Abstract: Provided are vitamin D3 derivatives of formula (I), pharmaceutical compositions thereof, and pharmaceutical or medical uses thereof for treating metabolic disease, a liver disease, obesity, diabetes, cardiovascular disease, or cancer in a patient in need thereof.

Abstract: The present invention relates to vitamin D3 derivatives of the following formula, wherein each symbol has the same meaning as defined herein, and pharmaceutical or medical use thereof for treating metabolic disease, liver disease, obesity, diabetes, cardiovascular disease, or cancer in a patient in need thereof.

Abstract: The present invention is intended to provide a compound useful to analyze a vitamin D compound. The present invention provides an alkyne compound represented by Formula (I): where in Formula (I), A is a linear carbon chain having an alkynyl group at an end and having a vinyl group at another end; X1 is CH or 13CH; X2 is CHY, CDY, 13CHY, 13CDY, CO, 13CO, C18O, or 13C18O; m is an integer from 1 to 4; when m is 2 or more, X2s are identical or different; Y is H, D, NH2, 15NH2, OH, 18OH, SH, OR, O(CO)R, OSO3H, OSO3Na, or a sugar substituent; when Formula (I) contains two or more Ys, Ys are identical or different; R is an alcohol protective group, an alkyl group, an alkenyl group, or an aryl group; X3 is C or 13C; and at least one selected from the group consisting of X1, X2(s), and X3 is modified with a stable isotope D, 13C, 18O, or 15N.

Abstract: Provided are vitamin D3 derivatives of formula (I), pharmaceutical compositions thereof, and pharmaceutical or medical uses thereof for treating metabolic disease, a liver disease, obesity, diabetes, cardiovascular disease, or cancer in a patient in need thereof.

Abstract: A display request including designation related to a display state of a stereoscopic shape in a three-dimensional space is transmitted from a receiving apparatus 200 to a transmitting apparatus 100, and the transmitting apparatus 100 extracts point cloud data of a part corresponding to the display request from among the point cloud data stored in a point cloud data storage unit 10 in response to the display request and transmits the extracted point cloud data to the receiving apparatus 200. Accordingly, only the point cloud data of the part which is necessary for the display state of the stereoscopic shape which is actually displayed in the three-dimensional space by the receiving apparatus 200 is transmitted, and thus it is possible to transmit only the point cloud data necessary for display within a practically acceptable short time on a communication network 300 even though the entire data amount of the point cloud data stored in the point cloud data storage unit 10 is huge.

Abstract: A display request including designation related to a display state of a stereoscopic shape in a three-dimensional space is transmitted from a receiving apparatus 200 to a transmitting apparatus 100, and the transmitting apparatus 100 extracts point cloud data of a part corresponding to the display request from among the point cloud data stored in a point cloud data storage unit 10 in response to the display request and transmits the extracted point cloud data to the receiving apparatus 200. Accordingly, only the point cloud data of the part which is necessary for the display state of the stereoscopic shape which is actually displayed in the three-dimensional space by the receiving apparatus 200 is transmitted, and thus it is possible to transmit only the point cloud data necessary for display within a practically acceptable short time on a communication network 300 even though the entire data amount of the point cloud data stored in the point cloud data storage unit 10 is huge.

Abstract: The present invention relates to vitamin D3 derivatives of the following formula, wherein each symbol has the same meaning as defined herein, and pharmaceutical or medical use thereof for treating metabolic disease, liver disease, obesity, diabetes, cardiovascular disease, or cancer in a patient in need thereof.

Abstract: An object of the present invention is to provide a sugar donating reagent comprising a sugar donor compound other than a sugar nucleotide and an enzyme capable of catalyzing a glycosyl transfer reaction using a sugar donor compound other than a sugar nucleotide. The present invention provides the following: a sugar donating reagent containing a compound of formula (A): wherein R1 is independently selected from hydrogen, or C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl in which each of the groups is unsubstituted or substituted with one or more groups selected from OH, F, Cl, Br, I, CN, NO2, and SO2, n is 0, 1, 2, 3, 4 or 5, m is 0 or 1, and X represents a monosaccharide bound via a ? bond on its anomeric carbon; a glycosyltransferase capable of catalyzing a glycosyl transfer reaction using the sugar donor; and a glycosyltransferase gene comprising DNA encoding the glycosyltransferase.

Abstract: An object of the present invention is to provide a sugar donating reagent comprising a sugar donor compound other than a sugar nucleotide and an enzyme capable of catalyzing a glycosyl transfer reaction using a sugar donor compound other than a sugar nucleotide. The present invention provides the following: a sugar donating reagent containing a compound of formula (A): wherein R1 is independently selected from hydrogen, or C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl in which each of the groups is unsubstituted or substituted with one or more groups selected from OH, F, Cl, Br, I, CN, NO2, and SO2, n is 0, 1, 2, 3, 4 or 5, m is 0 or 1, and X represents a monosaccharide bound via a ? bond on its anomeric carbon; a glycosyltransferase capable of catalyzing a glycosyl transfer reaction using the sugar donor; and a glycosyltransferase gene comprising DNA encoding the glycosyltransferase.

Abstract: Compound represented by formula (1) or a pharmaceutically acceptable solvate thereof, useful for treating or preventing Paget's disease of bone, hypercalcaemia, osteoporosis or asthma. (1) R1 represents a C1-C6 alkyl group or C7-C15 aralkyl group (the aromatic ring of which can be substituted by a C1-C6 alkyl group, C1-C6 alkoxy group, a hydroxyl group, a halogenatom or a trifluoromethyl group), R2 represents a C1-C6 alkyl group, and R3 represents a C1-C6 alkyl or alkoxy group, which can be substituted with a hydroxyl group.

Abstract: Compounds expressed by the following formula (1) or pharmaceutically permissible solvate thereof which is effective for treating Paget's disease of bone, hypercalcemia or osteoporosis. In the formula, R1 is a C2-C10 alkyl group, or a C7-C15 aralkyl group whose aromatic ring is optionally substituted with a C1-C6 alkyl group, a C1-C6 alkoxyl group, a hydroxyl group, a halogen atom or a trifluoromethyl group; and R2 is a C1-C10 alkyl group, or a C7-C15 aralkyl group whose aromatic ring is optionally substituted with a C1-C6 alkyl group, a C1-C6 alkoxyl group, a hydroxyl group, a halogen atom or a trifluoromethyl group.

Abstract: An atomic absorption spectrophotometer including a self reverse type hollow cathode lamp and a photomultiplier tube further includes a preliminary tester for measuring a strength of a signal L when a smaller current is supplied to the hollow cathode lamp and a strength of a signal H when a larger current is supplied while a voltage V applied between a cathode and an anode of the photomultiplier is changed. It also includes an optimal voltage detector for detecting a value V0 of the voltage V at which a super ratio U (which is defined as a ratio of a first ratio L0/H0 to a second ratio L1/H1) is closest to unity under a condition that two values V1 and V0 of the voltage V are arbitrarily chosen so that a ratio H1/H0 or a ratio L1/L0 is a predetermined value.

Abstract: Compounds expressed by the following formula (1) or pharmaceutically permissible solvate thereof which is effective for treating Paget's disease of bone, hypercalcemia or osteoporosis. In the formula, R1 is a C2-C10 alkyl group, or a C7-Cl5 aralkyl group whose aromatic ring is optionally substituted with a C1-C6 alkyl group, a C1-C6 alkoxyl group, a hydroxyl group, a halogen atom or a trifluoromethyl group; and R2 is a C1-C10 alkyl group, or a C7-C15 aralkyl group whose aromatic ring is optionally substituted with a C1-C6 alkyl group, a C1-C6 alkoxyl group, a hydroxyl group, a halogen atom or a trifluoromethyl group.

Abstract: An atomic absorption spectrophotometer including a self reverse type hollow cathode lamp and a photomultiplier tube further includes a preliminary tester for measuring a strength of a signal L when a smaller current is supplied to the hollow cathode lamp and a strength of a signal H when a larger current is supplied while a voltage V applied between a cathode and an anode of the photomultiplier is changed. It also includes an optimal voltage detector for detecting a value V0 of the voltage V at which a super ratio U (which is defined as a ratio of a first ratio L0/H0 to a second ratio L1/H1) is closest to unity under a condition that two values V1 and V0 of the voltage V are arbitrarily chosen so that a ratio H1/H0 or a ratio L1/L0 is a predetermined value.

Abstract: For calibrating a spectrophotometer having a monochromator with a rotary mechanism to rotate a diffraction grating for producing a monochromatic beam of light of a specified target wavelength, transmission errors by the rotary mechanism are preliminarily measured to obtain an error curve having peaks corresponding to feed angles. A smallest angular interval, greater than an allowable limit, between a pair of feed angles corresponding to a mutually adjacent pair of peaks in the error curve is selected. One or more lamps emitting bright lines with wavelength interval which corresponds to motion of the rotary mechanism by less than one half of the selected smallest angular interval are used as a light source. Control values to be supplied to the rotary mechanism for obtaining monochromatic beams of light from the bright lines emitted from the selected lamps are determined by measurements.

Abstract: Driving wheels for auxiliary rotary wheels are provided at the forward corners of a sweeper in a spaced relationship from driving wheels for a main rotary brush to provide a long wheel base.

Abstract: A hand sweeper according to the present invention comprises a base in the form of a dust box having a rotary brush and driving wheels for transmitting their rotation to the rotary brush and a cover body for covering the dust box. The cover body has a handle pivotably attached thereto and is removably connected to the dust box.

Abstract: A circuit block for an electronic watch comprises a time standard circuit, that is a timing module and a regulating element. The time standard circuit unit includes an oscillator, an oscillating circuit, a divider and a driving circuit all of which are collectively sealed in a vacuum or evacuated case. The regulating element serves to regulate the period of output signals from the time standard circuit unit at a value to be required. The time standard circuit unit and the regulating element are mounted on the same substrate.