Patents by Inventor Kazuo Hirayama
Kazuo Hirayama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9658234Abstract: The present invention provides a method for the analysis of a compound with amino group (e.g., an amino acid or peptide) contained in a sample and convenient manner with a high sensitivity. The compound with amino group in a sample containing the compound with amino group is labeled with a specific carbamate compound such as p-trimethylammonium anilyl-N-hydroxysuccinimidyl carbamate iodide to enhance the selectivity and sensitivity. The present invention is preferably used in conjunction with mass spectrometry such as MS/MS method to facilitate quantitative analysis. The present invention further provides labeling reagents for mass spectrometry.Type: GrantFiled: January 21, 2016Date of Patent: May 23, 2017Assignee: AJINOMOTO CO., INC.Inventors: Hiroshi Miyano, Akihisa Yahashi, Kazutaka Shimbo, Masakazu Nakazawa, Kazuo Hirayama
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Publication number: 20160139134Abstract: The present invention provides a method for the analysis of a compound with amino group (e.g., an amino acid or peptide) contained in a sample and convenient manner with a high sensitivity. The compound with amino group in a sample containing the compound with amino group is labeled with a specific carbamate compound such as p-trimethylammonium anilyl-N-hydroxysuccinimidyl carbamate iodide to enhance the selectivity and sensitivity. The present invention is preferably used in conjunction with mass spectrometry such as MS/MS method to facilitate quantitative analysis. The present invention further provides labeling reagents for mass spectrometry.Type: ApplicationFiled: January 21, 2016Publication date: May 19, 2016Applicant: AJINOMOTO CO., INC.Inventors: Hiroshi MIYANO, Akihisa YAHASHI, Kazutaka SHIMBO, Masakazu NAKAZAWA, Kazuo HIRAYAMA
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Patent number: 9274123Abstract: The present invention provides a method for the analysis of a compound with amino group (e.g., an amino acid or peptide) contained in a sample and convenient manner with a high sensitivity. The compound with amino group in a sample containing the compound with amino group is labeled with a specific carbamate compound such as p-trimethylammonium anilyl-N-hydroxysuccinimidyl carbamate iodide to enhance the selectivity and sensitivity. The present invention is preferably used in conjunction with mass spectrometry such as MS/MS method to facilitate quantitative analysis. The present invention further provides labeling reagents for mass spectrometry.Type: GrantFiled: September 1, 2006Date of Patent: March 1, 2016Assignee: AJINOMOTO CO., INC.Inventors: Hiroshi Miyano, Akihisa Yahashi, Kazutaka Shimbo, Masakazu Nakazawa, Kazuo Hirayama
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Publication number: 20090319234Abstract: This invention fragments ions ionized by an electro-spray ionization method or the like for a target protein whose three-dimensional structure is to be predicted, to fragment ions by a hexapole CID method or the like, and measures a fragmentation spectrum. The present invention determines fragment ion assignment information on an amino acid sequence of the target protein based on the measured fragmentation spectrum. The present invention specifies a region of the amino acid sequence of the target protein in which region the ions are dissociated to the fragment ions according to the determined fragment ion assignment information, and determines easily cleavable domain information on the amino acid sequence of the target protein according to the specified region. The present invention predicts the three-dimensional structure of the target protein.Type: ApplicationFiled: October 26, 2004Publication date: December 24, 2009Inventors: Naoyuki Yamada, Eiichiro Suzuki, Kazuo Hirayama, Hideaki Umeyama
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Patent number: 7553650Abstract: The present invention relates to a method for designing and preparing mutant transglutaminases on the basis of the three-dimensional structure of MTG derived from Streptoverticillium mobaraense (MTG), and the mutant MTG thus prepared. The present invention provides a method for modifying MTG on the basis of the three-dimensional structure, and transglutaminase having reactivity on the substrate improved by the method. In the present invention, the binding site of MTG for the substrate is extrapolated based on the three-dimensional structure obtained by X-ray crystal structure analysis of MTG crystals, and the mutant transglutaminases are designed and produced by replacing, inserting or deleting amino acid residues positioned at the substrate-binding site of the transglutaminase.Type: GrantFiled: August 17, 2006Date of Patent: June 30, 2009Assignee: Ajinomoto Co., Inc.Inventors: Tatsuki Kashiwagi, Nobuhisa Shimba, Kohki Ishikawa, Ei-ichiro Suzuki, Keiichi Yokoyama, Kazuo Hirayama
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Publication number: 20060286673Abstract: The present invention provides a method for the analysis of a compound with amino group (e.g., an amino acid or peptide) contained in a sample and convenient manner with a high sensitivity. The compound with amino group in a sample containing the compound with amino group is labeled with a specific carbamate compound such as p-trimethylammonium anilyl-N-hydroxysuccinimidyl carbamate iodide to enhance the selectivity and sensitivity. The present invention is preferably used in conjunction with mass spectrometry such as MS/MS method to facilitate quantitative analysis. The present invention further provides labeling reagents for mass spectrometry.Type: ApplicationFiled: September 1, 2006Publication date: December 21, 2006Applicant: AJINOMOTO CO. INCInventors: Hiroshi Miyano, Akihisa Yahashi, Kazutaka Shimbo, Masakazu Nakazawa, Kazuo Hirayama
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Patent number: 7148069Abstract: The present invention provides a method for the analysis of a compound with amino group (e.g., an amino acid or peptide) contained in a sample and convenient manner with a high sensitivity. The compound with amino group in a sample containing the compound with amino group is labeled with a specific carbamate compound such as p-trimethylammonium anilyl-N-hydroxysuccinimidyl carbamate iodide to enhance the selectivity and sensitivity. The present invention is preferably used in conjunction with mass spectrometry such as MS/MS method to facilitate quantitative analysis. The present invention further provides labeling reagents for mass spectrometry.Type: GrantFiled: August 16, 2004Date of Patent: December 12, 2006Assignee: Ajinomoto Co., Inc.Inventors: Hiroshi Miyano, Akihisa Yahashi, Kazutaka Shimbo, Masakazu Nakazawa, Kazuo Hirayama
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Publication number: 20060275872Abstract: The present invention relates to a method for designing and preparing mutant transglutaminases on the basis of the three-dimensional structure of MTG derived from Streptoverticillium mobaraense (MTG), and the mutant MTG thus prepared. The present invention provides a method for modifying MTG on the basis of the three-dimensional structure, and transglutaminase having reactivity on the substrate improved by the method. In the present invention, the binding site of MTG for the substrate is extrapolated based on the three-dimensional structure obtained by X-ray crystal structure analysis of MTG crystals, and the mutant transglutaminases are designed and produced by replacing, inserting or deleting amino acid residues positioned at the substrate-binding site of the transglutaminase.Type: ApplicationFiled: August 17, 2006Publication date: December 7, 2006Applicant: Ajinomoto Co., Inc.Inventors: Tatsuki Kashiwagi, Nobuhisa Shimba, Kohki Ishikawa, Ei-ichiro Suzuki, Keiichi Yokoyama, Kazuo Hirayama
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Publication number: 20050079624Abstract: The present invention provides a method for the analysis of a compound with amino group (e.g., an amino acid or peptide) contained in a sample and convenient manner with a high sensitivity. The compound with amino group in a sample containing the compound with amino group is labeled with a specific carbamate compound such as p-trimethylammonium anilyl-N-hydroxysuccinimidyl carbamate iodide to enhance the selectivity and sensitivity. The present invention is preferably used in conjunction with mass spectrometry such as MS/MS method to facilitate quantitative analysis. The present invention further provides labeling reagents for mass spectrometry.Type: ApplicationFiled: August 16, 2004Publication date: April 14, 2005Applicant: AJINOMOTO CO., INCInventors: Hiroshi Miyano, Akihisa Yahashi, Kazutaka Shimbo, Masakazu Nakazawa, Kazuo Hirayama
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Patent number: 6854783Abstract: The combination of a multi-layer instrument panel having a skin layer with an exposed surface and an opening therethrough and a first accessory that is mounted in the opening. The first accessory has an exposed surface that is substantially flush with the exposed surface of the skin layer with the first accessory mounted in the opening and operatively connected to the multi-layer instrument panel. The invention is also directed to a method of manufacturing the instrument panel with the first accessory.Type: GrantFiled: February 28, 2001Date of Patent: February 15, 2005Assignee: Mitsubishi Belting Ltd.Inventors: Sadao Teranishi, Kazuo Hirayama, Satoru Nitta, Masaaki Kobashi, Mano Osamu, Junji Yokoyama
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Publication number: 20040002144Abstract: The present invention relates to a method for designing and preparing mutant transglutaminases on the basis of the three-dimensional structure of MTG derived from Streptoverticillium mobaraense (MTG), and the mutant MTG thus prepared. The present invention provides a method for modifying MTG on the basis of the three-dimensional structure, and transglutaminase having reactivity on the substrate improved by the method. In the present invention, the binding site of MTG for the substrate is extrapolated based on the three-dimensional structure obtained by X-ray crystal structure analysis of MTG crystals, and the mutant transglutaminases are designed and produced by replacing, inserting or deleting amino acid residues positioned at the substrate-binding site of the transglutaminase.Type: ApplicationFiled: February 13, 2003Publication date: January 1, 2004Applicant: AJINOMOTO CO. INCInventors: Tatsuki Kashiwagi, Nobuhisa Shimba, Kohki Ishikawa, Ei-Ichiro Suzuki, Keiichi Yokoyama, Kazuo Hirayama
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Publication number: 20010030070Abstract: The combination of a multi-layer instrument panel having a skin layer with an exposed surface and an opening therethrough and a first accessory that is mounted in the opening. The first accessory has an exposed surface that is substantially flush with the exposed surface of the skin layer with the first accessory mounted in the opening and operatively connected to the multi-layer instrument panel. The invention is also directed to a method of manufacturing the instrument panel with the first accessory.Type: ApplicationFiled: February 28, 2001Publication date: October 18, 2001Inventors: Sadao Teranishi, Kazuo Hirayama, Satoru Nitta, Masaaki Kobashi, Mano Osamu, Junji Yokoyama
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Patent number: 6077814Abstract: A 1-phenyl, naphthyl or aralkyl-4-(N,N-di-substituted carbamoyl)-1,2,4-triazol-5-one derivative represented by the general formula (I) ##STR1## wherein A is an unsubstituted or substituted phenyl group, 1-naphthyl group, 5,6,7,8-tetrahydro-1-naphthyl group or an aralkyl group such as an unsubstituted or substituted benzyl group and so on, R.sub.1 is a lower alkyl group and so on, and R.sub.2 is an unsubstituted or substituted phenyl group and so on, was prepared as novel compounds. This 1-substituted-4-carbamoyl-1,2,4-triazol-5-one derivative does not substantially exhibit phytotoxicity to various agricultural crop plants and therefore is useful as a selective herbicide.Type: GrantFiled: August 23, 1999Date of Patent: June 20, 2000Assignee: Hokko Chemical Industry Co., Ltd.Inventors: Ken Morita, Tsunehiro Kido, Kazuo Hirayama, Hiroyuki Okita, Toshiharu Ohno, Yoshihisa Watanabe, Masahide Onoe
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Patent number: 4560748Abstract: A streptothricin-group compound having the formula: ##STR1## in which R represents ##STR2## is disclosed along with methods for producing this compound and a microorganism useful in its production.Type: GrantFiled: June 3, 1983Date of Patent: December 24, 1985Assignee: Ajinomoto Company IncorporatedInventors: Shigezo Udaka, Shigeyoshi Miyashiro, Kazuo Hirayama, Toshihiko Ando, Asao Murai, Tsuyoshi Shiio, Takao Kida, Hiroshiro Shibai