Abstract: The present application discloses an ophthalmic photographing device that enables easy detection of a pupil diameter. The present invention pertains to an ophthalmic photographing device that is provided with: an anterior ocular segment illumination means for illuminating an anterior ocular segment of an eye of a subject with invisible light; an imaging element that is sensitive to at least invisible light and that is for capturing an image of the eye of the subject; and a processing means for processing an image captured by the imaging element, wherein when an image of an index projected onto the anterior ocular segment fulfills a prescribed condition, the processing means starts detection of a pupil diameter of the eye of the subject using an image formed on the imaging element by means of light reflected from the anterior ocular segment that has been illuminated with the invisible light from the anterior ocular segment illumination means.

Abstract: The present invention provides a composition having a metabolism-improving action, which comprises a supernatant of brown adipocytes or a purified product thereof. The present invention also provides a method of preparing the supernatant without using a culture solution comprising a high concentration of glucose. The present invention also provides a method of producing brown adipocytes using pluripotent stem cells, which are useful for preparing the supernatant of brown adipocytes. The present invention has succeeded in obtaining a supernatant having a metabolism-improving action from brown adipocytes. It was also possible to obtain the supernatant without using a culture solution comprising a high concentration of glucose. The present invention has also succeeded in producing brown adipocytes from pluripotent stem cells using a feeder-free culture system without adding a cytokine cocktail or the like.

Abstract: Stimulus light is projected from a stimulus light source onto an ocular fundus of an eye under examination to locally stimulate the retina in order to perform a biological examination. During a biological examination, first background light is projected from an illumination light source via an objective lens, and second background light is projected from a light source from the periphery of the objective lens onto the ocular fundus. During alignment prior to a biological examination, the first background light is turned off and the second background light is projected onto the ocular fundus. During observation of the ocular fundus, the first background light projected onto the fundus is blocked, so that fundus observation or eye fixation is not disturbed by the background light. This enables accurate alignment to be carried out.

Abstract: An ophthalmologic examination apparatus has a main unit housing an illuminating optical system that illuminates a fundus of a subject's eye to be examined and an imaging optical system that images the illuminated eye fundus. First and second attachment units are removably and exchangeably mounted to the main unit for providing different ophthalmologic functions. The first attachment unit houses an imaging device that captures an image of the eye fundus via the imaging optical system housed in the main unit. The second attachment unit houses a light source that emits stimulating light for an electroretinogram and which is projected onto the eye fundus via the imaging optical system housed in the main unit.

Abstract: A stimulus light from a stimulus light source is projected to the retina of an ocular fundus under examination to stimulate the retina in localized fashion to generate a bioelectric signal from the retina. The stimulus light source is mounted on a movable block, and an operating lever is used to move the stimulus light source to change the stimulus light on the retina. The size of the stimulus light can also be varied using a panel having a plurality of openings with different diameters for allowing the stimulus light to pass through. This assures a reliable local ERG examination because the bioelectrical signal can be produced in a wider area of the retina. The operating lever is further fixed by inserting a cap to keep the projected stimulus light unchanged. This allows the burden on the examiner to be reduced remarkably, assuring a reliable local ERG examination.

Abstract: Stimulus light is projected from a stimulus light source onto an ocular fundus of an eye under examination to locally stimulate the retina in order to perform a biological examination. During a biological examination, first background light is projected from an illumination light source via an objective lens, and second background light is projected from a light source from the periphery of the objective lens onto the ocular fundus. During alignment prior to a biological examination, the first background light is turned off and the second background light is projected onto the ocular fundus. During observation of the ocular fundus, the first background light projected onto the fundus is blocked, so that fundus observation or eye fixation is not disturbed by the background light. This enables accurate alignment to be carried out.

Abstract: A stimulus light from a stimulus light source is projected to the retina of an ocular fundus under examination to stimulate the retina in localized fashion to generate a bioelectric signal from the retina. The stimulus light source is mounted on a movable block, and an operating lever is used to move the stimulus light source to change the stimulus light on the retina. The size of the stimulus light can also be varied using a panel having a plurality of openings with different diameters for allowing the stimulus light to pass through. This assures a reliable local ERG examination because the bioelectrical signal can be produced in a wider area of the retina. The operating lever is further fixed by inserting a cap to keep the projected stimulus light unchanged. This allows the burden on the examiner to be reduced remarkably, assuring a reliable local ERG examination.

Abstract: An ophthalmologic examination apparatus is provided which is capable of performing a variety of ophthalmologic examinations with a low-cost configuration. An illuminating optical system for illuminating an eye fundus and an imaging optical system for imaging the illuminated eye fundus, which are both necessary in an ophthalmologic examination, are housed in a main unit. A plurality of attachment units is removably mounted to the main unit. Each of the attachment units is provided with a different ophthalmologic function such as a function for planarly or stereographically observing or photographing the imaged eye fundus, a function for emitting stimulating light on the eye fundus or a function for spectroscopically analyzing the eye fundus. Such an arrangement allows the ophthalmologic examination apparatus to perform various functions merely by selecting the attachment unit and mounting it to the main unit.

Abstract: An ophthalmic photographic apparatus comprises a photographic mask for defining a fundus photography range, a photographic stop for eliminating light reflected from an anterior portion of the eye, and a focusing lens for bringing the fundus into focus. The photographic mask and the photographic stop are interlocked and move as one unit relative to the movement of the focusing lens in such a way that with respect to a photographic optical system, the photographic mask is maintained at a position substantially conjugate with an imaging plane of a CCD and the photographic stop is maintained at a position substantially conjugate with an anterior portion of the eye. The CCD is located at the image-side focal plane of the image-formation lens, the mask is located on the object-side focal plane of the focusing lens, and the photographic stop is located on the image-side focal plane of the focusing lens.

Abstract: An ophthalmic photographic apparatus is provided that is readily able to capture dynamic and still eye fundus images by infrared light-excited fluorescence. A CCD device that is sensitive to infrared light is used to capture images of the eye fundus as dynamic and still images. When the shutter button is pressed, infrared light-excited fluorescence images are obtained as still images and stored in a recording unit. The infrared light-excited fluorescence image of the eye fundus is captured as a still image with or without a flash from a strobe light source. Such an arrangement makes it possible to capture still images even when dynamic images are being recorded.

Abstract: A fundus photography apparatus is provided that enables optimal adjustment of exposure values according to the color characteristics of the anterior ocular segment of the subject eye. The fundus photography apparatus comprises means for photographing the anterior ocular segment of the eye, means for photographing the eye fundus, and means for detecting the spectral distribution of the iris of the eye based on images of the anterior ocular segment. The photographic exposure value is adjusted in preparation for fudus photography based on the detected spectral distribution of the iris.

Abstract: An ophthalmic photographic apparatus includes an illumination optical system for illuminating an eye fundus and a photographing optical system for photographing an image of the illuminated eye fundus. The ophthalmic photographic apparatus includes a first aperture stop, a second aperture stop having an outside diameter that is smaller than that of the first aperture stop, a third aperture stop that transmits more light than the first aperture stop, and means for selectively inserting the first to third aperture stops into the optical path of the illumination optical system. The ophthalmic photographic apparatus does not have a complicated structure, but can be readily used in the various photographing modes.

Abstract: A fundus photography apparatus is provided that enables optimal adjustment of exposure values according to the color characteristics of the anterior ocular segment of the subject eye. The fundus photography apparatus comprises means for photographing the anterior ocular segment of the eye, means for photographing the eye fundus, and means for detecting the spectral distribution of the iris of the eye based on images of the anterior ocular segment. The photographic exposure value is adjusted in preparation for fudus photography based on the detected spectral distribution of the iris.

Abstract: An ophthalmic photographic apparatus is provided that is readily able to capture dynamic and still eye fundus images by infrared light-excited fluorescence. A CCD device that is sensitive to infrared light is used to capture images of the eye fundus as dynamic and still images. When the shutter button is pressed, infrared light-excited fluorescence images are obtained as still images and stored in a recording unit. The infrared light-excited fluorescence image of the eye fundus is captured as a still image with or without a flash from a strobe light source. Such an arrangement makes it possible to capture still images even when dynamic images are being recorded.

Abstract: An ophthalmic photographic apparatus comprises a photographic mask for defining a fundus photography range, a photographic stop for eliminating light reflected from an anterior portion of the eye, and a focusing lens for bringing the fundus into focus. Interlocking means are provided to move the photographic mask and the photographic stop in an interlocked manner relative to the movement of the focusing lens in such a way that with respect to a photographic optical system the photographic mask may be kept at a position substantially conjugate with an imaging plane of a CCD and the photographic stop may be kept at a position substantially conjugate with an anterior portion of the eye. The CCD is located at the image-side focal plane of the image-formation lens, the mask is located on the object-side focal plane of the focusing lens, and the photographic stop is located on the image-side focal plane of the focusing lens.

Abstract: An ophthalmic photographic apparatus includes an illumination optical system for illuminating an eye fundus and a photographing optical system for photographing an image of the illuminated eye fundus. The ophthalmic photographic apparatus includes a first aperture stop, a second aperture stop having an outside diameter that is smaller than that of the first aperture stop, a third aperture stop that transmits more light than the first aperture stop, and means for selectively inserting the first to third aperture stops into the optical path of the illumination optical system. The ophthalmic photographic apparatus does not have a complicated structure, but can be readily used in the various photographing modes.