Patents by Inventor Kazunao Masubuchi

Kazunao Masubuchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1,4-diazocane compound or salt thereof
    Patent number: 12286417
    Abstract: A method may produce an isoquinoline-6-sulfonamide derivative useful as a medicinal drug; and an intermediate which is used for the method, and more specifically, a 1,4-diazocane compound of formula (8), wherein R4 is an amino protecting group, or a salt thereof.
    Type: Grant
    Filed: November 1, 2019
    Date of Patent: April 29, 2025
    Assignee: D. WESTERN THERAPEUTICS INSTITUTE, INC.
    Inventors: Kengo Sumi, Tomoyuki Koide, Osamu Kimata, Yuji Takashima, Kazunao Masubuchi
  • 1,4-DIAZOCANE COMPOUND OR SALT THEREOF
    Publication number: 20210371396
    Abstract: A method may produce an isoquinoline-6-sulfonamide derivative useful as a medicinal drug; and an intermediate which is used for the method, and more specifically, a 1,4-diazocane compound of formula (8), wherein R4 is an amino protecting group, or a salt thereof.
    Type: Application
    Filed: November 1, 2019
    Publication date: December 2, 2021
    Applicant: D. WESTERN THERAPEUTICS INSTITUTE, INC.
    Inventors: Kengo SUMI, Tomoyuki KOIDE, Osamu KIMATA, Yuji TAKASHIMA, Kazunao MASUBUCHI
  • PEG-MODIFIED HYDROXYAPATITE, PHARMACEUTICAL USING THE SAME AS BASE MATERIAL AND PRODUCTION PROCESS THEREOF
    Publication number: 20090324725
    Abstract: The present invention provides a PEG-modified HAP having a high degree of safety and novel functions by modifying the surface of hydroxyapatite particles with a polyethylene glycol derivative, applications thereof, and a production process of the same. The PEG-modified HAP of the present invention is a substance in which hydroxyapatite having a particle diameter of 50 ?m to 10 nm is bonded to a polyethylene glycol derivative having a carboxyl group as a terminal functional group through —O(CO) bonds, and the carbon content thereof is 10 to 0.1%. In addition, the present invention is a substance composed of this substance and a pharmaceutical active ingredient or pharmaceutical additive, in which the weight ratio of the pharmaceutical active ingredient is 1 to 30%, and the substance is obtained by treating hydroxyapatite having a particle diameter of 50 ?m to 10 nm and an active ester of polyethylene glycol derivative having a carboxyl group as a terminal functional group in an anhydrous organic solvent.
    Type: Application
    Filed: January 23, 2009
    Publication date: December 31, 2009
    Applicant: EBARA CORPORATION
    Inventors: Kazunao MASUBUCHI, Junichi Minowa, Kazuo Watanabe, Isao Umeda
  • Aerothricin derivatives
    Patent number: 6849709
    Abstract: The present invention relates to novel Aerothricins represented by the Formula (I), and pharmaceutically acceptable salts thereof. The present invention also relates to a pharmaceutical composition comprising an Aerothricin of the Formula (I) and a pharmaceutically acceptable carrier. Furthermore, the present invention relates to the use of such Aerothricins for the preparation of medicaments, as well as to processes for the preparation of the Aerothricins of the Formula (I).
    Type: Grant
    Filed: January 16, 2001
    Date of Patent: February 1, 2005
    Assignee: Basilea Pharmaceutica AG
    Inventors: Masami Kohchi, Kazunao Masubuchi, Takeshi Murata, Takehiro Okada, Nobuo Shimma
  • Cyclic compounds
    Patent number: 6489440
    Abstract: The present invention relates to novel Aerothricins represented by the Formula (I), wherein R1, R2, R3, R4, R5, X, Y, Z, and m are as defined in Claim 1; and pharmaceutically acceptable salts thereof. The present invention also relates to a pharmaceutical composition comprising an Aerothricin of the Formula (I) and a pharmaceutically acceptable carrier. Furthermore, the present invention relates to the use of such Aerothricins for the preparation of medicaments, as well as to processes and intermediates for the preparation of the Aerothricins of the Formula (I).
    Type: Grant
    Filed: July 23, 1999
    Date of Patent: December 3, 2002
    Assignee: Basilea Pharmaceutica AG
    Inventors: Masahiro Aoki, Masami Kohchi, Kazunao Masubuchi, Eisaku Mizuguchi, Takeshi Murata, Hiroaki Ohkuma, Takehiro Okada, Masahiro Sakaitani, Nobuo Shimma, Takahide Watanabe, Mieko Yanagisawa, Yuri Yasuda
  • Aerothricin derivatives
    Publication number: 20010031728
    Abstract: The present invention relates to novel Aerothricins represented by the Formula (I), 1
    Type: Application
    Filed: January 16, 2001
    Publication date: October 18, 2001
    Inventors: Masami Kohchi, Kazunao Masubuchi, Takeshi Murata, Takehiro Okada, Nobuo Shimma
  • Cyclohexane derivatives
    Patent number: 5719291
    Abstract: Compounds of the formula ##STR1## which have antifungal activity.
    Type: Grant
    Filed: May 3, 1995
    Date of Patent: February 17, 1998
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Yuhko Aoki, Hiromichi Kotaki, Kazunao Masubuchi, Toru Okuda, Nobuo Shimma, Takuo Tsukuda, Isao Umeda
  • Cyclohexane derivatives
    Patent number: 5449785
    Abstract: Compounds of the formula ##STR1## which have antifungal activity.
    Type: Grant
    Filed: July 10, 1992
    Date of Patent: September 12, 1995
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Yuhko Aoki, Hiromichi Kotaki, Kazunao Masubuchi, Toru Okuda, Nobuo Shimma, Takuo Tsukuda, Isao Umeda