Patents by Inventor Kazuo Shimanaka
Kazuo Shimanaka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20080038289Abstract: According to the present invention, an antitumor agent, an apoptosis-inducing agent or an angiogenesis-suppressing agent having the effect even via an oral route, containing a compound contained in an inexpensive edible basidiomycete or a composition derived from an edible basidiomycete, and a food having the antitumor activity, the apoptosis-inducing activity or the angiogenesis-suppressing activity containing the compound or the composition can be obtained. Therefore, the present invention is particularly useful, especially in the field of a medicine and a health food.Type: ApplicationFiled: May 30, 2005Publication date: February 14, 2008Inventors: Takashi Kawai, Shigetoshi Mizutani, Tatsuji Enoki, Hiroaki Sagawa, Takeshi Sakai, Kazuo Shimanaka, Ikunoshin Kato
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Patent number: 7125984Abstract: Three enzymes degrading sulfated glucuronofucan; processes for producing these enzymes; activators for these enzymes; glucuronofucan sulfate and degradation products thereof; and a novel microorganism.Type: GrantFiled: April 19, 2001Date of Patent: October 24, 2006Assignee: Takara Bio Inc.Inventors: Takeshi Sakai, Kumiko Ishizuka, Kaoru Kojima, Kazuo Shimanaka, Katsushige Ikai, Ikunoshin Kato
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Publication number: 20060166335Abstract: Three enzymes degrading sulfated glucuronofucan; processes for producing these enzymes; activators for these enzymes; glucuronofucan sulfate and degradation products thereof; and a novel microorganism.Type: ApplicationFiled: March 14, 2006Publication date: July 27, 2006Applicant: TAKARA BIO INC.Inventors: Takeshi Sakai, Kumiko Ishizuka, Kaoru Kojima, Kazuo Shimanaka, Katsushige Ikai, Ikunoshin Kato
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Patent number: 6927289Abstract: A smaller molecule obtainable by allowing a sulfated fucan-digesting enzyme which digests a novel sulfated polysaccharide derived from an alga belonging to Laminariales to act on a sulfated fucan, and a method for producing the same.Type: GrantFiled: October 28, 2003Date of Patent: August 9, 2005Assignee: Takara Bio Inc.Inventors: Takeshi Sakai, Hitomi Amarume, Takashi Kawai, Kaoru Kojima, Kazuo Shimanaka, Katsushige Ikai, Ikunoshin Kato
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Publication number: 20040146995Abstract: A smaller molecule obtainable by allowing a sulfated fucan-digesting enzyme which digests a novel sulfated polysaccharide derived from an alga belonging to Laminariales to act on a sulfated fucan, and a method for producing the same.Type: ApplicationFiled: October 28, 2003Publication date: July 29, 2004Applicant: TAKARA BIO INC.Inventors: Takeshi Sakai, Hitomi Amarume, Takashi Kawai, Kaoru Kojima, Kazuo Shimanaka, Katsushige Ikai, Ikunoshin Kato
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Patent number: 6720419Abstract: A smaller molecule obtainable by allowing a sulfated fucan-digesting enzyme which digests a novel sulfated polysaccharide derived from an alga belonging to Laminariales to act on a sulfated fucan, and a method for producing the same.Type: GrantFiled: October 24, 2002Date of Patent: April 13, 2004Assignee: Takara Bio Inc.Inventors: Takeshi Sakai, Hitomi Amarume, Takashi Kawai, Kaoru Kojima, Kazuo Shimanaka, Katsushige Ikai, Ikunoshin Kato
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Publication number: 20030186389Abstract: Three enzymes degrading sulfated glucuronofucan; processes for producing these enzymes; activators for these enzymes; glucuronofucan sulfate and degradation products thereof; and a novel microorganism.Type: ApplicationFiled: October 21, 2002Publication date: October 2, 2003Inventors: Takeshiara Sakai, Kumiko Ishizuka, Kaoru Kojima, Kazuo Shimanaka, Katsushige Ikai, Ikunoshin Kato
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Publication number: 20030176395Abstract: A sulfated saccharide represented by the following formula [I] or a sulfated polysaccharide where the said sulfated saccharide is an essential component of the constituting sugar as well as a salt thereof.Type: ApplicationFiled: February 18, 2003Publication date: September 18, 2003Inventors: Takeshi Sakai, Hitomi Kimura, Kaoru Katayama, Kazuo Shimanaka, Katsushige Ikai, Ikunoshin Kato
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Publication number: 20030171571Abstract: A smaller molecule obtainable by allowing a sulfated fucan-digesting enzyme which digests a novel sulfated polysaccharide derived from an alga belonging to Laminariales to act on a sulfated fucan, and a method for producing the same.Type: ApplicationFiled: October 24, 2002Publication date: September 11, 2003Applicant: TAKARA BIO INC.Inventors: Takeshi Sakai, Hitomi Amarume, Takashi Kawai, Kaoru Kojima, Kazuo Shimanaka, Katsushige Ikai, Ikunoshin Kato
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Patent number: 6593311Abstract: Apoptosis inducers, anticancer drugs and carcinostatic drugs containing sulfated-fucose-containing polysaccharide(s) and/or degradation product(s) thereof, and a method for inducing apoptosis by using sulfated-fucose-containing polysaccharide(s) and/or degradation product(s) thereof as the active ingredient. A degrading enzyme which is useful in the production of the degradation products of sulfated-fucose-containing polysaccharides.Type: GrantFiled: January 29, 2001Date of Patent: July 15, 2003Assignees: Takara Shuzo Co., Ltd., Research Institute for GlycotechnologyInventors: Takeshi Sakai, Hideo Kitano, Fu-Gong Yu, Shinji Nakayama, Kaoru Kojima, Hitomi Kimura, Yoshikuni Nakanishi, Kaoru Katayama, Takanari Tominaga, Kazuo Shimanaka, Katsushige Ikai, Ikunoshin Kato
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Patent number: 6590097Abstract: Sulfated fucogalactan or its salt useful as a reagent for sugar chain engineering or an HGF-production inducer; a degraded product or its salt obtained by treating the sulfated fucogalactan with a sulfated fucogalactan digesting enzyme; the sulfated fucogalactan digesting enzyme useful in sugar chain engineering; a process for producing the degraded product by treating sulfated fucogalactan or its salt with the above enzyme; and a process for producing the sulfated fucogalactan digesting enzyme.Type: GrantFiled: August 16, 2001Date of Patent: July 8, 2003Assignee: Takara Shuzo Co., Ltd.Inventors: Takeshi Sakai, Hitomi Kimura, Kaoru Kojima, Kaoru Katayama, Kazuo Shimanaka, Katsushige Ikai, Ikunoshin Kato
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Patent number: 6337410Abstract: The present invention has its object to provide a noble antifungal substance which is use of as clinical medicine in the therapy of fungal infectious diseases. The present invention is related to an antibiotic TKR459 having the following chemical formula (1) or its pharmacologically acceptable salt.Type: GrantFiled: December 7, 2000Date of Patent: January 8, 2002Assignee: Takara Shuzo Co., Ltd.Inventors: Kazutoh Takesako, Mitsuhiro Ueno, Naoyuki Awazu, Kazuo Shimanaka, Ikunoshin Kato
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Publication number: 20010034335Abstract: Apoptosis inducers, anticancer drugs and carcinostatic drugs containing sulfated-fucose-containing polysaccharide(s) and/or degradation product(s) thereof, and a method for inducing apoptosis by using sulfated-fucose-containing polysaccharide(s) and/or degradation product(s) thereof as the active ingredient. A degrading enzyme which is useful in the production of the degradation products of sulfated-fucose-containing polysaccharides.Type: ApplicationFiled: January 29, 2001Publication date: October 25, 2001Inventors: Takeshi Sakai, Hideo Kitano, Fu-Gong Yu, Shinji Nakayama, Kaoru Kojima, Hitomi Kimura, Yoshikuni Nakanishi, Kaoru Katayama, Takanari Tominaga, Kazuo Shimanaka, Katsushige Ikai, Ikunoshin Kato
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Publication number: 20010021520Abstract: The present invention has its object to provide a noble antifungal substance which is use of as clinical medicine in the therapy of fungal infectious diseases.Type: ApplicationFiled: December 7, 2000Publication date: September 13, 2001Inventors: Kazutoh Takesako, Mitsuhiro Ueno, Naoyuki Awazu, Kazuo Shimanaka, Ikunoshin Kato
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Patent number: 6207652Abstract: Apoptosis inducers, anticancer drugs and carcinostatic drugs containing sulfated-fucose-containing polysaccharide(s) and/or degradation product(s) thereof, and a method for inducing apoptosis by using sulfated-fucose-containing polysaccharide(s) and/or degradation product(s) thereof as the active ingredient. A degrading enzyme which is useful in the production of the degradation products of sulfated-fucose-containing polysaccharides.Type: GrantFiled: April 9, 1998Date of Patent: March 27, 2001Assignees: Takara Shuzo Co., Ltd., Research Institute for GlycotechnologyInventors: Takeshi Sakai, Hideo Kitano, Fu-Gong Yu, Shinji Nakayama, Kaoru Kojima, Hitomi Kimura, Yoshikuni Nakanishi, Kaoru Katayama, Takanari Tominaga, Kazuo Shimanaka, Katsushige Ikai, Ikunoshin Kato
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Patent number: 5260214Abstract: An antibiotic R106 represented by the general formula I): ##STR1## wherein: R is methyl or ethyl;X.sub.1 is MePhe, .beta.-HOMePhe or Phe;X.sub.2 is allo-Ile, Val or Leu;X.sub.3 is MeVal or Val;X.sub.4 is .beta.-HOMeVal, .gamma.-HOMeVal, MeVal, Val, N,.beta.-MeAsp, .beta.-HOMePhe, MePhe, MeDH.sub.2,3 Val or MeDH.sub.3,4 Valis produced by a process which comprises culturing a strain of the genus Aureobasidium that is capable of producing the said antibiotic R106 and collecting the said antibiotic from the fermentation broth. The antibiotic R106 compounds are useful in the treatment of fungal infection.Type: GrantFiled: March 30, 1992Date of Patent: November 9, 1993Assignee: Takara Shuzo Co.Inventors: Kazutoh Takesako, Katsushige Ikai, Kazuo Shimanaka, Junko Yamamoto, Fumiyo Haruna, Teruya Nakamura, Hideyo Yamaguchi, Katsuhisa Uchida
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Patent number: 5200505Abstract: There are provided R106 compounds represented by the following general formula (I): ##STR1## wherein: A.sub.1 is Phe, o-FPhe, m-FPhe, or Tyr;A.sub.2 is MePhe, o-FMePhe, m-FMePhe, MeTyr, Sar, MeSery, or .beta.-oxoMePhe;A.sub.3 is Pro, 4Hyp, or SPro;A.sub.4 is allo-Ile or Nle;A.sub.5 is Leu or Nva;A.sub.6 is .beta.-HOMeVal or Sar;excluding those wherein A.sub.1 is Phe and A.sub.2 is MePhe and A.sub.3 is Pro and A.sub.4 is allo-Ile and A.sub.5 is Leu and A.sub.6 is .beta.-HOMeVal (SEQ ID No. 4), which are useful as therapeutic agents for fungal infection.Type: GrantFiled: January 22, 1991Date of Patent: April 6, 1993Assignee: Takara Shuzo Co., Ltd.Inventors: Kazutoh Takesako, Katsushige Ikai, Kazuo Shimanaka, Junko Yamamoto, Fumiyo Haruna, Teruya Nakamura, Hideyo Yamaguchi, Katsuhisa Uchida
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Patent number: 5158876Abstract: An antibiotic R106 represented by the general formula (I): ##STR1## wherein: R is methyl or ethyl;X.sub.1 is MePhe, .beta.-HOMePhe or Phe;X.sub.2 is allo-Ile, Val or Leu;X.sub.3 is MeVal or Val;X.sub.4 is .beta.-HOMeVal, .gamma.HOMeVal, MeVal, Val, N,.beta.-MeAsp, .beta.-HOMePhe, MePhe, MeDH.sub.2,3 Val or MeDH.sub.3,4 Valis produced by a process which comprises culturing a strain of the genus Aureobasidium that is capable of producing the said antibiotic R106 and collecting the said antibiotic from the fermentation broth. The antibiotic R106 compounds are useful in the treatment of fungal infection.Type: GrantFiled: February 2, 1991Date of Patent: October 27, 1992Assignee: Takara Shuzo Co., Ltd.Inventors: Kazutoh Takesako, Katsushige Ikai, Kazuo Shimanaka, Junko Yamamoto, Fumiyo Haruna, Teruya Nakamura, Hideyo Yamaguchi, Katsuhisa Uchida
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Patent number: 5057493Abstract: An antibiotic R106 represented by the general formula (I): ##STR1## wherein: R is methyl or ethyl;X.sub.1 is MePhe, .beta.-HOMePhe or Phe;X.sub.2 is allo-Ile, Val or Leu;X.sub.3 is MeVal or Val;X.sub.4 is .beta.-HOMeVal, .gamma.-HOMeVal, MeVal, Val, N,.beta.-MeAsp, .beta.-HOMePhe, MePhe, MeDH.sub.2,3 Val or MeDH.sub.3,4 Valis produced by a process which comprises culturing a strain of the genus Aureobasidium that is capable of producing the said antibiotic R106 and collecting the said antibiotic from the fermentation broth. The antibiotic R106 compounds are useful in the treatment of fungal infection.Type: GrantFiled: July 13, 1989Date of Patent: October 15, 1991Assignee: Takara Shuzo Co., Ltd.Inventors: Kazutoh Takesako, Katsushige Ikai, Kazuo Shimanaka, Junko Yamamoto, Fumiyo Haruna, Teruya Nakamura, Hideyo Yamaguchi, Katsuhisa Uchida