Patents by Inventor Kazuro Shiomi
Kazuro Shiomi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20170215422Abstract: An objective of the present invention is to provide novel cyclic depsipeptide derivatives and harmful organism control agents including the same as each other. Specifically, the present invention provides compounds represented by formula (1) or stereoisomers thereof, harmful organism control agents containing them, and a process for producing them.Type: ApplicationFiled: April 17, 2017Publication date: August 3, 2017Inventors: Masaaki MITOMI, Masayo SAKAI, Ryo HORIKOSHI, Yasumichi ONOZAKI, Satoshi NAKAMURA, Satoshi OMURA, Toshiaki SUNAZUKA, Tomoyasu HIROSE, Kazuro SHIOMI, Rokuro MASUMA
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Publication number: 20150166608Abstract: An objective of the present invention is to provide novel cyclic depsipeptide derivatives and harmful organism control agents including the same as each other. Specifically, the present invention provides compounds represented by formula (1) or stereoisomers thereof, harmful organism control agents containing them, and a process for producing them.Type: ApplicationFiled: June 13, 2013Publication date: June 18, 2015Inventors: Masaaki Mitomi, Masayo Sakai, Ryo Horikoshi, Yasumichi Onozaki, Satoshi Nakamura, Satoshi Omura, Toshiaki Sunazuka, Tomoyasu Hirose, Kazuro Shiomi, Rokuro Masuma
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Patent number: 9000194Abstract: The present invention addresses the problem of providing an anti-trypanosomal drug having a novel skeleton, in order to solve issues that occur with conventional technologies. The present invention is based on the discovery of a microbe that produces an anti-trypanosomal drug having a novel skeleton. Specifically, this invention provides: a compound indicated by formula (I) having a trypanosomal inhibitory activity; an analog thereof; a production method therefor; and a Lechevalieria sp. K10-0216 strain that produces said compound.Type: GrantFiled: August 31, 2012Date of Patent: April 7, 2015Assignee: The Kitasato InstituteInventors: Satoshi Omura, Yoko Takahashi, Takuji Nakashima, Kazuhiko Otoguro, Kazuro Shiomi, Masato Iwatsuki, Atsuko Matsumoto
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Publication number: 20140206889Abstract: [Problem] The present invention addresses the problem of providing an anti-trypanosomal drug having a novel skeleton, in order to solve issues that occur with conventional technologies. [Solution] The present invention is based on the discovery of a microbe that produces an anti-trypanosomal drug having a novel skeleton. Specifically, this invention provides: a compound indicated by formula (I) having a trypanosomal inhibitory activity; an analog thereof; a production method therefor; and a Lechevalieria sp. Kl0-0216 strain that produces said compound.Type: ApplicationFiled: August 31, 2012Publication date: July 24, 2014Applicant: THE KITASATO INSTITUTEInventors: Satoshi Omura, Yoko Takahashi, Takuji Nakashima, Kazuhiko Otoguro, Kazuro Shiomi, Masato Iwatsuki, Atsuko Matsumoto
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Patent number: 8269051Abstract: The present invention includes wickerol and a method for producing the wickerol. In the method for producing the wickerol, Trichoderma atroviride strain FKI-3737 (FERM ABP-11099 corresponding to FERM BP-11099) belonging to filamentous fungi is cultured in a medium, and the wickerol is accumulated in a culture, and then the produced wickerol is isolated and purified from the culture. A substance having inhibitory activity against influenza virus replication and containing the wickerol as an active ingredient, and an anti-influenza drug containing the wickerol as an active ingredient are obtained.Type: GrantFiled: March 12, 2009Date of Patent: September 18, 2012Assignee: The Kitasato InstituteInventors: Satoshi Omura, Kazuro Shiomi, Rokuro Masuma, Hideaki Ui, Takayuki Nagai, Haruki Yamada
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Publication number: 20110021848Abstract: The present invention includes wickerol and a method for producing the wickerol. In the method for producing the wickerol, Trichoderma atroviride strain FKI-3737 (FERM ABP-11099 corresponding to FERM BP-11099) belonging to filamentous fungi is cultured in a medium, and the wickerol is accumulated in a culture, and then the produced wickerol is isolated and purified from the culture. A substance having inhibitory activity against influenza virus replication and containing the wickerol as an active ingredient, and an anti-influenza drug containing the wickerol as an active ingredient are obtained.Type: ApplicationFiled: March 12, 2009Publication date: January 27, 2011Applicant: THE KITASATO INSTITUTEInventors: Satoshi Omura, Kazuro Shiomi, Rokuro Masuma, Hideaki Ui, Takayuki Nagai, Haruki Yamada
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Patent number: 7541336Abstract: The present invention is comprised of culturing microorganism having ability to produce FKI-1033 substance represented by the formula: in a medium, accumulating FKI-1033 substance in the cultured medium, and isolating FKI-1033 substance from the cultured mass. The thus obtained FKI-1033 substance has ryanodine binding inhibition activity, insecticidal activity and anthelmintic activity, and is expected as useful drugs as agrochemicals, veterinary drugs and medicaments in effectiveness and toxicity.Type: GrantFiled: November 12, 2002Date of Patent: June 2, 2009Assignee: The Kitasato InstituteInventors: Satoshi Omura, Kazuro Shiomi, Rokuro Masuma
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Patent number: 7514455Abstract: An electron transport system complex II inhibitor comprising 2-pyridinol derivative represented by the general formula [I] wherein R is alkyl or alkenyl optionally having substituent containing halogen, or its tautomer 2-pyridone derivative represented by the general formula [II] wherein R is alkyl or alkenyl optionally having substituent containing halogen, or salt thereof as an active ingredient. The compound inhibits the complex II strongly with nM order activity. Consequently, 2-pyridinol derivative or its tautomer, 2-pyridone derivative, are useful as the complex II inhibitor.Type: GrantFiled: June 10, 2002Date of Patent: April 7, 2009Assignee: The Kitasato InstituteInventors: Satoshi Omura, Kazuro Shiomi, Hiroshi Tomoda, Rokuro Masuma, Kiyoshi Kita
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Patent number: 7132447Abstract: The present invention is comprised of culturing microorganism having ability to produce FKI-1083 substance represented by the formula: in a medium, accumulating FKI-1083 substance in the cultured medium, and isolating FKI-1083 substance from the cultured mass. The thus obtained FKI-1083 substance has growth inhibitory activities against microorganisms, nematodes and arthropods, and is useful as anthelmintic and insecticide.Type: GrantFiled: December 11, 2001Date of Patent: November 7, 2006Assignee: The Kitasato InstituteInventors: Satoshi Omura, Kazuro Shiomi, Rokuro Masuma
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Publication number: 20060111280Abstract: The present invention is comprised of culturing microorganism having ability to produce FKI-1033 substance represented by the formula: in a medium, accumulating FKI-1033 substance in the cultured medium, and isolating FKI-1033 substance from the cultured mass. The thus obtained FKI-1033 substance has ryanodine binding inhibition activity, insecticidal activity and anthelmintic activity, and is expected as useful drugs as agrochemicals, veterinary drugs and medicaments in effectiveness and toxicity.Type: ApplicationFiled: November 12, 2002Publication date: May 25, 2006Inventors: Satoshi Omura, Kazuro Shiomi, Rokuro Masuma
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Publication number: 20050148592Abstract: The invention relates to the use of riboflavin and of flavin derivatives with chitinase-inhibitory action for controlling arthropods, nematodes and chitin-containing fungi.Type: ApplicationFiled: February 28, 2005Publication date: July 7, 2005Applicant: Bayer AktiengesellschaftInventors: Andreas Turberg, Volker Gutsmann, Satosho Omura, Kazuro Shiomi
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Patent number: 6875766Abstract: The invention relates to the use of riboflavin and of flavin derivatives with chitinase-inhibitory action for controlling arthropods, nematodes and chitin-containing fungi.Type: GrantFiled: September 10, 2001Date of Patent: April 5, 2005Assignee: Bayer AGInventors: Andreas Turberg, Volker Gutsmann, Satosho Omura, Kazuro Shiomi
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Publication number: 20050032883Abstract: The present invention is comprised of culturing microorganism having ability to produce FKI-1083 substance represented by the formula: in a medium, accumulating FKI-1083 substance in the cultured medium, and isolating FKI-1083 substance from the cultured mass. The thus obtained FKI-1083 substance has growth inhibitory activities against microorganisms, nematodes and arthropods, and is useful as anthelmintic and insecticide.Type: ApplicationFiled: December 11, 2001Publication date: February 10, 2005Inventors: Satoshi Omura, Kazuro Shiomi, Rokuro Masuma
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Publication number: 20040266835Abstract: An electron transport system complex II inhibitor comprising 2-pyridinol derivative represented by the general formula [I] 1Type: ApplicationFiled: August 17, 2004Publication date: December 30, 2004Inventors: Satoshi Omura, Kazuro Shiomi, Hiroshi Tomoda, Rokuro Masuma, Kiyoshi Kita
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Patent number: 6835747Abstract: The present invention relates to obtain novel FT-0554A substance useful for infectious disease of parasite, especially helminth and more particularly relates to the novel FT-0554A substance represented by the following formula [I] or the tautomer thereof represented by the formula [II] obtained by treating FT-0554 substance represented by the formula [II] under alkaline condition.Type: GrantFiled: July 28, 2003Date of Patent: December 28, 2004Assignee: The Kitasato InstituteInventors: Satoshi Omura, Kazuro Shiomi, Tohru Nagamitsu, Toshiaki Sunazuka, Yuzuru Iwai
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Publication number: 20030191091Abstract: The invention relates to the use of riboflavin and of flavin derivatives with chitinase-inhibitory action for controlling arthropods, nematodes and chitin-containing fungi.Type: ApplicationFiled: March 14, 2003Publication date: October 9, 2003Inventors: Andreas Turberg, Volker Gutsmann, Satosho Omura, Kazuro Shiomi
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Patent number: 6486197Abstract: The present invention is to obtain novel FT-0554 substance which is useful for treatment of helminthiasis. The present invention comprising the steps of culturing the microorganism belonging to fungi having producing activity of FT-0554 substance represented by the following formula [I] subjected ho accumulation of FT-0554 substance in the cultured medium, and isolating FT-0554 substance from the said cultured mass. The medicament useful for treatment of parasitic infection, specifically helminthiasis can be obtained.Type: GrantFiled: August 3, 2000Date of Patent: November 26, 2002Assignee: The Kitasato InstituteInventors: Satoshi Omura, Kazuro Shiomi, Rokuro Masuma, Yuzuru Iwai
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Publication number: 20020156126Abstract: The present invention is to obtain novel FT-0554 substance which is useful for treatment of helminthiasis.Type: ApplicationFiled: April 12, 2002Publication date: October 24, 2002Applicant: THE KITASATO INSTITUTEInventors: Satoshi Omura, Kazuro Shiomi, Rokuro Masuma, Yuzuru Iwai
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Patent number: 5336783Abstract: A novel calpain inhibitory active and low molecular weight substance, cystamidin A and its production are provided. Cystamidin A of the following formula ##STR1## was produced by culturing Streptomyces sp. KP-1241 FERM BP-41 71 in a nutrient medium and isolating the active substance from the cultured mass.Type: GrantFiled: March 23, 1993Date of Patent: August 9, 1994Assignee: The Kitasato InstituteInventors: Satoshi Omura, Haruo Tanaka, Kazuro Shiomi, Jing R. Liu