Abstract: The present invention provides human cells that can be stably infected with coronavirus, as human cells for research on infection with coronavirus such as SARS-CoV-2, as well as, by utilizing the cells, a method for confirming the presence of a coronavirus in a sample, a method for producing a coronavirus, and a method for evaluating the presence or absence of anti-coronavirus activity of a test sample or a substance having an anti-coronavirus neutralizing action in a test sample. Specifically, the present invention relates to a method for preparing a coronavirus-infectious immortalized human myeloid cell, including introducing ACE2 and TMPRSS2 into an immortalized human myeloid cell, and the like.

Abstract: [Problem] To find a method having higher stability, reproducibility, economic efficiency, and operation easiness in an evaluation method of safety of a substance in vitro, by using human immortalized myeloid cells. [Solving Means] A method for evaluating the skin sensitizing property and/or the pyrogenic property of a test substance, a method for detecting a skin sensitizer and/or a pyrogen in a sample, and a method for evaluating the action of a sample on a function of immune cells, each using human immortalized myeloid cells and including measuring the production amount of IL-6 and/or IL-8 in a culture medium of human immortalized myeloid cells.

Abstract: The present invention has been made in view of a problem regarding stability, reproducibility, economy, and easiness of operation in studies for a monocyte- or dendritic cell-mediated infectious microorganism, and is directed to provide a method for maintenance culturing a monocyte- or dendritic cell-mediated infectious microorganism utilizing a monocyte having a proliferative capacity. The present invention is based on the finding that a dengue virus efficiently infects a proliferable human monocytic cell obtained by introducing a gene into a CD14-positive cell and a cell having a phagocytic capacity obtained by inducing the monocytic cell to differentiate (e.g., dendritic cell) and proliferates therein. Thus, provided is a novel method for evaluating a pharmaceutical such as a compound or a vaccine for treating an infection with a monocyte- or dendritic cell-mediated infectious microorganism.

Abstract: A braided hair washing method includes washing braided hair using a washing agent that includes a microbubble washing composition and microbubbles, the microbubble washing composition including a protease and a lipase. The braided hair washing method can conveniently and effectively wash braided hair without collapsing the hairstyle.

Abstract: The present invention provides a microbubble washing composition for washing a human body or an animal, a microbubble washing method using the microbubble washing composition, and a microbubble washing apparatus suitable for carrying out the method are provided which are capable of safely removing sebum and old keratin adhering to the surfaces of the pores in a short period of time, keeping the skin clean for a long period of time, preventing an odor. Specifically, the present invention provides a microbubble washing composition for washing a human body or an animal including a protease and a lipase, a microbubble washing method for washing a human body or an animal including washing a human body or an animal using a washing liquid containing the washing composition and microbubbles, and a microbubble washing apparatus.

Abstract: A braided hair washing method includes washing braided hair using a washing agent that includes a microbubble washing composition and microbubbles, the microbubble washing composition including a protease and a lipase. The braided hair washing method can conveniently and effectively wash braided hair without collapsing the hairstyle.

Abstract: A hair growth method includes repeatedly washing hair using a washing agent that includes a microbubble washing composition and microbubbles, the microbubble washing composition including a protease and a lipase. The hair growth method exhibits an excellent hair growth effect.

Abstract: The present invention provides a microbubble washing composition for washing a human body or an animal, a microbubble washing method using the microbubble washing composition, and a microbubble washing apparatus suitable for carrying out the method are provided which are capable of safely removing sebum and old keratin adhering to the surfaces of the pores in a short period of time, keeping the skin clean for a long period of time, preventing an odor. Specifically, the present invention provides a microbubble washing composition for washing a human body or an animal including a protease and a lipase, a microbubble washing method for washing a human body or an animal including washing a human body or an animal using a washing liquid containing the washing composition and microbubbles, and a microbubble washing apparatus.

Abstract: The present invention provides a microbubble washing composition for washing a human body or an animal, a microbubble washing method using the microbubble washing composition, and a microbubble washing apparatus suitable for carrying out the method are provided which are capable of safely removing sebum and old keratin adhering to the surfaces of the pores in a short period of time, keeping the skin clean for a long period of time, preventing an odor. Specifically, the present invention provides a microbubble washing composition for washing a human body or an animal including a protease and a lipase, a microbubble washing method for washing a human body or an animal including washing a human body or an animal using a washing liquid containing the washing composition and microbubbles, and a microbubble washing apparatus.

Abstract: A method for producing B-type crystals of nateglinide substantially free of H-type crystals is provided, which comprises drying solvated wet crystals of nateglinide at a low temperature until no solvent remains and making a crystal conversion thereof. According to this method, B-type crystals of nateglinide can be produced at an industrial scale without allowing other forms of the crystalline polymorphism to coexist.

Abstract: The present invention provides a microbubble washing composition for washing a human body or an animal, a microbubble washing method using the microbubble washing composition, and a microbubble washing apparatus suitable for carrying out the method are provided which are capable of safely removing sebum and old keratin adhering to the surfaces of the pores in a short period of time, keeping the skin clean for a long period of time, preventing an odor. Specifically, the present invention provides a microbubble washing composition for washing a human body or an animal including a protease and a lipase, a microbubble washing method for washing a human body or an animal including washing a human body or an animal using a washing liquid containing the washing composition and microbubbles, and a microbubble washing apparatus.

Abstract: A method for producing B-type crystals of nateglinide substantially free of H-type crystals is provided, which comprises drying solvated wet crystals of nateglinide at a low temperature until no solvent remains and making a crystal conversion thereof. According to this method, B-type crystals of nateglinide can be produced at an industrial scale without allowing other forms of the crystalline polymorphism to coexist.

Abstract: The present invention provides a filling valve which affords an excellent sterilization capability and a high maintenance capability. The valve includes a tubular nozzle 4, an operating rod 6 which is fitted in the nozzle 4 so as to be elevatable, and an opening/closing valve 22 formed by a valve seat 10a on the internal surface of the nozzle 4 at its bottom end and a valve element 6a formed at the bottom end of the operating rod 6. A portion 10c of a reducing diameter which gradually reduces the cross-sectional area of the filled liquid passage 10 in a downward direction and a portion 10e of an increasing diameter which gradually increases the cross-sectional area of the filled liquid passage 10 in the downward direction are formed on the internal surface of the nozzle 4 at an upper portion thereof. A plurality of straightening vanes 36 are formed on the internal surface of the nozzle 4 at a location below the portion 10e of an increasing diameter.

Abstract: The present invention provides a filling valve which affords an excellent sterilization capability and a high maintenance capability. The valve includes a tubular nozzle 4, an operating rod 6 which is fitted in the nozzle 4 so as to be elevatable, and an opening/closing valve 22 formed by a valve seat 10a on the internal surface of the nozzle 4 at its bottom end and a valve element 6a formed at the bottom end of the operating rod 6. A portion 10c of a reducing diameter which gradually reduces the cross-sectional area of the filled liquid passage 10 in a downward direction and a portion 10e of an increasing diameter which gradually increases the cross-sectional area of the filled liquid passage 10 in the downward direction are formed on the internal surface of the nozzle 4 at an upper portion thereof. A plurality of straightening vanes 34 are formed on the internal surface of the nozzle 4 at a location below the portion 10e of an increasing diameter.

Abstract: A method for producing B-type crystals of nateglinide substantially free of H-type crystals is provided, which comprises drying solvated wet crystals of nateglinide at a low temperature until no solvent remains and making a crystal conversion thereof. According to this method, B-type crystals of nateglinide can be produced at an industrial scale without allowing other forms of the crystalline polymorphism to coexist.

Abstract: A vessel conveying system includes a dryer disposed within a first sterile chamber. If a vessel stays within the dryer for a prolonged length of time, it will be deformed under heat. Accordingly, the vessel is removed by a reject wheel and dropped onto a discharge chute disposed below. A downstream portion of the discharge chute is surrounded by a second sterile chamber, which is separate from the first mentioned sterile chamber, A glove mounted on the wall of the second chamber enables access to the discharge chute while maintaining the chute in a sterile condition. A door is mounted on the wall of the second chamber, and the rejected vessel is discharged through the door. The sterile chambers are disposed within a processing chamber. The pressure within the first chamber is controlled to be higher than the pressure (atmospheric pressure) within the processing chamber and the pressure within the second chamber is controlled to be lower than the atmospheric pressure.

Abstract: A drier 8 is disposed within a sterile chamber 14. If a vessel 10 stays within the drier for a prolonged length of time, it will be deformed under heat, and accordingly, it is taken out by a reject wheel 28 and dropped onto a discharge chute 30 which is disposed below it. A downstream portion of the discharge chute is surrounded by a second sterile chamber 36 which is separate from the first mentioned sterile chamber, and a glove 38 mounted on the wall of the chamber 36 allows an access to the discharge chute while maintaining the chute in a sterile condition. A door 40 which can be opened and closed is mounted on the wall 36a of the second chamber, and the rejected vessel is discharged through the door which is then opened. Chambers 14 and 36 are disposed within a processing chamber 4.

Abstract: A display control system for a scan type display apparatus in which a display screen is divided into a plurality of split display regions on a video screen and each display region is scanned in parallel. A dual port memory having a random access port and a serial access port is used as a display memory and display data is inputted through the random access port and outputted through the serial access port. Display addresses for reading out sequentially display data corresponding to each raster of every split display region one by one from the dual port memory are generated and the display data of each of the split display regions read out from the dual port memory are stored into each of the buffer memories. The display data stored in the buffer memories is read out and transferred to the scan type display device.

Abstract: A method for continuously producing a liquid low molecular weight polymer of conjugated diolefin having a number average molecular weight of 300 to 10000. The method comprises the step of continuously polymerizing or copolymerizing conjugated diolefin in an inert hydrocarbon solvent at a temperature of 40.degree. to 70.degree. C. with maintaining the quantity of dissolved oxygen in the reaction system at 1 ppm or below and in the presence of a polymerization catalyst of an organic sodium compound and a chain transfer agent of an alkylaryl compound.

Abstract: The dot data to be displayed is divided and stored in an even address graphic memory and an odd address graphic memory. When data to be revised (refreshed) bridges over adjacent word units having different addresses, the CPU generates the word address of the odd address graphic memory and new dot data to be displayed. A peripheral control circuit generates the word address signal and an address signal of the adjacent address of the even address graphic memory so as to revise the dot data which bridges over two word addresses. In this way, the dot data which bridges over two addresses can be revised by only one access operation to the memory.