Patents by Inventor Kazuo Sakane

Kazuo Sakane has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5763437
    Abstract: Benzodiazepine derivatives of formula (I) wherein R.sup.1 is aryl which may have one or more suitable substituent(s), R.sup.2 is C.sub.3 -C.sub.8 cycloalkyl which may have one or more suitable substituent(s), A is lower alkylene, R.sup.3 is a heterocyclic group selected from the group consisting of tetrahydrofuryl, dioxolanyl, filryl, thienyl, isoxazolyl, pyridyl, benzimidazolyl, benzotiazolyl, benzoxazolyl, benzopyrany, quinolyl, isoquinolyl, tetrahydroisoquinolyl, benzothienyl and benzofuryl, each of which may have one or more suitable substituent(s), or a pharmaceutically acceptable salt thereof, which are useful as a medicament.
    Type: Grant
    Filed: January 29, 1997
    Date of Patent: June 9, 1998
    Assignees: Fujisawa Pharmaceutical Co., Ltd., Nippon Shokubai Co., Ltd.
    Inventors: Yoshinari Sato, Kazuo Sakane, Seiichiro Tabuchi, Hitoshi Mitsui, Ikuyo Katsumi, Yuichi Satoh
  • Patent number: 5663163
    Abstract: The present invention relates to new cephem compounds, pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the same and anti-bacterial methods of using the same. The subject cephem compounds comprise a thiadiazine ring bonded to the cephem through an iminoacetamido chain and a pyarzolium ring bonded to the cephem through a methylene chain.
    Type: Grant
    Filed: January 22, 1996
    Date of Patent: September 2, 1997
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Takao Takaya, Kazuo Sakane, Kenzi Miyai, Kohji Kawabata
  • Patent number: 5532354
    Abstract: Compounds of the formula: ##STR1## wherein R is a group of the formula: ##STR2## in which R.sup.3 and R.sup.4 are each lower alkyl or R.sup.3 and R.sup.4 are linked together to form C.sub.3 -C.sub.6 alkylene, A is lower alkylene, and R.sup.5 is hydroxy or a protected hydroxy group;or a group of the formula: ##STR3## in which R.sup.6 is lower alkyl, R.sup.7 and R.sup.8 are each hydroxy or a protected hydroxy group, and Y is N or CH, and salts thereof are intermediates for cephem compounds which show antimicrobial activities and which are useful in the treatment of microbial infections.
    Type: Grant
    Filed: November 29, 1994
    Date of Patent: July 2, 1996
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Hideaki Yamanaka, Yoshiki Yoshida, Jiro Goto, Takeshi Terasawa, Shinya Okuda, Kazuo Sakane
  • Patent number: 5401734
    Abstract: Cephem compounds of the formula: ##STR1## wherein R.sup.1 is amino or a protected amino group,Z is N or CH,R.sup.2 is lower alkyl, mono(or di or tri)halo(lower)alkyl, lower alkenyl, lower alkynyl, phenyl, naphthyl, phenyl(lower)alkyl, carboxy(lower)alkyl or protected carboxy(lower)alkyl, andR is a group of the formula: ##STR2## in which R.sup.3 and R.sup.4 are each lower alkyl,A is lower alkylene, andR.sup.5 is hydroxy or a protected hydroxy group; or pharmaceutically acceptable salts thereof show antimicrobial activities and are useful in the treatment of microbial infections.
    Type: Grant
    Filed: May 20, 1993
    Date of Patent: March 28, 1995
    Assignee: Fujisawa Phamaceutical Co., Ltd.
    Inventors: Hideaki Yamanaka, Yoshiki Yoshida, Jiro Goto, Takeshi Terasawa, Shinya Okuda, Kazuo Sakane
  • Patent number: 5376634
    Abstract: A polypeptide compound having antimicrobial activity of the following general formula: ##STR1## wherein R.sup.1 is hydrogen or acyl group, R.sup.2 is hydroxy or acyloxy,R.sup.3 is hydroxysulfonyloxy, andR.sup.4 is hydrogen or carbamoyl,with proviso thatR.sup.1 is not palmitoyl, when R.sup.2 is hydroxy,R.sup.3 is hydroxysulfonyloxy andR.sup.4 is carbamoyl,and a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: June 17, 1991
    Date of Patent: December 27, 1994
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Toshiro Iwamoto, Akihiko Fujie, Kumiko Nitta, Yasuhisa Tsurumi, Nobuharu Shigematsu, Chiyoshi Kasahara, Motohiro Hino, Masakuni Okuhara, Kazuo Sakane, Kohji Kawabata, Hidenori Ohki
  • Patent number: 5366970
    Abstract: The invention relates to a compound of the formula: ##STR1## of antimicrobial activity.
    Type: Grant
    Filed: September 2, 1992
    Date of Patent: November 22, 1994
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Kazuo Sakane, Kohji Kawabata, Yoshiko Inamoto
  • Patent number: 5359066
    Abstract: A compound represented by the following general formula: ##STR1## which is useful as an intermediate for production of a clinically excellent synthetic antibacterial, a salt thereof, and a process for producing the same.In said formula,R.sup.1 is a hydrogen atom or a carboxyl-protecting group;R.sup.2 is a hydrogen atom or a lower alkyl group;X.sup.1 is a hydrogen atom or a halogen atom;X.sup.2 is a halogen atom;X.sub.a.sup.5 is a hydrogen atom or a halogen atom;A is a methylene group; a group of >CH--COOR.sup.4, etc.,in which R.sup.4, R.sup.5 and R.sup.6 each are a hydrogen atom or a carboxyl-protecting group;B is a methylene group or a carbonyl group;provided that both A and B must not be methylene groups at the same time.
    Type: Grant
    Filed: June 15, 1993
    Date of Patent: October 25, 1994
    Assignees: Wakunaga Pharmaceutical Co., Ltd., Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Hideo Tsutsumi, Takeshi Terasawa, David Barrett, Masayoshi Murata, Kazuo Sakane, Akira Yazaki, Satoshi Inoue
  • Patent number: 5302712
    Abstract: The invention relates to compounds, useful as intermediates in the preparation of products of antimicrobial activity, of the formula: ##STR1## wherein R.sup.3 is hydrogen, lower alkyl, hydroxy(lower)alkyl, protected hydroxy(lower)alkyl, amino(lower)alkyl, protected amino (lower) alkyl, carbamoyl)lower)alkyl, N,N-di(lower) alkylcarbamoyl(lower)alkyl or an amino protective group, andR.sup.4 is hydrogen, lower alkyl, carboxy, protected carboxy, amino, protected amino or carbamoyl,or a salt thereof.
    Type: Grant
    Filed: February 23, 1993
    Date of Patent: April 12, 1994
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Kazuo Sakane, Kohji Kawabata, Yoshiko Inamoto
  • Patent number: 5244890
    Abstract: Cephem compounds having the following formula are disclosed: ##STR1## R.sup.1 =amino or protected amino R.sup.2 =an organic group ##STR2## R.sup.6 =lower alkyl R.sup.7, R.sup.8 .dbd.OH or protected OHY.dbd.N or CHThe compounds are useful as antimicrobial agents.
    Type: Grant
    Filed: May 20, 1992
    Date of Patent: September 14, 1993
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Hideaki Yamanaka, Yoshiki Yoshida, Jiro Goto, Takeshi Terasawa, Shinya Okuda, Kazuo Sakane
  • Patent number: 5215982
    Abstract: Cephem compounds of the following formula are disclosed: ##STR1## wherein R.sup.1 is amino or protected amino group. R.sup.2 is H or an organic group,R.sup.3 is H or an organic group,R.sup.4 is H, lower alkyl, carboxy, protected carboxy, amino, protected amino or carbamoyl, Z=N or CH. The compounds are useful as antimicrobial agents.
    Type: Grant
    Filed: October 26, 1990
    Date of Patent: June 1, 1993
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Kazuo Sakane, Kohji Kawabata, Yoshiko Inamoto
  • Patent number: 5210080
    Abstract: The invention relates to compounds of antimicrobial activity, of the formula ##STR1## wherein R.sup.1 is amino or protected amino,R.sup.2 is lower alkyl or lower alkenyl,R.sup.3 is lower alkyl, hydroxy(lower)alkyl or protected hydroxy(lower)alkyl,R.sup.4 is amino, protected amino, lower alkylamino, protected lower alkylamino, carboxy(lower)alkylamino, N-[protected carboxy(lower)alkyl]amino andR.sup.7 is hydrogen or lower alkyl, ora pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 9, 1991
    Date of Patent: May 11, 1993
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Takao Takaya, Kazuo Sakane, Kenzi Miyai, Kohji Kawabata
  • Patent number: 5194432
    Abstract: The invention relates to cephem compounds characterized by a substituted 2-pyrazolimethyl group and a 7-(aminothiazolyl) (hydroxyimino)-acetamido group and certain derivatives thereof, to pharmaceutical compositions comprising the same and to use for treatment of infectious diseases.
    Type: Grant
    Filed: July 17, 1990
    Date of Patent: March 16, 1993
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Takao Takaya, Kazuo Sakane, Kenzi Miyai, Kohji Kawabata
  • Patent number: 5187160
    Abstract: The invention relates to antimicrobial compounds of the formula: ##STR1## wherein R.sup.1 is amino or a protected amino, R.sup.2 is ethyl, propyl or lower alkenyl,R.sup.3 is COO .theta., carboxy or a protected carboxy,R.sup.4 is hydroxy(lower)alkyl or protected hydroxy(lower)alkyl,R.sup.5 is amino or a protected amino,X.sup..theta. is an anion, andn is 0 or 1,or,R.sup.1, R.sup.3, R.sup.5, X.sup..theta. and n are each as defined above,R.sup.2 is lower alkyl, andR.sup.4 is 3-hydroxypropyl, with proviso that(i) when R.sup.3 is COO.sup..theta., then n is 0, and(ii) when R.sup.3 is carboxy or a protected carboxy, then n is 1,or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: February 23, 1990
    Date of Patent: February 16, 1993
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Kazuo Sakane, Kohji Kawabata, Kenzi Miyai, Yoshiko Inamoto
  • Patent number: 5173485
    Abstract: The invention relates to an antimicrobial compound of the formula: ##STR1## wherein R.sup.1 is amino or a protected amino group,R.sup.2 is lower alkyl, lower alkenyl, carboxy (lower) alkyl or protected carboxy(lower)alkyl,R.sup.3 is hydrogen, lower alkyl, hydroxy(lower)alkyl, protected hydroxy(lower)alkyl, amino(lower)alkyl, protected amino(lower)alkyl or lower alkanoyl,R.sup.4 is hydrogen, lower alkyl or lower alkylthio, andZ is N or CHor a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: June 14, 1991
    Date of Patent: December 22, 1992
    Assignee: Fujisawa Pharmaceutical Company, Ltd.
    Inventors: Kazuo Sakane, Kohji Kawabata, Yoshiko Inamoto
  • Patent number: 5162520
    Abstract: The invention relates to intermediate compounds of the formula: ##STR1## wherein R.sup.3 is a lower alkyl, hydroxy(lower)alkyl or a protected hydroxy(lower)alkyl,R.sup.4 is amino or a protected amino group, andR.sup.5 is hydrogen or lower alkyl, or a salt thereof,useful in the preparation of compounds of antimicrobial activity.
    Type: Grant
    Filed: January 27, 1992
    Date of Patent: November 10, 1992
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Takao Takaya, Kazuo Sakane, Kenzi Miyai, Kohji Kawabata
  • Patent number: 5108997
    Abstract: The invention relates to a compound, of antimicrobial activity, of the formula: ##STR1## wherein R.sup.1 and R.sup.4 are each amino or a protected amino group,R.sup.2 is carboxy(lower) alkyl or a protected carboxy(lower) alkyl,R.sup.3 is lower alkyl, andR.sup.5 is hydrogen or lower alkyl, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: September 6, 1989
    Date of Patent: April 28, 1992
    Assignee: Fujisawa Pharmaceuticals Co., Ltd.
    Inventors: Takao Takaya, Kazuo Sakane, Kenzi Miyai, Kohji Kawabata
  • Patent number: 5109130
    Abstract: The invention relates to a highly stable antibacterial agent which is crystalline 7.beta.-[2-(5 -amino-1,2,4-thiadiazol-3-yl)-2-(1-carboxy-1-methylethoxyimino)acetamido]- 3-[3-amino-2-(2-hydroxyethyl)-1-pyrazolio]methyl-3-cephem-4-carboxylate hydrochloride (syn-isomer).
    Type: Grant
    Filed: February 22, 1991
    Date of Patent: April 28, 1992
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Kazuo Sakane, Kohji Kawabata, Shinya Okuda
  • Patent number: 5104866
    Abstract: A water-soluble antibiotic composition which comprises crystals of a cephem compound of the following formula: ##STR1## wherein R.sup.1 is a residue of an aliphatic hydrocarbon which may have suitable substituent(s), andR.sup.2 is a heteronio (lower)alkyl, or an acid addition salt thereof, and a pharmaceutically acceptable carbonic acid salt.And a salt of new cephem compound derived from the above-mentioned cephem compound.
    Type: Grant
    Filed: July 25, 1990
    Date of Patent: April 14, 1992
    Assignee: Fujisawa Pharmaceutical Company, Ltd.
    Inventors: Kazuo Sakane, Nobuyoshi Yasuda, Shintaro Nishimura
  • Patent number: 4960766
    Abstract: The invention relates to cephem compounds characterized by a substituted 2-pyrazoliomethyl group and a 7-(aminothiazolyl)(alkoxyimino)-acetamido group and certain derivatives thereof, to pharmaceutical compositions comprising the same and to use for treatment of infections diseases.
    Type: Grant
    Filed: November 14, 1986
    Date of Patent: October 2, 1990
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Takao Takaya, Kazuo Sakane, Kenzi Miyai, Kohji Kawabata
  • Patent number: 4952578
    Abstract: The object of the invention is a new cephem compound with antimicrobial activity used for the treatment of infectious diseases of the general formula: ##STR1## wherein R1 is amino or a protected aminoR2 is lower alkyl which may have 1 to 3 halogensR3 is COO.sup..crclbar., carboxy or a protected carboxyR4 is hydroxy(lower)alkyl or protected hydroxy(lower)alkylR5 is amino or a protected aminoR6 is hydrogen or lower alkylX.sup..crclbar. is an anion, andn is 0 or 1with proviso that(i) when R3 is COO.sup..crclbar., then n is 0, and(ii) when R3 is carboxy or a protected carboxy, then n is 1,and pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: September 7, 1988
    Date of Patent: August 28, 1990
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Kazuo Sakane, Kohji Kawabata, Kenzi Miyai, Yoshiko Inamoto