Abstract: Disclosed is an immunity-inducing agent having excellent ease of production and high immunostimulatory activity, the immunity-inducing agent comprising, as an active component, a polynucleotide/peptide conjugate in which an antigenic peptide is covalently bound to a single-stranded polynucleotide or polynucleotide derivative. Also disclosed is a pharmaceutical composition comprising said immunity-inducing agent.

Abstract: A population of ?-1,3-glucan/nucleic acid complexes, each of which contains ?-1,3-glucan and a nucleic acid containing a homo-polynucleotide that binds to ?-1,3-glucan via a hydrogen bond, and has a triple helical structure consisting of two ?-1,3-glucan chains and one nucleic acid chain containing the homo-polynucleotide that binds to ?-1,3-glucan via a hydrogen bond contained in the nucleic acid, where 30% or more of the ?-1,3-glucan/nucleic acid complexes contained in the population satisfy the following conditions: (i) they are homogeneous in the length of the homo-polynucleotide contained in the nucleic acid containing a homo-polynucleotide that bind to ?-1,3-glucan via a hydrogen bond constituting the complex, and (ii) the molecular number of the nucleic acid(s) containing a homo-polynucleotide that binds to ?-1,3-glucan via a hydrogen bond contained in one molecule of the complex is selected from the group consisting of 1, 2 and 3.

Abstract: Disclosed is an immunity-inducing agent having excellent ease of production and high immunostimulatory activity, the immunity-inducing agent comprising, as an active component, a polynucleotide/peptide conjugate in which an antigenic peptide is covalently bound to a single-stranded polynucleotide or polynucleotide derivative. Also disclosed is a pharmaceutical composition comprising said immunity-inducing agent.

Abstract: A vehicle body structure having a head-up display, includes: a window that defines a cabin and is used as a reflector of the head-up display; and an image projection device that projects an image toward the window. An image projection surface of the window that is positioned closest to the cabin includes a prescribed image projection area onto which the image is projected and a surrounding area that surrounds the image projection area. Of the image projection area and the surrounding area of the image projection surface, only the surrounding area is formed with a moth-eye structure.

Abstract: Particles using a polymer having a particle size suitable for a drug delivery system (DDS) or the like are provided. A drug and an anti-cancer agent using the particles are provided. Each of the particles comprises a polymer having a structure unit derived from a saccharide compound having a hydroxyl group and having an inclusion property and a structure unit derived from a monomer having a functional group to be reacted with a hydroxyl group, and has the average hydrodynamic radius (Rhav) of 5 to 100 nm. A method for producing the particles comprises a step of mixing a mixed composition comprising a saccharide compound, a monomer, a surfactant, and an alkaline aqueous solution having a pH of 12 or more. A drug compress a hydrophobic physiological active agent, such as ?-mangostin contained in the particle, and an anti-cancer agent comprising the drug.

Abstract: A vehicle body structure having a camera, includes: a light transmissive window defining a cabin; and a camera disposed to oppose a cabin-side surface of the window, wherein the window has a moth-eye structure formed on at least a part of the cabin-side surface located within an image capturing range of the camera.

Abstract: A vehicle body structure having a head-up display, includes: a window that defines a cabin and is used as a reflector of the head-up display; and an image projection device that projects an image toward the window. An image projection surface of the window that is positioned closest to the cabin includes a prescribed image projection area onto which the image is projected and a surrounding area that surrounds the image projection area. Of the image projection area and the surrounding area of the image projection surface, only the surrounding area is formed with a moth-eye structure.

Abstract: A vehicle body structure having an external environment sensor includes: a vehicle body; and a sensor mount member supporting an external environment sensor and mounted on the vehicle body. The external environment sensor includes: a sensor main body that irradiates an electromagnetic wave to an object and receives a reflected wave from the object; and a housing accommodating the sensor main body, wherein a moth-eye structure is formed on an electromagnetic wave passing part of the housing through which at least one of the electromagnetic wave and the reflected wave passes.

Abstract: Disclosed is an immunity-inducing agent having excellent ease of production and high immunostimulatory activity, the immunity-inducing agent comprising, as an active component, a polynucleotide/peptide conjugate in which an antigenic peptide is covalently bound to a single-stranded polynucleotide or polynucleotide derivative. Also disclosed is a pharmaceutical composition comprising said immunity-inducing agent.

Abstract: An object of the present invention is to provide novel double-stranded RNA having an RNA interference effect, in which the cellular uptake and the resistance to enzymatic degradation are improved, without reducing the RNA interference effect.

Abstract: An object of the present invention is to provide novel double-stranded RNA having an RNA interference effect, in which the cellular uptake and the resistance to enzymatic degradation are improved, without reducing the RNA interference effect.

Abstract: A nucleic acid-antigen peptide conjugate is described that is capable of forming a complex with polysaccharides that have a ?-1,3-glucan skeleton, such as schizophyllan, and which can efficiently present the antigen peptide in an antigen-presenting cell. A conjugate bonded, via a linker added to polydeoxyadenine and a disulfide bond, to an N-terminal cysteine residue of an antigen peptide that has eight or more amino acid residues having a cysteine residue at the N-terminal is capable of forming a complex with polysaccharides that have a ?-1,3-glucan skeleton, and can efficiently present the antigen peptide in an antigen-presenting cell.

Abstract: This peptide/?-1,3-glucan complex includes ?-1,3-glucan and a peptide/polynucleotide conjugate in which an antigenic peptide is bonded covalently to a polynucleotide or a derivative thereof. The polynucleotide or derivative thereof of the peptide/polynucleotide conjugate bonds via a hydrogen bond with ?-1,3-glucan, forming a complex having a triple helix structure including a single molecular chain of the polynucleotide or derivative thereof and two molecular chains of the ?-1,3-glucan. Alternatively, the side chain of the ?-1,3-glucan and the antigenic peptide are bonded covalently formed by either a cycloaddition reaction between an alkyne and an azide derivative, or a reaction between a maleimide group or a vinyl sulfone group and a thiol group.

Abstract: An object of the present invention is to provide a drug and a method for effectively inducing donor-specific immune tolerance in a recipient in transplantation therapy. A complex of an siRNA for a costimulatory factor and schizophyllan is delivered to a Dectin-1 expressing cell which specifically recognizes schizophyllan to regulate the function of the Dectin-1 expressing cell, and therefore can induce immunosuppression effect as well as induce immune tolerance effectively.

Abstract: A highly stable nucleic acid-polysaccharide complex of an siRNA and schizophyllan is formed by adding polydeoxyadenine in which at least part of the phosphodiester link portion is phosphorothioated to an siRNA and allowing the siRNA and schizophyllan to form a complex.

Abstract: This peptide/?-1,3-glucan complex includes ?-1,3-glucan and a peptide/polynucleotide conjugate in which an antigenic peptide is bonded covalently to a polynucleotide or a derivative thereof. The polynucleotide or derivative thereof of the peptide/polynucleotide conjugate bonds via a hydrogen bond with ?-1,3-glucan, forming a complex having a triple helix structure including a single molecular chain of the polynucleotide or derivative thereof and two molecular chains of the ?-1,3-glucan. Alternatively, the side chain of the ?-1,3-glucan and the antigenic peptide are bonded covalently formed by either a cycloaddition reaction between an alkyne and an azide derivative, or a reaction between a maleimide group or a vinyl sulfone group and a thiol group.

Abstract: As a means for solving the problem of providing a nucleic acid conjugate that does not undergo degradation at a DNA-RNA bonding site even in vivo, provided is a nucleic acid conjugate comprising a single-stranded DNA and a double-stranded RNA, wherein the 3? position of the 3?-terminal deoxyribonucleotide residue of the single-stranded DNA is bonded to the 5? position of the 5?-terminal ribonucleotide residue of one of the ribonucleotide strands of the double-stranded RNA, and the hydroxyl group at the 2? position of the 5?-terminal nucleotide of the ribonucleotide strand, which is bonded to the single-stranded DNA, is substituted with an alkoxy group or a halogen atom, and/or the phosphate diester group between the 3? position of the first ribonucleotide bonded to the single-stranded DNA and the 5? position of the adjacent ribonucleotide is substituted with any of phosphorothioate group, dithiophosphate diester group and trithiophosphate diester group.

Abstract: An object of the present invention is to provide a drug and a method for effectively inducing donor-specific immune tolerance in a recipient in transplantation therapy. A complex of an siRNA for a costimulatory factor and schizophyllan is delivered to a Dectin-1 expressing cell which specifically recognizes schizophyllan to regulate the function of the Dectin-1 expressing cell, and therefore can induce immunosuppression effect as well as induce immune tolerance effectively.

Abstract: A scroll compressor is constructed by combining a stationary scroll and an orbiting scroll formed by erecting a scroll-shape wrap upright on a base plate meshing with each other. A scroll member constructing the stationary scroll or the orbiting scroll is constructed of an inner layer member 601 forming a core metal and an outer layer member 600 arranged so as to surround the inner layer member and forming an outer layer part, the inner layer member is constructed of a material with higher modulus of elasticity than that of the outer layer member, and separation prevention parts (uneven parts 603, depressions 604, or holes 605) preventing the inner layer member and the outer layer member from separating with each other due to difference in coefficient of thermal expansion thereof are arranged in the inner layer member.

Abstract: An object of the present invention is to provide a highly stable nucleic acid-polysaccharide complex of an siRNA and schizophyllan. A nucleic acid-polysaccharide complex is formed by adding polydeoxyadenine in which at least part of the phosphodiester link portion is phosphorothioated to an siRNA and allowing the siRNA and schizophyllan to form a complex.