Abstract: The invention discloses a direct interaction between D-type cyclins and a novel myb-like transcription factor, DMP1, which specifically interacts with cyclin D2. The present invention also provides evidence that D-type cyclins regulate gene expression in an RB-independent manner. Also included is DMP1, the transcription factor composed of a central DNA-binding domain containing three atypical myb repeats flanked by highly acidic segments located at its amino- and carboxyterminal ends. The invention includes amino acid sequences coding for DMP1, and DNA and RNA nucleotide sequences that encode the amino acid sequences. A use of DMP1 as a transcription factor is disclosed due to its specificity in binding to oligonucleotides containing the nonamer consensus sequence CCCG(G/T)ATGT. In this aspect of the invention, DMP1 when transfected into mammalian cells, activates the transcription of a reporter gene driven by a minimal promoter containing concatamerized DMP1 binding sites.

Abstract: The invention discloses a direct interaction between D-type cyclins and a novel myb-like transcription factor, DMP1, which specifically interacts with cyclin D2. The present invention also provides evidence that D-type cyclins regulate gene expression in an RB-independent manner. Also included is DMP1, the transcription factor composed of a central DNA-binding domain containing three atypical myb repeats flanked by highly acidic segments located at its amino- and carboxyterminal ends. The invention includes amino acid sequences coding for DMP1, and DNA and RNA nucleotide sequences that encode the amino acid sequences. A use of DMP1 as a transcription factor is disclosed due to its specificity in binding to oligonucleotides containing the nonamer consensus sequence CCCG(G/T)ATGT. In this aspect of the invention, DMP1 when transfected into mammalian cells, activates the transcription of a reporter gene driven by a minimal promoter containing concatamerized DMP1 binding sites.

Abstract: The invention discloses a direct interaction between D-type cyclins and a novel myb-like transcription factor, DMP1, which specifically interacts with cyclin D2. The present invention also provides evidence that D-type cyclins regulate gene expression in an RB-independent manner. Also included is DMP1, the transcription factor composed of a central DNA-binding domain containing three atypical myb repeats flanked by highly acidic segments located at its amino- and carboxyterminal ends. The invention includes amino acid sequences coding for DMP1, and DNA and RNA nucleotide sequences that encode the amino acid sequences. A use of DMP1 as a transcription factor is disclosed due to its specificity in binding to oligonucleotides containing the nonamer consensus sequence CCCG(G/T)ATGT. In this aspect of the invention, DMP1 when transfected into mammalian cells, activates the transcription of a reporter gene driven by a minimal promoter containing concatamerized DMP1 binding sites.

Abstract: This invention provides a growth inhibitor for leukemia cells comprising an antisense oligonucleotide derivative to Wilms' tumor gene (WT1).

Abstract: The invention provides a method of detecting solid cancer cells which comprises determining the level of expression of WT1 gene in a test tissue, a method of detecting the atypia of a tissue which comprises determining the level of expression of WT1 gene in the tissue, and a method of testing a graft material tissue for bone marrow or peripheral blood stem cell transplantation which comprises determining the level of expression of WT1 gene in a CD34− cell fraction of the tissue to detect leukemic cells and solid cancer cells in the tissue.

Abstract: The invention discloses a direct interaction between D-type cyclins and a novel myb-like transcription factor, DMP1, which specifically interacts with cyclin D2. The present invention also provides evidence that D-type cyclins regulate gene expression in an RB-independent manner. Also included is DMP1, the transcription factor composed of a central DNA-binding domain containing three atypical myb repeats flanked by highly acidic segments located at its amino- and carboxyterminal ends. The invention includes amino acid sequences coding for DMP1, and DNA and RNA nucleotide sequences that encode the amino acid sequences. A use of DMP1 as a transcription factor is disclosed due to its specificity in binding to oligonucleotides containing the nonamer consensus sequence CCCG(G/T)ATGT. In this aspect of the invention, DMP1 when transfected into mammalian cells, activates the transcription of a reporter gene driven by a minimal promoter containing concatamerized DMP1 binding sites.

Abstract: A sewing machine with multiple needles employs, for each needle, a needle bar guide in the shape of the letter “c” and cooperates with a projection. The needle bar guide holds a needle bar by passing the needle bar through holes formed at upper and lower positions of the needle bar guide. Therefore, when the projection is rotated in a boss, the needle bar guide is also rotated, and the end of the needle is oscillated. When the projection is moved back and forth in the boss, the end of the needle is also moved in the same manner. Consequently, a deviation in the relative position between a needle and a rotary hook caused by a slight difference in machining and assembly accuracy can be adjusted for every needle.

Abstract: This invention provides a growth inhibitor for leukemia cells comprising an antisense oligonucleotide derivative to Wilms' tumor gene (WT1).

Abstract: A programmable electronic sewing machine includes input means for supplying input data when operated by a user, and sewing program composing means for composing a sewing program for the sewing machine on the basis of the input data supplied from the input means. The sewing program composing means composes the same sewing program on the basis of the input data supplied from the input means when the input means is operated in two or more different operating procedures.

Abstract: A sewing machine system provided with an electronically controlled sewing machine and a programmer, which is electronically connected to the sewing machine, for creating a sewing data in cooperation with the sewing machine. A selecting switch is provided and, when sewing data is being created, a user can switch a display condition of a displaying device of the programmer between a first mode for displaying numerical data related to currently created sewing data, and a second mode for displaying an image of the pattern in accordance with the sewing data which is being created.

Abstract: A programmable electronic sewing machine includes sewing means for executing a sewing operation according to a predetermined program, program composing means for composing the program, displaying means for displaying a plurality of icons representative of commands used in composition of the program respectively, and input means for entering data used in composition of the program and for selecting a desired one of the icons displayed by the displaying means.

Abstract: Disclosed is a sewing machine system, including an electronically controlled sewing machine, and a data editing device. In a sewing machine, a plurality of sewing programs stored in a data recording medium are read, and image data indicative of a sewing pattern corresponding to each sewing program is generated. The image data is then transmitted to the data editing device. In the data editing device, a plurality of sewing patterns are displayed in accordance with the received image data. When one of the displayed sewing patterns is selected by an operator, a predetermined operation is applied to a sewing program corresponding to the selected sewing pattern.

Abstract: A programmable electronic sewing machine includes means for delivering a plurality of option output signals for controlling an optional device optionally provided for the sewing machine, a condition table storing sequentially arranged data of conditions including operating states of a plurality of operating sections of the sewing machine and a plurality of conditions including ON-states and OFF-states of the plurality of option output signals respectively, and programming means for selecting and setting at least one of the conditions stored in the condition table, thereby being capable of setting a condition for delivering each option output signal.

Abstract: A programmable electronic sewing machine includes sewing control means for controlling sections of the machine including a main shaft on the basis of a preset program so that a sewing operation is executed, rotational speed setting means for setting a rotational speed of the main shaft according to an amount of operation thereof, upper limit calculating means for calculating an upper limit settable as the rotational speed of the main shaft on the basis of the preset program, and displaying means for displaying the rotational speed of the main shaft currently set by the rotational speed setting means with the upper limit calculated by the upper limit calculating means serving as an upper limit of the displayed rotational speed.

Abstract: An apparatus for modifying sewing data to control a sewing machine including (a) a stitch-forming device for forming stitches on at least one work sheet, (b) a work-holding device for holding the work sheet, and (c) a displacing device for displacing at least one of the stitch-forming device and the work-holding device, relative to each other, according to the sewing data, the sewing machine having a prescribed coordinate system, the apparatus including a plurality of detectable objects located at a plurality of fixed positions spaced apart from each other on the work-holding device, respectively; a position detector which detects an actual position of each of the detectable objects in the prescribed coordinate system of the sewing machine; and a data modifying device for modifying the sewing data based on a difference of the detected actual position of the each of the detectable objects from a corresponding one of respective reference positions of the detectable objects in the prescribed coordinate system of

Abstract: A main-presser driving apparatus for an automatic binding sewing machine including two sewing needles for carrying out a binding sewing operation and a pair of main pressers for pressing a base cloth on which a binding cloth is to be sewn, the main pressers being supported by a frame of the sewing machine such that the two pressers are opposed to each other and are movable independently of each other along a directional line in which the two pressers advance toward, and retract away from, each other, the driving apparatus including a pair of drive devices each of which includes an actuator for displacing a corresponding one of the main pressers in the above-indicated direction independently of the other of the main pressers, each actuator being controllable to be stopped at a desired operational position; a needle distance specifying device specifying a distance between the two sewing needles; a control command producing device producing, based on the specified needle distance, a control command for each of t

Abstract: A feeding device for independently feeding, by a preparatory device, a binder strip and flap strips to a garment held by a base presses. There are eight types of combination in feeding fashions, whether or not the binder strip is to be fed, whether or not one flap strip is to be fed, and whether or not another flap strip is to be fed (2.sup.3 =8). Various feeding fashions are provisionally set in order prior to actual sewing, and control means controls actual operations of the preparatory device in accordance with the feeding fashions and every feeding fashions.