Patents by Inventor Kazunori Kataoka

Kazunori Kataoka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CHARGE CONVERSIONAL TERNARY POLYPLEX
    Publication number: 20110060123
    Abstract: Disclosed is a polymer composite (polyplex) that contains nucleic acid, a cationic polymer, and an anionic polymer. The anionic polymer covers the surface of the composite comprising the cationic polymer and nucleic acid, has a negative charge at neutral pH, and can change so as to have a positive charge at mildly acidic pH.
    Type: Application
    Filed: April 30, 2009
    Publication date: March 10, 2011
    Inventors: Kazunori Kataoka, Yan Lee, Nobuhiro Nishiyama, Kanjiro Miyata, Makoto Oba, Shigehiro Hiki, Mai Sanjo, HyunJin Kim
  • COPOLYMER INCLUDING UNCHARGED HYDROPHILIC BLOCK AND CATIONIC POLYAMINO ACID BLOCK HAVING HYDROPHOBIC GROUP IN PART OF SIDE CHAINS, AND USE THEREOF
    Publication number: 20110052917
    Abstract: The present invention relates to a block copolymer containing an uncharged hydrophilic polymer chain block and a cationic polyamino acid chain block, wherein the hydrophilic polymer chain block is covalently bound to one end of the main chain of the polyamino acid chain block, and the hydrophobic group is covalently bound to the side chains of not less than 10% and not greater than 70% of amino acid repeating units in the polyamino acid chain block. This block copolymer forms a stable aggregate with siRNA, a small-molecule nucleic acid, under a physiological condition.
    Type: Application
    Filed: March 6, 2009
    Publication date: March 3, 2011
    Inventors: Kazunori Kataoka, Nobuhiro Nishiyama, Atsushi Ishii, Yasuki Kato, Kanjiro Miyata, Hyunjin Kim, Hiroyasu Takemoto
  • Composition containing fine particles for supporting biologically active substance thereon or having the same supported thereon and method for preparing these
    Patent number: 7897176
    Abstract: Provided are a dispersion comprising organic-inorganic hybrid type particles carried thereon with a biologically active substance, wherein the above particles can be obtained by allowing a block copolymer represented by Formula (I): PEG-block-poly(carbo)??(I) (wherein PEG represents a polyethylene glycol segment, and carbo represents a repetitive unit having a carboxylate ion on a side chain) and an aqueous medium system capable of forming hydroxyapatite to coexist with the biologically active substance, and a preparing method for the same.
    Type: Grant
    Filed: August 27, 2002
    Date of Patent: March 1, 2011
    Assignee: Toudai TLO, Ltd.
    Inventors: Kazunori Kataoka, Yoshinori Kakizawa
  • Polycationically charged polymer and the use of the same as a carrier for nucleic acid
    Patent number: 7829657
    Abstract: Disclosed is a composition for the delivery of nucleic acid to target cells or tissues, which comprises a polycationically charged polymer as a carrier of nucleic acid. The polycationically charged polymer is a polymer which may comprise a charged polymer segment having a main chain based on poly(amino acid), polysaccharide, polyester, polyether, polyurethane or vinyl polymer and having, as a side chain, a group of formula —NH—(CH2)a—(NH(CH2)2)e—NH2 (wherein a and e independently denote an integer of 1 to 5) which is connected to the main chain either directly or via a linker. The disclosed composition has low toxicity, and has a high efficiency in introducing nucleic acid into cells.
    Type: Grant
    Filed: February 8, 2006
    Date of Patent: November 9, 2010
    Assignee: The University of Tokyo
    Inventors: Kazunori Kataoka, Keiji Itaka, Nobuhiro Nishiyama, Shigeto Fukushima, Woo-Dong Jang, Kanjiro Miyata, Masataka Nakanishi, Shunsaku Asano, Naoki Kanayama
  • ORGANIC-INORGANIC HYBRID PARTICLES CONTAINING CONTRAST AGENT
    Publication number: 20100278737
    Abstract: This invention provides organic-inorganic hybrid particles containing as the essential components a block copolymer comprising an uncharged hydrophilic polymer chain segment and a polymer chain segment containing a repeated structural unit having a carboxylate ion group at its side chain; calcium ion (Ca2+), phosphate ion (PO43?) or carbonate ion (CO32?), or a mixture of these anions; and a contrast agent. The particles provide, in particular, carriers for stably delivering an MRI contrast agent to a target site.
    Type: Application
    Filed: September 4, 2007
    Publication date: November 4, 2010
    Inventors: Kazunori Kataoka, Michiaki Kumagai, Keisuke Aikawa
  • Method for producing polymerized coordination compounds of platinum complex
    Patent number: 7781607
    Abstract: There is provided a production method in which bis(nitrato)platinum complex, optionally in the concurrent presence of dihalo-platinum complex, and poly(ethylene glycol)-block-poly(glutamic acid) are used at specific ratios and reacted. Coordination compound of an anti-tumor platinum complex with a block copolymer having carboxyl groups on its side chains is efficiently produced.
    Type: Grant
    Filed: June 8, 2006
    Date of Patent: August 24, 2010
    Assignees: Nanocarrier Co., Ltd., The University of Tokyo
    Inventors: Katsutoshi Kobayashi, Shoko Nagasaki, Kazunori Kataoka, Chieko Tsuchiya
  • Polyethylene glycol/polycation block copolymers
    Patent number: 7780957
    Abstract: The invention provides block copolymers formed of poly(ethylene glycol) segments and poly(amino acid derivative) segments having side chains of at least one kind of specific amine residue. The invention also provides polyion complexes of such copolymers with polynucleotides and the like. These block copolymers are useful as carriers for in vivo delivery of active substances such as DNA.
    Type: Grant
    Filed: May 7, 2004
    Date of Patent: August 24, 2010
    Assignee: The University of Tokyo
    Inventors: Kazunori Kataoka, Naoki Kanayama, Keiji Itaka, Shigeto Fukushima, Atsushi Harada
  • Random copolymers of oxazoline
    Patent number: 7732561
    Abstract: The invention provides approximately monodispersible random copolymers obtained from monomeric mixtures of 2-ethyl-2-oxazoline with 2-isopropyl-2-oxazoline, production method thereof and 2-isopropyl-2-oxazoline homopolymer obtained by using special initiator. Such polymers exhibit temperature-responsiveness in an aqueous solution within a broad temperature range, and are useful materials in the technical fields of surface chemistry and biomaterials.
    Type: Grant
    Filed: August 30, 2006
    Date of Patent: June 8, 2010
    Assignee: Japan Science and Technology Agency
    Inventors: Kazunori Kataoka, Yuichi Yamasaki, Joon-Sik Park
  • Method of high-speed detection for biological analyte
    Patent number: 7732158
    Abstract: This invention provides a method to detect analyte which comprises preparing fine particles which have a chargeable group in their core and a hydrophilic polymer chain in their shell; obtaining an agglutinated matter by forming a biologically specific bond between a specific residue on the surface of fine particles and analyte, and by simultaneously forming a bond by the electrostatic interaction between impure protein and said particles; and subsequently cleaving only the latter bond by raising ionic intensity. Thus, this invention provides a method to detect analyte with rapidity and high sensitivity with use of agglutination reaction.
    Type: Grant
    Filed: September 6, 2004
    Date of Patent: June 8, 2010
    Assignee: Japan Science and Technology Agency
    Inventors: Yukio Nagasaki, Kazunori Kataoka, Takehiko Ishii, Tadahito Takahashi
  • Stimuli-responsive polymer utilizing keto-enol tautomerization and stimuli-responsive separating material and chemical-releasing capsule comprising the same
    Patent number: 7732550
    Abstract: A stimuli-responsive polymer derivative utilizing keto-enol tautomerization. Also disclosed are a simple process for producing an N-acyl(meth)acrylamide derivative which can be used as a monomer for the stimuli-responsive polymer, a process for the production of an intermediate thereof, and an intermediate thus produced.
    Type: Grant
    Filed: June 18, 2004
    Date of Patent: June 8, 2010
    Assignees: Agency of Industrial Science & Technology MITI, Chisso Corporation
    Inventors: Noriyuki Ohnishi, Kazumi Aoshima, Kazunori Kataoka, Katsuhiko Ueno
  • Polyethylene glycol/polycation block copolymers
    Publication number: 20100137512
    Abstract: The invention provides block copolymers formed of poly(ethylene glycol) segments and poly(amino acid derivative) segments having side chains of at least one kind of specific amine residue. The invention also provides polyion complexes of such copolymers with polynucleotides and the like. These block copolymers are useful as carriers for in vivo delivery of active substances such as DNA.
    Type: Application
    Filed: January 25, 2010
    Publication date: June 3, 2010
    Inventors: Kazunori Kataoka, Naoki Kanayama, Keiji Itaka, Shigeto Fukushima, Atsushi Harada
  • ENVIRONMENT-RESPONDING siRNA CARRIER USING DISULFIDE-CROSS-LINKED POLYMERIC MICELLE
    Publication number: 20100121043
    Abstract: Disclosed is a siRNA-encapsulating polymeric micelle complex (a polyion complex) having high monodispersibility and structural stability and excellent in the ability of transporting siRNA into a cell. Further disclosed are a nucleic acid delivery device, a nucleic acid delivery kit, a pharmaceutical composition, and a gene therapy agent, each of which uses the complex. The polyion complex is characterized by comprising: a block copolymer composed of a polyethylene glycol moiety and a polycation moiety having a thiol group as a side chain at the terminus; and siRNA.
    Type: Application
    Filed: November 22, 2007
    Publication date: May 13, 2010
    Inventors: Kazunori Kataoka, Nobuhiro Nishiyama, Satoru Matsumoto
  • CULTURED CELL CONSTRUCTION CONTAINING SPHEROIDS OF MESENCHYMAL STEM CELLS AND UTILIZATION THEREOF
    Publication number: 20100099190
    Abstract: Facing no ethical obstacle and easily to be isolated, multipotent concretely mesenchymal stem cells (MSCs) are one of the most powerful tools in reconstructive medicine. Here the inventors introduced 3D multicelluar spheroids culture construction based on photolithography and micropatterning techniques to improve multipotent differentiation efficiency of MSCs to adult cells. This invention, the 3D spheroid cultured construction for MSCs, leads to great improve of the differentiation efficiency. This invention relates to a cultured cell construct comprising a support; at least one island on the support; a hydrophilic and cytophobic substance applied on the surface of said support so as to encircle the island; and a spheroid which is derived from MSCs, said spheroid being in contact with the island.
    Type: Application
    Filed: October 21, 2008
    Publication date: April 22, 2010
    Applicant: Transparent Inc.
    Inventors: Wenjie WANG, Keiji Itaka, Shinsuke Ohba, Nobuhiro Nishiyama, Ung-il Chung, Yuichi Yamasaki, Kazunori Kataoka
  • Magnetic fine particles having lower critical solution temperature
    Patent number: 7695905
    Abstract: The present invention relates to magnetic fine particles having a lower critical solution temperature to which at least one substance selected from biotin and avidin is immobilized, and a method of converting a substance, a method of separating or concentrating a microorganism, a method of modifying a denatured protein, a method of detecting a nucleic acid, a separating agent, and a method of separating a biological substance using the same.
    Type: Grant
    Filed: August 20, 2001
    Date of Patent: April 13, 2010
    Assignees: National Institute of Advanced Industrial Science and Technology, Chisso Corporation
    Inventors: Hirotaka Furukawa, Noriyuki Ohnishi, Kazunori Kataoka, Katsuhiko Ueno
  • Cultured cell construct which contains spheroids of cultured animal cells and the use thereof
    Patent number: 7691369
    Abstract: Parenchymal cells are cultivated on cultivated endothelial cells or cultivated fibroblasts which have been separated by a surface of a specific hydrophilic polymer, and which have been patterned. A culture which contains thus formed patterned spheroids of cultivated parenchymal cells is thereby provided by this invention. This culture maintains a function which is specific to the parenchymal cells over a long period of time.
    Type: Grant
    Filed: September 8, 2008
    Date of Patent: April 6, 2010
    Assignee: Transparent Inc.
    Inventors: Kazunori Kataoka, Hidenori Otsuka, Teruo Okano, Yukio Nagasaki, Yasuhiro Horiike
  • Polymer micelle as monolayer or layer-laminated surface
    Patent number: 7674478
    Abstract: The present invention is directed to a coated biomedical device said micelle having a hydrophilic outer shell and a hydrophobic inner core, or a hydrophobic outer shell and a hydrophilic inner core said micelle comprised of a block copolymer having a HLB value ranging from about 1 to about 40. The medical device may have one coating thereon or multiple coatings. The present invention is also directed to the use of the micelle as a drug carrier.
    Type: Grant
    Filed: September 2, 2003
    Date of Patent: March 9, 2010
    Assignee: Johnson & Johnson Vision Care, Inc.
    Inventors: Kazunori Kataoka, Yukio Nagasaki, Kazunori Emoto, Michihiro Iijima
  • PEG-functional nucleic acid conjugate
    Patent number: 7642343
    Abstract: The invention provides a conjugate of functional oligonucleotide with poly(ethylene oxide), polyion complex of the conjugate with cationic polymer, and micelle thereof. The micelle improves stability of the oligonucleotide in animal cells and its specific bindability to target gene.
    Type: Grant
    Filed: April 14, 2005
    Date of Patent: January 5, 2010
    Assignee: Japan Science and Technology Agency
    Inventors: Yukio Nagasaki, Kazunori Kataoka, Shigeki Sasaki, Fumi Nagatsugi, Motoi Oishi
  • POLYMER MICELLE COMPLEX INCLUDING NUCLEIC ACID
    Publication number: 20090258416
    Abstract: It is an object of the present invention to provide a polyion complex used as a non-viral gene vector, which achieves sufficiently high gene expression efficiency to a target cell. The polyion complex of the present invention comprises a block copolymer formed by binding polyethylene glycol to polycation via a disulfide group and a nucleic acid.
    Type: Application
    Filed: September 4, 2006
    Publication date: October 15, 2009
    Applicant: The University of Tokyo
    Inventors: Kazunori Kataoka, Yuichi Yamasaki, Seiji Takae
  • COMPOSITIONS FOR DELIVERY OF THERAPEUTIC AGENTS
    Publication number: 20090232762
    Abstract: The invention provides a polyamide compounds and compositions, in addition to methods for their preparation and methods for their use. The invention also provides micelle compositions that include encapsulated therapeutic agents, for example, nucleic acids or prodrugs, and methods for their preparation. The invention further provides methods of delivering therapeutic agents to cells and methods of activating therapeutic prodrugs.
    Type: Application
    Filed: March 11, 2008
    Publication date: September 17, 2009
    Inventors: May Pang Xiong, Glen S. Kwon, Younsoo Bae, Kazunori Kataoka
  • Display device, method of production of the same, and projection type display device
    Patent number: 7588976
    Abstract: A display device able to raise a light resistance of pixel transistors without depending upon a light shielding structure and a method of production of same, wherein an average crystal grain size of a polycrystalline silicon film 111 forming an active layer of the pixel transistors is controlled to be relatively small so as to suppress a photo-leakage current. The smaller the crystal grain size, the larger the included crystal defects. Carriers excited by light irradiation are smoothly captured by a defect level, and an increase of a photo-leakage current is suppressed. On the other hand, the average crystal grain size of the polycrystalline silicon film 111 constituting the peripheral transistors is controlled so as to become relatively large. The larger the crystal grain size, the larger the mobility of the carriers, and the higher the drivability of the peripheral transistors.
    Type: Grant
    Filed: May 7, 2008
    Date of Patent: September 15, 2009
    Assignee: Sony Corporation
    Inventors: Shingo Makimura, Makoto Hashimoto, Yoshiro Okawa, Tomohiro Wada, Kazunori Kataoka