Abstract: An objective of the present disclosure is to provide an adsorption material that has a carrier material with retained physical strength, and efficiently adsorbs an immunosuppressive protein. The present disclosure provides an adsorption material for immunosuppressive protein. The adsorption material includes a water-insoluble carrier to which at least one nitrogen-containing compound selected from a polyamine represented by a predetermined formula and aliphatic amines represented by predetermined formulae is bound. A total content of amino groups on the water-insoluble carrier is more than 0 ?mol and 2500 ?mol or less per 1 g, and a content of primary amino groups on the water-insoluble carrier is 450 ?mol or less per 1 g.

Abstract: An objective of the present disclosure is to provide an adsorption material that has a carrier material with retained physical strength, and efficiently adsorbs an immunosuppressive protein. The present disclosure provides an adsorption material for immunosuppressive protein. The adsorption material includes a water-insoluble carrier to which at least one nitrogen-containing compound selected from a polyamine represented by a predetermined formula and aliphatic amines represented by predetermined formulae is bound. A total content of amino groups on the water-insoluble carrier is more than 0 ?mol and 2500 ?mol or less per 1 g, and a content of primary amino groups on the water-insoluble carrier is 450 ?mol or less per 1 g.

Abstract: An objective of the present disclosure is to provide an adsorption material that can selectively adsorb immunosuppressive leukocyte. The present disclosure provides an adsorption material for immunosuppressive leukocyte. The adsorption material includes a water-insoluble carrier to which at least one nitrogen-containing compound selected from a polyamine represented by a predetermined formula and aliphatic amines represented by predetermined formulae are bound. A form of the water-insoluble carrier is a fiber or a particle, a diameter of the fiber or the particle is 15 to 50 ?m, and an arithmetic mean roughness of a surface of the water-insoluble carrier is 0.1 to 3.0 ?m.

Abstract: This invention discloses an immunosuppressive cell-capturing material comprising a molded body that includes: a readily hydrolyzable condensation polymer having an amino group; a poorly hydrolyzable polymer coating the readily hydrolyzable condensation polymer; and a ligand-conjugated poorly hydrolyzable polymer coating the poorly hydrolyzable polymer, wherein the ligand is at least one selected from the group consisting of a NH2 group, a secondary amino group, a tertiary amino group, a polyamine residue, a basic cyclic polypeptide residue, an aminoglycosidic compound residue, chloroquine, primaquine, mefloquine, imiquimod, and nystatin, and wherein the content of the amino group in the molded body is 150 ?mol/g or less. The invention also discloses an immunosuppressive cell-capturing column filled with the capturing material.

Abstract: An adsorbent for immunosuppressive substance, which can adsorb an excessive immunosuppressive substance directly from a body fluid, can carry out extracorporeal perfusion safely and can be utilized in treatment of cancer. The excessive immunosuppressive substance may be involved in growth of cancer cells. The adsorbent for immunosuppressive substance includes a water-insoluble carrier and a hydrophilic amino group immobilized to the water-insoluble carrier. An extracorporeal perfusion column contains the adsorbent of the invention. A method for treating cancer carries out extracorporeal perfusion using the extracorporeal perfusion column. A method of adsorbing the transforming growth factor ? which is combined with another protein, includes adsorbing the transforming growth factor ? and protein on an adsorbent containing a water-insoluble carrier to which quaternary ammonium groups each having 3 to 18 carbon atoms per one nitrogen atom are attached, and having a specific surface area of 0.

Abstract: This invention discloses an immunosuppressive cell-capturing material comprising a molded body that includes: a readily hydrolyzable condensation polymer having an amino group; a poorly hydrolyzable polymer coating the readily hydrolyzable condensation polymer; and a ligand-conjugated poorly hydrolyzable polymer coating the poorly hydrolyzable polymer, wherein the ligand is at least one selected from the group consisting of a NH2 group, a secondary amino group, a tertiary amino group, a polyamine residue, a basic cyclic polypeptide residue, an aminoglycosidic compound residue, chloroquine, primaquine, mefloquine, imiquimod, and nystatin, and wherein the content of the amino group in the molded body is 150 ?mol/g or less. The invention also discloses an immunosuppressive cell-capturing column filled with the capturing material.

Abstract: The present invention provides an absorbent which can remove cells present in blood including activated leukocytes such as granulocytes and monocytes, and cancer cells as well as can remove cytokines which facilitate the activation of the remaining cells, and further has no concern for pressure loss and has high configuration stability. That is, the present invention provides an absorbent which absorbs the granulocytes and the monocytes in blood, an absorbent for cancer therapy which absorbs an immunosuppressive protein and an absorbent having a bilayer structure of a net and a nonwoven fabric, having a zeta potential of ?20 mV or more, as well as a blood circulation column containing any of the absorbents filled therein.

Abstract: Disclosed is a method of manufacturing a radial tire for a construction vehicle, wherein when a cylindrical band is formed by using one layer of carcass layer formed of steel cords in a band making step, a shape retaining layer formed of at least one layer of organic fiber cords is wrapped on the outer peripheral surface of the carcass layer so that the organic fiber cords cross the steel cords of the carcass layer. The radial tire having excellent uniformity without any uneven widening between the steel cords can be provided without using a shape retaining auxiliary apparatus.

Abstract: An adsorbent for immunosuppressive substance, which can adsorb an excessive immunosuppressive substance directly from a body fluid, can carry out extracorporeal perfusion safely and can be utilized in treatment of cancer. The excessive immunosuppressive substance may be involved in growth of cancer cells. The adsorbent for immunosuppressive substance includes a water-insoluble carrier and a hydrophilic amino group immobilized to the water-insoluble carrier. An extracorporeal perfusion column contains the adsorbent of the invention. A method for treating cancer carries out extracorporeal perfusion using the extracorporeal perfusion column. A method of adsorbing the transforming growth factor ? which is combined with another protein, includes adsorbing the transforming growth factor ? and protein on an adsorbent containing a water-insoluble carrier to which quaternary ammonium groups each having 3 to 18 carbon atoms per one nitrogen atom are attached, and having a specific surface area of 0.

Abstract: The present invention provides an absorbent which can remove cells present in blood including activated leukocytes such as granulocytes and monocytes, and cancer cells as well as can remove cytokines which facilitate the activation of the remaining cells, and further has no concern for pressure loss and has high configuration stability. That is, the present invention provides an absorbent which absorbs the granulocytes and the monocytes in blood, an absorbent for cancer therapy which absorbs an immunosuppressive protein and an absorbent having a bilayer structure of a net and a nonwoven fabric, having a zeta potential of ?20 mV or more, as well as a blood circulation column containing any of the absorbents filled therein.

Abstract: Disclosed is a method of manufacturing a radial tire for a construction vehicle, wherein when a cylindrical band is formed by using one layer of carcass layer formed of steel cords in a band making step, a shape retaining layer formed of at least one layer of organic fiber cords is wrapped on the outer peripheral surface of the carcass layer so that the organic fiber cords cross the steel cords of the carcass layer. The radial tire having excellent uniformity without any uneven widening between the steel cords can be provided without using a shape retaining auxiliary apparatus.

Abstract: An object of this invention is to provide an adsorbent for immunosuppressive substance, which adsorbent can highly efficiently and selectively adsorb an excessive immunosuppressive substance directly from the body fluid, can carry out extracorporeal perfusion safely and can be utilized in treatment of cancer. Such an excessive immunosuppressive substance may be involved in growth of cancer cells. An adsorbent for immunosuppressive substance of the invention includes a water-insoluble carrier and a hydrophilic amino group immobilized to the water-insoluble carrier. An extracorporeal perfusion column of the invention contains the adsorbent of the invention. A method for treating cancer of the invention carries out extracorporeal perfusion using the extracorporeal perfusion column of the invention.

Abstract: A large multicolor display apparatus displays pictures and animations of high quality with multiple colors. The apparatus is used for advertisement and information purposes. The apparatus comprises unit blocks, which are divided into a plurality of sections. In each of the sections, there is arranged a multicolor display element having a rotary color display member. The color of each unit block is determined by the multicolor display elements disposed in the unit block. Each of the unit blocks, therefore, can display multiple colors, to improve the quality of images displayed on the apparatus. Since the multicolor display elements can be prepared in small sizes, they operate at high speed to display animations and make the apparatus thinner and lighter.

Abstract: A large multicolor display apparatus displays pictures and animations of high quality with multiple colors. The apparatus is used for advertisement and information purposes. The apparatus comprises unit blocks, which are divided into a plurality of sections. In each of the sections, there is arranged a multicolor display element having a rotary color display member. The color of each unit block is determined by the multicolor display elements disposed in the unit block. Each of the unit blocks, therefore, can display multiple colors, to improve the quality of images displayed on the apparatus. Since the multicolor display elements can be prepared in small sizes, they operate at high speed to display animations and make the apparatus thinner and lighter.

Abstract: A large multicolor display apparatus displays pictures and animations of high quality with multiple colors. The apparatus is used for advertisement and information purposes. The apparatus comprises unit blocks, which are divided into a plurality of sections. In each of the sections, there is arranged a multicolor display element having a rotary color display member. The color of each unit block is determined by the multicolor display elements disposed in the unit block. Each of the unit blocks, therefore, can display multiple colors, to improve the quality of images displayed on the apparatus. Since the multicolor display elements can be prepared in small sizes, they operate at high speed to display animations and make the apparatus thinner and lighter.

Abstract: An aromatic polysulfone polymer, and a molded article thereof, having an aromatic nucleus to which is introduced a group having the following general formula (I):A--CH(R.sup.1)--CO--N(R.sup.2)--CH.sub.2 -- (I)wherein, A is a halogen atom, hydroxyl group, amino compound residual group, acyloxyl group, alkoxyl group, phenoxyl group, or sulfide group, R.sup.1 and R.sup.2 are a hydrogen atom or lower alkyl group, and R.sup.1 and R.sup.2 may be the same or different to a main chain of aromatic polysulfone as a side chain.

Abstract: Lipopolysaccharides derived from the cell walls of Gram-negative bacteria, also known as endotoxins or pyrogens, are immobilized on a solid, insoluble carrier. The blood, blood plasma or blood serum of a tumor-bearing patient is passed over the immobilized lipopolysaccharide-containing blood treating material to treat the patient's tumor.

Abstract: The present invention provides (1) an endotoxin detoxifying material comprising a fibrous carrier to which Polymyxin is fixed, (2) an endotoxin detoxifying material comprising a carrier to which Polymyxin and a basic nitrogen atom are fixed, and (3) a method of removing endotoxin from a fluid by contacting the fluid with the endotoxin detoxifying material comprising a carrier to which Polymyxin is fixed.The present invention makes it possible to contact blood with Polymixin directly and safely and gives a new method of therapy endotoxemia or prophylaxis of endotoxemia.

Abstract: The present invention provides (1) an endotoxin detoxifying material comprising a fibrous carrier to which Polymyxin is fixed, (2) an endotoxin detoxifying material comprising a carrier to which Polymyxin and a basic nitrogen atom are fixed, and (3) a method of removing endotoxin from a fluid by contacting the fluid with the endotoxin detoxifying material comprising a carrier to which Polymyxin is fixed.The present invention makes it possible to contact blood with Polymixin directly and safely and gives a new method of therapy of endotoxemia or prophylaxis of endotoxemia.

Abstract: A metal ion that inhibits enzyme deactivation is bonded to a carrier and inhibits enzyme deactivation when contacted with a substrate for the enzyme. A carrier-bound metal ion such as ions of iron is particularly suitable for inhibiting deactivation of glucose isomerase when isomerizing glucose to fructose. Glucose isomerase life is remarkably prolonged by contacting carrier-bound iron ions with a glucose substrate solution prior to isomerizing with glucose isomerase.