Abstract: Since treatment effects of conventional external preparations were not satisfactory, it is aimed to provide a novel external preparation that is excellent in drug permeability to nail, capable of fully exhibiting effects of an antifungal drug, and effective for treatments of diseases such as nail mycosis and nail candidiasis, particularly, treatments for nail tinea. The external preparation of this invention is a pharmaceutical composition for nail characterized by containing an antifungal drug, alkylpyrrolidone or a derivative thereof, and a crosslinking hydrogel.

Abstract: Since treatment effects of conventional external preparations were not satisfactory, it is aimed to provide a novel external preparation that is excellent in drug permeability to nail, capable of fully exhibiting effects of an antifungal drug, and effective for treatments of diseases such as nail mycosis and nail candidiasis, particularly, treatments for nail tinea. The external preparation of this invention is a pharmaceutical composition for nail characterized by containing an antifungal drug, alkylpyrrolidone or a derivative thereof, and a crosslinking hydrogel.

Abstract: The present invention provides a method for effectively producing an optically active form of tetrasubstituted-5-azaspiro[2.4]heptane derivative, which serves as a useful production intermediate for quinolonecarboxylic acid antibacterial agents, and intermediates for the derivative. The present invention is directed to a method for producing a compound (VII) according to the following scheme.

Abstract: A 1,6-?-glucan synthetase inhibitor is provided, having potent growth inhibition and having excellent safety. A compound is provided, capable of expressing in a wide spectral range and specifically or selectively, an antifungal effect based on its functional mechanism of 1,6-?-glucan synthesis inhibition. Also provided is a drug, a salt or hydrate thereof, especially an antifungal that contains the compound.

Abstract: The present invention provides a method for effectively producing an optically active form of tetrasubstituted-5-azaspiro[2.4]heptane derivative, which serves as a useful production intermediate for quinolonecarboxylic acid antibacterial agents, and intermediates for the derivative. The present invention is directed to a method for producing a compound (VII) according to the following scheme.

Abstract: Since treatment effects of conventional external preparations were not satisfactory, it is aimed to provide a novel external preparation that is excellent in drug permeability to nail, capable of fully exhibiting effects of an antifungal drug, and effective for treatments of diseases such as nail mycosis and nail candidiasis, particularly, treatments for nail tinea. The external preparation of this invention is a pharmaceutical composition for nail characterized by containing an antifungal drug, alkylpyrrolidone or a derivative thereof, and a crosslinking hydrogel.

Abstract: A 1,6-?-glucan synthetase inhibitor is provided, having potent growth inhibition and having excellent safety. A compound is provided, capable of expressing in a wide spectral range and specifically or selectively, an antifungal effect based on its functional mechanism of 1,6-?-glucan synthesis inhibition. Also provided is a drug, especially an antifungal that contains the compound, its salt or their hydrate.

Abstract: A compound which can specifically or selectively expresses an antifungal activity with a broad spectrum, based on the functional mechanism of 1,6-?-glucan synthesis inhibition, is provided, and an antifungal agent which comprises such a compound, a salt thereof or a solvate thereof is provided. A compound represented by the following formula (I), a salt thereof or a solvate thereof.

Abstract: A compound reprsented by the following formula (I), its salts or nsolvates thereof capable of specifically or selectively expressig an antifungal activity in a broad spectrum based on the novel mechanism thereof of 1,6-?-glucan synthesis inhibition, and an antifungal agent containing any of them.

Abstract: A monitoring system includes a factory automation (FA) computer for receiving information from a manufacturing apparatus, an information collecting computer for receiving the information on a LAN from the FA computer and sending the received information to a facility operation monitoring host computer, and the facility operation monitoring host computer constructs a database based on the received information and displaying the information for a supervisor in accordance with the constructed database. The facility operation monitoring host computer includes databases, and displays information stored in the databases on a monitor, linking the information from the databases.

Abstract: A monitoring system includes a FA computer for receiving information from a manufacturing apparatus, an information collecting computer for receiving the information on a LAN from the FA computer and sending the received information to a facility operation monitoring host computer, and the facility operation monitoring host computer for constructing a database based on the received information and displaying the information for a supervisor in accordance with the constructed database. The facility operation monitoring host computer includes a plurality of databases constructed therein, and displays information stored in the plurality of databases on a monitor in a manner linking such information with each other.

Abstract: A handy terminal comprises reading unit, a vibration unit, an acoustic unit and a control unit, wherein an application software is installed into the control unit and the control unit is provided with means for controlling the vibration unit or means for controlling the acoustic unit available from the application software. The application software may be provided with a plurality of vibration patterns or a plurality of acoustic patterns and the control unit controls the vibration unit or the acoustic unit according to one of the plurality of vibration patterns or the plurality of acoustic patterns.

Abstract: R-(+)-(E)-?4-(2-Chlorophenyl)-1,3-dithiolan-2-ylidene!-1-imidazolylacetonit rile, R-(-)-(E)-?4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene!-1-imidazolylace tonitrile, and pharmaceutically acceptable salts thereof which can be used as a pharmaceutical agent are disclosed. A process for producing them and a method for treating mycoses using them are also disclosed.

Abstract: Pyridazinone derivatives of formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a methyl group which may be substituted with an aliphatic cyclic amino group optionally containing a hetero atom in the ring thereof; each of X.sup.1 and X.sup.2 independently represents a hydrogen atom, a halogen atom, an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, a cyano group, a nitro group or a group shown by --CO--NR.sup.2 R.sup.3 (wherein each of R.sup.2 and R.sup.3 independently represents an alkyl group having 1 to 6 carbon atoms); Y represents a halogen atom; Z represents an alkoxy group having 1 to 6 carbon atoms; l represents 0 or an integer of 1 to 3; A represents CH or N; m represents 0 or an integer of 1 or 2; and n represents an integer of 1 to 8, exhibit a platelet aggregation inhibiting activity and are useful for the treatment of circulatory disorders such as cerebral infarction.

Abstract: A composition for enhancing hair growth which comprises a compound represented by the following formula (I) as an active ingredient: ##STR1## wherein R.sup.1 represents an alkyl group having 1 to 8 carbon atoms, R.sup.2 represents an alkyl group having 1 to 10 carbon atoms, an alkenyl group having 2 to 6 carbon atoms or a cycloalkyl group having 3 to 8 carbon atoms and X represents --O-- or --NH-- and a carrier or diluent acceptable for topical composition.The composition for enhancing hair growth of the present invention has a hair growth enhancing activity and therefore is useful as a hair growth preparation.

Abstract: Topical compositions are disclosed that comprise a compound represented by formula (I) ##STR1## wherein R.sup.1, R.sup.2 and X are as defined in the specification as an effective ingredient that are effective for accelerating wound healing.

Abstract: An apparatus for manufacturing a rapidly cooled solidified slag, which comprises: a pair of cooling drums, the peripheral surfaces of said pair of cooling drums being in contact with each other and rotating in directions opposite to each other at the same peripheral speed; a pair of weirs provided at the both ends of said pair of cooling drums so as to be in contact with the both ends of said pair of cooling drums, said pair of weirs forming a slag sump in cooperation with the upper half of the peripheral surface of each of said pair of cooling drums, and a molten slag being poured into said slag sump; a pair of gas nozzles provided adjacent the peripheral surface of each of said pair of cooling drums, said pair of gas nozzles uniformly ejecting a gas onto the molten slag, which has been deposited on the surface of said pair of cooling drums in said slag sump, to blow part of said molten slag back into said slag sump, thereby uniformly reducing the thickness of said molten slag deposited on the peripheral sur

Abstract: An improved apparatus for manufacturing a rapidly cooled solidified slag, the improvement relating to the use of pairs of weirs having an annular shape and a hollow portion therein; each of said pair of weirs being fixed to each edge of the peripheral surface of one of a pair of cooling drums so as to form a circular flange at right angles to the axial line of the one cooling drum around the entire circumference thereof.

Abstract: An apparatus for manufacturing a rapidly cooled solidified slag, which comprises: at least one rotating cooling drum rotating around a horizontal center axis thereof, said cooling drum being cooled by a cooling medium, and having an outer peripheral surface comprising a plurality of jogs over the entire surface thereof; a slag sump arranged at a position where said peripheral surface of said cooling drum begins to rise, the depositing molten slag onto said peripheral surface of said cooling drum; a scraper proved at the lower part of said peripheral surface of said cooling drum; and a slag feeding means arranged above said cooling drum, for pouring said molten slag into said slag sump; whereby said molten slag poured into said slag sump is deposited onto said peripheral surface of said cooling drum, rapidly cooled through heat exchange with said cooling medium along with rotation of said cooling drum to become a solidified slag, and peeled off from said peripheral surface of said cooling drum by said scraper.