Patents by Inventor Kazuo Teramoto

Kazuo Teramoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200246776
    Abstract: An objective of the present disclosure is to provide an adsorption material that has a carrier material with retained physical strength, and efficiently adsorbs an immunosuppressive protein. The present disclosure provides an adsorption material for immunosuppressive protein. The adsorption material includes a water-insoluble carrier to which at least one nitrogen-containing compound selected from a polyamine represented by a predetermined formula and aliphatic amines represented by predetermined formulae is bound. A total content of amino groups on the water-insoluble carrier is more than 0 ?mol and 2500 ?mol or less per 1 g, and a content of primary amino groups on the water-insoluble carrier is 450 ?mol or less per 1 g.
    Type: Application
    Filed: September 7, 2018
    Publication date: August 6, 2020
    Applicants: TORAY INDUSTRIES, INC., NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE
    Inventors: Junichi KASUYA, Ryo MATSUNAGA, Yoshiyuki UENO, Yuji UEDA, Kazuo TERAMOTO, Kazumasa OGASAWARA
  • Publication number: 20200215253
    Abstract: An objective of the present disclosure is to provide an adsorption material that can selectively adsorb immunosuppressive leukocyte. The present disclosure provides an adsorption material for immunosuppressive leukocyte. The adsorption material includes a water-insoluble carrier to which at least one nitrogen-containing compound selected from a polyamine represented by a predetermined formula and aliphatic amines represented by predetermined formulae are bound. A form of the water-insoluble carrier is a fiber or a particle, a diameter of the fiber or the particle is 15 to 50 ?m, and an arithmetic mean roughness of a surface of the water-insoluble carrier is 0.1 to 3.0 ?m.
    Type: Application
    Filed: September 7, 2018
    Publication date: July 9, 2020
    Applicants: TORAY INDUSTRIES, INC., NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE
    Inventors: Yoshiyuki UENO, Junichi KASUYA, Toru ARAKANE, Ryo MATSUNAGA, Yumiko SEKIYA, Yuji UEDA, Kazuo TERAMOTO, Kazumasa OGASAWARA
  • Patent number: 9127250
    Abstract: This invention discloses an immunosuppressive cell-capturing material comprising a molded body that includes: a readily hydrolyzable condensation polymer having an amino group; a poorly hydrolyzable polymer coating the readily hydrolyzable condensation polymer; and a ligand-conjugated poorly hydrolyzable polymer coating the poorly hydrolyzable polymer, wherein the ligand is at least one selected from the group consisting of a NH2 group, a secondary amino group, a tertiary amino group, a polyamine residue, a basic cyclic polypeptide residue, an aminoglycosidic compound residue, chloroquine, primaquine, mefloquine, imiquimod, and nystatin, and wherein the content of the amino group in the molded body is 150 ?mol/g or less. The invention also discloses an immunosuppressive cell-capturing column filled with the capturing material.
    Type: Grant
    Filed: March 27, 2012
    Date of Patent: September 8, 2015
    Assignee: Shiga University of Medical Science
    Inventors: Kazumasa Ogasawara, Kazuo Teramoto, Yuji Ueda, Yasushi Itoh, Hirohito Ishigaki
  • Patent number: 8932590
    Abstract: An adsorbent for immunosuppressive substance, which can adsorb an excessive immunosuppressive substance directly from a body fluid, can carry out extracorporeal perfusion safely and can be utilized in treatment of cancer. The excessive immunosuppressive substance may be involved in growth of cancer cells. The adsorbent for immunosuppressive substance includes a water-insoluble carrier and a hydrophilic amino group immobilized to the water-insoluble carrier. An extracorporeal perfusion column contains the adsorbent of the invention. A method for treating cancer carries out extracorporeal perfusion using the extracorporeal perfusion column. A method of adsorbing the transforming growth factor ? which is combined with another protein, includes adsorbing the transforming growth factor ? and protein on an adsorbent containing a water-insoluble carrier to which quaternary ammonium groups each having 3 to 18 carbon atoms per one nitrogen atom are attached, and having a specific surface area of 0.
    Type: Grant
    Filed: June 15, 2011
    Date of Patent: January 13, 2015
    Assignee: TORAY Industries, Inc.
    Inventors: Kazuo Teramoto, Toshio Yoshioka, Masaaki Shimagaki, Takeo Matsunase, Koji Watanabe, Yuji Ueda, Yoshiki Yamamoto
  • Publication number: 20140017667
    Abstract: This invention discloses an immunosuppressive cell-capturing material comprising a molded body that includes: a readily hydrolyzable condensation polymer having an amino group; a poorly hydrolyzable polymer coating the readily hydrolyzable condensation polymer; and a ligand-conjugated poorly hydrolyzable polymer coating the poorly hydrolyzable polymer, wherein the ligand is at least one selected from the group consisting of a NH2 group, a secondary amino group, a tertiary amino group, a polyamine residue, a basic cyclic polypeptide residue, an aminoglycosidic compound residue, chloroquine, primaquine, mefloquine, imiquimod, and nystatin, and wherein the content of the amino group in the molded body is 150 ?mol/g or less. The invention also discloses an immunosuppressive cell-capturing column filled with the capturing material.
    Type: Application
    Filed: March 27, 2012
    Publication date: January 16, 2014
    Applicant: SHIGA UNIVERSITY OF MEDICAL SCIENCE
    Inventors: Kazumasa Ogasawara, Kazuo Teramoto, Yuji Ueda, Yasushi Itoh, Hirohito Ishigaki
  • Patent number: 8584869
    Abstract: The present invention provides an absorbent which can remove cells present in blood including activated leukocytes such as granulocytes and monocytes, and cancer cells as well as can remove cytokines which facilitate the activation of the remaining cells, and further has no concern for pressure loss and has high configuration stability. That is, the present invention provides an absorbent which absorbs the granulocytes and the monocytes in blood, an absorbent for cancer therapy which absorbs an immunosuppressive protein and an absorbent having a bilayer structure of a net and a nonwoven fabric, having a zeta potential of ?20 mV or more, as well as a blood circulation column containing any of the absorbents filled therein.
    Type: Grant
    Filed: March 31, 2006
    Date of Patent: November 19, 2013
    Assignee: Toray Industries, Inc.
    Inventors: Masaaki Shimagaki, Yasufumi Yamamura, Katsuhisa Sato, Kazuo Teramoto, Takeshige Oozeki, Shigehisa Wada
  • Patent number: 8328973
    Abstract: Disclosed is a method of manufacturing a radial tire for a construction vehicle, wherein when a cylindrical band is formed by using one layer of carcass layer formed of steel cords in a band making step, a shape retaining layer formed of at least one layer of organic fiber cords is wrapped on the outer peripheral surface of the carcass layer so that the organic fiber cords cross the steel cords of the carcass layer. The radial tire having excellent uniformity without any uneven widening between the steel cords can be provided without using a shape retaining auxiliary apparatus.
    Type: Grant
    Filed: October 1, 2004
    Date of Patent: December 11, 2012
    Assignee: The Yokohama Rubber Co., Ltd.
    Inventors: Ken Takahashi, Kazuo Teramoto, Tsuyoshi Maekawa
  • Publication number: 20110240560
    Abstract: An adsorbent for immunosuppressive substance, which can adsorb an excessive immunosuppressive substance directly from a body fluid, can carry out extracorporeal perfusion safely and can be utilized in treatment of cancer. The excessive immunosuppressive substance may be involved in growth of cancer cells. The adsorbent for immunosuppressive substance includes a water-insoluble carrier and a hydrophilic amino group immobilized to the water-insoluble carrier. An extracorporeal perfusion column contains the adsorbent of the invention. A method for treating cancer carries out extracorporeal perfusion using the extracorporeal perfusion column. A method of adsorbing the transforming growth factor ? which is combined with another protein, includes adsorbing the transforming growth factor ? and protein on an adsorbent containing a water-insoluble carrier to which quaternary ammonium groups each having 3 to 18 carbon atoms per one nitrogen atom are attached, and having a specific surface area of 0.
    Type: Application
    Filed: June 15, 2011
    Publication date: October 6, 2011
    Inventors: Kazuo Teramoto, Toshio Yoshioka, Masaaki Shimagaki, Takeo Matsunase, Koji Watanabe, Yuji Ueda, Yoshiki Yamamoto
  • Publication number: 20090275874
    Abstract: The present invention provides an absorbent which can remove cells present in blood including activated leukocytes such as granulocytes and monocytes, and cancer cells as well as can remove cytokines which facilitate the activation of the remaining cells, and further has no concern for pressure loss and has high configuration stability. That is, the present invention provides an absorbent which absorbs the granulocytes and the monocytes in blood, an absorbent for cancer therapy which absorbs an immunosuppressive protein and an absorbent having a bilayer structure of a net and a nonwoven fabric, having a zeta potential of ?20 mV or more, as well as a blood circulation column containing any of the absorbents filled therein.
    Type: Application
    Filed: March 31, 2006
    Publication date: November 5, 2009
    Applicant: TORAY INDUSTRIES, INC.
    Inventors: Masaaki Shimagaki, Yasufumi Yamamura, Katsuhisa Sato, Kazuo Teramoto, Takeshige Oozeki, Shigehisa Wada
  • Publication number: 20070199639
    Abstract: Disclosed is a method of manufacturing a radial tire for a construction vehicle, wherein when a cylindrical band is formed by using one layer of carcass layer formed of steel cords in a band making step, a shape retaining layer formed of at least one layer of organic fiber cords is wrapped on the outer peripheral surface of the carcass layer so that the organic fiber cords cross the steel cords of the carcass layer. The radial tire having excellent uniformity without any uneven widening between the steel cords can be provided without using a shape retaining auxiliary apparatus.
    Type: Application
    Filed: October 1, 2004
    Publication date: August 30, 2007
    Inventors: Ken Takahashi, Kazuo Teramoto, Tsuyoshi Maekawa
  • Publication number: 20060165647
    Abstract: An object of this invention is to provide an adsorbent for immunosuppressive substance, which adsorbent can highly efficiently and selectively adsorb an excessive immunosuppressive substance directly from the body fluid, can carry out extracorporeal perfusion safely and can be utilized in treatment of cancer. Such an excessive immunosuppressive substance may be involved in growth of cancer cells. An adsorbent for immunosuppressive substance of the invention includes a water-insoluble carrier and a hydrophilic amino group immobilized to the water-insoluble carrier. An extracorporeal perfusion column of the invention contains the adsorbent of the invention. A method for treating cancer of the invention carries out extracorporeal perfusion using the extracorporeal perfusion column of the invention.
    Type: Application
    Filed: April 3, 2003
    Publication date: July 27, 2006
    Inventors: Kazuo Teramoto, Toshio Yoshioka, Masaaki Shimagaki, Takeo Matsunase, Koji Watanabe, Yuji Ueda, Yoshiki Yamamoto
  • Patent number: 5627563
    Abstract: A large multicolor display apparatus displays pictures and animations of high quality with multiple colors. The apparatus is used for advertisement and information purposes. The apparatus comprises unit blocks, which are divided into a plurality of sections. In each of the sections, there is arranged a multicolor display element having a rotary color display member. The color of each unit block is determined by the multicolor display elements disposed in the unit block. Each of the unit blocks, therefore, can display multiple colors, to improve the quality of images displayed on the apparatus. Since the multicolor display elements can be prepared in small sizes, they operate at high speed to display animations and make the apparatus thinner and lighter.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: May 6, 1997
    Assignees: Citizen Watch Co., Ltd., T.I.C.-Citizen Co., Ltd.
    Inventors: Tadahiko Nakagiri, Kazuo Teramoto, Mitsuhiro Okamoto
  • Patent number: 5526016
    Abstract: A large multicolor display apparatus displays pictures and animations of high quality with multiple colors. The apparatus is used for advertisement and information purposes. The apparatus comprises unit blocks, which are divided into a plurality of sections. In each of the sections, there is arranged a multicolor display element having a rotary color display member. The color of each unit block is determined by the multicolor display elements disposed in the unit block. Each of the unit blocks, therefore, can display multiple colors, to improve the quality of images displayed on the apparatus. Since the multicolor display elements can be prepared in small sizes, they operate at high speed to display animations and make the apparatus thinner and lighter.
    Type: Grant
    Filed: February 3, 1995
    Date of Patent: June 11, 1996
    Assignees: Citizen Watch Co., Ltd., T.I.C.-Citizen Co., Ltd.
    Inventors: Tadahiko Nakagiri, Kazuo Teramoto
  • Patent number: 5515075
    Abstract: A large multicolor display apparatus displays pictures and animations of high quality with multiple colors. The apparatus is used for advertisement and information purposes. The apparatus comprises unit blocks, which are divided into a plurality of sections. In each of the sections, there is arranged a multicolor display element having a rotary color display member. The color of each unit block is determined by the multicolor display elements disposed in the unit block. Each of the unit blocks, therefore, can display multiple colors, to improve the quality of images displayed on the apparatus. Since the multicolor display elements can be prepared in small sizes, they operate at high speed to display animations and make the apparatus thinner and lighter.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: May 7, 1996
    Assignees: Citizen Watch Co., Ltd, T.I.C. Citizen Co., Ltd.
    Inventors: Tadahiko Nakagiri, Kazuo Teramoto, Mitsuhiro Okamoto
  • Patent number: 5451438
    Abstract: An aromatic polysulfone polymer, and a molded article thereof, having an aromatic nucleus to which is introduced a group having the following general formula (I):A--CH(R.sup.1)--CO--N(R.sup.2)--CH.sub.2 -- (I)wherein, A is a halogen atom, hydroxyl group, amino compound residual group, acyloxyl group, alkoxyl group, phenoxyl group, or sulfide group, R.sup.1 and R.sup.2 are a hydrogen atom or lower alkyl group, and R.sup.1 and R.sup.2 may be the same or different to a main chain of aromatic polysulfone as a side chain.
    Type: Grant
    Filed: December 28, 1993
    Date of Patent: September 19, 1995
    Assignee: Biomaterial Research Institute Co., Ltd.
    Inventors: Kazuo Teramoto, Naoto Hokari
  • Patent number: 5171738
    Abstract: Lipopolysaccharides derived from the cell walls of Gram-negative bacteria, also known as endotoxins or pyrogens, are immobilized on a solid, insoluble carrier. The blood, blood plasma or blood serum of a tumor-bearing patient is passed over the immobilized lipopolysaccharide-containing blood treating material to treat the patient's tumor.
    Type: Grant
    Filed: August 30, 1989
    Date of Patent: December 15, 1992
    Assignee: Toray Industries, Inc.
    Inventors: Masashi Kodama, Yutaka Katayama, deceased, by Shigemasa Katayama, heir, by Nobuko Katayama, heir, by Yoshimasa Katayama, heir, Toru Tani, Kazuo Teramoto, Mutsuo Murakami
  • Patent number: 4771104
    Abstract: The present invention provides (1) an endotoxin detoxifying material comprising a fibrous carrier to which Polymyxin is fixed, (2) an endotoxin detoxifying material comprising a carrier to which Polymyxin and a basic nitrogen atom are fixed, and (3) a method of removing endotoxin from a fluid by contacting the fluid with the endotoxin detoxifying material comprising a carrier to which Polymyxin is fixed.The present invention makes it possible to contact blood with Polymixin directly and safely and gives a new method of therapy endotoxemia or prophylaxis of endotoxemia.
    Type: Grant
    Filed: March 6, 1987
    Date of Patent: September 13, 1988
    Assignee: Toray Industries, Inc.
    Inventors: Masashi Kodama, Toru Tani, Kazuyoshi Hanazawa, Totaro Oka, Kazuo Teramoto, Shiro Nishiumi
  • Patent number: 4661260
    Abstract: The present invention provides (1) an endotoxin detoxifying material comprising a fibrous carrier to which Polymyxin is fixed, (2) an endotoxin detoxifying material comprising a carrier to which Polymyxin and a basic nitrogen atom are fixed, and (3) a method of removing endotoxin from a fluid by contacting the fluid with the endotoxin detoxifying material comprising a carrier to which Polymyxin is fixed.The present invention makes it possible to contact blood with Polymixin directly and safely and gives a new method of therapy of endotoxemia or prophylaxis of endotoxemia.
    Type: Grant
    Filed: February 21, 1986
    Date of Patent: April 28, 1987
    Assignee: Toray Industries, Inc.
    Inventors: Masashi Kodama, Toru Tani, Kazuyoshi Hanazawa, Totaro Oka, Kazuo Teramoto, Shiro Nishiumi
  • Patent number: 4563425
    Abstract: A metal ion that inhibits enzyme deactivation is bonded to a carrier and inhibits enzyme deactivation when contacted with a substrate for the enzyme. A carrier-bound metal ion such as ions of iron is particularly suitable for inhibiting deactivation of glucose isomerase when isomerizing glucose to fructose. Glucose isomerase life is remarkably prolonged by contacting carrier-bound iron ions with a glucose substrate solution prior to isomerizing with glucose isomerase.
    Type: Grant
    Filed: April 2, 1984
    Date of Patent: January 7, 1986
    Assignee: Toray Industries, Inc.
    Inventors: Toshio Yoshioka, Kazuo Teramoto, Masaharu Shimamura
  • Patent number: 4347316
    Abstract: An enzymatically active product for use in isomerization of glucose into fructose is provided. The active product comprises an organic polymeric material predominantly comprised of a monovinyl aromatic compound polymer having .beta.-aminopropionamidomethyl group as side chains represented by the formula I: ##STR1## wherein R.sub.1 is selected from H, C(1-6) alkyl and C(2-6) hydroxyalkyl, R.sub.2 is selected from C(1-6) alkyl, C(2-6) hydroxyalkyl, ##STR2## (where X, Z.sub.1 and Z.sub.2 are selected from H and C(1-6) alkyl, and n is from 2 to 6), or R.sub.1 and R.sub.2 form together with the N atom, to which R.sub.1 and R.sub.2 are bonded, heterocyclic structure of the formula: ##STR3## where A is --CH.sub.2 --, --O-- or --NR.sub.6 -- (wherein R.sub.6 is H or C(1-6) alkyl), and R.sub.3, R.sub.4 and R.sub.5 are selected from H and methyl. The organic polymeric material has glucose isomerase immobilized with the .beta.-aminopropionamidomethyl group side chain of the organic polymeric material.
    Type: Grant
    Filed: May 22, 1981
    Date of Patent: August 31, 1982
    Assignee: Toray Industries, Inc.
    Inventors: Toshio Yoshioka, Kazuo Teramoto, Masaharu Shimamura