Patent number: 5661159
Abstract: This invention relates to new quinolylbenzofuran derivatives having activities as leukotrien and Slow Reacting Substance of Anaphylaxis antagonists and inhibitors and represented by the general formula (I): ##STR1## wherein R.sup.1 is halogen, etc.,R.sup.2 is hydrogen or halogen,R.sup.3 is hydrogen, halogen, hydroxy, lower alkyl or lower alkoxy,R.sup.4 is hydrogen, acyl, cyano, nitro, substituted or unsubstituted aryl, or substituted or unsubstituted lower alkyl,R.sup.5 is hydrogen, hydroxy, lower alkyl or lower alkoxy,A is lower alkylene, lower alkenylene or a single bond,X is a single bond, O, NH, S, SO or SO.sub.2, andY is O or S,provided that when R.sup.3 is hydrogen, R.sup.4 is hydrogen,R.sup.5 is hydrogen, A is a single bond and X is a single bond, then R.sup.1 is halogen, etc.,and pharmaceutically acceptable salts thereof to processes for the preparation thereof and to a pharmaceutical composition comprising the same.
Type:
Grant
Filed:
August 2, 1994
Date of Patent:
August 26, 1997
Assignee:
Fujisawa Pharmaceutical Co., Ltd.
Inventors:
Masaaki Matsuo, Kazuo Okumura, Shinji Shigenaga
Patent number: 4581356
Abstract: New triazine derivatives represented by the formula: ##STR1## wherein R.sup.1 is a 1,2,3,4-tetrahydroquinolyl, 2-oxo-1,2,3,4-tetrahydroquinolyl, 2-oxo-1,2-dihydroquinolyl, indolyl, 2-oxoindolinyl, benzothiazolyl, 2-oxobenzothiazolinyl, 3,4-dihydro-1H-2,1-benzothiazinyl in which the S atom being optionally oxidized, or 3-oxo-2,3-dihydro-4H-1,4-benzoxazinyl, each of which may have one or more substituent(s) selected from lower alkyl, hydroxy(lower)alkyl, lower alkylamino, lower alkanoyl, cyclic lower alkanoyl, lower alkoxy(lower)alkyl, lower alkylamino(lower)alkanoyl, benzyl, benzyloxy(lower)alkyl, lower alkoxycarbonyl(lower)alkyl and 4-(2-hydroxyethyl)piperazin-1-yl-carbonylmethyl;R.sup.2 is a hydrogen, lower alkenyl, benzyl, carboxy(lower)alkyl or lower alkoxycarbonyl(lower)alkyl;R.sup.3 and R.sup.4, which may be the same or different, are each hydrogen or lower alkyl or together represent a bond;provided that when R.sup.
Type:
Grant
Filed:
March 12, 1984
Date of Patent:
April 8, 1986
Assignee:
Fujisawa Pharmaceutical Co., Ltd.
Inventors:
Tsutomu Teraji, Youichi Shiokawa, Kazuo Okumura, Yoshinari Sato