), wherein m is an integer of 1-18.

Abstract: A patch preparation containing a support and an adhesive layer formed on one surface of the support, wherein the adhesive layer contains 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine or a physiologically acceptable acid addition salt thereof, an acrylic polymer, lactic acid, sesame oil and one or more kinds of stabilizers selected from 2-mercaptobenzimidazole, 2,6-di-tert-butyl-4-methylphenol and propyl gallate. A patch preparation containing a support and an adhesive layer containing lactic acid and magnesium aluminometasilicate and formed on at least one surface of the support, which preparation is superior in both skin permeability and adhesiveness in the presence of water.

Abstract: The present invention relates to an external preparation for transdermal administration, which remarkably enhances the skin permeability of 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine (compound A). The adhesive preparation of the present invention has an adhesive layer formed on one surface of a support, and the adhesive layer contains (i) compound A or a physiologically acceptable acid addition salt thereof, (ii) an adhesive, (iii) lactic acid, and (iv) an additive containing a particular permeation enhancer, whereby remarkably superior skin permeability is provided.

Abstract: In a multiple disc clutch apparatus 10, a cam member 41 which is disposed on a side of a clutch inner member 16 is formed into an annular shape. The cam member 41 extends in a radial direction so that an outer circumferential surface of the cam member 41 is brought into abutment with a cylindrical face 19d on an inner circumferential surface of a clutch center member 19.

Abstract: A multi-plate clutch system includes an outer clutch member having a plurality of first clutch plates thereon, a central spool having a plurality of second clutch plates thereon interspaced with the first clutch plates. The clutch system also includes a cam mechanism including a protruding cam and a recessed cam. The protruding cam and the recessed cam respectively include first inclined faces and second inclined faces, which are inclined in the same direction with respect to the circumferential direction. The protruding cam is thus brought into a point contact with the recessed cam during clutch engagement. As such, the multi-plate clutch system can maintain constant variable characteristics of the clutch capacity even when there is a variation in processing accuracy at the time of the production.

Abstract: In a multiple disc clutch apparatus 10, a cam member 41 which is disposed on a side of a clutch inner member 16 is formed into an annular shape. The cam member 41 extends in a radial direction so that an outer circumferential surface of the cam member 41 is brought into abutment with a cylindrical face 19d on an inner circumferential surface of a clutch center member 19.

Abstract: A dog clutch includes a first engagement face and a second engagement face provided on a surface of a driving rotor and a driven rotor with the two surfaces being opposite each other. The first engagement face engaging with its counterpart when a driving force of the driving members is generated. The second engagement face engaging with its counterpart when the driving member receives the driving force from the driven member. The strength of the engagement portion is balanced reflecting the operational torque changing as a power transmission direction changes. A projection drawing to a plane perpendicular to a rotational axis of a driving rotor and of a driven rotor, the inward extension line of the first engagement face passes through a position offset from the position representing the rotational axis, and the inward extension line of the second engagement face passes through the position representing the rotational axis.

Abstract: A clutch for effectively prevents a clutch outer from tilting at the time when torque is varied. The clutch includes damper springs for transmitting, to a clutch outer, torque inputted to a driven gear, and a thrust washer for regulating positional change of a position of the clutch outer with respect to the driven gear in a direction of the shaft axis. The thrust washer is disposed between the driven gear and the clutch outer in an axial direction. The thrust washer is disposed only outward of the damper springs in a radial direction.

Abstract: A multi-plate clutch system includes an outer clutch member having a plurality of first clutch plates thereon, a central spool having a plurality of second clutch plates thereon interspaced with the first clutch plates. The clutch system also includes a cam mechanism including a protruding cam and a recessed cam. The protruding cam and the recessed cam respectively include first inclined faces and second inclined faces, which are inclined in the same direction with respect to the circumferential direction. The protruding cam is thus brought into a point contact with the recessed cam during clutch engagement. As such, the multi-plate clutch system can maintain constant variable characteristics of the clutch capacity even when there is a variation in processing accuracy at the time of the production.

Abstract: A dog clutch includes a first engagement face and a second engagement face provided on a surface of a driving rotor and a driven rotor with the two surfaces being opposite each other. The first engagement face engaging with its counterpart when a driving force of the driving members is generated. The second engagement face engaging with its counterpart when the driving member receives the driving force from the driven member. The strength of the engagement portion is balanced reflecting the operational torque changing as a power transmission direction changes. A projection drawing to a plane perpendicular to a rotational axis of a driving rotor and of a driven rotor, the inward extension line of the first engagement face passes through a position offset from the position representing the rotational axis, and the inward extension line of the second engagement face passes through the position representing the rotational axis.

Abstract: A clutch for effectively prevents a clutch outer from tilting at the time when torque is varied. The clutch includes damper springs for transmitting, to a clutch outer, torque inputted to a driven gear, and a thrust washer for regulating positional change of a position of the clutch outer with respect to the driven gear in a direction of the shaft axis. The thrust washer is disposed between the driven gear and the clutch outer in an axial direction. The thrust washer is disposed only outward of the damper springs in a radial direction.

Abstract: To provide a starter for an internal combustion engine which is capable of reducing a press-fit amount of a press-fit portion of a torque absorbing mechanism of a rotation transmitting means for transmitting the rotation of a kick shaft to a crank shaft, thereby enhancing the durability of the starter and making the starter compact. A kick-type starter for an internal combustion engine includes a rotation transmitting mechanism (a kick drive gear, a boss having a ratchet portion, a pinion gear, and an idler gear) for transmitting the rotation of a kick shaft to a crank shaft. The rotation transmitting mechanism is provided with a torque absorbing mechanism for absorbing an excessive torque due to an excessive input from the kick shaft. The torque absorbing mechanism is provided on the kick shaft, and includes a gear set composed of the boss having the ratchet and the pinion gear which are press-fitted to each other.